PMC:7321036 / 22118-23113
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T177 | 31-38 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T178 | 142-145 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T179 | 156-159 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T180 | 210-216 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
| T181 | 251-259 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T182 | 275-278 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T183 | 382-385 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T184 | 440-448 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T185 | 597-600 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T186 | 929-937 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T187 | 959-962 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T114 | 94-103 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T115 | 959-972 | Disease | denotes | HIV infection | http://purl.obolibrary.org/obo/MONDO_0005109 |
| T116 | 963-972 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T66503 | 845-846 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T51162 | 901-906 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T148 | 31-38 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T149 | 251-259 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T150 | 440-448 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T151 | 612-614 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T152 | 929-937 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T120 | 71-86 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T121 | 275-289 | http://purl.obolibrary.org/obo/GO_0006396 | denotes | RNA processing |
| T122 | 316-326 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T123 | 382-397 | http://purl.obolibrary.org/obo/GO_0039703 | denotes | RNA replication |
| T124 | 455-470 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T125 | 624-637 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T126 | 726-736 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | Regulation |
| T127 | 746-761 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T128 | 790-800 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T129 | 813-826 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T130 | 867-882 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
| T131 | 883-893 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 383 | 291-297 | Gene | denotes | LARP4B | Gene:23185 |
| 384 | 302-307 | Gene | denotes | CRTC3 | Gene:64784 |
| 385 | 412-416 | Gene | denotes | Nsp8 | Gene:43740578 |
| 386 | 482-487 | Gene | denotes | LARP7 | Gene:51574 |
| 387 | 492-501 | Gene | denotes | MPHOSPH10 | Gene:10199 |
| 388 | 518-524 | Gene | denotes | CCDC86 | Gene:79080 |
| 389 | 553-558 | Gene | denotes | LARP7 | Gene:51574 |
| 390 | 563-568 | Gene | denotes | MEPCE | Gene:56257 |
| 391 | 710-715 | Gene | denotes | snRNP | Gene:57819 |
| 392 | 856-860 | Gene | denotes | CDK9 | Gene:1025 |
| 393 | 94-103 | Disease | denotes | infection | MESH:D007239 |
| 394 | 848-854 | Disease | denotes | P-TEFb | MESH:C000656865 |
| 395 | 959-972 | Disease | denotes | HIV infection | MESH:D015658 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T147 | 0-104 | Sentence | denotes | For Nsp12, the majority of its protein interactors displayed decreased phosphorylation during infection. |
| T148 | 105-398 | Sentence | denotes | Because Nsp12 is known to encode the RNA-dependent RNA polymerase, responsible for replicating the viral genome, and several of these interacting proteins are related to RNA processing (LARP4B and CRTC3), their regulation may possess functional implications for Nsp12 in viral RNA replication. |
| T149 | 399-543 | Sentence | denotes | In addition, Nsp8 interacts with several proteins whose phosphorylation increases (LARP7 and MPHOSPH10) and decreases (CCDC86) on several sites. |
| T150 | 544-725 | Sentence | denotes | Notably, LARP7 and MEPCE are important regulators of RNA polymerase II-mediated transcription elongation as part of the 7SK small nuclear ribonucleoprotein particle (snRNP) complex. |
| T151 | 726-995 | Sentence | denotes | Regulation of these phosphorylation sites may contribute to the regulation of positive transcription elongation factor b (P-TEFb [CDK9]) and transcriptional regulation of the virus, similar to how these proteins are regulated during HIV infection (Mbonye et al., 2015). |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32645325-25900325-20773062 | 989-993 | 25900325 | denotes | 2015 |