PMC:7319919 / 4383-5591
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T16 | 50-57 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T17 | 101-109 | Body_part | denotes | tyrosine | http://purl.org/sig/ont/fma/fma82768 |
| T18 | 133-141 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T19 | 444-448 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T20 | 657-665 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T21 | 684-697 | Body_part | denotes | interleukin-6 | http://purl.org/sig/ont/fma/fma264829 |
| T22 | 924-929 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T9 | 444-448 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T23 | 62-65 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
| T24 | 194-197 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
| T25 | 438-455 | Disease | denotes | acute lung injury | http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796 |
| T27 | 449-455 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T28 | 514-529 | Disease | denotes | pulmonary edema | http://purl.obolibrary.org/obo/MONDO_0006932 |
| T29 | 702-707 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T30 | 1089-1097 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T31 | 1193-1201 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T45 | 231-234 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T46 | 271-279 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T47 | 444-448 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T48 | 444-448 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T49 | 471-472 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T50 | 684-697 | http://purl.obolibrary.org/obo/PR_000001393 | denotes | interleukin-6 |
| T51 | 702-729 | http://purl.obolibrary.org/obo/PR_000000134 | denotes | tumor necrosis factor-alpha |
| T52 | 769-779 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T53 | 844-845 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T54 | 887-893 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
| T55 | 918-929 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cells |
| T56 | 932-938 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 4], [5 |
| T57 | 957-958 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T58 | 970-971 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T59 | 1168-1169 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T29 | 50-57 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T30 | 62-65 | Chemical | denotes | ABL | http://purl.obolibrary.org/obo/CHEBI_30805 |
| T31 | 67-75 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T32 | 101-109 | Chemical | denotes | tyrosine | http://purl.obolibrary.org/obo/CHEBI_18186 |
| T33 | 194-197 | Chemical | denotes | ABL | http://purl.obolibrary.org/obo/CHEBI_30805 |
| T34 | 288-292 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T35 | 381-389 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T36 | 497-501 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T37 | 724-729 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T38 | 840-842 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T41 | 953-955 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T44 | 1022-1030 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 125 | 58-65 | Gene | denotes | BCR-ABL | Gene:25 |
| 126 | 684-697 | Gene | denotes | interleukin-6 | Gene:16193 |
| 127 | 702-729 | Gene | denotes | tumor necrosis factor-alpha | Gene:21926 |
| 128 | 840-845 | Gene | denotes | NF-κB | Gene:4790 |
| 129 | 953-958 | Gene | denotes | NF-κB | Gene:4790 |
| 130 | 410-416 | Species | denotes | Murine | Tax:10090 |
| 131 | 918-923 | Species | denotes | human | Tax:9606 |
| 132 | 1089-1099 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 133 | 67-75 | Chemical | denotes | imatinib | MESH:D000068877 |
| 134 | 381-389 | Chemical | denotes | imatinib | MESH:D000068877 |
| 135 | 1022-1030 | Chemical | denotes | imatinib | MESH:D000068877 |
| 136 | 427-433 | Disease | denotes | sepsis | MESH:D018805 |
| 137 | 444-455 | Disease | denotes | lung injury | MESH:D055370 |
| 138 | 514-529 | Disease | denotes | pulmonary edema | MESH:D011654 |
| 139 | 1193-1201 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T16 | 427-433 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T17 | 438-455 | Phenotype | denotes | acute lung injury | http://www.orpha.net/ORDO/Orphanet_178320 |
| T18 | 514-529 | Phenotype | denotes | pulmonary edema | http://purl.obolibrary.org/obo/HP_0100598 |
| T19 | 702-707 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 150-156 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T4 | 708-716 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T5 | 708-716 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T6 | 708-716 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T7 | 708-716 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T8 | 819-839 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factor |
| T9 | 819-832 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T10 | 1065-1080 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T37 | 0-333 | Sentence | denotes | Although developed targeting the oncogenic fusion protein BCR-ABL, imatinib is able to inhibit other tyrosine kinases such as c-KIT, platelet-derived growth factor receptor and Abelson kinases (ABL) type 1 and 2 [4]; therefore, it has been postulated that the biological activity of this drug is not restricted to anticancer effects. |
| T38 | 334-409 | Sentence | denotes | In this regard, immunomodulatory properties of imatinib have been reported. |
| T39 | 410-736 | Sentence | denotes | Murine models of sepsis and acute lung injury have suggested a protective role of this drug by reducing pulmonary edema, preventing histological damage and improving endothelial barrier dysfunction, probably through attenuation of proinflammatory cytokine release including interleukin-6 and tumor necrosis factor-alpha [4,5]. |
| T40 | 737-946 | Sentence | denotes | These effects over inflammatory activation might be mediated by the inhibition of transcription factor NF-κB according to previous evidence from both animal models and studies with human cells [[4], [5], [6]]. |
| T41 | 947-1100 | Sentence | denotes | Since NF-κB represents a key element in several inflammatory pathways [7], imatinib could be helpful to modulate host immune response against SARS-CoV-2. |
| T42 | 1101-1208 | Sentence | denotes | This is particularly noteworthy given that hyperinflammation plays a central role in severe COVID-19 [3,8]. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T51 | 58-65 | PR:000044437 | denotes | BCR-ABL |
| T52 | 67-75 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T53 | 128-131 | PR:000002065 | denotes | KIT |
| T54 | 133-141 | CL:0000233 | denotes | platelet |
| T55 | 194-197 | PR:000003582 | denotes | ABL |
| T56 | 288-292 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T57 | 381-389 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T58 | 410-416 | NCBITaxon:39107 | denotes | Murine |
| T59 | 444-448 | UBERON:0002048 | denotes | lung |
| T60 | 497-501 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T61 | 514-523 | UBERON:0002048 | denotes | pulmonary |
| T62 | 576-587 | UBERON:0001986 | denotes | endothelial |
| T63 | 684-697 | PR:000001393 | denotes | interleukin-6 |
| T64 | 702-729 | PR:000000134 | denotes | tumor necrosis factor-alpha |
| T65 | 840-842 | GO:0005883 | denotes | NF |
| T66 | 887-893 | NCBITaxon:33208 | denotes | animal |
| T67 | 918-923 | SP_6;NCBITaxon:9606 | denotes | human |
| T68 | 953-955 | GO:0005883 | denotes | NF |
| T69 | 1022-1030 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T70 | 1051-1059 | GO:0065007 | denotes | modulate |
| T71 | 1060-1064 | GO:0006955 | denotes | host |
| T72 | 1065-1071 | UBERON:0002405;GO:0006955 | denotes | immune |
| T73 | 1072-1080 | GO:0006955 | denotes | response |
| T74 | 1089-1099 | SP_7 | denotes | SARS-CoV-2 |
| T75 | 1193-1201 | SP_7 | denotes | COVID-19 |
| T22209 | 58-65 | PR:000044437 | denotes | BCR-ABL |
| T79261 | 67-75 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T9446 | 128-131 | PR:000002065 | denotes | KIT |
| T51677 | 133-141 | CL:0000233 | denotes | platelet |
| T32254 | 194-197 | PR:000003582 | denotes | ABL |
| T17766 | 288-292 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T78113 | 381-389 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T87073 | 410-416 | NCBITaxon:39107 | denotes | Murine |
| T98969 | 444-448 | UBERON:0002048 | denotes | lung |
| T45000 | 497-501 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T91193 | 514-523 | UBERON:0002048 | denotes | pulmonary |
| T72793 | 576-587 | UBERON:0001986 | denotes | endothelial |
| T90859 | 684-697 | PR:000001393 | denotes | interleukin-6 |
| T79792 | 702-729 | PR:000000134 | denotes | tumor necrosis factor-alpha |
| T26493 | 840-842 | GO:0005883 | denotes | NF |
| T65412 | 887-893 | NCBITaxon:33208 | denotes | animal |
| T8786 | 918-923 | SP_6;NCBITaxon:9606 | denotes | human |
| T63433 | 953-955 | GO:0005883 | denotes | NF |
| T57349 | 1022-1030 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T48360 | 1051-1059 | GO:0065007 | denotes | modulate |
| T59414 | 1060-1064 | GO:0006955 | denotes | host |
| T66468 | 1065-1071 | UBERON:0002405;GO:0006955 | denotes | immune |
| T87096 | 1072-1080 | GO:0006955 | denotes | response |
| T74991 | 1089-1099 | SP_7 | denotes | SARS-CoV-2 |
| T32706 | 1193-1201 | SP_7 | denotes | COVID-19 |