PMC:7321036 / 17903-19360
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T123 | 36-43 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T124 | 58-65 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T125 | 113-116 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T126 | 194-201 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T127 | 218-221 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T128 | 333-341 | Body_part | denotes | arginine | http://purl.org/sig/ont/fma/fma82763 |
| T129 | 342-348 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T130 | 395-398 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T131 | 463-471 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T132 | 518-524 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T133 | 525-533 | Body_part | denotes | arginine | http://purl.org/sig/ont/fma/fma82763 |
| T134 | 539-546 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T135 | 590-597 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T136 | 789-796 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T137 | 1002-1005 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T138 | 1223-1228 | Body_part | denotes | wrist | http://purl.org/sig/ont/fma/fma24922 |
| T139 | 1291-1294 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T140 | 1377-1384 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T141 | 1436-1439 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T93 | 350-352 | Disease | denotes | RS | http://purl.obolibrary.org/obo/MONDO_0010725 |
| T94 | 506-514 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T95 | 579-587 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T96 | 707-715 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T97 | 778-786 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T98 | 820-822 | Disease | denotes | RS | http://purl.obolibrary.org/obo/MONDO_0010725 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T40113 | 45-46 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T51900 | 350-352 | http://purl.obolibrary.org/obo/CLO_0008882 | denotes | RS |
| T98396 | 422-424 | http://purl.obolibrary.org/obo/CLO_0001236 | denotes | 2A |
| T25732 | 535-537 | http://purl.obolibrary.org/obo/CLO_0009126 | denotes | SR |
| T69173 | 724-725 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T17099 | 820-822 | http://purl.obolibrary.org/obo/CLO_0008882 | denotes | RS |
| T46908 | 1034-1035 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T105 | 36-43 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T106 | 58-65 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T107 | 194-201 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T108 | 333-341 | Chemical | denotes | arginine | http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696 |
| T111 | 342-348 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T112 | 350-352 | Chemical | denotes | RS | http://purl.obolibrary.org/obo/CHEBI_73819 |
| T113 | 354-363 | Chemical | denotes | dipeptide | http://purl.obolibrary.org/obo/CHEBI_46761 |
| T114 | 463-471 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T115 | 518-524 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T116 | 525-533 | Chemical | denotes | arginine | http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696 |
| T119 | 539-546 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T120 | 590-597 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T121 | 789-796 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T122 | 820-822 | Chemical | denotes | RS | http://purl.obolibrary.org/obo/CHEBI_73819 |
| T123 | 1377-1384 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T96 | 9-24 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T97 | 301-316 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T98 | 606-617 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | translation |
| T99 | 668-683 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T100 | 789-812 | http://purl.obolibrary.org/obo/GO_0006468 | denotes | protein phosphorylation |
| T101 | 797-812 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T102 | 1105-1120 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T103 | 1422-1447 | http://purl.obolibrary.org/obo/GO_1905214 | denotes | regulation of RNA binding |
| T104 | 1422-1432 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 294 | 168-169 | Gene | denotes | N | Gene:43740575 |
| 295 | 34-35 | Gene | denotes | N | Gene:43740575 |
| 296 | 449-460 | Species | denotes | coronavirus | Tax:11118 |
| 297 | 506-514 | Species | denotes | SARS-CoV | Tax:694009 |
| 298 | 579-587 | Species | denotes | SARS-CoV | Tax:694009 |
| 299 | 707-717 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 300 | 778-786 | Species | denotes | SARS-CoV | Tax:694009 |
| 301 | 333-341 | Chemical | denotes | arginine | MESH:D001120 |
| 302 | 342-348 | Chemical | denotes | serine | MESH:D012694 |
| 303 | 354-363 | Chemical | denotes | dipeptide | MESH:D004151 |
| 304 | 518-524 | Chemical | denotes | serine | MESH:D012694 |
| 305 | 939-952 | Disease | denotes | viral fitness |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T120 | 0-136 | Sentence | denotes | Finally, phosphorylation sites in N protein, a structural protein that binds to and assists with packaging viral RNA, were investigated. |
| T121 | 137-285 | Sentence | denotes | Most sites occurred within the N-terminal portion of the protein, at or near the RNA binding region, but avoided the C-terminal dimerization domain. |
| T122 | 286-472 | Sentence | denotes | The cluster of phosphorylation sites within an arginine/serine (RS)-dipeptide rich region, C-terminal to the RNA binding region (Figure 2A), is conserved in other coronavirus N proteins. |
| T123 | 473-649 | Sentence | denotes | This region is phosphorylated in SARS-CoV by serine-arginine (SR) protein kinases, modulating the role of SARS-CoV N protein in host translation inhibition (Peng et al., 2008). |
| T124 | 650-739 | Sentence | denotes | It is likely that phosphorylation of this same region in SARS-CoV-2 plays a similar role. |
| T125 | 740-953 | Sentence | denotes | Interestingly, in vitro inhibition of SARS-CoV N protein phosphorylation at the RS-rich region results in reduced viral load and cytopathic effects (Wu et al., 2009), highlighting its importance for viral fitness. |
| T126 | 954-1096 | Sentence | denotes | In addition, sites spanning the sequence of the RNA binding domain, which forms a claw-like structure, have been observed (Kang et al., 2020). |
| T127 | 1097-1310 | Sentence | denotes | Several phosphorylation sites cluster in the structural model, predicted to affect the surface charge of the so-called acidic wrist region (Figure 2F) but not the positive surface charge of the RNA binding pocket. |
| T128 | 1311-1457 | Sentence | denotes | We hypothesize that this surface charge difference may modulate N protein function, potentially via allosteric regulation of RNA binding capacity. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32645325-18631359-20773056 | 643-647 | 18631359 | denotes | 2008 |
| 32645325-19106108-20773057 | 900-904 | 19106108 | denotes | 2009 |