PMC:7321036 / 27783-28575 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T215","span":{"begin":480,"end":497},"obj":"Body_part"},{"id":"T216","span":{"begin":480,"end":487},"obj":"Body_part"},{"id":"T217","span":{"begin":553,"end":568},"obj":"Body_part"},{"id":"T218","span":{"begin":631,"end":639},"obj":"Body_part"}],"attributes":[{"id":"A215","pred":"fma_id","subj":"T215","obj":"http://purl.org/sig/ont/fma/fma67906"},{"id":"A216","pred":"fma_id","subj":"T216","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A217","pred":"fma_id","subj":"T217","obj":"http://purl.org/sig/ont/fma/fma67906"},{"id":"A218","pred":"fma_id","subj":"T218","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Figure S2 Full Kinase Activities, Correlated Conditions, and Regulated Complexes, Related to Figure 4\n(A) Changes in predicted kinase activities across different time points post-infection. (B) Correlation of kinase activity profiles of each time point with other biological conditions. Kinase activities were estimated for a wide-range of biological conditions obtained from previously published phosphoproteomics datasets (Ochoa et al., 2016). (C) Changes in phosphorylation in protein complexes. Overall phosphorylation change (-log10 (p value) of a protein complex was derived from change in phosphorylation of sites in member proteins. (D) Kinase activity estimates when using either the 0- or 24-h mock controls for those top regulated kinase activities from the 0-h control comparison."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T132","span":{"begin":179,"end":188},"obj":"Disease"}],"attributes":[{"id":"A132","pred":"mondo_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Figure S2 Full Kinase Activities, Correlated Conditions, and Regulated Complexes, Related to Figure 4\n(A) Changes in predicted kinase activities across different time points post-infection. (B) Correlation of kinase activity profiles of each time point with other biological conditions. Kinase activities were estimated for a wide-range of biological conditions obtained from previously published phosphoproteomics datasets (Ochoa et al., 2016). (C) Changes in phosphorylation in protein complexes. Overall phosphorylation change (-log10 (p value) of a protein complex was derived from change in phosphorylation of sites in member proteins. (D) Kinase activity estimates when using either the 0- or 24-h mock controls for those top regulated kinase activities from the 0-h control comparison."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T33492","span":{"begin":7,"end":9},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T13980","span":{"begin":7,"end":9},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T15478","span":{"begin":22,"end":32},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T60106","span":{"begin":103,"end":104},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T27255","span":{"begin":134,"end":144},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T81821","span":{"begin":191,"end":192},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T79341","span":{"begin":216,"end":224},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T85246","span":{"begin":294,"end":304},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T22052","span":{"begin":324,"end":325},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T84357","span":{"begin":480,"end":497},"obj":"http://purl.obolibrary.org/obo/GO_0043234"},{"id":"T55630","span":{"begin":551,"end":552},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T13360","span":{"begin":553,"end":568},"obj":"http://purl.obolibrary.org/obo/GO_0043234"},{"id":"T35949","span":{"begin":652,"end":660},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T18312","span":{"begin":749,"end":759},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Figure S2 Full Kinase Activities, Correlated Conditions, and Regulated Complexes, Related to Figure 4\n(A) Changes in predicted kinase activities across different time points post-infection. (B) Correlation of kinase activity profiles of each time point with other biological conditions. Kinase activities were estimated for a wide-range of biological conditions obtained from previously published phosphoproteomics datasets (Ochoa et al., 2016). (C) Changes in phosphorylation in protein complexes. Overall phosphorylation change (-log10 (p value) of a protein complex was derived from change in phosphorylation of sites in member proteins. (D) Kinase activity estimates when using either the 0- or 24-h mock controls for those top regulated kinase activities from the 0-h control comparison."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T176","span":{"begin":7,"end":9},"obj":"Chemical"},{"id":"T177","span":{"begin":480,"end":487},"obj":"Chemical"},{"id":"T178","span":{"begin":553,"end":560},"obj":"Chemical"},{"id":"T179","span":{"begin":631,"end":639},"obj":"Chemical"}],"attributes":[{"id":"A176","pred":"chebi_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A177","pred":"chebi_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A178","pred":"chebi_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A179","pred":"chebi_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Figure S2 Full Kinase Activities, Correlated Conditions, and Regulated Complexes, Related to Figure 4\n(A) Changes in predicted kinase activities across different time points post-infection. (B) Correlation of kinase activity profiles of each time point with other biological conditions. Kinase activities were estimated for a wide-range of biological conditions obtained from previously published phosphoproteomics datasets (Ochoa et al., 2016). (C) Changes in phosphorylation in protein complexes. Overall phosphorylation change (-log10 (p value) of a protein complex was derived from change in phosphorylation of sites in member proteins. (D) Kinase activity estimates when using either the 0- or 24-h mock controls for those top regulated kinase activities from the 0-h control comparison."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T173","span":{"begin":127,"end":144},"obj":"http://purl.obolibrary.org/obo/GO_0016301"},{"id":"T174","span":{"begin":209,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0016301"},{"id":"T175","span":{"begin":287,"end":304},"obj":"http://purl.obolibrary.org/obo/GO_0016301"},{"id":"T176","span":{"begin":461,"end":476},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T177","span":{"begin":507,"end":522},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T178","span":{"begin":596,"end":611},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T179","span":{"begin":645,"end":660},"obj":"http://purl.obolibrary.org/obo/GO_0016301"},{"id":"T180","span":{"begin":742,"end":759},"obj":"http://purl.obolibrary.org/obo/GO_0016301"}],"text":"Figure S2 Full Kinase Activities, Correlated Conditions, and Regulated Complexes, Related to Figure 4\n(A) Changes in predicted kinase activities across different time points post-infection. (B) Correlation of kinase activity profiles of each time point with other biological conditions. Kinase activities were estimated for a wide-range of biological conditions obtained from previously published phosphoproteomics datasets (Ochoa et al., 2016). (C) Changes in phosphorylation in protein complexes. Overall phosphorylation change (-log10 (p value) of a protein complex was derived from change in phosphorylation of sites in member proteins. (D) Kinase activity estimates when using either the 0- or 24-h mock controls for those top regulated kinase activities from the 0-h control comparison."}

{"project":"LitCovid-PubTator","denotations":[{"id":"419","span":{"begin":179,"end":188},"obj":"Disease"}],"attributes":[{"id":"A419","pred":"tao:has_database_id","subj":"419","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Figure S2 Full Kinase Activities, Correlated Conditions, and Regulated Complexes, Related to Figure 4\n(A) Changes in predicted kinase activities across different time points post-infection. (B) Correlation of kinase activity profiles of each time point with other biological conditions. Kinase activities were estimated for a wide-range of biological conditions obtained from previously published phosphoproteomics datasets (Ochoa et al., 2016). (C) Changes in phosphorylation in protein complexes. Overall phosphorylation change (-log10 (p value) of a protein complex was derived from change in phosphorylation of sites in member proteins. (D) Kinase activity estimates when using either the 0- or 24-h mock controls for those top regulated kinase activities from the 0-h control comparison."}

{"project":"LitCovid-sentences","denotations":[{"id":"T182","span":{"begin":0,"end":101},"obj":"Sentence"},{"id":"T183","span":{"begin":102,"end":286},"obj":"Sentence"},{"id":"T184","span":{"begin":287,"end":498},"obj":"Sentence"},{"id":"T185","span":{"begin":499,"end":792},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure S2 Full Kinase Activities, Correlated Conditions, and Regulated Complexes, Related to Figure 4\n(A) Changes in predicted kinase activities across different time points post-infection. (B) Correlation of kinase activity profiles of each time point with other biological conditions. Kinase activities were estimated for a wide-range of biological conditions obtained from previously published phosphoproteomics datasets (Ochoa et al., 2016). (C) Changes in phosphorylation in protein complexes. Overall phosphorylation change (-log10 (p value) of a protein complex was derived from change in phosphorylation of sites in member proteins. (D) Kinase activity estimates when using either the 0- or 24-h mock controls for those top regulated kinase activities from the 0-h control comparison."}

{"project":"2_test","denotations":[{"id":"32645325-27909043-20773065","span":{"begin":439,"end":443},"obj":"27909043"}],"text":"Figure S2 Full Kinase Activities, Correlated Conditions, and Regulated Complexes, Related to Figure 4\n(A) Changes in predicted kinase activities across different time points post-infection. (B) Correlation of kinase activity profiles of each time point with other biological conditions. Kinase activities were estimated for a wide-range of biological conditions obtained from previously published phosphoproteomics datasets (Ochoa et al., 2016). (C) Changes in phosphorylation in protein complexes. Overall phosphorylation change (-log10 (p value) of a protein complex was derived from change in phosphorylation of sites in member proteins. (D) Kinase activity estimates when using either the 0- or 24-h mock controls for those top regulated kinase activities from the 0-h control comparison."}