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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T1 0-13 GO:0007567 denotes Preterm birth
T2 49-57 SP_7 denotes COVID-19
T3 79-90 NCBITaxon:11118 denotes coronavirus
T4 100-108 SP_7 denotes COVID-19
T5 134-146 SP_7 denotes severe acute
T6 147-158 SP_7;UBERON:0001004 denotes respiratory
T7 159-181 SP_7 denotes syndrome coronavirus 2
T8 183-193 SP_7 denotes SARS-CoV-2
T9 251-256 UBERON:0010230 denotes globe
T10 310-315 SP_6;NCBITaxon:9606 denotes human
T11 527-538 UBERON:0001004 denotes respiratory
T12 568-578 SP_7 denotes SARS-CoV-2
T13 765-775 GO:0007596 denotes thrombosis
T14 790-802 GO:0001525 denotes angiogenesis
T15 869-877 SP_7 denotes COVID-19
T16 1081-1090 GO:0008152 denotes metabolic
T17 1249-1255 UBERON:0000467 denotes health
T18 1261-1267 UBERON:0000467 denotes system
T19 1372-1380 SP_7 denotes COVID-19
T20 1405-1409 GO:0007567 denotes born
T21 1410-1421 NCBITaxon:1 denotes individuals
T22 1434-1447 GO:0007567 denotes preterm birth
T23 1552-1563 GO:0007567 denotes prematurity
T24 1782-1800 UBERON:0001004;GO:0060541 denotes respiratory system
T25 1801-1812 GO:0060541 denotes development
T26 1897-1906 MOP:0000568 denotes oxidative
T27 1946-1975 PR:000001322 denotes Angiotensin-converting enzyme
T28 1977-1981 PR:000003622;G_3;PG_10 denotes ACE2
T29 1992-2002 GO:0010467 denotes expression
T30 2004-2015 GO:0007567 denotes Prematurity
T31 2028-2032 UBERON:0000104 denotes life
T32 2081-2088 UBERON:0000467 denotes systems
T33 2124-2142 UBERON:0001004 denotes respiratory system
T34 2204-2215 UBERON:0001004 denotes respiratory
T35 2222-2229 GO:0065007 denotes control
T36 2398-2402 GO:0007567 denotes born
T37 2403-2414 NCBITaxon:1 denotes individuals
T38 2446-2450 GO:0007567 denotes born
T39 2569-2580 GO:0007567 denotes prematurity
T40 2623-2630 GO:0002087 denotes control
T41 2635-2642 UBERON:0005396 denotes carotid
T42 2685-2694 GO:0007567;UBERON:0012101 denotes perinatal
T43 2761-2771 UBERON:0001062 denotes anatomical
T44 2803-2814 GO:0007567 denotes prematurity
T45 2858-2869 UBERON:0001004 denotes respiratory
T46 3082-3090 SP_7 denotes COVID-19
T47 3222-3233 UBERON:0001004 denotes respiratory
T48 3321-3329 SP_7 denotes COVID-19
T49 3347-3355 GO:0065007 denotes modulate
T50 3392-3401 GO:0008152 denotes metabolic
T51 3553-3557 GO:0007567 denotes born
T52 3558-3569 NCBITaxon:1 denotes individuals
T53 3605-3613 SP_7 denotes COVID-19
T54 3691-3700 UBERON:0002048 denotes pulmonary
T55 3723-3731 SP_7 denotes COVID-19
T56 3793-3811 UBERON:0002012 denotes pulmonary arteries
T57 3819-3833 UBERON:0001629 denotes carotid bodies
T58 3885-3898 GO:0002087 denotes regulation of
T59 4044-4048 GO:0007567 denotes born
T60 4049-4060 NCBITaxon:1 denotes individuals
T61 4112-4116 UBERON:0002048 denotes lung
T62 4121-4135 UBERON:0001629 denotes carotid bodies
T63 4147-4160 GO:0005739 denotes mitochondrial
T64 4198-4210 GO:0005739 denotes mitochondria
T65 4214-4223 MOP:0000568 denotes oxidative
T66 4324-4332 SP_7 denotes COVID-19
T67 4362-4371 MOP:0000568 denotes oxidative
T68 4411-4415 GO:0007567 denotes born
T69 4416-4427 NCBITaxon:1 denotes individuals
T70 4568-4578 GO:0065007 denotes modulation
T71 4636-4640 GO:0007567 denotes born
T72 4641-4648 NCBITaxon:9606 denotes persons
T73 4674-4682 SP_7 denotes COVID-19
T74 4701-4710 MOP:0000568 denotes oxidative
T75 4725-4734 MOP:0000568 denotes oxidative
T76 4792-4802 GO:0065007 denotes regulation
T77 4893-4902 MOP:0000568 denotes Oxidative
T78 4931-4939 MOP:0000568;CHEBI:60156;CHEBI:60156 denotes oxidized
T79 4940-4953 CHEBI:60156;CHEBI:60156 denotes phospholipids
T80 4975-4983 SP_7 denotes COVID-19
T81 4992-4997 UBERON:0000170 denotes lungs
T82 4999-5007 MOP:0000568;CHEBI:60156;CHEBI:60156 denotes Oxidized
T83 5008-5021 CHEBI:60156;CHEBI:60156 denotes phospholipids
T84 5042-5053 GO:0050817 denotes coagulation
T85 5076-5084 CL:0000233 denotes platelet
T86 5138-5146 SP_7 denotes COVID-19
T87 5184-5192 SP_7 denotes COVID-19
T88 5252-5261 MOP:0000568 denotes oxidative
T89 5379-5387 SP_7 denotes COVID-19
T90 5424-5433 MOP:0000568 denotes oxidative
T91 5458-5469 GO:0007567 denotes prematurity
T92 5628-5632 G_3;PG_10;PR:000003622 denotes ACE2
T93 5649-5659 GO:0010467 denotes expression
T94 5682-5687 G_3;PG_10;PR:000003622 denotes ACE-2
T95 5724-5734 SP_7 denotes SARS-CoV-2
T96 5798-5803 SP_6;NCBITaxon:9606 denotes human
T97 5815-5828 NCBITaxon:11118 denotes coronaviruses
T98 5839-5849 SP_7 denotes SARS-CoV-2
T99 5868-5872 G_3;PG_10;PR:000003622 denotes ACE2
T100 5882-5892 GO:0010467 denotes expression
T101 5912-5916 GO:0007567 denotes born
T102 5917-5928 NCBITaxon:1 denotes individuals
T103 5953-5961 SP_7 denotes COVID-19
T104 6037-6041 G_3;PG_10;PR:000003622 denotes ACE2
T105 6122-6126 CHEBI:23888;CHEBI:23888 denotes drug
T106 6161-6171 CHEBI:35222;CHEBI:35222 denotes inhibitors
T107 6179-6193 DG_37 denotes angiotensin II
T108 6231-6235 G_3;PG_10;PR:000003622 denotes ACE2
T109 6261-6265 GO:0007567 denotes born
T110 6266-6274 SP_7 denotes COVID-19
T111 6361-6365 G_3;PG_10;PR:000003622 denotes ACE2
T112 6402-6407 NCBITaxon:10239 denotes virus
T113 6557-6566 MOP:0000568 denotes oxidation
T114 6580-6592 CHEBI:33694;CHEBI:33694 denotes biomolecules
T115 6603-6616 CHEBI:16247;CHEBI:16247 denotes phospholipids
T116 6657-6661 UBERON:0002048 denotes lung
T117 6670-6679 MOP:0000568 denotes Oxidative
T118 6705-6717 GO:0005739 denotes mitochondria
T119 6738-6746 SP_7 denotes COVID-19
T120 6912-6930 UBERON:0001004 denotes respiratory system
T121 6950-6954 GO:0007567 denotes born
T122 6955-6965 NCBITaxon:1 denotes individual
T123 7048-7052 GO:0007567 denotes born
T124 7053-7064 NCBITaxon:1 denotes individuals
T125 7109-7117 SP_7 denotes COVID-19
T126 7300-7311 GO:0007567 denotes prematurity
T127 7316-7324 SP_7 denotes COVID-19
T67842 0-13 GO:0007567 denotes Preterm birth
T6286 49-57 SP_7 denotes COVID-19
T33977 79-90 NCBITaxon:11118 denotes coronavirus
T54693 100-108 SP_7 denotes COVID-19
T19687 134-146 SP_7 denotes severe acute
T80926 147-158 SP_7;UBERON:0001004 denotes respiratory
T41664 159-181 SP_7 denotes syndrome coronavirus 2
T27805 183-193 SP_7 denotes SARS-CoV-2
T12112 251-256 UBERON:0010230 denotes globe
T95977 310-315 SP_6;NCBITaxon:9606 denotes human
T49425 527-538 UBERON:0001004 denotes respiratory
T58804 568-578 SP_7 denotes SARS-CoV-2
T51112 765-775 GO:0007596 denotes thrombosis
T74794 790-802 GO:0001525 denotes angiogenesis
T55040 869-877 SP_7 denotes COVID-19
T78757 1081-1090 GO:0008152 denotes metabolic
T59988 1249-1255 UBERON:0000467 denotes health
T59568 1261-1267 UBERON:0000467 denotes system
T49798 1372-1380 SP_7 denotes COVID-19
T9439 1405-1409 GO:0007567 denotes born
T82743 1410-1421 NCBITaxon:1 denotes individuals
T59112 1434-1447 GO:0007567 denotes preterm birth
T52406 1552-1563 GO:0007567 denotes prematurity
T51892 1782-1800 UBERON:0001004;GO:0060541 denotes respiratory system
T46481 1801-1812 GO:0060541 denotes development
T82864 1897-1906 MOP:0000568 denotes oxidative
T56875 1946-1975 PR:000001322 denotes Angiotensin-converting enzyme
T99491 1977-1981 PR:000003622;G_3;PG_10 denotes ACE2
T70399 1992-2002 GO:0010467 denotes expression
T85816 2004-2015 GO:0007567 denotes Prematurity
T70834 2028-2032 UBERON:0000104 denotes life
T39274 2081-2088 UBERON:0000467 denotes systems
T51001 2124-2142 UBERON:0001004 denotes respiratory system
T1619 2204-2215 UBERON:0001004 denotes respiratory
T24876 2222-2229 GO:0065007 denotes control
T7441 2398-2402 GO:0007567 denotes born
T2438 2403-2414 NCBITaxon:1 denotes individuals
T83936 2446-2450 GO:0007567 denotes born
T68721 2569-2580 GO:0007567 denotes prematurity
T60994 2623-2630 GO:0002087 denotes control
T89216 2635-2642 UBERON:0005396 denotes carotid
T90729 2685-2694 GO:0007567;UBERON:0012101 denotes perinatal
T77896 2761-2771 UBERON:0001062 denotes anatomical
T32987 2803-2814 GO:0007567 denotes prematurity
T34696 2858-2869 UBERON:0001004 denotes respiratory
T73562 3082-3090 SP_7 denotes COVID-19
T89223 3222-3233 UBERON:0001004 denotes respiratory
T75997 3321-3329 SP_7 denotes COVID-19
T66751 3347-3355 GO:0065007 denotes modulate
T38741 3392-3401 GO:0008152 denotes metabolic
T76875 3553-3557 GO:0007567 denotes born
T52054 3558-3569 NCBITaxon:1 denotes individuals
T24259 3605-3613 SP_7 denotes COVID-19
T33181 3691-3700 UBERON:0002048 denotes pulmonary
T72002 3723-3731 SP_7 denotes COVID-19
T70034 3793-3811 UBERON:0002012 denotes pulmonary arteries
T10071 3819-3833 UBERON:0001629 denotes carotid bodies
T15971 3885-3898 GO:0002087 denotes regulation of
T80508 4044-4048 GO:0007567 denotes born
T90215 4049-4060 NCBITaxon:1 denotes individuals
T57295 4112-4116 UBERON:0002048 denotes lung
T1083 4121-4135 UBERON:0001629 denotes carotid bodies
T24773 4147-4160 GO:0005739 denotes mitochondrial
T81064 4198-4210 GO:0005739 denotes mitochondria
T70508 4214-4223 MOP:0000568 denotes oxidative
T69230 4324-4332 SP_7 denotes COVID-19
T2262 4362-4371 MOP:0000568 denotes oxidative
T61512 4411-4415 GO:0007567 denotes born
T24626 4416-4427 NCBITaxon:1 denotes individuals
T77790 4568-4578 GO:0065007 denotes modulation
T40102 4636-4640 GO:0007567 denotes born
T70977 4641-4648 NCBITaxon:9606 denotes persons
T79446 4674-4682 SP_7 denotes COVID-19
T97104 4701-4710 MOP:0000568 denotes oxidative
T588 4725-4734 MOP:0000568 denotes oxidative
T3518 4792-4802 GO:0065007 denotes regulation
T20606 4893-4902 MOP:0000568 denotes Oxidative
T20774 4931-4939 MOP:0000568;CHEBI:60156;CHEBI:60156 denotes oxidized
T1362 4940-4953 CHEBI:60156;CHEBI:60156 denotes phospholipids
T87866 4975-4983 SP_7 denotes COVID-19
T66042 4992-4997 UBERON:0000170 denotes lungs
T4721 4999-5007 MOP:0000568;CHEBI:60156;CHEBI:60156 denotes Oxidized
T89600 5008-5021 CHEBI:60156;CHEBI:60156 denotes phospholipids
T43418 5042-5053 GO:0050817 denotes coagulation
T82797 5076-5084 CL:0000233 denotes platelet
T81388 5138-5146 SP_7 denotes COVID-19
T88622 5184-5192 SP_7 denotes COVID-19
T2753 5252-5261 MOP:0000568 denotes oxidative
T37382 5379-5387 SP_7 denotes COVID-19
T83273 5424-5433 MOP:0000568 denotes oxidative
T53875 5458-5469 GO:0007567 denotes prematurity
T38487 5628-5632 G_3;PG_10;PR:000003622 denotes ACE2
T29778 5649-5659 GO:0010467 denotes expression
T5033 5682-5687 G_3;PG_10;PR:000003622 denotes ACE-2
T62086 5724-5734 SP_7 denotes SARS-CoV-2
T5970 5798-5803 SP_6;NCBITaxon:9606 denotes human
T62135 5815-5828 NCBITaxon:11118 denotes coronaviruses
T78198 5839-5849 SP_7 denotes SARS-CoV-2
T26439 5868-5872 G_3;PG_10;PR:000003622 denotes ACE2
T83020 5882-5892 GO:0010467 denotes expression
T28084 5912-5916 GO:0007567 denotes born
T9860 5917-5928 NCBITaxon:1 denotes individuals
T70597 5953-5961 SP_7 denotes COVID-19
T86139 6037-6041 G_3;PG_10;PR:000003622 denotes ACE2
T70794 6122-6126 CHEBI:23888;CHEBI:23888 denotes drug
T66606 6161-6171 CHEBI:35222;CHEBI:35222 denotes inhibitors
T7504 6179-6193 DG_37 denotes angiotensin II
T88363 6231-6235 G_3;PG_10;PR:000003622 denotes ACE2
T72412 6261-6265 GO:0007567 denotes born
T97617 6266-6274 SP_7 denotes COVID-19
T27305 6361-6365 G_3;PG_10;PR:000003622 denotes ACE2
T82968 6402-6407 NCBITaxon:10239 denotes virus
T74303 6557-6566 MOP:0000568 denotes oxidation
T53175 6580-6592 CHEBI:33694;CHEBI:33694 denotes biomolecules
T76689 6603-6616 CHEBI:16247;CHEBI:16247 denotes phospholipids
T77422 6657-6661 UBERON:0002048 denotes lung
T14186 6670-6679 MOP:0000568 denotes Oxidative
T39931 6705-6717 GO:0005739 denotes mitochondria
T31003 6738-6746 SP_7 denotes COVID-19
T74764 6912-6930 UBERON:0001004 denotes respiratory system
T10239 6950-6954 GO:0007567 denotes born
T92930 6955-6965 NCBITaxon:1 denotes individual
T11700 7048-7052 GO:0007567 denotes born
T48125 7053-7064 NCBITaxon:1 denotes individuals
T28108 7109-7117 SP_7 denotes COVID-19
T76303 7300-7311 GO:0007567 denotes prematurity
T8584 7316-7324 SP_7 denotes COVID-19

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 1782-1800 Body_part denotes respiratory system http://purl.org/sig/ont/fma/fma7158
T2 2124-2142 Body_part denotes respiratory system http://purl.org/sig/ont/fma/fma7158
T3 2643-2656 Body_part denotes chemoreceptor http://purl.org/sig/ont/fma/fma85604
T4 3793-3811 Body_part denotes pulmonary arteries http://purl.org/sig/ont/fma/fma66326
T5 3803-3811 Body_part denotes arteries http://purl.org/sig/ont/fma/fma63812
T6 3819-3833 Body_part denotes carotid bodies http://purl.org/sig/ont/fma/fma50095
T7 4112-4116 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T8 4121-4135 Body_part denotes carotid bodies http://purl.org/sig/ont/fma/fma50095
T9 4940-4953 Body_part denotes phospholipids http://purl.org/sig/ont/fma/fma82779
T10 4992-4997 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T11 5008-5021 Body_part denotes phospholipids http://purl.org/sig/ont/fma/fma82779
T12 5076-5084 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T13 5735-5739 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T14 5776-5780 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T15 6603-6616 Body_part denotes phospholipids http://purl.org/sig/ont/fma/fma82779
T16 6657-6661 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T17 6912-6930 Body_part denotes respiratory system http://purl.org/sig/ont/fma/fma7158

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1782-1800 Body_part denotes respiratory system http://purl.obolibrary.org/obo/UBERON_0001004
T2 2124-2142 Body_part denotes respiratory system http://purl.obolibrary.org/obo/UBERON_0001004
T3 2643-2656 Body_part denotes chemoreceptor http://purl.obolibrary.org/obo/UBERON_0018391
T4 3793-3811 Body_part denotes pulmonary arteries http://purl.obolibrary.org/obo/UBERON_0002012
T5 4112-4116 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T6 6657-6661 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 6912-6930 Body_part denotes respiratory system http://purl.obolibrary.org/obo/UBERON_0001004

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 49-57 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 100-108 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 134-181 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 134-167 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T5 183-191 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 316-326 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T7 527-556 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T8 568-576 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 579-588 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 765-775 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T11 869-877 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 1069-1076 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T13 1372-1380 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 3082-3090 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 3321-3329 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 3427-3439 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T17 3605-3613 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T18 3723-3731 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 4324-4332 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T20 4650-4662 Disease denotes Inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T21 4674-4682 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 4764-4776 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T23 4975-4983 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 5138-5146 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T25 5184-5192 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T26 5379-5387 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T27 5724-5732 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 5839-5847 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 5953-5961 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T30 6097-6109 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T31 6113-6121 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T32 6266-6274 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T33 6325-6334 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T34 6433-6442 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T35 6662-6668 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T36 6738-6746 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T37 7109-7117 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T38 7316-7324 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 195-198 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T2 206-207 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 295-296 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 310-315 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T5 500-503 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T6 616-617 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 1008-1012 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T8 1008-1012 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T9 1574-1575 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 1782-1800 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory system
T11 1983-1991 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T12 2124-2142 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory system
T13 3060-3061 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 3637-3640 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T15 3756-3757 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 3793-3811 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary arteries
T17 3793-3811 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary arteries
T18 4112-4116 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T19 4112-4116 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T20 4468-4472 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T21 4508-4511 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T22 4778-4779 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T23 4992-4997 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T24 5633-5641 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T25 5675-5679 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T26 5735-5739 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T27 5776-5780 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T28 5798-5803 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T29 5873-5881 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T30 5981-5984 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T31 6042-6050 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T32 6366-6374 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T33 6402-6407 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T34 6449-6450 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T35 6657-6661 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T36 6657-6661 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T37 6886-6887 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 6912-6930 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory system

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 1008-1012 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T2 1946-1957 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T3 3766-3772 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T4 4090-4096 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T5 4305-4311 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T6 4931-4953 Chemical denotes oxidized phospholipids http://purl.obolibrary.org/obo/CHEBI_60156
T7 4940-4953 Chemical denotes phospholipids http://purl.obolibrary.org/obo/CHEBI_16247
T8 5008-5021 Chemical denotes phospholipids http://purl.obolibrary.org/obo/CHEBI_16247
T9 6122-6126 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T10 6157-6171 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T11 6161-6171 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T12 6179-6193 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T15 6179-6190 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T16 6191-6193 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T17 6603-6616 Chemical denotes phospholipids http://purl.obolibrary.org/obo/CHEBI_16247
T18 6690-6696 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T19 7514-7520 Chemical denotes Letter http://purl.obolibrary.org/obo/CHEBI_6446
T20 7698-7704 Chemical denotes Letter http://purl.obolibrary.org/obo/CHEBI_6446

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 49-57 Disease denotes COVID-19 MESH:C000657245
18 134-181 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
19 183-193 Species denotes SARS-CoV-2 Tax:2697049
20 310-315 Species denotes human Tax:9606
21 878-886 Species denotes patients Tax:9606
22 73-98 Disease denotes novel coronavirus disease MESH:C000657245
23 100-108 Disease denotes COVID-19 MESH:C000657245
24 316-326 Disease denotes infections MESH:D007239
25 527-556 Disease denotes respiratory distress syndrome MESH:D012128
26 568-588 Disease denotes SARS-CoV-2 infection MESH:C000657245
27 663-670 Disease denotes dyspnea MESH:D004417
28 734-756 Disease denotes vascular abnormalities MESH:D000783
29 765-775 Disease denotes thrombosis MESH:D013927
30 869-877 Disease denotes COVID-19 MESH:C000657245
31 953-962 Disease denotes mortality MESH:D003643
32 1069-1076 Disease denotes obesity MESH:D009765
33 1081-1103 Disease denotes metabolic dysfunctions MESH:D008659
37 1946-1975 Gene denotes Angiotensin-converting enzyme Gene:1636
38 1977-1981 Gene denotes ACE2 Gene:59272
39 1372-1380 Disease denotes COVID-19 MESH:C000657245
42 2635-2668 Disease denotes carotid chemoreceptor dysfunction MESH:D002340
43 2695-2704 Disease denotes hyperoxia MESH:D018496
56 3614-3622 Species denotes patients Tax:9606
57 2858-2881 Disease denotes respiratory dysfunction MESH:D012131
58 2919-2926 Disease denotes hypoxia MESH:D000860
59 2956-2965 Disease denotes hypoxemia MESH:D000860
60 3047-3056 Disease denotes Hypoxemia MESH:D000860
61 3082-3090 Disease denotes COVID-19 MESH:C000657245
62 3141-3150 Disease denotes mortality MESH:D003643
63 3321-3329 Disease denotes COVID-19 MESH:C000657245
64 3419-3424 Disease denotes fever MESH:D005334
65 3427-3439 Disease denotes inflammation MESH:D007249
66 3528-3537 Disease denotes hypoxemia MESH:D000860
67 3605-3613 Disease denotes COVID-19 MESH:C000657245
72 3732-3740 Species denotes patients Tax:9606
73 3766-3772 Chemical denotes oxygen MESH:D010100
74 3666-3675 Disease denotes hypoxemia MESH:D000860
75 3723-3731 Disease denotes COVID-19 MESH:C000657245
81 4641-4648 Species denotes persons Tax:9606
82 4090-4096 Chemical denotes oxygen MESH:D010100
83 4305-4311 Chemical denotes oxygen MESH:D010100
84 4324-4332 Disease denotes COVID-19 MESH:C000657245
85 4610-4620 Disease denotes hypoxaemia
97 4984-4991 Species denotes patient Tax:9606
98 4940-4953 Chemical denotes phospholipids MESH:D010743
99 5008-5021 Chemical denotes phospholipids MESH:D010743
100 4650-4662 Disease denotes Inflammation MESH:D007249
101 4674-4682 Disease denotes COVID-19 MESH:C000657245
102 4764-4776 Disease denotes inflammation MESH:D007249
103 4975-4983 Disease denotes COVID-19 MESH:C000657245
104 5042-5067 Disease denotes coagulation abnormalities MESH:D025861
105 5138-5146 Disease denotes COVID-19 MESH:C000657245
106 5184-5192 Disease denotes COVID-19 MESH:C000657245
107 5379-5387 Disease denotes COVID-19 MESH:C000657245
121 5628-5632 Gene denotes ACE2 Gene:59272
122 5682-5687 Gene denotes ACE-2 Gene:59272
123 5868-5872 Gene denotes ACE2 Gene:59272
124 6037-6041 Gene denotes ACE2 Gene:59272
125 6157-6160 Gene denotes ACE Gene:1636
126 6231-6235 Gene denotes ACE2 Gene:59272
127 5724-5734 Species denotes SARS-CoV-2 Tax:2697049
128 5798-5803 Species denotes human Tax:9606
129 5815-5828 Species denotes coronaviruses Tax:11118
130 5839-5849 Species denotes SARS-CoV-2 Tax:2697049
131 5953-5961 Disease denotes COVID-19 MESH:C000657245
132 6097-6109 Disease denotes hypertension MESH:D006973
133 6113-6121 Disease denotes diabetes MESH:D003920
147 6361-6365 Gene denotes ACE2 Gene:59272
148 6275-6283 Species denotes patients Tax:9606
149 7118-7126 Species denotes patients Tax:9606
150 6603-6616 Chemical denotes phospholipids MESH:D010743
151 6690-6696 Chemical denotes oxygen MESH:D010100
152 6266-6274 Disease denotes COVID-19 MESH:C000657245
153 6325-6334 Disease denotes infection MESH:D007239
154 6433-6442 Disease denotes infection MESH:D007239
155 6657-6668 Disease denotes lung injury MESH:D055370
156 6738-6746 Disease denotes COVID-19 MESH:C000657245
157 6755-6764 Disease denotes hypoxemia MESH:D000860
158 7109-7117 Disease denotes COVID-19 MESH:C000657245
159 7316-7324 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 527-547 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T2 663-670 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T3 710-730 Phenotype denotes intrapulmonary shunt http://purl.obolibrary.org/obo/HP_0031225
T4 734-756 Phenotype denotes vascular abnormalities http://purl.obolibrary.org/obo/HP_0002597
T5 1069-1076 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T6 1897-1913 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T7 2919-2926 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T8 2956-2965 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T9 3047-3056 Phenotype denotes Hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T10 3419-3424 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T11 3528-3537 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T12 3666-3675 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T13 4214-4230 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T14 4362-4378 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T15 4701-4717 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T16 4725-4741 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T17 4893-4909 Phenotype denotes Oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T18 5042-5067 Phenotype denotes coagulation abnormalities http://purl.obolibrary.org/obo/HP_0001928
T19 5072-5091 Phenotype denotes low platelet counts http://purl.obolibrary.org/obo/HP_0001873
T20 5252-5268 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T21 5424-5440 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T22 6097-6109 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T23 6755-6764 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 790-802 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T2 1782-1812 http://purl.obolibrary.org/obo/GO_0060541 denotes respiratory system development
T3 1794-1812 http://purl.obolibrary.org/obo/GO_0048731 denotes system development
T4 2907-2926 http://purl.obolibrary.org/obo/GO_0001666 denotes response to hypoxia
T5 3427-3439 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T6 3885-3895 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T7 4650-4662 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T8 4764-4776 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T9 4792-4802 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10 5042-5053 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-14 Sentence denotes Preterm birth:
T2 15-67 Sentence denotes Potential risk factor for greater COVID-19 severity?
T3 69-257 Sentence denotes The novel coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major health (& economic) issue across the globe.
T4 258-357 Sentence denotes As of June 20th, more than eight and a half million human infections have been confirmed worldwide.
T5 358-522 Sentence denotes While the exact pathophysiology is still investigated, significant individual variability in the disease severity and subsequent consequences has been demonstrated.
T6 523-828 Sentence denotes The respiratory distress syndrome related to SARS-CoV-2 infection seems highly specific with a desaturation despite sometimes an absence of dyspnea and distinct manifestations like large intrapulmonary shunt or vascular abnormalities such as thrombosis and increased angiogenesis (Ackermann et al., 2020).
T7 829-1125 Sentence denotes Current evidence from large prospective COVID-19 patients cohort studies suggests that the key independent risk factors for mortality and severe complications include higher age, male sex and chronic comorbidities, predominantly related to obesity and metabolic dysfunctions (Liang et al., 2020).
T8 1126-1291 Sentence denotes Fast identification of “more-at-risk” populations is key for optimization of therapy selection and timing, especially when health care system capacities are limited.
T9 1292-1422 Sentence denotes One such, to-date neglected population that is potentially more »vulnerable« to COVID-19 consists of prematurely born individuals.
T10 1423-1611 Sentence denotes Given that preterm birth prevalence is currently estimated at approximately 10 % births worldwide, the potential consequences of prematurity relate to a significant part of the population.
T11 1612-1732 Sentence denotes We argue, that three important features associated with prematurity constitute the basis of such probable vulnerability:
T12 1733-1835 Sentence denotes First, the detrimental long-term consequences on respiratory system development, control and function.
T13 1836-2003 Sentence denotes Second, higher levels of (and possibly reduced tolerance to) oxidative stress and third, potentially elevated Angiotensin-converting enzyme (ACE2) activity/expression.
T14 2004-2143 Sentence denotes Prematurity can provoke life-long adverse sequelae in numerous physiological systems but might predominantly affect the respiratory system.
T15 2144-2291 Sentence denotes Importantly, recent accumulating evidence suggests that the respiratory drive/control might be particularly compromised under hypoxemic conditions.
T16 2292-2537 Sentence denotes Indeed, it is well established that the ventilatory response to hypoxic stimuli is blunted in prematurely born individuals as compared to their full-term born and physical capacity matched counterparts (Bates et al., 2014; Debevec et al., 2019).
T17 2538-2754 Sentence denotes Whilst the exact mechanisms of prematurity-related altered resting cardiorespiratory control and carotid chemoreceptor dysfunction remain unknown, perinatal hyperoxia was hypothesized to be the key underlying factor.
T18 2755-2882 Sentence denotes Other anatomical and functional consequences of prematurity might even further exacerbate the observed respiratory dysfunction.
T19 2883-2966 Sentence denotes The reduced ventilatory response to hypoxia may lead to greater systemic hypoxemia.
T20 2967-3046 Sentence denotes This can be particularly problematic in already hypoxemic clinical populations.
T21 3047-3283 Sentence denotes Hypoxemia is a defining feature of COVID-19 that is independently associated with in-hospital mortality (Xie et al., 2020) and might importantly underline the disease-related respiratory challenges and end-point outcomes in this cohort.
T22 3284-3623 Sentence denotes Whilst other factors associated with COVID-19 also importantly modulate the ventilatory drive (i.e., higher metabolic drive related to fever & inflammation) the potentially blunted hypoxic ventilatory response and subsequently greater systemic hypoxemia in prematurely born individuals should be considered when managing COVID-19 patients.
T23 3624-3856 Sentence denotes Recently, it has been speculated that the hypoxemia and associated pulmonary pathology observed in COVID-19 patients may arise from a reduced oxygen-sensing capacity in pulmonary arteries and in carotid bodies (Archer et al., 2020).
T24 3857-4061 Sentence denotes The resulting dysfunctional regulation of ventilation may be particularly deleterious in combination with pre-existing deficits of the ventilatory response, as is the case in prematurely born individuals.
T25 4062-4170 Sentence denotes It is well established that oxygen sensing in the lung and carotid bodies depends on mitochondrial function.
T26 4171-4474 Sentence denotes The known vulnerability of mitochondria to oxidative stress suggests an additional feature of prematurity to be relevant for impaired oxygen sensing and COVID-19 severity; potentially higher oxidative stress levels as compared to full-term born individuals (Filippone et al., 2012; Martin et al., 2018).
T27 4475-4649 Sentence denotes This difference in redox balance has indeed been hypothesized to be directly involved in the modulation of the ventilatory response to hypoxaemia in prematurely born persons.
T28 4650-4777 Sentence denotes Inflammation related to COVID-19 further increases oxidative stress, while oxidative stress, in turn, can promote inflammation.
T29 4778-4892 Sentence denotes A basal redox regulation deficit thus might increase the risk to get trapped in this detrimental feedforward loop.
T30 4893-4998 Sentence denotes Oxidative stress furthermore leads to oxidized phospholipids, commonly present in COVID-19 patient lungs.
T31 4999-5172 Sentence denotes Oxidized phospholipids have been linked to coagulation abnormalities and low platelet counts, which are associated with adverse outcome of COVID-19 (Merad and Martin, 2020).
T32 5173-5388 Sentence denotes Given that COVID-19 risk factors/conditions are commonly characterized by high oxidative stress levels it seems plausible that redox balance deficits are among the underlying mechanisms of vulnerability to COVID-19.
T33 5389-5532 Sentence denotes Therefore, the potentially altered oxidative stress status linked to prematurity must be considered as it might exacerbate the clinical status.
T34 5533-5681 Sentence denotes Finally, accumulating evidence indicates that prematurity might also be associated with higher ACE2 activity and/or expression (South et al., 2018).
T35 5682-5850 Sentence denotes ACE-2 is known to be directly involved in SARS-CoV-2 cell-binding, representing the main host cell receptor for all human pathogenic coronaviruses including SARS-CoV-2.
T36 5851-5971 Sentence denotes Thus, the higher ACE2 activity/expression in the prematurely born individuals might result in greater COVID-19 severity.
T37 5972-6236 Sentence denotes One also has to bear in mind that the prematurity-related higher ACE2 activity might be additionally heightened by potential hypertension or diabetes drug therapies which often include ACE inhibitors and/or angiotensin II receptor blockers, both upregulating ACE2.
T38 6237-6355 Sentence denotes In summary, prematurely born COVID-19 patients could be particularly vulnerable to both infection and adverse outcome.
T39 6356-6448 Sentence denotes High ACE2 activity levels may enable enhanced virus-binding, thus increasing infection risk.
T40 6449-6669 Sentence denotes A pre-existing adverse redox balance could then contribute to the aggravation of inflammatory mechanisms by oxidation of different biomolecules including phospholipids, incidentally exacerbating vascular and lung injury.
T41 6670-6966 Sentence denotes Oxidative damage to oxygen-sensing mitochondria in conjunction with COVID-19-related hypoxemia and prematurity-associated ventilator response deficits may synergistically deteriorate the health status facilitated by a potentially compromised respiratory system of the prematurely born individual.
T42 6967-7127 Sentence denotes We believe that the above-summarized data and mechanisms observed in prematurely born individuals should be considered when managing/treating COVID-19 patients.
T43 7128-7420 Sentence denotes As no sound epidemiological data currently exist on the topic, future epidemiological and experimental efforts are urgently warranted to elucidate the relationship between prematurity and COVID-19 severity and thereby optimize therapeutic approaches for this, up-to-now neglected, population.
T44 7422-7451 Sentence denotes Author contribution statement
T45 7452-7521 Sentence denotes All authors contributed to the preparation and writing of the Letter.
T46 7522-7588 Sentence denotes All authors read and approved the final version of the manuscript.
T47 7590-7623 Sentence denotes Declaration of Competing Interest
T48 7624-7705 Sentence denotes The authors declare no conflicts of interest related to the topic of this Letter.