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PMC:7321036 / 55833-56724 JSONTXT

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LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T286 69-83 Disease denotes ovarian cancer http://purl.obolibrary.org/obo/MONDO_0008170
T287 77-83 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T288 168-182 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T289 272-294 Disease denotes acute myeloid leukemia http://purl.obolibrary.org/obo/MONDO_0015667|http://purl.obolibrary.org/obo/MONDO_0018874
T291 278-294 Disease denotes myeloid leukemia http://purl.obolibrary.org/obo/MONDO_0004643
T292 286-294 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T293 379-387 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T294 870-878 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T295 881-890 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T739 198-206 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T740 473-482 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T741 659-668 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T742 680-681 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T743 701-704 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T744 723-724 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T745 809-810 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T33558 188-197 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T5587 220-232 Chemical denotes gilteritinib http://purl.obolibrary.org/obo/CHEBI_145372
T16731 250-254 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T55232 335-348 Chemical denotes AXL inhibitor http://purl.obolibrary.org/obo/CHEBI_62434
T55122 339-348 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T58497 690-699 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T21382 746-755 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T416 459-491 http://purl.obolibrary.org/obo/GO_0035556 denotes intracellular signaling pathways
T417 473-482 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T418 559-563 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T419 659-668 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T420 824-853 http://purl.obolibrary.org/obo/GO_0042325 denotes regulation by phosphorylation
T421 824-834 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T422 838-853 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T12 69-83 Phenotype denotes ovarian cancer http://purl.obolibrary.org/obo/HP_0100615
T13 168-182 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T14 272-294 Phenotype denotes acute myeloid leukemia http://purl.obolibrary.org/obo/HP_0004808

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1261 335-338 Gene denotes AXL Gene:558
1262 426-429 Gene denotes AXL Gene:558
1263 554-557 Gene denotes ERK Gene:5594
1264 569-572 Gene denotes p38 Gene:5594
1265 595-598 Gene denotes AXL Gene:558
1266 655-658 Gene denotes p38 Gene:5594
1267 0-11 Chemical denotes Ralimetinib
1268 220-232 Chemical denotes gilteritinib MESH:C000609080
1269 350-361 Chemical denotes bencentinib
1270 670-678 Chemical denotes Apilimod MESH:C504227
1271 69-83 Disease denotes ovarian cancer MESH:D010051
1272 168-182 Disease denotes cardiomyopathy MESH:D009202
1273 272-294 Disease denotes acute myeloid leukemia MESH:D015470
1274 379-387 Disease denotes COVID-19 MESH:C000657245
1275 870-890 Disease denotes SARS-CoV-2 infection MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T361 0-183 Sentence denotes Ralimetinib is currently in phase 2 clinical trials for treatment of ovarian cancer (Patnaik et al., 2016), and ARRY-797 is in phase 3 clinical trials for treatment of cardiomyopathy.
T362 184-425 Sentence denotes The antiviral activity observed for gilteritinib, an FDA-approved drug for treatment of acute myeloid leukemia, is supported by involvement of another AXL inhibitor, bencentinib, in the RECOVERY COVID-19 clinical trial in the United Kingdom.
T363 426-669 Sentence denotes AXL is known to regulate various intracellular signaling pathways (Allen et al., 2002; Hafizi and Dahlbäck 2006), including Ras/ERK, PI3K, and p38 (Allen et al., 2002); AXL inhibition here may contribute to the downregulation of p38 signaling.
T364 670-783 Sentence denotes Apilimod, a PIKFYVE inhibitor, has been described in a recent study to have antiviral capacity (Ou et al., 2020).
T365 784-891 Sentence denotes Here we expand this into a mechanism of regulation by phosphorylation of PIKFYVE upon SARS-CoV-2 infection.

2_test

Id Subject Object Predicate Lexical cue
32645325-26581242-20773093 101-105 26581242 denotes 2016
32645325-11756555-20773094 507-511 11756555 denotes 2002
32645325-16737840-20773095 533-537 16737840 denotes 2006
32645325-11756555-20773096 588-592 11756555 denotes 2002
32645325-32221306-20773097 777-781 32221306 denotes 2020