PMC:7321036 / 110114-111390 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T35 82-86 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T36 383-387 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T389 838-847 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T74 68-78 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T75 82-91 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T76 108-109 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77 153-157 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T78 179-180 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 383-387 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T80 450-460 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T81 496-497 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82 523-531 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T83 748-756 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T84 781-785 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T85 960-968 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T31298 309-313 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T55659 326-339 Chemical denotes chlorzoxazone http://purl.obolibrary.org/obo/CHEBI_3655
T66943 341-351 Chemical denotes paclitaxel http://purl.obolibrary.org/obo/CHEBI_45863
T86581 354-364 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T22512 1146-1150 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T25 61-78 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activities
T26 383-393 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T27 443-460 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activities
T28 953-968 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activity

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2351 326-339 Chemical denotes chlorzoxazone MESH:D002753
2352 341-351 Chemical denotes paclitaxel MESH:D017239
2353 838-847 Disease denotes infection MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T940 0-422 Sentence denotes In addition to the time-course experiment, we also estimated kinase activities of cell line perturbation in a range of biological conditions using the K-test based approach, from a large resource of previously published phosphoproteomics datasets comprising of 435 biological conditions which include several drug treatments (chlorzoxazone, paclitaxel), inhibitors (EGFRi, AKTi) and cell cycle states (Ochoa et al., 2016).
T941 423-656 Sentence denotes After selecting for kinase activities derived from 3 or more substrates, a total of 214 kinases had activity estimates for at least one biological condition including all 97 kinases which were estimated in the time-course experiment.
T942 657-807 Sentence denotes Of the 435 conditions, 309 conditions with at least one kinase with significantly changing activity (-log10(p value) from Z-test > 2.5) were selected.
T943 808-978 Sentence denotes Individual time points of the infection experiment were correlated with each selected biological condition based on Pearson correlation of their kinase activity profiles.
T944 979-1073 Sentence denotes Conditions with significant correlation (5% FDR) with one or more time points were identified.
T945 1074-1193 Sentence denotes Several conditions corresponded to the same biological treatment (i.e., drug perturbation) in different concentrations.
T946 1194-1276 Sentence denotes In such cases, the conditions are represented together with strongest correlation.

2_test

Id Subject Object Predicate Lexical cue
32645325-27909043-20773121 416-420 27909043 denotes 2016