PMC:7318948 / 11675-12492 JSONTXT

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{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T47","span":{"begin":434,"end":440},"obj":"Body_part"},{"id":"T48","span":{"begin":565,"end":570},"obj":"Body_part"}],"attributes":[{"id":"A47","pred":"uberon_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A48","pred":"uberon_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"Recent proposals regarding the pathophysiology of COVID-19 suggest a hyper-inflammatory state resulting in COVID-19 related acute respiratory distress syndrome (ARDS) [3]. Once infected, there is loss of primary antiviral defense because of virus-induced interferon suppression with lymphopenia [8]. Subsequently, the body activates a second defense mechanism, known as the “second wave,” which results in a cytokine storm and severe tissue damage [3]. Increases in many inflammatory markers, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum ferritin, interleukins 6, 8, and 10, procalcitonin, and interleukin-receptor have been found in COVID-19 patients [9]. Interleukin-6 (IL-6) is a marker of recent interest because of its role in the “second wave” and resulting cytokine storm. [10]"}

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{"project":"LitCovid-PD-CLO","denotations":[{"id":"T159","span":{"begin":67,"end":68},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T160","span":{"begin":241,"end":246},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T161","span":{"begin":323,"end":332},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T162","span":{"begin":333,"end":334},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T163","span":{"begin":406,"end":407},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T164","span":{"begin":501,"end":512},"obj":"http://purl.obolibrary.org/obo/CL_0000232"},{"id":"T165","span":{"begin":581,"end":595},"obj":"http://purl.obolibrary.org/obo/PR_000001393"},{"id":"T166","span":{"begin":690,"end":703},"obj":"http://purl.obolibrary.org/obo/PR_000001393"},{"id":"T167","span":{"begin":714,"end":715},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Recent proposals regarding the pathophysiology of COVID-19 suggest a hyper-inflammatory state resulting in COVID-19 related acute respiratory distress syndrome (ARDS) [3]. Once infected, there is loss of primary antiviral defense because of virus-induced interferon suppression with lymphopenia [8]. Subsequently, the body activates a second defense mechanism, known as the “second wave,” which results in a cytokine storm and severe tissue damage [3]. Increases in many inflammatory markers, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum ferritin, interleukins 6, 8, and 10, procalcitonin, and interleukin-receptor have been found in COVID-19 patients [9]. Interleukin-6 (IL-6) is a marker of recent interest because of its role in the “second wave” and resulting cytokine storm. [10]"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T132","span":{"begin":212,"end":221},"obj":"Chemical"},{"id":"T133","span":{"begin":255,"end":265},"obj":"Chemical"},{"id":"T134","span":{"begin":550,"end":557},"obj":"Chemical"},{"id":"T135","span":{"begin":581,"end":593},"obj":"Chemical"},{"id":"T136","span":{"begin":705,"end":707},"obj":"Chemical"}],"attributes":[{"id":"A132","pred":"chebi_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A133","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A135","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_52998"},{"id":"A136","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A137","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"Recent proposals regarding the pathophysiology of COVID-19 suggest a hyper-inflammatory state resulting in COVID-19 related acute respiratory distress syndrome (ARDS) [3]. Once infected, there is loss of primary antiviral defense because of virus-induced interferon suppression with lymphopenia [8]. Subsequently, the body activates a second defense mechanism, known as the “second wave,” which results in a cytokine storm and severe tissue damage [3]. Increases in many inflammatory markers, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum ferritin, interleukins 6, 8, and 10, procalcitonin, and interleukin-receptor have been found in COVID-19 patients [9]. Interleukin-6 (IL-6) is a marker of recent interest because of its role in the “second wave” and resulting cytokine storm. [10]"}

{"project":"LitCovid-PubTator","denotations":[{"id":"288","span":{"begin":539,"end":557},"obj":"Gene"},{"id":"289","span":{"begin":559,"end":562},"obj":"Gene"},{"id":"290","span":{"begin":690,"end":703},"obj":"Gene"},{"id":"291","span":{"begin":705,"end":709},"obj":"Gene"},{"id":"292","span":{"begin":676,"end":684},"obj":"Species"},{"id":"293","span":{"begin":50,"end":58},"obj":"Disease"},{"id":"294","span":{"begin":107,"end":115},"obj":"Disease"},{"id":"295","span":{"begin":124,"end":159},"obj":"Disease"},{"id":"296","span":{"begin":161,"end":165},"obj":"Disease"},{"id":"297","span":{"begin":177,"end":185},"obj":"Disease"},{"id":"298","span":{"begin":283,"end":294},"obj":"Disease"},{"id":"299","span":{"begin":667,"end":675},"obj":"Disease"}],"attributes":[{"id":"A288","pred":"tao:has_database_id","subj":"288","obj":"Gene:1401"},{"id":"A289","pred":"tao:has_database_id","subj":"289","obj":"Gene:1401"},{"id":"A290","pred":"tao:has_database_id","subj":"290","obj":"Gene:3569"},{"id":"A291","pred":"tao:has_database_id","subj":"291","obj":"Gene:3569"},{"id":"A292","pred":"tao:has_database_id","subj":"292","obj":"Tax:9606"},{"id":"A293","pred":"tao:has_database_id","subj":"293","obj":"MESH:C000657245"},{"id":"A294","pred":"tao:has_database_id","subj":"294","obj":"MESH:C000657245"},{"id":"A295","pred":"tao:has_database_id","subj":"295","obj":"MESH:D012128"},{"id":"A296","pred":"tao:has_database_id","subj":"296","obj":"MESH:D012128"},{"id":"A297","pred":"tao:has_database_id","subj":"297","obj":"MESH:D007239"},{"id":"A298","pred":"tao:has_database_id","subj":"298","obj":"MESH:D008231"},{"id":"A299","pred":"tao:has_database_id","subj":"299","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Recent proposals regarding the pathophysiology of COVID-19 suggest a hyper-inflammatory state resulting in COVID-19 related acute respiratory distress syndrome (ARDS) [3]. Once infected, there is loss of primary antiviral defense because of virus-induced interferon suppression with lymphopenia [8]. Subsequently, the body activates a second defense mechanism, known as the “second wave,” which results in a cytokine storm and severe tissue damage [3]. Increases in many inflammatory markers, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum ferritin, interleukins 6, 8, and 10, procalcitonin, and interleukin-receptor have been found in COVID-19 patients [9]. Interleukin-6 (IL-6) is a marker of recent interest because of its role in the “second wave” and resulting cytokine storm. [10]"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T23","span":{"begin":130,"end":150},"obj":"Phenotype"},{"id":"T24","span":{"begin":283,"end":294},"obj":"Phenotype"},{"id":"T25","span":{"begin":408,"end":422},"obj":"Phenotype"},{"id":"T26","span":{"begin":797,"end":811},"obj":"Phenotype"}],"attributes":[{"id":"A23","pred":"hp_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0001888"},{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"Recent proposals regarding the pathophysiology of COVID-19 suggest a hyper-inflammatory state resulting in COVID-19 related acute respiratory distress syndrome (ARDS) [3]. Once infected, there is loss of primary antiviral defense because of virus-induced interferon suppression with lymphopenia [8]. Subsequently, the body activates a second defense mechanism, known as the “second wave,” which results in a cytokine storm and severe tissue damage [3]. Increases in many inflammatory markers, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum ferritin, interleukins 6, 8, and 10, procalcitonin, and interleukin-receptor have been found in COVID-19 patients [9]. Interleukin-6 (IL-6) is a marker of recent interest because of its role in the “second wave” and resulting cytokine storm. [10]"}

{"project":"LitCovid-sentences","denotations":[{"id":"T116","span":{"begin":0,"end":171},"obj":"Sentence"},{"id":"T117","span":{"begin":172,"end":299},"obj":"Sentence"},{"id":"T118","span":{"begin":300,"end":452},"obj":"Sentence"},{"id":"T119","span":{"begin":453,"end":689},"obj":"Sentence"},{"id":"T120","span":{"begin":690,"end":817},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Recent proposals regarding the pathophysiology of COVID-19 suggest a hyper-inflammatory state resulting in COVID-19 related acute respiratory distress syndrome (ARDS) [3]. Once infected, there is loss of primary antiviral defense because of virus-induced interferon suppression with lymphopenia [8]. Subsequently, the body activates a second defense mechanism, known as the “second wave,” which results in a cytokine storm and severe tissue damage [3]. Increases in many inflammatory markers, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum ferritin, interleukins 6, 8, and 10, procalcitonin, and interleukin-receptor have been found in COVID-19 patients [9]. Interleukin-6 (IL-6) is a marker of recent interest because of its role in the “second wave” and resulting cytokine storm. [10]"}