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PMC:7321036 / 71-1121 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T2 27-38 NCBITaxon:11118 denotes coronavirus
T3 53-61 SP_7 denotes COVID-19
T4 73-85 SP_7 denotes severe acute
T5 86-97 SP_7;UBERON:0001004 denotes respiratory
T6 98-120 SP_7 denotes syndrome coronavirus 2
T7 122-132 SP_7 denotes SARS-CoV-2
T8 193-199 NCBITaxon:9606 denotes people
T9 354-364 SP_7 denotes SARS-CoV-2
T10 378-382 CL_6 denotes Vero
T11 452-457 NCBITaxon:10239 denotes viral
T12 468-478 SP_7 denotes SARS-CoV-2
T13 525-528 PR:000008220;GO:0000187 denotes p38
T14 529-533 GO:0000187;PR:000000103 denotes MAPK
T15 534-544 GO:0000187 denotes activation
T16 595-602 GO:0007067 denotes mitotic
T17 625-635 GO:0007050 denotes cell cycle
T18 749-754 NCBITaxon:10239 denotes viral
T19 779-784 CHEBI:23888;CHEBI:23888 denotes drugs
T20 789-798 CHEBI:36357;CHEBI:36357 denotes compounds
T21 861-873 GO:0065007 denotes dysregulated
T22 905-918 CHEBI:52217;CHEBI:52217 denotes pharmacologic
T23 937-940 PR:000008220 denotes p38
T24 1031-1039 SP_7 denotes COVID-19
T50663 27-38 NCBITaxon:11118 denotes coronavirus
T75055 53-61 SP_7 denotes COVID-19
T31809 73-85 SP_7 denotes severe acute
T78021 86-97 SP_7;UBERON:0001004 denotes respiratory
T59836 98-120 SP_7 denotes syndrome coronavirus 2
T17117 122-132 SP_7 denotes SARS-CoV-2
T85062 193-199 NCBITaxon:9606 denotes people
T78173 354-364 SP_7 denotes SARS-CoV-2
T61255 378-382 CL_6 denotes Vero
T10677 452-457 NCBITaxon:10239 denotes viral
T47649 468-478 SP_7 denotes SARS-CoV-2
T16084 525-528 PR:000008220;GO:0000187 denotes p38
T58882 529-533 GO:0000187;PR:000000103 denotes MAPK
T51337 534-544 GO:0000187 denotes activation
T21669 595-602 GO:0007067 denotes mitotic
T31315 625-635 GO:0007050 denotes cell cycle
T97490 749-754 NCBITaxon:10239 denotes viral
T33194 779-784 CHEBI:23888;CHEBI:23888 denotes drugs
T59691 789-798 CHEBI:36357;CHEBI:36357 denotes compounds
T77793 861-873 GO:0065007 denotes dysregulated
T44088 905-918 CHEBI:52217;CHEBI:52217 denotes pharmacologic
T2452 937-940 PR:000008220 denotes p38
T31032 1031-1039 SP_7 denotes COVID-19

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T68056 386-391 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T14003 458-466 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T64412 568-577 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T62262 625-629 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T3 27-51 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T4 53-61 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 73-120 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T6 73-106 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T7 122-130 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 354-362 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 365-374 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 468-476 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 479-488 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 644-653 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T13 1031-1039 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T31254 135-138 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T63961 287-288 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6044 378-391 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T65872 534-544 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T17477 625-629 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T7552 670-671 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 250-259 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T2 458-466 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T3 512-514 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T4 779-784 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T5 988-997 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3721 424-439 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T23088 529-544 http://purl.obolibrary.org/obo/GO_0000187 denotes MAPK activation
T80020 529-533 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T30030 625-642 http://purl.obolibrary.org/obo/GO_0007050 denotes cell cycle arrest
T24122 625-635 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T79650 741-748 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T37166 833-848 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
17 525-533 Gene denotes p38 MAPK Gene:26416
18 937-940 Gene denotes p38 Gene:5594
19 952-955 Gene denotes AXL Gene:558
20 73-120 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
21 122-132 Species denotes SARS-CoV-2 Tax:2697049
22 193-199 Species denotes people Tax:9606
23 27-51 Disease denotes coronavirus disease 2019 MESH:C000657245
24 53-61 Disease denotes COVID-19 MESH:C000657245
25 139-147 Disease denotes infected MESH:D007239
26 354-374 Disease denotes SARS-CoV-2 infection MESH:C000657245
27 468-488 Disease denotes SARS-CoV-2 infection MESH:C000657245
28 636-642 Disease denotes arrest MESH:D006323
29 644-653 Disease denotes Infection MESH:D007239
30 1031-1039 Disease denotes COVID-19 MESH:C000657245
31 383-385 CellLine denotes E6 CVCL:4582

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-270 Sentence denotes The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies.
T4 271-467 Sentence denotes Here we present a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins.
T5 468-643 Sentence denotes SARS-CoV-2 infection promoted casein kinase II (CK2) and p38 MAPK activation, production of diverse cytokines, and shutdown of mitotic kinases, resulting in cell cycle arrest.
T6 644-765 Sentence denotes Infection also stimulated a marked induction of CK2-containing filopodial protrusions possessing budding viral particles.
T7 766-895 Sentence denotes Eighty-seven drugs and compounds were identified by mapping global phosphorylation profiles to dysregulated kinases and pathways.
T8 896-1050 Sentence denotes We found pharmacologic inhibition of the p38, CK2, CDK, AXL, and PIKFYVE kinases to possess antiviral efficacy, representing potential COVID-19 therapies.