PMC:7321036 / 31029-31306 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":159,"end":162},"obj":"https://glytoucan.org/Structures/Glycans/G00065MO"}],"text":"Kinases downstream of the Rho/Rac/Cdc42 GTPases (PAK1/2 and ROCK1/2) and several well-characterized phosphorylation site targets of PAK1/2 kinase in vimentin (VIM S39 and S56) and stathmin (STMN1 S16 and S25) were found to be downregulated during infection (Figures 5A and 5B)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T238","span":{"begin":149,"end":157},"obj":"Body_part"}],"attributes":[{"id":"A238","pred":"fma_id","subj":"T238","obj":"http://purl.org/sig/ont/fma/fma67330"}],"text":"Kinases downstream of the Rho/Rac/Cdc42 GTPases (PAK1/2 and ROCK1/2) and several well-characterized phosphorylation site targets of PAK1/2 kinase in vimentin (VIM S39 and S56) and stathmin (STMN1 S16 and S25) were found to be downregulated during infection (Figures 5A and 5B)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T139","span":{"begin":247,"end":256},"obj":"Disease"}],"attributes":[{"id":"A139","pred":"mondo_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Kinases downstream of the Rho/Rac/Cdc42 GTPases (PAK1/2 and ROCK1/2) and several well-characterized phosphorylation site targets of PAK1/2 kinase in vimentin (VIM S39 and S56) and stathmin (STMN1 S16 and S25) were found to be downregulated during infection (Figures 5A and 5B)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T245","span":{"begin":26,"end":29},"obj":"http://purl.obolibrary.org/obo/CLO_0051142"},{"id":"T246","span":{"begin":149,"end":157},"obj":"http://purl.obolibrary.org/obo/PR_000017298"},{"id":"T247","span":{"begin":159,"end":162},"obj":"http://purl.obolibrary.org/obo/PR_000017298"}],"text":"Kinases downstream of the Rho/Rac/Cdc42 GTPases (PAK1/2 and ROCK1/2) and several well-characterized phosphorylation site targets of PAK1/2 kinase in vimentin (VIM S39 and S56) and stathmin (STMN1 S16 and S25) were found to be downregulated during infection (Figures 5A and 5B)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T203","span":{"begin":273,"end":275},"obj":"Chemical"}],"attributes":[{"id":"A203","pred":"chebi_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/CHEBI_27560"}],"text":"Kinases downstream of the Rho/Rac/Cdc42 GTPases (PAK1/2 and ROCK1/2) and several well-characterized phosphorylation site targets of PAK1/2 kinase in vimentin (VIM S39 and S56) and stathmin (STMN1 S16 and S25) were found to be downregulated during infection (Figures 5A and 5B)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T212","span":{"begin":100,"end":115},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"Kinases downstream of the Rho/Rac/Cdc42 GTPases (PAK1/2 and ROCK1/2) and several well-characterized phosphorylation site targets of PAK1/2 kinase in vimentin (VIM S39 and S56) and stathmin (STMN1 S16 and S25) were found to be downregulated during infection (Figures 5A and 5B)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"562","span":{"begin":30,"end":33},"obj":"Gene"},{"id":"563","span":{"begin":49,"end":55},"obj":"Gene"},{"id":"564","span":{"begin":60,"end":67},"obj":"Gene"},{"id":"565","span":{"begin":132,"end":138},"obj":"Gene"},{"id":"566","span":{"begin":149,"end":157},"obj":"Gene"},{"id":"567","span":{"begin":180,"end":188},"obj":"Gene"},{"id":"568","span":{"begin":190,"end":195},"obj":"Gene"},{"id":"578","span":{"begin":34,"end":39},"obj":"Gene"},{"id":"580","span":{"begin":247,"end":256},"obj":"Disease"},{"id":"584","span":{"begin":171,"end":174},"obj":"CellLine"}],"attributes":[{"id":"A562","pred":"tao:has_database_id","subj":"562","obj":"Gene:207"},{"id":"A563","pred":"tao:has_database_id","subj":"563","obj":"Gene:5058"},{"id":"A564","pred":"tao:has_database_id","subj":"564","obj":"Gene:6093"},{"id":"A565","pred":"tao:has_database_id","subj":"565","obj":"Gene:5058"},{"id":"A566","pred":"tao:has_database_id","subj":"566","obj":"Gene:7431"},{"id":"A567","pred":"tao:has_database_id","subj":"567","obj":"Gene:3925"},{"id":"A568","pred":"tao:has_database_id","subj":"568","obj":"Gene:3925"},{"id":"A578","pred":"tao:has_database_id","subj":"578","obj":"Gene:998"},{"id":"A580","pred":"tao:has_database_id","subj":"580","obj":"MESH:D007239"},{"id":"A584","pred":"tao:has_database_id","subj":"584","obj":"CVCL:J280"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Kinases downstream of the Rho/Rac/Cdc42 GTPases (PAK1/2 and ROCK1/2) and several well-characterized phosphorylation site targets of PAK1/2 kinase in vimentin (VIM S39 and S56) and stathmin (STMN1 S16 and S25) were found to be downregulated during infection (Figures 5A and 5B)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T200","span":{"begin":0,"end":277},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Kinases downstream of the Rho/Rac/Cdc42 GTPases (PAK1/2 and ROCK1/2) and several well-characterized phosphorylation site targets of PAK1/2 kinase in vimentin (VIM S39 and S56) and stathmin (STMN1 S16 and S25) were found to be downregulated during infection (Figures 5A and 5B)."}