PMC:7323532 / 3125-4210 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7323532","sourcedb":"PMC","sourceid":"7323532","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7323532","text":"The patient’s condition worsened, and he had a PaO2/FIO2 ratio \u003c140 mm Hg with FIO2 of 100%. We performed a tracheal aspirate on day 4 and sent samples to the mycology laboratory. PCR for Aspergillus fumigatus was positive (430 copies/mL; 2.6 log), but galactomannan in the aspirate assay was negative, and culture on Sabouraud agar remained sterile. Results of testing of a second tracheal aspiration performed on day 9 yielded branched septate hyphae suggestive of Aspergillus sp. under microscopic examination after silver staining (Figure). A. fumigatus PCR was once again positive with a higher number of copies (3,600 copies/mL; 3.55 log); the galactomannan assay was not available. The patient died that day of severe respiratory failure. Culture on Sabouraud agar later grew a mold identified as A. fumigatus by mass spectrometry. Of note, SARS-CoV-2 RNA still was detectable in the tracheal aspirations. Results of serum analyses, including galactomannan index determination, β-D-glucan assay, and A. fumigatus PCR, were negative in serum samples collected on day 4 and day 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