PMC:7319613 / 69-1291 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T3","span":{"begin":10,"end":21},"obj":"NCBITaxon:11118"},{"id":"T4","span":{"begin":31,"end":39},"obj":"SP_7"},{"id":"T5","span":{"begin":65,"end":77},"obj":"SP_7"},{"id":"T6","span":{"begin":78,"end":89},"obj":"SP_7;UBERON:0001004"},{"id":"T7","span":{"begin":90,"end":112},"obj":"SP_7"},{"id":"T8","span":{"begin":114,"end":124},"obj":"SP_7"},{"id":"T9","span":{"begin":182,"end":187},"obj":"UBERON:0010230"},{"id":"T10","span":{"begin":241,"end":246},"obj":"SP_6;NCBITaxon:9606"},{"id":"T11","span":{"begin":458,"end":469},"obj":"UBERON:0001004"},{"id":"T12","span":{"begin":499,"end":509},"obj":"SP_7"},{"id":"T13","span":{"begin":696,"end":706},"obj":"GO:0007596"},{"id":"T14","span":{"begin":721,"end":733},"obj":"GO:0001525"},{"id":"T15","span":{"begin":800,"end":808},"obj":"SP_7"},{"id":"T16","span":{"begin":1012,"end":1021},"obj":"GO:0008152"},{"id":"T17","span":{"begin":1180,"end":1186},"obj":"UBERON:0000467"},{"id":"T18","span":{"begin":1192,"end":1198},"obj":"UBERON:0000467"},{"id":"T33977","span":{"begin":10,"end":21},"obj":"NCBITaxon:11118"},{"id":"T54693","span":{"begin":31,"end":39},"obj":"SP_7"},{"id":"T19687","span":{"begin":65,"end":77},"obj":"SP_7"},{"id":"T80926","span":{"begin":78,"end":89},"obj":"SP_7;UBERON:0001004"},{"id":"T41664","span":{"begin":90,"end":112},"obj":"SP_7"},{"id":"T27805","span":{"begin":114,"end":124},"obj":"SP_7"},{"id":"T12112","span":{"begin":182,"end":187},"obj":"UBERON:0010230"},{"id":"T95977","span":{"begin":241,"end":246},"obj":"SP_6;NCBITaxon:9606"},{"id":"T49425","span":{"begin":458,"end":469},"obj":"UBERON:0001004"},{"id":"T58804","span":{"begin":499,"end":509},"obj":"SP_7"},{"id":"T51112","span":{"begin":696,"end":706},"obj":"GO:0007596"},{"id":"T74794","span":{"begin":721,"end":733},"obj":"GO:0001525"},{"id":"T55040","span":{"begin":800,"end":808},"obj":"SP_7"},{"id":"T78757","span":{"begin":1012,"end":1021},"obj":"GO:0008152"},{"id":"T59988","span":{"begin":1180,"end":1186},"obj":"UBERON:0000467"},{"id":"T59568","span":{"begin":1192,"end":1198},"obj":"UBERON:0000467"}],"text":"The novel coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major health (\u0026 economic) issue across the globe. As of June 20th, more than eight and a half million human infections have been confirmed worldwide. While the exact pathophysiology is still investigated, significant individual variability in the disease severity and subsequent consequences has been demonstrated. The respiratory distress syndrome related to SARS-CoV-2 infection seems highly specific with a desaturation despite sometimes an absence of dyspnea and distinct manifestations like large intrapulmonary shunt or vascular abnormalities such as thrombosis and increased angiogenesis (Ackermann et al., 2020). Current evidence from large prospective COVID-19 patients cohort studies suggests that the key independent risk factors for mortality and severe complications include higher age, male sex and chronic comorbidities, predominantly related to obesity and metabolic dysfunctions (Liang et al., 2020). Fast identification of “more-at-risk” populations is key for optimization of therapy selection and timing, especially when health care system capacities are limited."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T2","span":{"begin":31,"end":39},"obj":"Disease"},{"id":"T3","span":{"begin":65,"end":112},"obj":"Disease"},{"id":"T4","span":{"begin":65,"end":98},"obj":"Disease"},{"id":"T5","span":{"begin":114,"end":122},"obj":"Disease"},{"id":"T6","span":{"begin":247,"end":257},"obj":"Disease"},{"id":"T7","span":{"begin":458,"end":487},"obj":"Disease"},{"id":"T8","span":{"begin":499,"end":507},"obj":"Disease"},{"id":"T9","span":{"begin":510,"end":519},"obj":"Disease"},{"id":"T10","span":{"begin":696,"end":706},"obj":"Disease"},{"id":"T11","span":{"begin":800,"end":808},"obj":"Disease"},{"id":"T12","span":{"begin":1000,"end":1007},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"}],"text":"The novel coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major health (\u0026 economic) issue across the globe. As of June 20th, more than eight and a half million human infections have been confirmed worldwide. While the exact pathophysiology is still investigated, significant individual variability in the disease severity and subsequent consequences has been demonstrated. The respiratory distress syndrome related to SARS-CoV-2 infection seems highly specific with a desaturation despite sometimes an absence of dyspnea and distinct manifestations like large intrapulmonary shunt or vascular abnormalities such as thrombosis and increased angiogenesis (Ackermann et al., 2020). Current evidence from large prospective COVID-19 patients cohort studies suggests that the key independent risk factors for mortality and severe complications include higher age, male sex and chronic comorbidities, predominantly related to obesity and metabolic dysfunctions (Liang et al., 2020). Fast identification of “more-at-risk” populations is key for optimization of therapy selection and timing, especially when health care system capacities are limited."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":126,"end":129},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T2","span":{"begin":137,"end":138},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T3","span":{"begin":226,"end":227},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":241,"end":246},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T5","span":{"begin":431,"end":434},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T6","span":{"begin":547,"end":548},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T7","span":{"begin":939,"end":943},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T8","span":{"begin":939,"end":943},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"}],"text":"The novel coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major health (\u0026 economic) issue across the globe. As of June 20th, more than eight and a half million human infections have been confirmed worldwide. While the exact pathophysiology is still investigated, significant individual variability in the disease severity and subsequent consequences has been demonstrated. The respiratory distress syndrome related to SARS-CoV-2 infection seems highly specific with a desaturation despite sometimes an absence of dyspnea and distinct manifestations like large intrapulmonary shunt or vascular abnormalities such as thrombosis and increased angiogenesis (Ackermann et al., 2020). Current evidence from large prospective COVID-19 patients cohort studies suggests that the key independent risk factors for mortality and severe complications include higher age, male sex and chronic comorbidities, predominantly related to obesity and metabolic dysfunctions (Liang et al., 2020). Fast identification of “more-at-risk” populations is key for optimization of therapy selection and timing, especially when health care system capacities are limited."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":939,"end":943},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_30780"}],"text":"The novel coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major health (\u0026 economic) issue across the globe. As of June 20th, more than eight and a half million human infections have been confirmed worldwide. While the exact pathophysiology is still investigated, significant individual variability in the disease severity and subsequent consequences has been demonstrated. The respiratory distress syndrome related to SARS-CoV-2 infection seems highly specific with a desaturation despite sometimes an absence of dyspnea and distinct manifestations like large intrapulmonary shunt or vascular abnormalities such as thrombosis and increased angiogenesis (Ackermann et al., 2020). Current evidence from large prospective COVID-19 patients cohort studies suggests that the key independent risk factors for mortality and severe complications include higher age, male sex and chronic comorbidities, predominantly related to obesity and metabolic dysfunctions (Liang et al., 2020). Fast identification of “more-at-risk” populations is key for optimization of therapy selection and timing, especially when health care system capacities are limited."}

{"project":"LitCovid-PubTator","denotations":[{"id":"18","span":{"begin":65,"end":112},"obj":"Species"},{"id":"19","span":{"begin":114,"end":124},"obj":"Species"},{"id":"20","span":{"begin":241,"end":246},"obj":"Species"},{"id":"21","span":{"begin":809,"end":817},"obj":"Species"},{"id":"22","span":{"begin":4,"end":29},"obj":"Disease"},{"id":"23","span":{"begin":31,"end":39},"obj":"Disease"},{"id":"24","span":{"begin":247,"end":257},"obj":"Disease"},{"id":"25","span":{"begin":458,"end":487},"obj":"Disease"},{"id":"26","span":{"begin":499,"end":519},"obj":"Disease"},{"id":"27","span":{"begin":594,"end":601},"obj":"Disease"},{"id":"28","span":{"begin":665,"end":687},"obj":"Disease"},{"id":"29","span":{"begin":696,"end":706},"obj":"Disease"},{"id":"30","span":{"begin":800,"end":808},"obj":"Disease"},{"id":"31","span":{"begin":884,"end":893},"obj":"Disease"},{"id":"32","span":{"begin":1000,"end":1007},"obj":"Disease"},{"id":"33","span":{"begin":1012,"end":1034},"obj":"Disease"}],"attributes":[{"id":"A18","pred":"tao:has_database_id","subj":"18","obj":"Tax:2697049"},{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"Tax:2697049"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"Tax:9606"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Tax:9606"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"MESH:C000657245"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"MESH:C000657245"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"MESH:D007239"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"MESH:D012128"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"MESH:C000657245"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"MESH:D004417"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:D000783"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:D013927"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:C000657245"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"MESH:D003643"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:D009765"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:D008659"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The novel coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major health (\u0026 economic) issue across the globe. As of June 20th, more than eight and a half million human infections have been confirmed worldwide. While the exact pathophysiology is still investigated, significant individual variability in the disease severity and subsequent consequences has been demonstrated. The respiratory distress syndrome related to SARS-CoV-2 infection seems highly specific with a desaturation despite sometimes an absence of dyspnea and distinct manifestations like large intrapulmonary shunt or vascular abnormalities such as thrombosis and increased angiogenesis (Ackermann et al., 2020). Current evidence from large prospective COVID-19 patients cohort studies suggests that the key independent risk factors for mortality and severe complications include higher age, male sex and chronic comorbidities, predominantly related to obesity and metabolic dysfunctions (Liang et al., 2020). Fast identification of “more-at-risk” populations is key for optimization of therapy selection and timing, especially when health care system capacities are limited."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":458,"end":478},"obj":"Phenotype"},{"id":"T2","span":{"begin":594,"end":601},"obj":"Phenotype"},{"id":"T3","span":{"begin":641,"end":661},"obj":"Phenotype"},{"id":"T4","span":{"begin":665,"end":687},"obj":"Phenotype"},{"id":"T5","span":{"begin":1000,"end":1007},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0002094"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0031225"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0002597"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0001513"}],"text":"The novel coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major health (\u0026 economic) issue across the globe. As of June 20th, more than eight and a half million human infections have been confirmed worldwide. While the exact pathophysiology is still investigated, significant individual variability in the disease severity and subsequent consequences has been demonstrated. The respiratory distress syndrome related to SARS-CoV-2 infection seems highly specific with a desaturation despite sometimes an absence of dyspnea and distinct manifestations like large intrapulmonary shunt or vascular abnormalities such as thrombosis and increased angiogenesis (Ackermann et al., 2020). Current evidence from large prospective COVID-19 patients cohort studies suggests that the key independent risk factors for mortality and severe complications include higher age, male sex and chronic comorbidities, predominantly related to obesity and metabolic dysfunctions (Liang et al., 2020). Fast identification of “more-at-risk” populations is key for optimization of therapy selection and timing, especially when health care system capacities are limited."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":721,"end":733},"obj":"http://purl.obolibrary.org/obo/GO_0001525"}],"text":"The novel coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major health (\u0026 economic) issue across the globe. As of June 20th, more than eight and a half million human infections have been confirmed worldwide. While the exact pathophysiology is still investigated, significant individual variability in the disease severity and subsequent consequences has been demonstrated. The respiratory distress syndrome related to SARS-CoV-2 infection seems highly specific with a desaturation despite sometimes an absence of dyspnea and distinct manifestations like large intrapulmonary shunt or vascular abnormalities such as thrombosis and increased angiogenesis (Ackermann et al., 2020). Current evidence from large prospective COVID-19 patients cohort studies suggests that the key independent risk factors for mortality and severe complications include higher age, male sex and chronic comorbidities, predominantly related to obesity and metabolic dysfunctions (Liang et al., 2020). Fast identification of “more-at-risk” populations is key for optimization of therapy selection and timing, especially when health care system capacities are limited."}

{"project":"LitCovid-sentences","denotations":[{"id":"T3","span":{"begin":0,"end":188},"obj":"Sentence"},{"id":"T4","span":{"begin":189,"end":288},"obj":"Sentence"},{"id":"T5","span":{"begin":289,"end":453},"obj":"Sentence"},{"id":"T6","span":{"begin":454,"end":759},"obj":"Sentence"},{"id":"T7","span":{"begin":760,"end":1056},"obj":"Sentence"},{"id":"T8","span":{"begin":1057,"end":1222},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The novel coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major health (\u0026 economic) issue across the globe. As of June 20th, more than eight and a half million human infections have been confirmed worldwide. While the exact pathophysiology is still investigated, significant individual variability in the disease severity and subsequent consequences has been demonstrated. The respiratory distress syndrome related to SARS-CoV-2 infection seems highly specific with a desaturation despite sometimes an absence of dyspnea and distinct manifestations like large intrapulmonary shunt or vascular abnormalities such as thrombosis and increased angiogenesis (Ackermann et al., 2020). Current evidence from large prospective COVID-19 patients cohort studies suggests that the key independent risk factors for mortality and severe complications include higher age, male sex and chronic comorbidities, predominantly related to obesity and metabolic dysfunctions (Liang et al., 2020). Fast identification of “more-at-risk” populations is key for optimization of therapy selection and timing, especially when health care system capacities are limited."}