PMC:7321036 / 32253-33827
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T249 | 32-40 | Body_part | denotes | Proteins | http://purl.org/sig/ont/fma/fma67257 |
| T250 | 44-49 | Body_part | denotes | Actin | http://purl.org/sig/ont/fma/fma67843 |
| T251 | 351-356 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T252 | 436-443 | Body_part | denotes | F-actin | http://purl.org/sig/ont/fma/fma67844 |
| T253 | 450-457 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T254 | 513-520 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T255 | 725-730 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T256 | 806-811 | Body_part | denotes | actin | http://purl.org/sig/ont/fma/fma67843 |
| T257 | 920-925 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T258 | 1006-1013 | Body_part | denotes | F-actin | http://purl.org/sig/ont/fma/fma67844 |
| T259 | 1017-1024 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T260 | 1244-1251 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T261 | 1279-1284 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T262 | 1319-1326 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T263 | 1520-1524 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T11 | 551-554 | Body_part | denotes | tip | http://purl.obolibrary.org/obo/UBERON_2001840 |
| T12 | 819-822 | Body_part | denotes | tip | http://purl.obolibrary.org/obo/UBERON_2001840 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T145 | 95-103 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T146 | 371-379 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T147 | 745-753 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T148 | 940-948 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T149 | 1488-1496 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T261 | 63-64 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T262 | 208-216 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T263 | 261-269 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T264 | 272-273 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T265 | 307-315 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T266 | 336-337 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T267 | 344-350 | http://purl.obolibrary.org/obo/CLO_0002172 | denotes | Caco-2 |
| T268 | 344-350 | http://purl.obolibrary.org/obo/CLO_0051943 | denotes | Caco-2 |
| T269 | 344-350 | http://purl.obolibrary.org/obo/CLO_0051958 | denotes | Caco-2 |
| T270 | 344-350 | http://purl.obolibrary.org/obo/CLO_0051960 | denotes | Caco-2 |
| T271 | 351-356 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T272 | 482-483 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T273 | 718-724 | http://purl.obolibrary.org/obo/CLO_0002172 | denotes | Caco-2 |
| T274 | 718-724 | http://purl.obolibrary.org/obo/CLO_0051943 | denotes | Caco-2 |
| T275 | 718-724 | http://purl.obolibrary.org/obo/CLO_0051958 | denotes | Caco-2 |
| T276 | 718-724 | http://purl.obolibrary.org/obo/CLO_0051960 | denotes | Caco-2 |
| T277 | 725-730 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T278 | 879-886 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T279 | 903-907 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
| T280 | 913-919 | http://purl.obolibrary.org/obo/CLO_0002172 | denotes | Caco-2 |
| T281 | 913-919 | http://purl.obolibrary.org/obo/CLO_0051943 | denotes | Caco-2 |
| T282 | 913-919 | http://purl.obolibrary.org/obo/CLO_0051958 | denotes | Caco-2 |
| T283 | 913-919 | http://purl.obolibrary.org/obo/CLO_0051960 | denotes | Caco-2 |
| T284 | 920-925 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T285 | 1272-1278 | http://purl.obolibrary.org/obo/CLO_0002172 | denotes | Caco-2 |
| T286 | 1272-1278 | http://purl.obolibrary.org/obo/CLO_0051943 | denotes | Caco-2 |
| T287 | 1272-1278 | http://purl.obolibrary.org/obo/CLO_0051958 | denotes | Caco-2 |
| T288 | 1272-1278 | http://purl.obolibrary.org/obo/CLO_0051960 | denotes | Caco-2 |
| T289 | 1279-1284 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T290 | 1512-1524 | http://purl.obolibrary.org/obo/CLO_0051719 | denotes | Vero E6 cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T208 | 66-73 | Chemical | denotes | Pathway | http://purl.obolibrary.org/obo/CHEBI_34922 |
| T209 | 450-457 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T210 | 513-520 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T211 | 863-865 | Chemical | denotes | SD | http://purl.obolibrary.org/obo/CHEBI_74807 |
| T212 | 1017-1024 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T213 | 1044-1046 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T214 | 1244-1251 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T215 | 1319-1326 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T216 | 1390-1392 | Chemical | denotes | SD | http://purl.obolibrary.org/obo/CHEBI_74807 |
| T217 | 1413-1421 | Chemical | denotes | electron | http://purl.obolibrary.org/obo/CHEBI_10545 |
| T218 | 1454-1462 | Chemical | denotes | electron | http://purl.obolibrary.org/obo/CHEBI_10545 |
| T219 | 1571-1573 | Chemical | denotes | S3 | http://purl.obolibrary.org/obo/CHEBI_29388 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T218 | 275-285 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | Regulation |
| T219 | 300-315 | http://purl.obolibrary.org/obo/GO_0016301 | denotes | kinase activity |
| T220 | 513-533 | http://purl.obolibrary.org/obo/GO_0008104 | denotes | protein localization |
| T221 | 521-533 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localization |
| T222 | 1499-1506 | http://purl.obolibrary.org/obo/GO_0007114 | denotes | budding |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 505 | 95-105 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 511 | 448-449 | Gene | denotes | M | Gene:43740571 |
| 512 | 511-512 | Gene | denotes | M | Gene:43740571 |
| 513 | 371-381 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 514 | 357-365 | Disease | denotes | infected | MESH:D007239 |
| 515 | 344-350 | CellLine | denotes | Caco-2 | CVCL:0025 |
| 519 | 745-755 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 520 | 709-717 | Disease | denotes | infected | MESH:D007239 |
| 521 | 718-724 | CellLine | denotes | Caco-2 | CVCL:0025 |
| 526 | 1015-1016 | Gene | denotes | N | Gene:43740575 |
| 527 | 940-950 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 528 | 926-934 | Disease | denotes | infected | MESH:D007239 |
| 529 | 913-919 | CellLine | denotes | Caco-2 | CVCL:0025 |
| 532 | 1263-1271 | Disease | denotes | infected | MESH:D007239 |
| 533 | 1272-1278 | CellLine | denotes | Caco-2 | CVCL:0025 |
| 536 | 1488-1498 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 537 | 1517-1519 | CellLine | denotes | E6 | CVCL:4582 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T207 | 62-167 | Sentence | denotes | (A) Pathway of regulated PHs and SARS-CoV-2 interaction partners involved in cytoskeletal reorganization. |
| T208 | 168-270 | Sentence | denotes | Dashed lines indicate downregulation of activity, while solid lines indicate upregulation of activity. |
| T209 | 271-339 | Sentence | denotes | (B) Regulation of individual kinase activity or PHs depicted in (A). |
| T210 | 340-472 | Sentence | denotes | (C) Caco-2 cells infected with SARS-CoV-2 at an MOI of 0.1 for 24 h prior to immunostaining for F-actin and M protein, as indicated. |
| T211 | 473-619 | Sentence | denotes | Shown is a confocal section revealing M protein localization along and to the tip of filopodia (left) and magnification of the dashed box (right). |
| T212 | 620-756 | Sentence | denotes | (D) Dot plot quantification of the number and length of filopodia in untreated (mock) or infected Caco-2 cells for 24 h with SARS-CoV-2. |
| T213 | 757-841 | Sentence | denotes | Filopodium length was measured from the cortical actin to the tip of the filopodium. |
| T214 | 842-866 | Sentence | denotes | Error bars represent SD. |
| T215 | 867-908 | Sentence | denotes | Statistical testing by Mann-Whitney test. |
| T216 | 909-1073 | Sentence | denotes | (E) Caco-2 cells infected with SARS-CoV-2 at an MOI of 0.01 for 24 h prior to immunostaining for F-actin, N protein, and casein kinase II (CK2) as indicated (left). |
| T217 | 1074-1142 | Sentence | denotes | Shown is magnification of the dashed box as single channels (right). |
| T218 | 1143-1285 | Sentence | denotes | (F) Magnification of the dashed box from (E) with quantification of colocalization between CK2 and N protein throughout infected Caco-2 cells. |
| T219 | 1286-1368 | Sentence | denotes | Displayed is the proportion of N protein-positive particles colocalizing with CK2. |
| T220 | 1369-1393 | Sentence | denotes | Error bars represent SD. |
| T221 | 1394-1554 | Sentence | denotes | (G and H) Scanning electron microscopy (G) and transmission electron microscopy (H) images of SARS-CoV-2 budding from Vero E6 cell filopodia (black arrow in H). |
| T222 | 1555-1574 | Sentence | denotes | See also Figure S3. |