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PMC:7321036 / 45571-47325 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T367 285-290 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T368 449-457 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T369 489-493 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T370 573-578 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T371 662-669 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T372 983-988 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T373 1164-1168 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T374 1169-1185 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T375 1180-1185 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T376 1287-1290 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T377 1466-1470 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T378 1613-1618 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T16 1164-1168 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T223 67-75 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T224 175-183 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T225 186-195 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T226 355-363 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T227 366-375 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T228 1128-1136 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T229 1139-1148 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T230 1243-1251 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T231 1254-1263 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T232 1378-1386 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T233 1713-1721 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T234 1724-1733 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T556 89-90 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T557 149-157 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T558 274-275 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T559 277-290 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T560 380-382 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T561 446-448 http://purl.obolibrary.org/obo/CLO_0008192 denotes NP
T562 489-493 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T563 561-562 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T564 565-578 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T565 727-728 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T566 795-803 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T567 816-825 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T568 971-972 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T569 975-988 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T570 1154-1158 http://purl.obolibrary.org/obo/CLO_0001601 denotes A549
T571 1154-1158 http://purl.obolibrary.org/obo/CLO_0050025 denotes A549
T572 1154-1158 http://purl.obolibrary.org/obo/CLO_0054264 denotes A549
T573 1154-1158 http://purl.obolibrary.org/obo/CLO_0054265 denotes A549
T574 1154-1158 http://purl.obolibrary.org/obo/CLO_0054266 denotes A549
T575 1154-1158 http://purl.obolibrary.org/obo/CLO_0054267 denotes A549
T576 1154-1158 http://purl.obolibrary.org/obo/CLO_0054268 denotes A549
T577 1154-1158 http://purl.obolibrary.org/obo/CLO_0054269 denotes A549
T578 1164-1185 http://purl.obolibrary.org/obo/CL_0000082 denotes lung epithelial cells
T579 1324-1329 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T580 1333-1337 http://purl.obolibrary.org/obo/CLO_0001601 denotes A549
T581 1333-1337 http://purl.obolibrary.org/obo/CLO_0050025 denotes A549
T582 1333-1337 http://purl.obolibrary.org/obo/CLO_0054264 denotes A549
T583 1333-1337 http://purl.obolibrary.org/obo/CLO_0054265 denotes A549
T584 1333-1337 http://purl.obolibrary.org/obo/CLO_0054266 denotes A549
T585 1333-1337 http://purl.obolibrary.org/obo/CLO_0054267 denotes A549
T586 1333-1337 http://purl.obolibrary.org/obo/CLO_0054268 denotes A549
T587 1333-1337 http://purl.obolibrary.org/obo/CLO_0054269 denotes A549
T588 1352-1353 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T589 1466-1470 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T590 1592-1596 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T591 1592-1596 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T592 1603-1607 http://purl.obolibrary.org/obo/CLO_0001601 denotes A549
T593 1603-1607 http://purl.obolibrary.org/obo/CLO_0050025 denotes A549
T594 1603-1607 http://purl.obolibrary.org/obo/CLO_0054264 denotes A549
T595 1603-1607 http://purl.obolibrary.org/obo/CLO_0054265 denotes A549
T596 1603-1607 http://purl.obolibrary.org/obo/CLO_0054266 denotes A549
T597 1603-1607 http://purl.obolibrary.org/obo/CLO_0054267 denotes A549
T598 1603-1607 http://purl.obolibrary.org/obo/CLO_0054268 denotes A549
T599 1603-1607 http://purl.obolibrary.org/obo/CLO_0054269 denotes A549
T600 1613-1618 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T313 99-109 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T314 258-262 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T315 308-318 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T316 425-429 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T317 446-448 Chemical denotes NP http://purl.obolibrary.org/obo/CHEBI_50803|http://purl.obolibrary.org/obo/CHEBI_53793|http://purl.obolibrary.org/obo/CHEBI_73425
T320 546-548 Chemical denotes SD http://purl.obolibrary.org/obo/CHEBI_74807
T321 605-614 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T322 662-669 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T323 838-843 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T324 943-955 Chemical denotes gilteritinib http://purl.obolibrary.org/obo/CHEBI_145372
T325 1006-1019 Chemical denotes AXL inhibitor http://purl.obolibrary.org/obo/CHEBI_62434
T326 1010-1019 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T327 1020-1032 Chemical denotes gilteritinib http://purl.obolibrary.org/obo/CHEBI_145372
T328 1052-1061 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T329 1093-1102 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T330 1215-1224 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T331 1645-1654 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T332 1675-1688 Chemical denotes CDK inhibitor http://purl.obolibrary.org/obo/CHEBI_82665
T333 1679-1688 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T324 38-55 http://purl.obolibrary.org/obo/GO_0033673 denotes Kinase Inhibitors
T325 92-109 http://purl.obolibrary.org/obo/GO_0033673 denotes Kinase inhibitors
T326 788-803 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activity
T327 816-833 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T328 816-825 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T329 1389-1406 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T330 1389-1406 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T331 1675-1688 http://purl.obolibrary.org/obo/GO_0004861 denotes CDK inhibitor

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
929 67-77 Species denotes SARS-CoV-2 Tax:2697049
931 175-195 Disease denotes SARS-CoV-2 infection MESH:C000657245
935 308-318 Chemical denotes remdesivir MESH:C000606551
936 355-375 Disease denotes SARS-CoV-2 infection MESH:C000657245
937 282-284 CellLine denotes E6 CVCL:4582
942 678-685 Gene denotes CSNK2A2 Gene:1459
943 660-661 Gene denotes N Gene:43740575
944 615-628 Chemical denotes silmitasertib
945 570-572 CellLine denotes E6 CVCL:4582
950 812-815 Gene denotes p38 Gene:5594
951 894-900 Gene denotes MAPK13 Gene:5603
952 881-892 Chemical denotes ralimetinib
953 943-955 Chemical denotes gilteritinib MESH:C000609080
962 1006-1009 Gene denotes AXL Gene:103234725
963 1042-1051 Gene denotes MAPK11/14 Gene:103223551
964 1086-1092 Gene denotes MAPK13 Gene:103221595
965 1103-1109 Gene denotes MAPK13 Gene:103221595
966 1020-1032 Chemical denotes gilteritinib MESH:C000609080
967 1062-1073 Chemical denotes ralimetinib
968 1128-1148 Disease denotes SARS-CoV-2 infection MESH:C000657245
969 980-982 CellLine denotes E6 CVCL:4582
975 1159-1163 Gene denotes ACE2 Gene:59272
976 1208-1214 Gene denotes MAPK14 Gene:1432
977 1225-1233 Chemical denotes ARRY-797 MESH:C000592910
978 1243-1263 Disease denotes SARS-CoV-2 infection MESH:C000657245
979 1154-1158 CellLine denotes A549 CVCL:0023
985 1312-1315 Gene denotes p38 Gene:5594
986 1338-1342 Gene denotes ACE2 Gene:59272
987 1490-1494 Gene denotes ACE2 Gene:59272
988 1378-1388 Species denotes SARS-CoV-2 Tax:2697049
989 1333-1337 CellLine denotes A549 CVCL:0023
994 1689-1699 Chemical denotes dinaciclib MESH:C553669
995 1713-1733 Disease denotes SARS-CoV-2 infection MESH:C000657245
996 1597-1599 CellLine denotes E6 CVCL:4582
997 1603-1612 CellLine denotes A549-ACE2 CVCL:0023
999 1751-1753 Gene denotes S6

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T300 0-87 Sentence denotes Figure 7 Mapping Regulated Kinases to Kinase Inhibitors Identifies SARS-CoV-2 Therapies
T301 88-196 Sentence denotes (A) Kinase inhibitors (left) mapped to kinases (right) whose activity was regulated by SARS-CoV-2 infection.
T302 197-272 Sentence denotes Lines connecting them indicate known kinase targets for each drug/compound.
T303 273-385 Sentence denotes (B) Vero E6 cells pre-treated with remdesivir at the indicated doses, followed by SARS-CoV-2 infection for 48 h.
T304 386-524 Sentence denotes Percent viral titer compared with mock drug treatment (anti-NP antibody; red line, dots, and text) and cell viability (black) is depicted.
T305 525-549 Sentence denotes Error bars represent SD.
T306 550-564 Sentence denotes (C) As in (B).
T307 565-629 Sentence denotes Vero E6 cells were treated with the CK2 inhibitor silmitasertib.
T308 630-763 Sentence denotes Physical interactions between N protein and the CSNK2A2 and CSNK2B CK2 subunits were observed in a prior study (Gordon et al., 2020).
T309 764-957 Sentence denotes (D) Predicted increased kinase activity for the p38 signaling pathway and drugs/compounds targeting pathway members (ralimetinib, MAPK13-IN-1, and ARRY-797) and upstream drivers (gilteritinib).
T310 958-974 Sentence denotes (E–G) As in (B).
T311 975-1149 Sentence denotes Vero E6 cells treated with the AXL inhibitor gilteritinib (E), the MAPK11/14 inhibitor ralimetinib (F), or the MAPK13 inhibitor MAPK13-IN-1 (G) prior to SARS-CoV-2 infection.
T312 1150-1264 Sentence denotes (H) A549-ACE2 lung epithelial cells were treated with the MAPK14 inhibitor ARRY-797 prior to SARS-CoV-2 infection.
T313 1265-1489 Sentence denotes (I) Small interfering RNA (siRNA) knockdown of p38 pathway genes in A549-ACE2 leads to a significant decrease in SARS-CoV-2 viral replication (red), as assessed by qRT-PCR in the absence of effects on cell viability (black).
T314 1490-1581 Sentence denotes ACE2 and non-targeting siRNAs are included as positive and negative controls, respectively.
T315 1582-1734 Sentence denotes (J and K) Vero E6 or A549-ACE2 cells were treated with PIKFYVE inhibitor apilimod (J) or the CDK inhibitor dinaciclib (K) prior to SARS-CoV-2 infection.
T316 1735-1754 Sentence denotes See also Figure S6.