PMC:7319613 / 5533-6236 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T92","span":{"begin":95,"end":99},"obj":"G_3;PG_10;PR:000003622"},{"id":"T93","span":{"begin":116,"end":126},"obj":"GO:0010467"},{"id":"T94","span":{"begin":149,"end":154},"obj":"G_3;PG_10;PR:000003622"},{"id":"T95","span":{"begin":191,"end":201},"obj":"SP_7"},{"id":"T96","span":{"begin":265,"end":270},"obj":"SP_6;NCBITaxon:9606"},{"id":"T97","span":{"begin":282,"end":295},"obj":"NCBITaxon:11118"},{"id":"T98","span":{"begin":306,"end":316},"obj":"SP_7"},{"id":"T99","span":{"begin":335,"end":339},"obj":"G_3;PG_10;PR:000003622"},{"id":"T100","span":{"begin":349,"end":359},"obj":"GO:0010467"},{"id":"T101","span":{"begin":379,"end":383},"obj":"GO:0007567"},{"id":"T102","span":{"begin":384,"end":395},"obj":"NCBITaxon:1"},{"id":"T103","span":{"begin":420,"end":428},"obj":"SP_7"},{"id":"T104","span":{"begin":504,"end":508},"obj":"G_3;PG_10;PR:000003622"},{"id":"T105","span":{"begin":589,"end":593},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T106","span":{"begin":628,"end":638},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T107","span":{"begin":646,"end":660},"obj":"DG_37"},{"id":"T108","span":{"begin":698,"end":702},"obj":"G_3;PG_10;PR:000003622"},{"id":"T38487","span":{"begin":95,"end":99},"obj":"G_3;PG_10;PR:000003622"},{"id":"T29778","span":{"begin":116,"end":126},"obj":"GO:0010467"},{"id":"T5033","span":{"begin":149,"end":154},"obj":"G_3;PG_10;PR:000003622"},{"id":"T62086","span":{"begin":191,"end":201},"obj":"SP_7"},{"id":"T5970","span":{"begin":265,"end":270},"obj":"SP_6;NCBITaxon:9606"},{"id":"T62135","span":{"begin":282,"end":295},"obj":"NCBITaxon:11118"},{"id":"T78198","span":{"begin":306,"end":316},"obj":"SP_7"},{"id":"T26439","span":{"begin":335,"end":339},"obj":"G_3;PG_10;PR:000003622"},{"id":"T83020","span":{"begin":349,"end":359},"obj":"GO:0010467"},{"id":"T28084","span":{"begin":379,"end":383},"obj":"GO:0007567"},{"id":"T9860","span":{"begin":384,"end":395},"obj":"NCBITaxon:1"},{"id":"T70597","span":{"begin":420,"end":428},"obj":"SP_7"},{"id":"T86139","span":{"begin":504,"end":508},"obj":"G_3;PG_10;PR:000003622"},{"id":"T70794","span":{"begin":589,"end":593},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T66606","span":{"begin":628,"end":638},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T7504","span":{"begin":646,"end":660},"obj":"DG_37"},{"id":"T88363","span":{"begin":698,"end":702},"obj":"G_3;PG_10;PR:000003622"}],"text":"Finally, accumulating evidence indicates that prematurity might also be associated with higher ACE2 activity and/or expression (South et al., 2018). ACE-2 is known to be directly involved in SARS-CoV-2 cell-binding, representing the main host cell receptor for all human pathogenic coronaviruses including SARS-CoV-2. Thus, the higher ACE2 activity/expression in the prematurely born individuals might result in greater COVID-19 severity. One also has to bear in mind that the prematurity-related higher ACE2 activity might be additionally heightened by potential hypertension or diabetes drug therapies which often include ACE inhibitors and/or angiotensin II receptor blockers, both upregulating ACE2."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T13","span":{"begin":202,"end":206},"obj":"Body_part"},{"id":"T14","span":{"begin":243,"end":247},"obj":"Body_part"}],"attributes":[{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Finally, accumulating evidence indicates that prematurity might also be associated with higher ACE2 activity and/or expression (South et al., 2018). ACE-2 is known to be directly involved in SARS-CoV-2 cell-binding, representing the main host cell receptor for all human pathogenic coronaviruses including SARS-CoV-2. Thus, the higher ACE2 activity/expression in the prematurely born individuals might result in greater COVID-19 severity. One also has to bear in mind that the prematurity-related higher ACE2 activity might be additionally heightened by potential hypertension or diabetes drug therapies which often include ACE inhibitors and/or angiotensin II receptor blockers, both upregulating ACE2."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T27","span":{"begin":191,"end":199},"obj":"Disease"},{"id":"T28","span":{"begin":306,"end":314},"obj":"Disease"},{"id":"T29","span":{"begin":420,"end":428},"obj":"Disease"},{"id":"T30","span":{"begin":564,"end":576},"obj":"Disease"},{"id":"T31","span":{"begin":580,"end":588},"obj":"Disease"}],"attributes":[{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0005015"}],"text":"Finally, accumulating evidence indicates that prematurity might also be associated with higher ACE2 activity and/or expression (South et al., 2018). ACE-2 is known to be directly involved in SARS-CoV-2 cell-binding, representing the main host cell receptor for all human pathogenic coronaviruses including SARS-CoV-2. Thus, the higher ACE2 activity/expression in the prematurely born individuals might result in greater COVID-19 severity. One also has to bear in mind that the prematurity-related higher ACE2 activity might be additionally heightened by potential hypertension or diabetes drug therapies which often include ACE inhibitors and/or angiotensin II receptor blockers, both upregulating ACE2."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T24","span":{"begin":100,"end":108},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T25","span":{"begin":142,"end":146},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T26","span":{"begin":202,"end":206},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T27","span":{"begin":243,"end":247},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T28","span":{"begin":265,"end":270},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T29","span":{"begin":340,"end":348},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T30","span":{"begin":448,"end":451},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T31","span":{"begin":509,"end":517},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Finally, accumulating evidence indicates that prematurity might also be associated with higher ACE2 activity and/or expression (South et al., 2018). ACE-2 is known to be directly involved in SARS-CoV-2 cell-binding, representing the main host cell receptor for all human pathogenic coronaviruses including SARS-CoV-2. Thus, the higher ACE2 activity/expression in the prematurely born individuals might result in greater COVID-19 severity. One also has to bear in mind that the prematurity-related higher ACE2 activity might be additionally heightened by potential hypertension or diabetes drug therapies which often include ACE inhibitors and/or angiotensin II receptor blockers, both upregulating ACE2."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T9","span":{"begin":589,"end":593},"obj":"Chemical"},{"id":"T10","span":{"begin":624,"end":638},"obj":"Chemical"},{"id":"T11","span":{"begin":628,"end":638},"obj":"Chemical"},{"id":"T12","span":{"begin":646,"end":660},"obj":"Chemical"},{"id":"T15","span":{"begin":646,"end":657},"obj":"Chemical"},{"id":"T16","span":{"begin":658,"end":660},"obj":"Chemical"}],"attributes":[{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_35457"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A13","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_48432"},{"id":"A14","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_58506"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A16","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"}],"text":"Finally, accumulating evidence indicates that prematurity might also be associated with higher ACE2 activity and/or expression (South et al., 2018). ACE-2 is known to be directly involved in SARS-CoV-2 cell-binding, representing the main host cell receptor for all human pathogenic coronaviruses including SARS-CoV-2. Thus, the higher ACE2 activity/expression in the prematurely born individuals might result in greater COVID-19 severity. One also has to bear in mind that the prematurity-related higher ACE2 activity might be additionally heightened by potential hypertension or diabetes drug therapies which often include ACE inhibitors and/or angiotensin II receptor blockers, both upregulating ACE2."}

{"project":"LitCovid-PubTator","denotations":[{"id":"121","span":{"begin":95,"end":99},"obj":"Gene"},{"id":"122","span":{"begin":149,"end":154},"obj":"Gene"},{"id":"123","span":{"begin":335,"end":339},"obj":"Gene"},{"id":"124","span":{"begin":504,"end":508},"obj":"Gene"},{"id":"125","span":{"begin":624,"end":627},"obj":"Gene"},{"id":"126","span":{"begin":698,"end":702},"obj":"Gene"},{"id":"127","span":{"begin":191,"end":201},"obj":"Species"},{"id":"128","span":{"begin":265,"end":270},"obj":"Species"},{"id":"129","span":{"begin":282,"end":295},"obj":"Species"},{"id":"130","span":{"begin":306,"end":316},"obj":"Species"},{"id":"131","span":{"begin":420,"end":428},"obj":"Disease"},{"id":"132","span":{"begin":564,"end":576},"obj":"Disease"},{"id":"133","span":{"begin":580,"end":588},"obj":"Disease"}],"attributes":[{"id":"A121","pred":"tao:has_database_id","subj":"121","obj":"Gene:59272"},{"id":"A122","pred":"tao:has_database_id","subj":"122","obj":"Gene:59272"},{"id":"A123","pred":"tao:has_database_id","subj":"123","obj":"Gene:59272"},{"id":"A124","pred":"tao:has_database_id","subj":"124","obj":"Gene:59272"},{"id":"A125","pred":"tao:has_database_id","subj":"125","obj":"Gene:1636"},{"id":"A126","pred":"tao:has_database_id","subj":"126","obj":"Gene:59272"},{"id":"A127","pred":"tao:has_database_id","subj":"127","obj":"Tax:2697049"},{"id":"A128","pred":"tao:has_database_id","subj":"128","obj":"Tax:9606"},{"id":"A129","pred":"tao:has_database_id","subj":"129","obj":"Tax:11118"},{"id":"A130","pred":"tao:has_database_id","subj":"130","obj":"Tax:2697049"},{"id":"A131","pred":"tao:has_database_id","subj":"131","obj":"MESH:C000657245"},{"id":"A132","pred":"tao:has_database_id","subj":"132","obj":"MESH:D006973"},{"id":"A133","pred":"tao:has_database_id","subj":"133","obj":"MESH:D003920"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Finally, accumulating evidence indicates that prematurity might also be associated with higher ACE2 activity and/or expression (South et al., 2018). ACE-2 is known to be directly involved in SARS-CoV-2 cell-binding, representing the main host cell receptor for all human pathogenic coronaviruses including SARS-CoV-2. Thus, the higher ACE2 activity/expression in the prematurely born individuals might result in greater COVID-19 severity. One also has to bear in mind that the prematurity-related higher ACE2 activity might be additionally heightened by potential hypertension or diabetes drug therapies which often include ACE inhibitors and/or angiotensin II receptor blockers, both upregulating ACE2."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T22","span":{"begin":564,"end":576},"obj":"Phenotype"}],"attributes":[{"id":"A22","pred":"hp_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/HP_0000822"}],"text":"Finally, accumulating evidence indicates that prematurity might also be associated with higher ACE2 activity and/or expression (South et al., 2018). ACE-2 is known to be directly involved in SARS-CoV-2 cell-binding, representing the main host cell receptor for all human pathogenic coronaviruses including SARS-CoV-2. Thus, the higher ACE2 activity/expression in the prematurely born individuals might result in greater COVID-19 severity. One also has to bear in mind that the prematurity-related higher ACE2 activity might be additionally heightened by potential hypertension or diabetes drug therapies which often include ACE inhibitors and/or angiotensin II receptor blockers, both upregulating ACE2."}

{"project":"LitCovid-sentences","denotations":[{"id":"T34","span":{"begin":0,"end":148},"obj":"Sentence"},{"id":"T35","span":{"begin":149,"end":317},"obj":"Sentence"},{"id":"T36","span":{"begin":318,"end":438},"obj":"Sentence"},{"id":"T37","span":{"begin":439,"end":703},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Finally, accumulating evidence indicates that prematurity might also be associated with higher ACE2 activity and/or expression (South et al., 2018). ACE-2 is known to be directly involved in SARS-CoV-2 cell-binding, representing the main host cell receptor for all human pathogenic coronaviruses including SARS-CoV-2. Thus, the higher ACE2 activity/expression in the prematurely born individuals might result in greater COVID-19 severity. One also has to bear in mind that the prematurity-related higher ACE2 activity might be additionally heightened by potential hypertension or diabetes drug therapies which often include ACE inhibitors and/or angiotensin II receptor blockers, both upregulating ACE2."}