PMC:7318948 / 15081-16189 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T221","span":{"begin":20,"end":37},"obj":"CHEBI:35705;CHEBI:35705"},{"id":"T222","span":{"begin":78,"end":86},"obj":"SP_7"},{"id":"T223","span":{"begin":141,"end":147},"obj":"UBERON:0002405;GO:0006955"},{"id":"T224","span":{"begin":148,"end":156},"obj":"GO:0006955"},{"id":"T225","span":{"begin":169,"end":174},"obj":"NCBITaxon:10239"},{"id":"T226","span":{"begin":262,"end":279},"obj":"CHEBI:35705;CHEBI:35705"},{"id":"T227","span":{"begin":385,"end":390},"obj":"NCBITaxon:10239"},{"id":"T228","span":{"begin":555,"end":559},"obj":"SP_10"},{"id":"T229","span":{"begin":589,"end":594},"obj":"NCBITaxon:10239"},{"id":"T230","span":{"begin":794,"end":799},"obj":"UBERON:0002107"},{"id":"T231","span":{"begin":846,"end":854},"obj":"SP_7"},{"id":"T232","span":{"begin":952,"end":962},"obj":"CL:0000542"},{"id":"T233","span":{"begin":1000,"end":1004},"obj":"PR:000001393"},{"id":"T234","span":{"begin":1074,"end":1082},"obj":"SP_7"},{"id":"T4621","span":{"begin":20,"end":37},"obj":"CHEBI:35705;CHEBI:35705"},{"id":"T9248","span":{"begin":78,"end":86},"obj":"SP_7"},{"id":"T85163","span":{"begin":141,"end":147},"obj":"UBERON:0002405;GO:0006955"},{"id":"T41905","span":{"begin":148,"end":156},"obj":"GO:0006955"},{"id":"T33200","span":{"begin":169,"end":174},"obj":"NCBITaxon:10239"},{"id":"T45112","span":{"begin":262,"end":279},"obj":"CHEBI:35705;CHEBI:35705"},{"id":"T53815","span":{"begin":385,"end":390},"obj":"NCBITaxon:10239"},{"id":"T54517","span":{"begin":555,"end":559},"obj":"SP_10"},{"id":"T90338","span":{"begin":589,"end":594},"obj":"NCBITaxon:10239"},{"id":"T14177","span":{"begin":794,"end":799},"obj":"UBERON:0002107"},{"id":"T32097","span":{"begin":846,"end":854},"obj":"SP_7"},{"id":"T53579","span":{"begin":952,"end":962},"obj":"CL:0000542"},{"id":"T54424","span":{"begin":1000,"end":1004},"obj":"PR:000001393"},{"id":"T55605","span":{"begin":1074,"end":1082},"obj":"SP_7"}],"text":"Close monitoring of immunosuppressive therapy in SOT recipients infected with COVID-19 is necessary. There is a balance of allowing adequate immune response to suppress viral load and preventing transplant rejection. Previous case reports have hypothesized that immunosuppressive therapy protects SOT recipients by dampening the cytokine storm [17]. Other case reports have noted that viral RNA levels remain positive for a longer period than in immunocompetent patients [4]. This is notable because previous studies have demonstrated that ARDS occurs in SARS patients despite a decreased viral load [18]. This is important because it indicates antiviral therapy alone is inadequate treatment and supports the hypothesis that the ARDS results from the cytokine storm [18]. One case report of a liver transplant recipient that tested positive for COVID-19 suffered from acute transplant rejection despite maintaining adequate immunosuppression based on lymphocyte subtests. 4 This suggests that early IL-6 intervention to prevent the cytokine storm could improve outcomes in COVID-19 positive, SOT recipients."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T84","span":{"begin":329,"end":337},"obj":"Body_part"},{"id":"T85","span":{"begin":391,"end":394},"obj":"Body_part"},{"id":"T86","span":{"begin":752,"end":760},"obj":"Body_part"},{"id":"T87","span":{"begin":794,"end":799},"obj":"Body_part"},{"id":"T88","span":{"begin":952,"end":962},"obj":"Body_part"},{"id":"T89","span":{"begin":1033,"end":1041},"obj":"Body_part"}],"attributes":[{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Close monitoring of immunosuppressive therapy in SOT recipients infected with COVID-19 is necessary. There is a balance of allowing adequate immune response to suppress viral load and preventing transplant rejection. Previous case reports have hypothesized that immunosuppressive therapy protects SOT recipients by dampening the cytokine storm [17]. Other case reports have noted that viral RNA levels remain positive for a longer period than in immunocompetent patients [4]. This is notable because previous studies have demonstrated that ARDS occurs in SARS patients despite a decreased viral load [18]. This is important because it indicates antiviral therapy alone is inadequate treatment and supports the hypothesis that the ARDS results from the cytokine storm [18]. One case report of a liver transplant recipient that tested positive for COVID-19 suffered from acute transplant rejection despite maintaining adequate immunosuppression based on lymphocyte subtests. 4 This suggests that early IL-6 intervention to prevent the cytokine storm could improve outcomes in COVID-19 positive, SOT recipients."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T51","span":{"begin":794,"end":799},"obj":"Body_part"}],"attributes":[{"id":"A51","pred":"uberon_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"Close monitoring of immunosuppressive therapy in SOT recipients infected with COVID-19 is necessary. There is a balance of allowing adequate immune response to suppress viral load and preventing transplant rejection. Previous case reports have hypothesized that immunosuppressive therapy protects SOT recipients by dampening the cytokine storm [17]. Other case reports have noted that viral RNA levels remain positive for a longer period than in immunocompetent patients [4]. This is notable because previous studies have demonstrated that ARDS occurs in SARS patients despite a decreased viral load [18]. This is important because it indicates antiviral therapy alone is inadequate treatment and supports the hypothesis that the ARDS results from the cytokine storm [18]. One case report of a liver transplant recipient that tested positive for COVID-19 suffered from acute transplant rejection despite maintaining adequate immunosuppression based on lymphocyte subtests. 4 This suggests that early IL-6 intervention to prevent the cytokine storm could improve outcomes in COVID-19 positive, SOT recipients."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T78","span":{"begin":78,"end":86},"obj":"Disease"},{"id":"T79","span":{"begin":540,"end":544},"obj":"Disease"},{"id":"T80","span":{"begin":555,"end":559},"obj":"Disease"},{"id":"T81","span":{"begin":730,"end":734},"obj":"Disease"},{"id":"T82","span":{"begin":846,"end":854},"obj":"Disease"},{"id":"T83","span":{"begin":1074,"end":1082},"obj":"Disease"}],"attributes":[{"id":"A78","pred":"mondo_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A79","pred":"mondo_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A81","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Close monitoring of immunosuppressive therapy in SOT recipients infected with COVID-19 is necessary. There is a balance of allowing adequate immune response to suppress viral load and preventing transplant rejection. Previous case reports have hypothesized that immunosuppressive therapy protects SOT recipients by dampening the cytokine storm [17]. Other case reports have noted that viral RNA levels remain positive for a longer period than in immunocompetent patients [4]. This is notable because previous studies have demonstrated that ARDS occurs in SARS patients despite a decreased viral load [18]. This is important because it indicates antiviral therapy alone is inadequate treatment and supports the hypothesis that the ARDS results from the cytokine storm [18]. One case report of a liver transplant recipient that tested positive for COVID-19 suffered from acute transplant rejection despite maintaining adequate immunosuppression based on lymphocyte subtests. 4 This suggests that early IL-6 intervention to prevent the cytokine storm could improve outcomes in COVID-19 positive, SOT recipients."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T203","span":{"begin":110,"end":111},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T204","span":{"begin":422,"end":423},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T205","span":{"begin":577,"end":578},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T206","span":{"begin":601,"end":603},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T207","span":{"begin":768,"end":770},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T208","span":{"begin":792,"end":793},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T209","span":{"begin":794,"end":799},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T210","span":{"begin":794,"end":799},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T211","span":{"begin":826,"end":832},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"text":"Close monitoring of immunosuppressive therapy in SOT recipients infected with COVID-19 is necessary. There is a balance of allowing adequate immune response to suppress viral load and preventing transplant rejection. Previous case reports have hypothesized that immunosuppressive therapy protects SOT recipients by dampening the cytokine storm [17]. Other case reports have noted that viral RNA levels remain positive for a longer period than in immunocompetent patients [4]. This is notable because previous studies have demonstrated that ARDS occurs in SARS patients despite a decreased viral load [18]. This is important because it indicates antiviral therapy alone is inadequate treatment and supports the hypothesis that the ARDS results from the cytokine storm [18]. One case report of a liver transplant recipient that tested positive for COVID-19 suffered from acute transplant rejection despite maintaining adequate immunosuppression based on lymphocyte subtests. 4 This suggests that early IL-6 intervention to prevent the cytokine storm could improve outcomes in COVID-19 positive, SOT recipients."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T171","span":{"begin":645,"end":654},"obj":"Chemical"},{"id":"T172","span":{"begin":1000,"end":1002},"obj":"Chemical"}],"attributes":[{"id":"A171","pred":"chebi_id","subj":"T171","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A172","pred":"chebi_id","subj":"T172","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A173","pred":"chebi_id","subj":"T172","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"Close monitoring of immunosuppressive therapy in SOT recipients infected with COVID-19 is necessary. There is a balance of allowing adequate immune response to suppress viral load and preventing transplant rejection. Previous case reports have hypothesized that immunosuppressive therapy protects SOT recipients by dampening the cytokine storm [17]. Other case reports have noted that viral RNA levels remain positive for a longer period than in immunocompetent patients [4]. This is notable because previous studies have demonstrated that ARDS occurs in SARS patients despite a decreased viral load [18]. This is important because it indicates antiviral therapy alone is inadequate treatment and supports the hypothesis that the ARDS results from the cytokine storm [18]. One case report of a liver transplant recipient that tested positive for COVID-19 suffered from acute transplant rejection despite maintaining adequate immunosuppression based on lymphocyte subtests. 4 This suggests that early IL-6 intervention to prevent the cytokine storm could improve outcomes in COVID-19 positive, SOT recipients."}

{"project":"LitCovid-PubTator","denotations":[{"id":"378","span":{"begin":1000,"end":1004},"obj":"Gene"},{"id":"379","span":{"begin":462,"end":470},"obj":"Species"},{"id":"380","span":{"begin":560,"end":568},"obj":"Species"},{"id":"381","span":{"begin":64,"end":72},"obj":"Disease"},{"id":"382","span":{"begin":78,"end":86},"obj":"Disease"},{"id":"383","span":{"begin":540,"end":544},"obj":"Disease"},{"id":"384","span":{"begin":555,"end":559},"obj":"Disease"},{"id":"385","span":{"begin":730,"end":734},"obj":"Disease"},{"id":"386","span":{"begin":846,"end":854},"obj":"Disease"},{"id":"387","span":{"begin":1074,"end":1082},"obj":"Disease"}],"attributes":[{"id":"A378","pred":"tao:has_database_id","subj":"378","obj":"Gene:3569"},{"id":"A379","pred":"tao:has_database_id","subj":"379","obj":"Tax:9606"},{"id":"A380","pred":"tao:has_database_id","subj":"380","obj":"Tax:9606"},{"id":"A381","pred":"tao:has_database_id","subj":"381","obj":"MESH:D007239"},{"id":"A382","pred":"tao:has_database_id","subj":"382","obj":"MESH:C000657245"},{"id":"A383","pred":"tao:has_database_id","subj":"383","obj":"MESH:D012128"},{"id":"A384","pred":"tao:has_database_id","subj":"384","obj":"MESH:D045169"},{"id":"A385","pred":"tao:has_database_id","subj":"385","obj":"MESH:D012128"},{"id":"A386","pred":"tao:has_database_id","subj":"386","obj":"MESH:C000657245"},{"id":"A387","pred":"tao:has_database_id","subj":"387","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Close monitoring of immunosuppressive therapy in SOT recipients infected with COVID-19 is necessary. There is a balance of allowing adequate immune response to suppress viral load and preventing transplant rejection. Previous case reports have hypothesized that immunosuppressive therapy protects SOT recipients by dampening the cytokine storm [17]. Other case reports have noted that viral RNA levels remain positive for a longer period than in immunocompetent patients [4]. This is notable because previous studies have demonstrated that ARDS occurs in SARS patients despite a decreased viral load [18]. This is important because it indicates antiviral therapy alone is inadequate treatment and supports the hypothesis that the ARDS results from the cytokine storm [18]. One case report of a liver transplant recipient that tested positive for COVID-19 suffered from acute transplant rejection despite maintaining adequate immunosuppression based on lymphocyte subtests. 4 This suggests that early IL-6 intervention to prevent the cytokine storm could improve outcomes in COVID-19 positive, SOT recipients."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T30","span":{"begin":329,"end":343},"obj":"Phenotype"},{"id":"T31","span":{"begin":752,"end":766},"obj":"Phenotype"},{"id":"T32","span":{"begin":1033,"end":1047},"obj":"Phenotype"}],"attributes":[{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A32","pred":"hp_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"Close monitoring of immunosuppressive therapy in SOT recipients infected with COVID-19 is necessary. There is a balance of allowing adequate immune response to suppress viral load and preventing transplant rejection. Previous case reports have hypothesized that immunosuppressive therapy protects SOT recipients by dampening the cytokine storm [17]. Other case reports have noted that viral RNA levels remain positive for a longer period than in immunocompetent patients [4]. This is notable because previous studies have demonstrated that ARDS occurs in SARS patients despite a decreased viral load [18]. This is important because it indicates antiviral therapy alone is inadequate treatment and supports the hypothesis that the ARDS results from the cytokine storm [18]. One case report of a liver transplant recipient that tested positive for COVID-19 suffered from acute transplant rejection despite maintaining adequate immunosuppression based on lymphocyte subtests. 4 This suggests that early IL-6 intervention to prevent the cytokine storm could improve outcomes in COVID-19 positive, SOT recipients."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T35","span":{"begin":141,"end":156},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"Close monitoring of immunosuppressive therapy in SOT recipients infected with COVID-19 is necessary. There is a balance of allowing adequate immune response to suppress viral load and preventing transplant rejection. Previous case reports have hypothesized that immunosuppressive therapy protects SOT recipients by dampening the cytokine storm [17]. Other case reports have noted that viral RNA levels remain positive for a longer period than in immunocompetent patients [4]. This is notable because previous studies have demonstrated that ARDS occurs in SARS patients despite a decreased viral load [18]. This is important because it indicates antiviral therapy alone is inadequate treatment and supports the hypothesis that the ARDS results from the cytokine storm [18]. One case report of a liver transplant recipient that tested positive for COVID-19 suffered from acute transplant rejection despite maintaining adequate immunosuppression based on lymphocyte subtests. 4 This suggests that early IL-6 intervention to prevent the cytokine storm could improve outcomes in COVID-19 positive, SOT recipients."}

{"project":"LitCovid-sentences","denotations":[{"id":"T137","span":{"begin":0,"end":100},"obj":"Sentence"},{"id":"T138","span":{"begin":101,"end":216},"obj":"Sentence"},{"id":"T139","span":{"begin":217,"end":349},"obj":"Sentence"},{"id":"T140","span":{"begin":350,"end":475},"obj":"Sentence"},{"id":"T141","span":{"begin":476,"end":605},"obj":"Sentence"},{"id":"T142","span":{"begin":606,"end":772},"obj":"Sentence"},{"id":"T143","span":{"begin":773,"end":972},"obj":"Sentence"},{"id":"T144","span":{"begin":973,"end":1108},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Close monitoring of immunosuppressive therapy in SOT recipients infected with COVID-19 is necessary. There is a balance of allowing adequate immune response to suppress viral load and preventing transplant rejection. Previous case reports have hypothesized that immunosuppressive therapy protects SOT recipients by dampening the cytokine storm [17]. Other case reports have noted that viral RNA levels remain positive for a longer period than in immunocompetent patients [4]. This is notable because previous studies have demonstrated that ARDS occurs in SARS patients despite a decreased viral load [18]. This is important because it indicates antiviral therapy alone is inadequate treatment and supports the hypothesis that the ARDS results from the cytokine storm [18]. One case report of a liver transplant recipient that tested positive for COVID-19 suffered from acute transplant rejection despite maintaining adequate immunosuppression based on lymphocyte subtests. 4 This suggests that early IL-6 intervention to prevent the cytokine storm could improve outcomes in COVID-19 positive, SOT recipients."}