PMC:7319919 / 38-7025
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 488-496 | Body_part | denotes | tyrosine | http://purl.org/sig/ont/fma/fma82768 |
| T2 | 745-756 | Body_part | denotes | endothelium | http://purl.org/sig/ont/fma/fma63916 |
| T3 | 1255-1260 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T4 | 1271-1276 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T5 | 1470-1475 | Body_part | denotes | chest | http://purl.org/sig/ont/fma/fma9576 |
| T6 | 1547-1554 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T7 | 1614-1624 | Body_part | denotes | lymphocyte | http://purl.org/sig/ont/fma/fma62863 |
| T8 | 1643-1648 | Body_part | denotes | Chest | http://purl.org/sig/ont/fma/fma9576 |
| T9 | 2315-2319 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T10 | 2367-2377 | Body_part | denotes | Neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T11 | 2425-2435 | Body_part | denotes | Lymphocyte | http://purl.org/sig/ont/fma/fma62863 |
| T12 | 2538-2545 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T13 | 3972-3977 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T14 | 4089-4094 | Body_part | denotes | chest | http://purl.org/sig/ont/fma/fma9576 |
| T15 | 4253-4258 | Body_part | denotes | chest | http://purl.org/sig/ont/fma/fma9576 |
| T16 | 4395-4402 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T17 | 4446-4454 | Body_part | denotes | tyrosine | http://purl.org/sig/ont/fma/fma82768 |
| T18 | 4478-4486 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T19 | 4789-4793 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T20 | 5002-5010 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T21 | 5029-5042 | Body_part | denotes | interleukin-6 | http://purl.org/sig/ont/fma/fma264829 |
| T22 | 5269-5274 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T23 | 5823-5827 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T24 | 5912-5917 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 745-756 | Body_part | denotes | endothelium | http://purl.obolibrary.org/obo/UBERON_0001986 |
| T2 | 1255-1260 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T3 | 1271-1276 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T4 | 1470-1475 | Body_part | denotes | chest | http://purl.obolibrary.org/obo/UBERON_0001443 |
| T5 | 1643-1648 | Body_part | denotes | Chest | http://purl.obolibrary.org/obo/UBERON_0001443 |
| T6 | 3972-3977 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T7 | 4089-4094 | Body_part | denotes | chest | http://purl.obolibrary.org/obo/UBERON_0001443 |
| T8 | 4253-4258 | Body_part | denotes | chest | http://purl.obolibrary.org/obo/UBERON_0001443 |
| T9 | 4789-4793 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T2 | 21-30 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T3 | 83-130 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T4 | 83-116 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T5 | 132-140 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T6 | 202-210 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T7 | 367-375 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T8 | 537-542 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T9 | 586-610 | Disease | denotes | chronic myeloid leukemia | http://purl.obolibrary.org/obo/MONDO_0011996 |
| T10 | 594-610 | Disease | denotes | myeloid leukemia | http://purl.obolibrary.org/obo/MONDO_0004643 |
| T11 | 602-610 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
| T12 | 615-646 | Disease | denotes | gastrointestinal stromal tumors | http://purl.obolibrary.org/obo/MONDO_0011719 |
| T13 | 640-646 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T14 | 815-823 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T15 | 895-903 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T16 | 906-915 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T17 | 958-966 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T18 | 967-976 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T19 | 1675-1684 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T20 | 1721-1729 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T21 | 3528-3547 | Disease | denotes | bacterial infection | http://purl.obolibrary.org/obo/MONDO_0005113 |
| T22 | 3538-3547 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T23 | 4407-4410 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
| T24 | 4539-4542 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
| T25 | 4783-4800 | Disease | denotes | acute lung injury | http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796 |
| T27 | 4794-4800 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T28 | 4859-4874 | Disease | denotes | pulmonary edema | http://purl.obolibrary.org/obo/MONDO_0006932 |
| T29 | 5047-5052 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T30 | 5434-5442 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T31 | 5538-5546 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T32 | 5622-5655 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T33 | 5750-5758 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T34 | 5996-6004 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T35 | 6007-6016 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T36 | 6108-6116 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T37 | 6171-6179 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T38 | 6182-6191 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T39 | 6599-6607 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T40 | 6856-6864 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 144-147 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T3 | 155-156 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T4 | 233-234 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T5 | 260-272 | http://purl.obolibrary.org/obo/OBI_0000245 | denotes | Organization |
| T6 | 486-487 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T7 | 519-520 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T8 | 543-551 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T9 | 698-701 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T10 | 745-756 | http://purl.obolibrary.org/obo/UBERON_0001986 | denotes | endothelium |
| T11 | 843-846 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T12 | 943-944 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T13 | 1126-1127 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T14 | 1182-1185 | http://purl.obolibrary.org/obo/CLO_0001602 | denotes | a 6 |
| T15 | 1182-1185 | http://purl.obolibrary.org/obo/CLO_0001603 | denotes | a 6 |
| T16 | 1182-1185 | http://purl.obolibrary.org/obo/CLO_0050248 | denotes | a 6 |
| T17 | 1182-1185 | http://purl.obolibrary.org/obo/CLO_0052463 | denotes | a 6 |
| T18 | 1255-1260 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T19 | 1255-1260 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T20 | 1271-1276 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T21 | 1271-1276 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T22 | 1271-1276 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T23 | 1271-1276 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T24 | 1470-1475 | http://www.ebi.ac.uk/efo/EFO_0000965 | denotes | chest |
| T25 | 1516-1517 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T26 | 1605-1606 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T27 | 1643-1648 | http://www.ebi.ac.uk/efo/EFO_0000965 | denotes | Chest |
| T28 | 1712-1716 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
| T29 | 2315-2319 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T30 | 2804-2805 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T31 | 2952-2953 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T32 | 3043-3044 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T33 | 3938-3940 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T34 | 3972-3977 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T35 | 3972-3977 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T36 | 3978-3983 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tests |
| T37 | 4067-4068 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T38 | 4078-4079 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T39 | 4089-4094 | http://www.ebi.ac.uk/efo/EFO_0000965 | denotes | chest |
| T40 | 4183-4185 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T41 | 4200-4201 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T42 | 4253-4258 | http://www.ebi.ac.uk/efo/EFO_0000965 | denotes | chest |
| T43 | 4277-4279 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T44 | 4312-4314 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
| T45 | 4576-4579 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T46 | 4616-4624 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T47 | 4789-4793 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T48 | 4789-4793 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T49 | 4816-4817 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T50 | 5029-5042 | http://purl.obolibrary.org/obo/PR_000001393 | denotes | interleukin-6 |
| T51 | 5047-5074 | http://purl.obolibrary.org/obo/PR_000000134 | denotes | tumor necrosis factor-alpha |
| T52 | 5114-5124 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T53 | 5189-5190 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T54 | 5232-5238 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
| T55 | 5263-5274 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cells |
| T56 | 5277-5283 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 4], [5 |
| T57 | 5302-5303 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T58 | 5315-5316 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T59 | 5513-5514 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T60 | 5576-5579 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T61 | 5605-5613 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T62 | 5782-5786 | http://purl.obolibrary.org/obo/CLO_0053407 | denotes | ABL2 |
| T63 | 5817-5822 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T64 | 5823-5827 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T65 | 5912-5917 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T66 | 6300-6301 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T67 | 6573-6574 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T68 | 6739-6740 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 488-513 | Chemical | denotes | tyrosine kinase inhibitor | http://purl.obolibrary.org/obo/CHEBI_38637 |
| T2 | 488-496 | Chemical | denotes | tyrosine | http://purl.obolibrary.org/obo/CHEBI_18186 |
| T3 | 504-513 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T4 | 693-697 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T5 | 713-722 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T6 | 834-842 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T7 | 990-998 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T8 | 1055-1073 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T9 | 1084-1103 | Chemical | denotes | lopinavir/ritonavir | http://purl.obolibrary.org/obo/CHEBI_145924 |
| T10 | 1084-1093 | Chemical | denotes | lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T11 | 1094-1103 | Chemical | denotes | ritonavir | http://purl.obolibrary.org/obo/CHEBI_45409 |
| T12 | 1352-1358 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
| T13 | 1547-1554 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T14 | 1565-1572 | Chemical | denotes | lactate | http://purl.obolibrary.org/obo/CHEBI_24996 |
| T15 | 1834-1845 | Chemical | denotes | ceftriaxone | http://purl.obolibrary.org/obo/CHEBI_29007 |
| T16 | 2003-2011 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T17 | 2041-2049 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T18 | 2079-2087 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T19 | 2265-2272 | Chemical | denotes | lactate | http://purl.obolibrary.org/obo/CHEBI_24996 |
| T20 | 2538-2545 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T21 | 2777-2783 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
| T22 | 3151-3159 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T23 | 3210-3219 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T24 | 3277-3281 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T25 | 3390-3398 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T26 | 3458-3469 | Chemical | denotes | ceftriaxone | http://purl.obolibrary.org/obo/CHEBI_29007 |
| T27 | 3602-3608 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
| T28 | 3763-3771 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T29 | 4395-4402 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T30 | 4407-4410 | Chemical | denotes | ABL | http://purl.obolibrary.org/obo/CHEBI_30805 |
| T31 | 4412-4420 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T32 | 4446-4454 | Chemical | denotes | tyrosine | http://purl.obolibrary.org/obo/CHEBI_18186 |
| T33 | 4539-4542 | Chemical | denotes | ABL | http://purl.obolibrary.org/obo/CHEBI_30805 |
| T34 | 4633-4637 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T35 | 4726-4734 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T36 | 4842-4846 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T37 | 5069-5074 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T38 | 5185-5187 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T41 | 5298-5300 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T44 | 5367-5375 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T45 | 5567-5575 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T46 | 5595-5604 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T47 | 5952-5960 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T48 | 6071-6080 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T49 | 6100-6104 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T50 | 6218-6226 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T51 | 6543-6551 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
| T52 | 6806-6825 | Chemical | denotes | lopinavir/ritonavir | http://purl.obolibrary.org/obo/CHEBI_145924 |
| T53 | 6806-6815 | Chemical | denotes | lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T54 | 6816-6825 | Chemical | denotes | ritonavir | http://purl.obolibrary.org/obo/CHEBI_45409 |
| T55 | 6827-6835 | Chemical | denotes | imatinib | http://purl.obolibrary.org/obo/CHEBI_45783 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 25 | 83-130 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | Tax:2697049 |
| 26 | 132-142 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 27 | 376-384 | Species | denotes | patients | Tax:9606 |
| 28 | 945-952 | Species | denotes | patient | Tax:9606 |
| 29 | 474-482 | Chemical | denotes | Imatinib | MESH:D000068877 |
| 30 | 834-842 | Chemical | denotes | imatinib | MESH:D000068877 |
| 31 | 990-998 | Chemical | denotes | imatinib | MESH:D000068877 |
| 32 | 1055-1073 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 33 | 1075-1078 | Chemical | denotes | HCQ | MESH:D006886 |
| 34 | 1084-1103 | Chemical | denotes | lopinavir/ritonavir | MESH:C558899 |
| 35 | 1105-1110 | Chemical | denotes | LPV/r | MESH:C558899 |
| 36 | 21-30 | Disease | denotes | pneumonia | MESH:D011014 |
| 37 | 202-210 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 38 | 367-375 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 39 | 537-542 | Disease | denotes | tumor | MESH:D009369 |
| 40 | 568-575 | Disease | denotes | cancers | MESH:D009369 |
| 41 | 594-610 | Disease | denotes | myeloid leukemia | MESH:D007951 |
| 42 | 615-646 | Disease | denotes | gastrointestinal stromal tumors | MESH:D046152 |
| 43 | 815-823 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 44 | 895-915 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 45 | 958-976 | Disease | denotes | COVID-19 pneumonia | MESH:C000657245 |
| 47 | 2127-2130 | Gene | denotes | CRP | Gene:1401 |
| 50 | 2521-2524 | Gene | denotes | CRP | Gene:1401 |
| 51 | 2527-2545 | Gene | denotes | C-reactive protein | Gene:1401 |
| 65 | 1536-1554 | Gene | denotes | C-reactive protein | Gene:1401 |
| 66 | 1556-1559 | Gene | denotes | CRP | Gene:1401 |
| 67 | 1140-1145 | Species | denotes | woman | Tax:9606 |
| 68 | 1721-1731 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 69 | 1352-1358 | Chemical | denotes | oxygen | MESH:D010100 |
| 70 | 1787-1790 | Chemical | denotes | HCQ | MESH:D006886 |
| 71 | 1795-1800 | Chemical | denotes | LPV/r | MESH:C558899 |
| 72 | 1834-1845 | Chemical | denotes | ceftriaxone | MESH:D002443 |
| 73 | 1201-1206 | Disease | denotes | fever | MESH:D005334 |
| 74 | 1220-1230 | Disease | denotes | arthralgia | MESH:D018771 |
| 75 | 1232-1239 | Disease | denotes | malaise | MESH:D005221 |
| 76 | 1244-1249 | Disease | denotes | cough | MESH:D003371 |
| 77 | 1675-1684 | Disease | denotes | pneumonia | MESH:D011014 |
| 94 | 2876-2879 | Gene | denotes | CRP | Gene:1401 |
| 95 | 2666-2673 | Species | denotes | patient | Tax:9606 |
| 96 | 3798-3805 | Species | denotes | patient | Tax:9606 |
| 97 | 2777-2783 | Chemical | denotes | oxygen | MESH:D010100 |
| 98 | 3092-3095 | Chemical | denotes | HCQ | MESH:D006886 |
| 99 | 3100-3105 | Chemical | denotes | LPV/r | MESH:C558899 |
| 100 | 3151-3159 | Chemical | denotes | imatinib | MESH:D000068877 |
| 101 | 3390-3398 | Chemical | denotes | imatinib | MESH:D000068877 |
| 102 | 3458-3469 | Chemical | denotes | ceftriaxone | MESH:D002443 |
| 103 | 3602-3608 | Chemical | denotes | oxygen | MESH:D010100 |
| 104 | 3763-3771 | Chemical | denotes | imatinib | MESH:D000068877 |
| 105 | 3888-3891 | Chemical | denotes | HCQ | MESH:D006886 |
| 106 | 3896-3901 | Chemical | denotes | LPV/r | MESH:C558899 |
| 107 | 2745-2750 | Disease | denotes | fever | MESH:D005334 |
| 108 | 3528-3547 | Disease | denotes | bacterial infection | MESH:D001424 |
| 109 | 3570-3575 | Disease | denotes | fever | MESH:D005334 |
| 125 | 4403-4410 | Gene | denotes | BCR-ABL | Gene:25 |
| 126 | 5029-5042 | Gene | denotes | interleukin-6 | Gene:16193 |
| 127 | 5047-5074 | Gene | denotes | tumor necrosis factor-alpha | Gene:21926 |
| 128 | 5185-5190 | Gene | denotes | NF-κB | Gene:4790 |
| 129 | 5298-5303 | Gene | denotes | NF-κB | Gene:4790 |
| 130 | 4755-4761 | Species | denotes | Murine | Tax:10090 |
| 131 | 5263-5268 | Species | denotes | human | Tax:9606 |
| 132 | 5434-5444 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 133 | 4412-4420 | Chemical | denotes | imatinib | MESH:D000068877 |
| 134 | 4726-4734 | Chemical | denotes | imatinib | MESH:D000068877 |
| 135 | 5367-5375 | Chemical | denotes | imatinib | MESH:D000068877 |
| 136 | 4772-4778 | Disease | denotes | sepsis | MESH:D018805 |
| 137 | 4789-4800 | Disease | denotes | lung injury | MESH:D055370 |
| 138 | 4859-4874 | Disease | denotes | pulmonary edema | MESH:D011654 |
| 139 | 5538-5546 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 147 | 5693-5706 | Species | denotes | coronaviruses | Tax:11118 |
| 148 | 5750-5760 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 149 | 5888-5901 | Species | denotes | coronaviruses | Tax:11118 |
| 150 | 5567-5575 | Chemical | denotes | imatinib | MESH:D000068877 |
| 151 | 5952-5960 | Chemical | denotes | imatinib | MESH:D000068877 |
| 152 | 5996-6016 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 153 | 6108-6116 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 158 | 6218-6226 | Chemical | denotes | imatinib | MESH:D000068877 |
| 159 | 6543-6551 | Chemical | denotes | imatinib | MESH:D000068877 |
| 160 | 6171-6191 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 161 | 6599-6607 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 167 | 6865-6873 | Species | denotes | patients | Tax:9606 |
| 168 | 6806-6825 | Chemical | denotes | lopinavir/ritonavir | MESH:C558899 |
| 169 | 6827-6835 | Chemical | denotes | imatinib | MESH:D000068877 |
| 170 | 6841-6852 | Chemical | denotes | baricitinib | MESH:C000596027 |
| 171 | 6856-6864 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 21-30 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T2 | 537-542 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
| T3 | 586-610 | Phenotype | denotes | chronic myeloid leukemia | http://purl.obolibrary.org/obo/HP_0005506 |
| T4 | 615-646 | Phenotype | denotes | gastrointestinal stromal tumors | http://purl.obolibrary.org/obo/HP_0100723 |
| T5 | 967-976 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T6 | 1201-1206 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T7 | 1220-1230 | Phenotype | denotes | arthralgia | http://purl.obolibrary.org/obo/HP_0002829 |
| T8 | 1232-1239 | Phenotype | denotes | malaise | http://purl.obolibrary.org/obo/HP_0012378 |
| T9 | 1244-1249 | Phenotype | denotes | cough | http://purl.obolibrary.org/obo/HP_0012735 |
| T10 | 1458-1466 | Phenotype | denotes | wheezing | http://purl.obolibrary.org/obo/HP_0030828 |
| T11 | 1675-1684 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T12 | 2745-2750 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T13 | 3570-3575 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T14 | 3656-3675 | Phenotype | denotes | pulmonary opacities | http://purl.obolibrary.org/obo/HP_0031457 |
| T15 | 4015-4034 | Phenotype | denotes | pulmonary opacities | http://purl.obolibrary.org/obo/HP_0031457 |
| T16 | 4772-4778 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T17 | 4783-4800 | Phenotype | denotes | acute lung injury | http://www.orpha.net/ORDO/Orphanet_178320 |
| T18 | 4859-4874 | Phenotype | denotes | pulmonary edema | http://purl.obolibrary.org/obo/HP_0100598 |
| T19 | 5047-5052 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 497-513 | http://purl.obolibrary.org/obo/GO_0033673 | denotes | kinase inhibitor |
| T2 | 1392-1401 | http://purl.obolibrary.org/obo/GO_0007585 | denotes | breathing |
| T3 | 4495-4501 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T4 | 5053-5061 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T5 | 5053-5061 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T6 | 5053-5061 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T7 | 5053-5061 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T8 | 5164-5184 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factor |
| T9 | 5164-5177 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T10 | 5410-5425 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T11 | 5823-5834 | http://purl.obolibrary.org/obo/GO_0140253 | denotes | cell fusion |
| T12 | 5823-5834 | http://purl.obolibrary.org/obo/GO_0045026 | denotes | cell fusion |
| T13 | 5823-5834 | http://purl.obolibrary.org/obo/GO_0000768 | denotes | cell fusion |
| T14 | 5823-5834 | http://purl.obolibrary.org/obo/GO_0000747 | denotes | cell fusion |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 0-291 | Sentence | denotes | Since first cases of pneumonia of unknown etiology were reported on December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global health issue and its related disease (COVID-19) was finally declared a pandemic by World Health Organization on March 2020 [1]. |
| T4 | 292-473 | Sentence | denotes | To date, there is no evidence that consistently supports any treatment for COVID-19 patients, so identifying new therapeutic options seems crucial in the management of this disease. |
| T5 | 474-647 | Sentence | denotes | Imatinib is a tyrosine kinase inhibitor with a well-known anti-tumor activity against several cancers including chronic myeloid leukemia and gastrointestinal stromal tumors. |
| T6 | 648-824 | Sentence | denotes | According to previously published data, this drug has also shown antiviral, immunomodulatory and endothelium-protective properties which may be potentially helpful in COVID-19. |
| T7 | 825-920 | Sentence | denotes | In fact, imatinib has been pointed out as an unexplored treatment for SARS-CoV-2 infection [2]. |
| T8 | 921-1112 | Sentence | denotes | We report the case of a patient with COVID-19 pneumonia who received imatinib due to clinical deterioration despite dual therapy with hydroxychloroquine (HCQ) and lopinavir/ritonavir (LPV/r). |
| T9 | 1113-1250 | Sentence | denotes | On March 12, a 38-year-old woman was admitted to our department with a 6-day history of fever up to 39 °C, arthralgia, malaise and cough. |
| T10 | 1251-1319 | Sentence | denotes | Her blood pressure, heart rate and respiratory rate were all normal. |
| T11 | 1320-1414 | Sentence | denotes | Her temperature was 37.1 °C and oxygen saturation was 96% while she was breathing ambient air. |
| T12 | 1415-1489 | Sentence | denotes | Physical examination only revealed minimal wheezing on chest auscultation. |
| T13 | 1490-1642 | Sentence | denotes | Laboratory results showed a mild elevation of C-reactive protein (CRP) and lactate dehydrogenase (LDH) levels, and a normal lymphocyte count (Table 1 ). |
| T14 | 1643-1685 | Sentence | denotes | Chest X-ray confirmed bilateral pneumonia. |
| T15 | 1686-1898 | Sentence | denotes | Polymerase chain reaction test for SARS-CoV-2 in nasopharyngeal swab was positive, so treatment with HCQ and LPV/r, as well as empiric therapy with ceftriaxone, was initiated in accordance with hospital protocol. |
| T16 | 1899-1928 | Sentence | denotes | Table 1 - Laboratory results. |
| T17 | 1929-2126 | Sentence | denotes | Variable Day 6 of symptoms Day 10 of symptoms Day 13 of symptoms(day 2 of imatinib) Day 14 of symptoms(day 3 of imatinib) Day 16 of symptoms(day 5 of imatinib and discharge) 20 days after discharge |
| T18 | 2127-2171 | Sentence | denotes | CRP, mg/dL 4.79⁎ 21.00⁎ – 25.04⁎ 7.52⁎ 0.57⁎ |
| T19 | 2172-2218 | Sentence | denotes | Procalcitonin, ng/mL – 0.1 0.09 0.06 0.05 0.01 |
| T20 | 2219-2257 | Sentence | denotes | LDH, IU/L 338⁎ 532⁎ 318⁎ 306⁎ 326⁎ 222 |
| T21 | 2258-2308 | Sentence | denotes | Venous lactate, mmol/L 1.0 3.2⁎ 2.7⁎ 2.5⁎ 1.6⁎ 1.1 |
| T22 | 2309-2366 | Sentence | denotes | White-cell count, × 109/L 7.09 8.48 10.19 9.67 7.61 10.25 |
| T23 | 2367-2424 | Sentence | denotes | Neutrophil count, × 109/L 5.44 6.76 8.29⁎ 7.92⁎ 5.56 6.07 |
| T24 | 2425-2481 | Sentence | denotes | Lymphocyte count, × 109/L 1.17 1.31 1.09 0.84† 1.35 3.14 |
| T25 | 2482-2520 | Sentence | denotes | D-dimer, ng/mL – 580⁎ 760⁎ 1129⁎ – 449 |
| T26 | 2521-2575 | Sentence | denotes | CRP = C-reactive protein; LDH = Lactate dehydrogenase. |
| T27 | 2576-2618 | Sentence | denotes | ⁎ The value was above the reference range. |
| T28 | 2619-2661 | Sentence | denotes | † The value was below the reference range. |
| T29 | 2662-2842 | Sentence | denotes | The patient reported initial improvement; however, on March 15 (day 9 of symptoms) fever recurred and supplemental oxygen by nasal cannula at a rate of 3 l per minute was required. |
| T30 | 2843-2955 | Sentence | denotes | Furthermore, both an increase in CRP levels (Table 1) and radiological deterioration were observed (Fig. 1 , a). |
| T31 | 2956-3348 | Sentence | denotes | These clinical changes suggested that the disease was progressing to an early phase of a hyperinflammatory state despite treatment with HCQ and LPV/r; thus, after assessing the safety profile of imatinib [3] and reviewing previous publications about its antiviral and immunomodulatory properties, we considered that this drug may have potentially beneficial effects in such clinical scenario. |
| T32 | 3349-3548 | Sentence | denotes | Hence, informed consent was obtained and imatinib (400 mg once daily) was added on day 12 of symptoms, while ceftriaxone was interrupted since there was no evidence of concurrent bacterial infection. |
| T33 | 3549-3690 | Sentence | denotes | Three days later the fever disappeared, supplemental oxygen was discontinued and radiological stability of pulmonary opacities was confirmed. |
| T34 | 3691-3902 | Sentence | denotes | Moreover, improvement in laboratory parameters was observed on day 5 of imatinib so it was stopped and the patient was subsequently discharged on day 16 of symptoms after also completing 9 days of HCQ and LPV/r. |
| T35 | 3903-4070 | Sentence | denotes | She remained asymptomatic on April 11 (20 days after discharge), her blood tests were then normal (Table 1) and pulmonary opacities had almost disappeared (Fig. 1, b). |
| T36 | 4071-4344 | Sentence | denotes | Fig. 1 a Portable chest X-ray showing radiological deterioration with bilateral patchy opacities (March 17, day 11 of symptoms). b Marked improvement of opacities in posteroanterior chest radiograph (April 11, day 20 after discharge and day 36 after the onset of symptoms). |
| T37 | 4345-4678 | Sentence | denotes | Although developed targeting the oncogenic fusion protein BCR-ABL, imatinib is able to inhibit other tyrosine kinases such as c-KIT, platelet-derived growth factor receptor and Abelson kinases (ABL) type 1 and 2 [4]; therefore, it has been postulated that the biological activity of this drug is not restricted to anticancer effects. |
| T38 | 4679-4754 | Sentence | denotes | In this regard, immunomodulatory properties of imatinib have been reported. |
| T39 | 4755-5081 | Sentence | denotes | Murine models of sepsis and acute lung injury have suggested a protective role of this drug by reducing pulmonary edema, preventing histological damage and improving endothelial barrier dysfunction, probably through attenuation of proinflammatory cytokine release including interleukin-6 and tumor necrosis factor-alpha [4,5]. |
| T40 | 5082-5291 | Sentence | denotes | These effects over inflammatory activation might be mediated by the inhibition of transcription factor NF-κB according to previous evidence from both animal models and studies with human cells [[4], [5], [6]]. |
| T41 | 5292-5445 | Sentence | denotes | Since NF-κB represents a key element in several inflammatory pathways [7], imatinib could be helpful to modulate host immune response against SARS-CoV-2. |
| T42 | 5446-5553 | Sentence | denotes | This is particularly noteworthy given that hyperinflammation plays a central role in severe COVID-19 [3,8]. |
| T43 | 5554-5766 | Sentence | denotes | In addition, imatinib has shown in vitro antiviral activity against severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses [9], which are phylogenetically related to SARS-CoV-2 [10]. |
| T44 | 5767-5922 | Sentence | denotes | In this sense, ABL2 appears to be involved in the virus-cell fusion process, so its blockage could modulate the entry of coronaviruses into host cells [9]. |
| T45 | 5923-6117 | Sentence | denotes | These data also suggest that imatinib might be useful in early stages of SARS-CoV-2 infection, although further research is needed to ascertain the antiviral properties of this drug in COVID-19. |
| T46 | 6118-6227 | Sentence | denotes | To our knowledge, this is the first reported case of SARS-CoV-2 infection successfully treated with imatinib. |
| T47 | 6228-6462 | Sentence | denotes | However, elucidating the relevance of any therapeutic intervention from a single case report is always controversial since clinical outcomes may be influenced by some confounding factors such as the concomitant use of other therapies. |
| T48 | 6463-6608 | Sentence | denotes | Nevertheless, taking into account all the above mentioned data, we believe that imatinib should be considered a potential treatment for COVID-19. |
| T49 | 6610-6617 | Sentence | denotes | Funding |
| T50 | 6618-6651 | Sentence | denotes | No external funding was received. |
| T51 | 6653-6686 | Sentence | denotes | Declaration of Competing Interest |
| T52 | 6687-6874 | Sentence | denotes | David Bernal-Bello is the principal investigator of a non-sponsored randomized trial assessing the therapeutic role of lopinavir/ritonavir, imatinib, and baricitinib in COVID-19 patients. |
| T53 | 6875-6937 | Sentence | denotes | The rest of the authors are sub-investigators in this project. |
| T54 | 6938-6987 | Sentence | denotes | All authors declare no other competing interests. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 83-95 | SP_7 | denotes | severe acute |
| T3 | 96-107 | SP_7;UBERON:0001004 | denotes | respiratory |
| T4 | 108-130 | SP_7 | denotes | syndrome coronavirus 2 |
| T5 | 132-142 | SP_7 | denotes | SARS-CoV-2 |
| T6 | 202-210 | SP_7 | denotes | COVID-19 |
| T7 | 367-375 | SP_7 | denotes | COVID-19 |
| T8 | 504-513 | CHEBI:38637;CHEBI:38637 | denotes | inhibitor |
| T9 | 594-601 | CL:0000763 | denotes | myeloid |
| T10 | 615-639 | UBERON:0003929 | denotes | gastrointestinal stromal |
| T11 | 693-697 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T12 | 745-756 | UBERON:0001986 | denotes | endothelium |
| T13 | 815-823 | SP_7 | denotes | COVID-19 |
| T14 | 834-842 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T15 | 895-905 | SP_7 | denotes | SARS-CoV-2 |
| T16 | 958-966 | SP_7 | denotes | COVID-19 |
| T17 | 990-998 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T18 | 1055-1073 | CHEBI:5801;CHEBI:5801;DG_20 | denotes | hydroxychloroquine |
| T19 | 1084-1093 | DG_23 | denotes | lopinavir |
| T20 | 1094-1103 | DG_30 | denotes | ritonavir |
| T21 | 1255-1260 | UBERON:0000178 | denotes | blood |
| T22 | 1271-1276 | UBERON:0000948 | denotes | heart |
| T23 | 1286-1297 | UBERON:0001004 | denotes | respiratory |
| T24 | 1470-1475 | UBERON:0001443 | denotes | chest |
| T25 | 1536-1554 | PR:000005897 | denotes | C-reactive protein |
| T26 | 1556-1559 | PR:000005897 | denotes | CRP |
| T27 | 1565-1572 | CHEBI:24996;CHEBI:24996 | denotes | lactate |
| T28 | 1614-1624 | CL:0000542 | denotes | lymphocyte |
| T29 | 1721-1731 | SP_7 | denotes | SARS-CoV-2 |
| T30 | 1735-1749 | UBERON:0001728 | denotes | nasopharyngeal |
| T31 | 1834-1845 | CHEBI:29007;CHEBI:29007 | denotes | ceftriaxone |
| T32 | 2003-2011 | CHEBI:14434;CHEBI:14434 | denotes | imatinib |
| T33 | 2041-2049 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T34 | 2079-2087 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T35 | 2527-2545 | PR:000005897 | denotes | C-reactive protein |
| T37 | 2787-2792 | UBERON:0000004 | denotes | nasal |
| T38 | 3151-3159 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T39 | 3277-3281 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T40 | 3390-3398 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T41 | 3458-3469 | CHEBI:29007;CHEBI:29007 | denotes | ceftriaxone |
| T42 | 3528-3537 | NCBITaxon:2 | denotes | bacterial |
| T43 | 3656-3665 | UBERON:0002048 | denotes | pulmonary |
| T44 | 3763-3771 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T45 | 3972-3977 | UBERON:0000178 | denotes | blood |
| T46 | 4015-4024 | UBERON:0002048 | denotes | pulmonary |
| T47 | 4089-4094 | UBERON:0001443 | denotes | chest |
| T48 | 4253-4258 | UBERON:0001443 | denotes | chest |
| T51 | 4403-4410 | PR:000044437 | denotes | BCR-ABL |
| T52 | 4412-4420 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T53 | 4473-4476 | PR:000002065 | denotes | KIT |
| T54 | 4478-4486 | CL:0000233 | denotes | platelet |
| T55 | 4539-4542 | PR:000003582 | denotes | ABL |
| T56 | 4633-4637 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T57 | 4726-4734 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T58 | 4755-4761 | NCBITaxon:39107 | denotes | Murine |
| T59 | 4789-4793 | UBERON:0002048 | denotes | lung |
| T60 | 4842-4846 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T61 | 4859-4868 | UBERON:0002048 | denotes | pulmonary |
| T62 | 4921-4932 | UBERON:0001986 | denotes | endothelial |
| T63 | 5029-5042 | PR:000001393 | denotes | interleukin-6 |
| T64 | 5047-5074 | PR:000000134 | denotes | tumor necrosis factor-alpha |
| T65 | 5185-5187 | GO:0005883 | denotes | NF |
| T66 | 5232-5238 | NCBITaxon:33208 | denotes | animal |
| T67 | 5263-5268 | SP_6;NCBITaxon:9606 | denotes | human |
| T68 | 5298-5300 | GO:0005883 | denotes | NF |
| T69 | 5367-5375 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T70 | 5396-5404 | GO:0065007 | denotes | modulate |
| T71 | 5405-5409 | GO:0006955 | denotes | host |
| T72 | 5410-5416 | UBERON:0002405;GO:0006955 | denotes | immune |
| T73 | 5417-5425 | GO:0006955 | denotes | response |
| T74 | 5434-5444 | SP_7 | denotes | SARS-CoV-2 |
| T75 | 5538-5546 | SP_7 | denotes | COVID-19 |
| T76 | 5567-5575 | CHEBI:14434;CHEBI:14434 | denotes | imatinib |
| T77 | 5635-5646 | UBERON:0001004 | denotes | respiratory |
| T78 | 5672-5683 | UBERON:0001004 | denotes | respiratory |
| T79 | 5693-5706 | NCBITaxon:11118 | denotes | coronaviruses |
| T80 | 5750-5760 | SP_7 | denotes | SARS-CoV-2 |
| T81 | 5782-5786 | PR:000003583 | denotes | ABL2 |
| T82 | 5817-5822 | NCBITaxon:10239 | denotes | virus |
| T83 | 5823-5834 | GO:0061025 | denotes | cell fusion |
| T84 | 5866-5874 | GO:0065007 | denotes | modulate |
| T85 | 5888-5901 | NCBITaxon:11118 | denotes | coronaviruses |
| T86 | 5952-5960 | CHEBI:14434;CHEBI:14434 | denotes | imatinib |
| T87 | 5996-6006 | SP_7 | denotes | SARS-CoV-2 |
| T88 | 6100-6104 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T89 | 6108-6116 | SP_7 | denotes | COVID-19 |
| T90 | 6171-6181 | SP_7 | denotes | SARS-CoV-2 |
| T91 | 6218-6226 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T92 | 6543-6551 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T93 | 6599-6607 | SP_7 | denotes | COVID-19 |
| T94 | 6806-6815 | DG_23 | denotes | lopinavir |
| T95 | 6816-6825 | DG_30 | denotes | ritonavir |
| T96 | 6827-6835 | CHEBI:14434;CHEBI:14434 | denotes | imatinib |
| T97 | 6841-6852 | DG_41 | denotes | baricitinib |
| T98 | 6856-6864 | SP_7 | denotes | COVID-19 |
| T24374 | 83-95 | SP_7 | denotes | severe acute |
| T33932 | 96-107 | SP_7;UBERON:0001004 | denotes | respiratory |
| T56060 | 108-130 | SP_7 | denotes | syndrome coronavirus 2 |
| T26460 | 132-142 | SP_7 | denotes | SARS-CoV-2 |
| T26060 | 202-210 | SP_7 | denotes | COVID-19 |
| T27789 | 367-375 | SP_7 | denotes | COVID-19 |
| T76138 | 504-513 | CHEBI:38637;CHEBI:38637 | denotes | inhibitor |
| T3230 | 594-601 | CL:0000763 | denotes | myeloid |
| T40836 | 615-639 | UBERON:0003929 | denotes | gastrointestinal stromal |
| T26513 | 693-697 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T58114 | 745-756 | UBERON:0001986 | denotes | endothelium |
| T53288 | 815-823 | SP_7 | denotes | COVID-19 |
| T30388 | 834-842 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T2688 | 895-905 | SP_7 | denotes | SARS-CoV-2 |
| T35262 | 958-966 | SP_7 | denotes | COVID-19 |
| T96047 | 990-998 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T20501 | 1055-1073 | CHEBI:5801;CHEBI:5801;DG_20 | denotes | hydroxychloroquine |
| T65802 | 1084-1093 | DG_23 | denotes | lopinavir |
| T69496 | 1094-1103 | DG_30 | denotes | ritonavir |
| T60602 | 1255-1260 | UBERON:0000178 | denotes | blood |
| T2899 | 1271-1276 | UBERON:0000948 | denotes | heart |
| T59609 | 1286-1297 | UBERON:0001004 | denotes | respiratory |
| T50907 | 1470-1475 | UBERON:0001443 | denotes | chest |
| T83820 | 1536-1554 | PR:000005897 | denotes | C-reactive protein |
| T92864 | 1556-1559 | PR:000005897 | denotes | CRP |
| T18754 | 1565-1572 | CHEBI:24996;CHEBI:24996 | denotes | lactate |
| T30315 | 1614-1624 | CL:0000542 | denotes | lymphocyte |
| T73244 | 1721-1731 | SP_7 | denotes | SARS-CoV-2 |
| T27173 | 1735-1749 | UBERON:0001728 | denotes | nasopharyngeal |
| T15380 | 1834-1845 | CHEBI:29007;CHEBI:29007 | denotes | ceftriaxone |
| T53094 | 2003-2011 | CHEBI:14434;CHEBI:14434 | denotes | imatinib |
| T18528 | 2041-2049 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T84378 | 2079-2087 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T90530 | 2527-2545 | PR:000005897 | denotes | C-reactive protein |
| T73943 | 2787-2792 | UBERON:0000004 | denotes | nasal |
| T67666 | 3151-3159 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T83555 | 3277-3281 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T32599 | 3390-3398 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T58104 | 3458-3469 | CHEBI:29007;CHEBI:29007 | denotes | ceftriaxone |
| T6628 | 3528-3537 | NCBITaxon:2 | denotes | bacterial |
| T74081 | 3656-3665 | UBERON:0002048 | denotes | pulmonary |
| T62264 | 3763-3771 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T47136 | 3972-3977 | UBERON:0000178 | denotes | blood |
| T65080 | 4015-4024 | UBERON:0002048 | denotes | pulmonary |
| T64685 | 4089-4094 | UBERON:0001443 | denotes | chest |
| T35076 | 4253-4258 | UBERON:0001443 | denotes | chest |
| T22209 | 4403-4410 | PR:000044437 | denotes | BCR-ABL |
| T79261 | 4412-4420 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T9446 | 4473-4476 | PR:000002065 | denotes | KIT |
| T51677 | 4478-4486 | CL:0000233 | denotes | platelet |
| T32254 | 4539-4542 | PR:000003582 | denotes | ABL |
| T17766 | 4633-4637 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T78113 | 4726-4734 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T87073 | 4755-4761 | NCBITaxon:39107 | denotes | Murine |
| T98969 | 4789-4793 | UBERON:0002048 | denotes | lung |
| T45000 | 4842-4846 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T91193 | 4859-4868 | UBERON:0002048 | denotes | pulmonary |
| T72793 | 4921-4932 | UBERON:0001986 | denotes | endothelial |
| T90859 | 5029-5042 | PR:000001393 | denotes | interleukin-6 |
| T79792 | 5047-5074 | PR:000000134 | denotes | tumor necrosis factor-alpha |
| T26493 | 5185-5187 | GO:0005883 | denotes | NF |
| T65412 | 5232-5238 | NCBITaxon:33208 | denotes | animal |
| T8786 | 5263-5268 | SP_6;NCBITaxon:9606 | denotes | human |
| T63433 | 5298-5300 | GO:0005883 | denotes | NF |
| T57349 | 5367-5375 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T48360 | 5396-5404 | GO:0065007 | denotes | modulate |
| T59414 | 5405-5409 | GO:0006955 | denotes | host |
| T66468 | 5410-5416 | UBERON:0002405;GO:0006955 | denotes | immune |
| T87096 | 5417-5425 | GO:0006955 | denotes | response |
| T74991 | 5434-5444 | SP_7 | denotes | SARS-CoV-2 |
| T32706 | 5538-5546 | SP_7 | denotes | COVID-19 |
| T45081 | 5567-5575 | CHEBI:14434;CHEBI:14434 | denotes | imatinib |
| T88775 | 5635-5646 | UBERON:0001004 | denotes | respiratory |
| T61507 | 5672-5683 | UBERON:0001004 | denotes | respiratory |
| T25185 | 5693-5706 | NCBITaxon:11118 | denotes | coronaviruses |
| T11544 | 5750-5760 | SP_7 | denotes | SARS-CoV-2 |
| T8102 | 5782-5786 | PR:000003583 | denotes | ABL2 |
| T86755 | 5817-5822 | NCBITaxon:10239 | denotes | virus |
| T99959 | 5823-5834 | GO:0061025 | denotes | cell fusion |
| T94733 | 5866-5874 | GO:0065007 | denotes | modulate |
| T61456 | 5888-5901 | NCBITaxon:11118 | denotes | coronaviruses |
| T8366 | 5952-5960 | CHEBI:14434;CHEBI:14434 | denotes | imatinib |
| T88154 | 5996-6006 | SP_7 | denotes | SARS-CoV-2 |
| T36497 | 6100-6104 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T63516 | 6108-6116 | SP_7 | denotes | COVID-19 |
| T9771 | 6171-6181 | SP_7 | denotes | SARS-CoV-2 |
| T25132 | 6218-6226 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T75604 | 6543-6551 | CHEBI:45783;CHEBI:45783 | denotes | imatinib |
| T47222 | 6599-6607 | SP_7 | denotes | COVID-19 |
| T99569 | 6806-6815 | DG_23 | denotes | lopinavir |
| T38180 | 6816-6825 | DG_30 | denotes | ritonavir |
| T67623 | 6827-6835 | CHEBI:14434;CHEBI:14434 | denotes | imatinib |
| T63693 | 6841-6852 | DG_41 | denotes | baricitinib |
| T80737 | 6856-6864 | SP_7 | denotes | COVID-19 |