PMC:7321036 / 1143-1482 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T25","span":{"begin":44,"end":54},"obj":"SP_7"},{"id":"T26","span":{"begin":125,"end":128},"obj":"PR:000008220"},{"id":"T27","span":{"begin":129,"end":133},"obj":"PR:000000103"},{"id":"T28","span":{"begin":134,"end":141},"obj":"GO:0038066"},{"id":"T29","span":{"begin":167,"end":174},"obj":"GO:0007067"},{"id":"T30","span":{"begin":250,"end":257},"obj":"NCBITaxon:4892;GO:0007114"},{"id":"T31","span":{"begin":258,"end":263},"obj":"NCBITaxon:10239"},{"id":"T32","span":{"begin":310,"end":319},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T33","span":{"begin":320,"end":325},"obj":"CHEBI:36044;CHEBI:36044"},{"id":"T34","span":{"begin":330,"end":339},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T9784","span":{"begin":44,"end":54},"obj":"SP_7"},{"id":"T47193","span":{"begin":125,"end":128},"obj":"PR:000008220"},{"id":"T93693","span":{"begin":129,"end":133},"obj":"PR:000000103"},{"id":"T77189","span":{"begin":134,"end":141},"obj":"GO:0038066"},{"id":"T82911","span":{"begin":167,"end":174},"obj":"GO:0007067"},{"id":"T8644","span":{"begin":250,"end":257},"obj":"NCBITaxon:4892;GO:0007114"},{"id":"T80142","span":{"begin":258,"end":263},"obj":"NCBITaxon:10239"},{"id":"T99756","span":{"begin":310,"end":319},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T13643","span":{"begin":320,"end":325},"obj":"CHEBI:36044;CHEBI:36044"},{"id":"T26665","span":{"begin":330,"end":339},"obj":"CHEBI:36357;CHEBI:36357"}],"text":"Highlights\n• Phosphoproteomics analysis of SARS-CoV-2-infected cells uncovers signaling rewiring\n• Infection promotes host p38 MAPK cascade activity and shutdown of mitotic kinases\n• Infection stimulates CK2-containing filopodial protrusions with budding virus\n• Kinase activity analysis identifies potent antiviral drugs and compounds"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T85537","span":{"begin":64,"end":69},"obj":"Body_part"}],"attributes":[{"id":"A57709","pred":"fma_id","subj":"T85537","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Highlights\n• Phosphoproteomics analysis of SARS-CoV-2-infected cells uncovers signaling rewiring\n• Infection promotes host p38 MAPK cascade activity and shutdown of mitotic kinases\n• Infection stimulates CK2-containing filopodial protrusions with budding virus\n• Kinase activity analysis identifies potent antiviral drugs and compounds"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T14","span":{"begin":44,"end":52},"obj":"Disease"},{"id":"T15","span":{"begin":101,"end":110},"obj":"Disease"},{"id":"T16","span":{"begin":186,"end":195},"obj":"Disease"}],"attributes":[{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Highlights\n• Phosphoproteomics analysis of SARS-CoV-2-infected cells uncovers signaling rewiring\n• Infection promotes host p38 MAPK cascade activity and shutdown of mitotic kinases\n• Infection stimulates CK2-containing filopodial protrusions with budding virus\n• Kinase activity analysis identifies potent antiviral drugs and compounds"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T20161","span":{"begin":64,"end":69},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T36852","span":{"begin":79,"end":88},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T35786","span":{"begin":142,"end":150},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T54254","span":{"begin":258,"end":263},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T78497","span":{"begin":274,"end":282},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Highlights\n• Phosphoproteomics analysis of SARS-CoV-2-infected cells uncovers signaling rewiring\n• Infection promotes host p38 MAPK cascade activity and shutdown of mitotic kinases\n• Infection stimulates CK2-containing filopodial protrusions with budding virus\n• Kinase activity analysis identifies potent antiviral drugs and compounds"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T6","span":{"begin":310,"end":325},"obj":"Chemical"},{"id":"T7","span":{"begin":310,"end":319},"obj":"Chemical"},{"id":"T8","span":{"begin":320,"end":325},"obj":"Chemical"}],"attributes":[{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_36044"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Highlights\n• Phosphoproteomics analysis of SARS-CoV-2-infected cells uncovers signaling rewiring\n• Infection promotes host p38 MAPK cascade activity and shutdown of mitotic kinases\n• Infection stimulates CK2-containing filopodial protrusions with budding virus\n• Kinase activity analysis identifies potent antiviral drugs and compounds"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T36282","span":{"begin":79,"end":88},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T19942","span":{"begin":125,"end":141},"obj":"http://purl.obolibrary.org/obo/GO_0038066"},{"id":"T67452","span":{"begin":129,"end":141},"obj":"http://purl.obolibrary.org/obo/GO_0000165"},{"id":"T91218","span":{"begin":129,"end":133},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T78834","span":{"begin":250,"end":257},"obj":"http://purl.obolibrary.org/obo/GO_0007114"},{"id":"T65228","span":{"begin":267,"end":282},"obj":"http://purl.obolibrary.org/obo/GO_0016301"}],"text":"Highlights\n• Phosphoproteomics analysis of SARS-CoV-2-infected cells uncovers signaling rewiring\n• Infection promotes host p38 MAPK cascade activity and shutdown of mitotic kinases\n• Infection stimulates CK2-containing filopodial protrusions with budding virus\n• Kinase activity analysis identifies potent antiviral drugs and compounds"}

{"project":"LitCovid-PubTator","denotations":[{"id":"33","span":{"begin":44,"end":63},"obj":"Disease"},{"id":"36","span":{"begin":125,"end":133},"obj":"Gene"},{"id":"37","span":{"begin":101,"end":110},"obj":"Disease"},{"id":"39","span":{"begin":186,"end":195},"obj":"Disease"}],"attributes":[{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:C000657245"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"Gene:26416"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D007239"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Highlights\n• Phosphoproteomics analysis of SARS-CoV-2-infected cells uncovers signaling rewiring\n• Infection promotes host p38 MAPK cascade activity and shutdown of mitotic kinases\n• Infection stimulates CK2-containing filopodial protrusions with budding virus\n• Kinase activity analysis identifies potent antiviral drugs and compounds"}

{"project":"LitCovid-sentences","denotations":[{"id":"T10","span":{"begin":0,"end":10},"obj":"Sentence"},{"id":"T11","span":{"begin":11,"end":97},"obj":"Sentence"},{"id":"T12","span":{"begin":98,"end":182},"obj":"Sentence"},{"id":"T13","span":{"begin":183,"end":263},"obj":"Sentence"},{"id":"T14","span":{"begin":264,"end":339},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Highlights\n• Phosphoproteomics analysis of SARS-CoV-2-infected cells uncovers signaling rewiring\n• Infection promotes host p38 MAPK cascade activity and shutdown of mitotic kinases\n• Infection stimulates CK2-containing filopodial protrusions with budding virus\n• Kinase activity analysis identifies potent antiviral drugs and compounds"}