PMC:7321036 / 37347-37611 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T293","span":{"begin":27,"end":34},"obj":"Body_part"},{"id":"T294","span":{"begin":213,"end":217},"obj":"Body_part"},{"id":"T295","span":{"begin":228,"end":233},"obj":"Body_part"}],"attributes":[{"id":"A293","pred":"fma_id","subj":"T293","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A294","pred":"fma_id","subj":"T294","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A295","pred":"fma_id","subj":"T295","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"P response element-binding protein (CREB) and phospho-ATF-1 at their respective MAPKAPK2 sites (S133 in both) confirmed activation of the p38/MAPK pathway during SARS-CoV-2 infection in ACE2-expressing A549 human lung carcinoma cells (ACE2-A549) (Figure 6C). Furth"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T13","span":{"begin":213,"end":217},"obj":"Body_part"}],"attributes":[{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"P response element-binding protein (CREB) and phospho-ATF-1 at their respective MAPKAPK2 sites (S133 in both) confirmed activation of the p38/MAPK pathway during SARS-CoV-2 infection in ACE2-expressing A549 human lung carcinoma cells (ACE2-A549) (Figure 6C). Furth"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T166","span":{"begin":162,"end":170},"obj":"Disease"},{"id":"T167","span":{"begin":173,"end":182},"obj":"Disease"},{"id":"T168","span":{"begin":213,"end":227},"obj":"Disease"},{"id":"T169","span":{"begin":218,"end":227},"obj":"Disease"}],"attributes":[{"id":"A166","pred":"mondo_id","subj":"T166","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A167","pred":"mondo_id","subj":"T167","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A168","pred":"mondo_id","subj":"T168","obj":"http://purl.obolibrary.org/obo/MONDO_0005138"},{"id":"A169","pred":"mondo_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/MONDO_0004993"}],"text":"P response element-binding protein (CREB) and phospho-ATF-1 at their respective MAPKAPK2 sites (S133 in both) confirmed activation of the p38/MAPK pathway during SARS-CoV-2 infection in ACE2-expressing A549 human lung carcinoma cells (ACE2-A549) (Figure 6C). Furth"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T345","span":{"begin":58,"end":62},"obj":"http://purl.obolibrary.org/obo/CLO_0001757"},{"id":"T346","span":{"begin":120,"end":130},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T347","span":{"begin":202,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0001601"},{"id":"T348","span":{"begin":202,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0050025"},{"id":"T349","span":{"begin":202,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0054264"},{"id":"T350","span":{"begin":202,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0054265"},{"id":"T351","span":{"begin":202,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0054266"},{"id":"T352","span":{"begin":202,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0054267"},{"id":"T353","span":{"begin":202,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0054268"},{"id":"T354","span":{"begin":202,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0054269"},{"id":"T355","span":{"begin":207,"end":212},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T356","span":{"begin":213,"end":217},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T357","span":{"begin":213,"end":217},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T358","span":{"begin":228,"end":233},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T359","span":{"begin":240,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0001601"},{"id":"T360","span":{"begin":240,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0050025"},{"id":"T361","span":{"begin":240,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0054264"},{"id":"T362","span":{"begin":240,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0054265"},{"id":"T363","span":{"begin":240,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0054266"},{"id":"T364","span":{"begin":240,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0054267"},{"id":"T365","span":{"begin":240,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0054268"},{"id":"T366","span":{"begin":240,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0054269"}],"text":"P response element-binding protein (CREB) and phospho-ATF-1 at their respective MAPKAPK2 sites (S133 in both) confirmed activation of the p38/MAPK pathway during SARS-CoV-2 infection in ACE2-expressing A549 human lung carcinoma cells (ACE2-A549) (Figure 6C). Furth"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T248","span":{"begin":27,"end":34},"obj":"Chemical"},{"id":"T249","span":{"begin":46,"end":53},"obj":"Chemical"},{"id":"T250","span":{"begin":254,"end":256},"obj":"Chemical"}],"attributes":[{"id":"A248","pred":"chebi_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A249","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_48108"},{"id":"A250","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_27594"}],"text":"P response element-binding protein (CREB) and phospho-ATF-1 at their respective MAPKAPK2 sites (S133 in both) confirmed activation of the p38/MAPK pathway during SARS-CoV-2 infection in ACE2-expressing A549 human lung carcinoma cells (ACE2-A549) (Figure 6C). Furth"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T242","span":{"begin":142,"end":146},"obj":"http://purl.obolibrary.org/obo/GO_0004707"}],"text":"P response element-binding protein (CREB) and phospho-ATF-1 at their respective MAPKAPK2 sites (S133 in both) confirmed activation of the p38/MAPK pathway during SARS-CoV-2 infection in ACE2-expressing A549 human lung carcinoma cells (ACE2-A549) (Figure 6C). Furth"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T5","span":{"begin":218,"end":227},"obj":"Phenotype"}],"attributes":[{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0030731"}],"text":"P response element-binding protein (CREB) and phospho-ATF-1 at their respective MAPKAPK2 sites (S133 in both) confirmed activation of the p38/MAPK pathway during SARS-CoV-2 infection in ACE2-expressing A549 human lung carcinoma cells (ACE2-A549) (Figure 6C). Furth"}

{"project":"LitCovid-PubTator","denotations":[{"id":"746","span":{"begin":36,"end":40},"obj":"Gene"},{"id":"747","span":{"begin":54,"end":59},"obj":"Gene"},{"id":"748","span":{"begin":80,"end":88},"obj":"Gene"},{"id":"749","span":{"begin":138,"end":141},"obj":"Gene"},{"id":"750","span":{"begin":186,"end":190},"obj":"Gene"},{"id":"751","span":{"begin":235,"end":239},"obj":"Gene"},{"id":"760","span":{"begin":207,"end":212},"obj":"Species"},{"id":"762","span":{"begin":162,"end":182},"obj":"Disease"},{"id":"763","span":{"begin":213,"end":227},"obj":"Disease"},{"id":"766","span":{"begin":202,"end":206},"obj":"CellLine"},{"id":"767","span":{"begin":240,"end":244},"obj":"CellLine"}],"attributes":[{"id":"A746","pred":"tao:has_database_id","subj":"746","obj":"Gene:1385"},{"id":"A747","pred":"tao:has_database_id","subj":"747","obj":"Gene:466"},{"id":"A748","pred":"tao:has_database_id","subj":"748","obj":"Gene:9261"},{"id":"A749","pred":"tao:has_database_id","subj":"749","obj":"Gene:5594"},{"id":"A750","pred":"tao:has_database_id","subj":"750","obj":"Gene:59272"},{"id":"A751","pred":"tao:has_database_id","subj":"751","obj":"Gene:59272"},{"id":"A760","pred":"tao:has_database_id","subj":"760","obj":"Tax:9606"},{"id":"A762","pred":"tao:has_database_id","subj":"762","obj":"MESH:C000657245"},{"id":"A763","pred":"tao:has_database_id","subj":"763","obj":"MESH:D008175"},{"id":"A766","pred":"tao:has_database_id","subj":"766","obj":"CVCL:0023"},{"id":"A767","pred":"tao:has_database_id","subj":"767","obj":"CVCL:0023"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"P response element-binding protein (CREB) and phospho-ATF-1 at their respective MAPKAPK2 sites (S133 in both) confirmed activation of the p38/MAPK pathway during SARS-CoV-2 infection in ACE2-expressing A549 human lung carcinoma cells (ACE2-A549) (Figure 6C). Furth"}