PMC:7321036 / 48606-48982 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7321036","sourcedb":"PMC","sourceid":"7321036","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7321036","text":"Potent antiviral activity was observed for gilteritinib (Figure 7E; IC50 = 0.807 μM), an inhibitor of AXL kinase, upstream of p38; ralimetinib (Figure 7F; IC50 = 0.873 μM), an inhibitor of MAPK11 (p38ɑ) and MAPK14 (p38β); MAPK13-IN-1 (Figure 7G; IC50 = 4.63 μM), an inhibitor of MAPK13 (p38-δ); and ARRY-797 (Figure 7H; IC50 = 0.913 μM) in A549-ACE2 cells, a MAPK14 inhibitor.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T384","span":{"begin":350,"end":355},"obj":"Body_part"}],"attributes":[{"id":"A384","pred":"fma_id","subj":"T384","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T384","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T618","span":{"begin":17,"end":25},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T619","span":{"begin":340,"end":344},"obj":"http://purl.obolibrary.org/obo/CLO_0001601"},{"id":"T620","span":{"begin":340,"end":344},"obj":"http://purl.obolibrary.org/obo/CLO_0050025"},{"id":"T621","span":{"begin":340,"end":344},"obj":"http://purl.obolibrary.org/obo/CLO_0054264"},{"id":"T622","span":{"begin":340,"end":344},"obj":"http://purl.obolibrary.org/obo/CLO_0054265"},{"id":"T623","span":{"begin":340,"end":344},"obj":"http://purl.obolibrary.org/obo/CLO_0054266"},{"id":"T624","span":{"begin":340,"end":344},"obj":"http://purl.obolibrary.org/obo/CLO_0054267"},{"id":"T625","span":{"begin":340,"end":344},"obj":"http://purl.obolibrary.org/obo/CLO_0054268"},{"id":"T626","span":{"begin":340,"end":344},"obj":"http://purl.obolibrary.org/obo/CLO_0054269"},{"id":"T627","span":{"begin":350,"end":355},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T628","span":{"begin":357,"end":358},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T618","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T619","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T620","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T621","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T622","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T623","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T624","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T625","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T626","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T627","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T628","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T349","span":{"begin":7,"end":16},"obj":"Chemical"},{"id":"T350","span":{"begin":43,"end":55},"obj":"Chemical"},{"id":"T351","span":{"begin":89,"end":98},"obj":"Chemical"},{"id":"T352","span":{"begin":176,"end":185},"obj":"Chemical"},{"id":"T353","span":{"begin":266,"end":275},"obj":"Chemical"},{"id":"T354","span":{"begin":366,"end":375},"obj":"Chemical"}],"attributes":[{"id":"A349","pred":"chebi_id","subj":"T349","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A350","pred":"chebi_id","subj":"T350","obj":"http://purl.obolibrary.org/obo/CHEBI_145372"},{"id":"A351","pred":"chebi_id","subj":"T351","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A352","pred":"chebi_id","subj":"T352","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A353","pred":"chebi_id","subj":"T353","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A354","pred":"chebi_id","subj":"T354","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"subj":"T349","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T350","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T351","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T352","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T353","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T354","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1069","span":{"begin":102,"end":105},"obj":"Gene"},{"id":"1070","span":{"begin":126,"end":129},"obj":"Gene"},{"id":"1071","span":{"begin":189,"end":195},"obj":"Gene"},{"id":"1072","span":{"begin":197,"end":201},"obj":"Gene"},{"id":"1073","span":{"begin":207,"end":213},"obj":"Gene"},{"id":"1074","span":{"begin":215,"end":219},"obj":"Gene"},{"id":"1075","span":{"begin":222,"end":228},"obj":"Gene"},{"id":"1076","span":{"begin":279,"end":285},"obj":"Gene"},{"id":"1077","span":{"begin":287,"end":292},"obj":"Gene"},{"id":"1078","span":{"begin":359,"end":365},"obj":"Gene"},{"id":"1090","span":{"begin":340,"end":349},"obj":"CellLine"}],"attributes":[{"id":"A1069","pred":"tao:has_database_id","subj":"1069","obj":"Gene:558"},{"id":"A1070","pred":"tao:has_database_id","subj":"1070","obj":"Gene:5594"},{"id":"A1071","pred":"tao:has_database_id","subj":"1071","obj":"Gene:5600"},{"id":"A1072","pred":"tao:has_database_id","subj":"1072","obj":"Gene:1432"},{"id":"A1073","pred":"tao:has_database_id","subj":"1073","obj":"Gene:1432"},{"id":"A1074","pred":"tao:has_database_id","subj":"1074","obj":"Gene:5600"},{"id":"A1075","pred":"tao:has_database_id","subj":"1075","obj":"Gene:5603"},{"id":"A1076","pred":"tao:has_database_id","subj":"1076","obj":"Gene:5603"},{"id":"A1077","pred":"tao:has_database_id","subj":"1077","obj":"Gene:5603"},{"id":"A1078","pred":"tao:has_database_id","subj":"1078","obj":"Gene:1432"},{"id":"A1090","pred":"tao:has_database_id","subj":"1090","obj":"CVCL:0023"},{"subj":"1069","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1070","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1071","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1072","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1073","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1074","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1075","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1076","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1077","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1078","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1090","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T324","span":{"begin":0,"end":376},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T324","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecb7","default":true},{"id":"LitCovid-PD-CLO","color":"#ec9d93"},{"id":"LitCovid-PD-CHEBI","color":"#93a3ec"},{"id":"LitCovid-PubTator","color":"#bdec93"},{"id":"LitCovid-sentences","color":"#ec93d7"}]}]}}