PMC:7321036 / 56725-57251 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T432","span":{"begin":49,"end":52},"obj":"Body_part"}],"attributes":[{"id":"A432","pred":"fma_id","subj":"T432","obj":"http://purl.org/sig/ont/fma/fma278683"}],"text":"Similar to successful antiretroviral therapy for HIV, a combinatorial drug cocktail may be a viable treatment option for SARS-CoV-2 infection. Specifically, combining remdesivir with the kinase inhibitors identified in this study as well as with translation inhibitors and/or modulators of sigma-1 receptor (Gordon et al., 2020) warrants further testing. Furthermore, pairing genetic and pharmacological perturbations in a systematic fashion could identify new combination therapy approaches and illuminate disease mechanisms."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T296","span":{"begin":121,"end":129},"obj":"Disease"},{"id":"T297","span":{"begin":132,"end":141},"obj":"Disease"}],"attributes":[{"id":"A296","pred":"mondo_id","subj":"T296","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A297","pred":"mondo_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Similar to successful antiretroviral therapy for HIV, a combinatorial drug cocktail may be a viable treatment option for SARS-CoV-2 infection. Specifically, combining remdesivir with the kinase inhibitors identified in this study as well as with translation inhibitors and/or modulators of sigma-1 receptor (Gordon et al., 2020) warrants further testing. Furthermore, pairing genetic and pharmacological perturbations in a systematic fashion could identify new combination therapy approaches and illuminate disease mechanisms."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T746","span":{"begin":54,"end":55},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T747","span":{"begin":91,"end":92},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T748","span":{"begin":346,"end":353},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T749","span":{"begin":421,"end":422},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Similar to successful antiretroviral therapy for HIV, a combinatorial drug cocktail may be a viable treatment option for SARS-CoV-2 infection. Specifically, combining remdesivir with the kinase inhibitors identified in this study as well as with translation inhibitors and/or modulators of sigma-1 receptor (Gordon et al., 2020) warrants further testing. Furthermore, pairing genetic and pharmacological perturbations in a systematic fashion could identify new combination therapy approaches and illuminate disease mechanisms."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T29073","span":{"begin":70,"end":74},"obj":"Chemical"},{"id":"T90047","span":{"begin":167,"end":177},"obj":"Chemical"},{"id":"T57071","span":{"begin":194,"end":204},"obj":"Chemical"},{"id":"T70316","span":{"begin":258,"end":268},"obj":"Chemical"}],"attributes":[{"id":"A85440","pred":"chebi_id","subj":"T29073","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A80277","pred":"chebi_id","subj":"T90047","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A9623","pred":"chebi_id","subj":"T57071","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A86680","pred":"chebi_id","subj":"T70316","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"Similar to successful antiretroviral therapy for HIV, a combinatorial drug cocktail may be a viable treatment option for SARS-CoV-2 infection. Specifically, combining remdesivir with the kinase inhibitors identified in this study as well as with translation inhibitors and/or modulators of sigma-1 receptor (Gordon et al., 2020) warrants further testing. Furthermore, pairing genetic and pharmacological perturbations in a systematic fashion could identify new combination therapy approaches and illuminate disease mechanisms."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T423","span":{"begin":187,"end":204},"obj":"http://purl.obolibrary.org/obo/GO_0033673"},{"id":"T424","span":{"begin":246,"end":257},"obj":"http://purl.obolibrary.org/obo/GO_0006412"}],"text":"Similar to successful antiretroviral therapy for HIV, a combinatorial drug cocktail may be a viable treatment option for SARS-CoV-2 infection. Specifically, combining remdesivir with the kinase inhibitors identified in this study as well as with translation inhibitors and/or modulators of sigma-1 receptor (Gordon et al., 2020) warrants further testing. Furthermore, pairing genetic and pharmacological perturbations in a systematic fashion could identify new combination therapy approaches and illuminate disease mechanisms."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1278","span":{"begin":167,"end":177},"obj":"Chemical"},{"id":"1279","span":{"begin":121,"end":141},"obj":"Disease"}],"attributes":[{"id":"A1278","pred":"tao:has_database_id","subj":"1278","obj":"MESH:C000606551"},{"id":"A1279","pred":"tao:has_database_id","subj":"1279","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Similar to successful antiretroviral therapy for HIV, a combinatorial drug cocktail may be a viable treatment option for SARS-CoV-2 infection. Specifically, combining remdesivir with the kinase inhibitors identified in this study as well as with translation inhibitors and/or modulators of sigma-1 receptor (Gordon et al., 2020) warrants further testing. Furthermore, pairing genetic and pharmacological perturbations in a systematic fashion could identify new combination therapy approaches and illuminate disease mechanisms."}

{"project":"LitCovid-sentences","denotations":[{"id":"T366","span":{"begin":0,"end":142},"obj":"Sentence"},{"id":"T367","span":{"begin":143,"end":354},"obj":"Sentence"},{"id":"T368","span":{"begin":355,"end":526},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Similar to successful antiretroviral therapy for HIV, a combinatorial drug cocktail may be a viable treatment option for SARS-CoV-2 infection. Specifically, combining remdesivir with the kinase inhibitors identified in this study as well as with translation inhibitors and/or modulators of sigma-1 receptor (Gordon et al., 2020) warrants further testing. Furthermore, pairing genetic and pharmacological perturbations in a systematic fashion could identify new combination therapy approaches and illuminate disease mechanisms."}