PMC:7318948 / 1082-2416
Annnotations
LitCovid-PMC-OGER-BB
{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T23","span":{"begin":82,"end":90},"obj":"SP_7"},{"id":"T24","span":{"begin":113,"end":119},"obj":"GO:0016265"},{"id":"T25","span":{"begin":168,"end":179},"obj":"NCBITaxon:11118"},{"id":"T26","span":{"begin":286,"end":294},"obj":"SP_7"},{"id":"T27","span":{"begin":303,"end":309},"obj":"GO:0016265"},{"id":"T28","span":{"begin":359,"end":367},"obj":"SP_7"},{"id":"T29","span":{"begin":424,"end":436},"obj":"UBERON:0001852"},{"id":"T30","span":{"begin":595,"end":603},"obj":"SP_7"},{"id":"T31","span":{"begin":638,"end":643},"obj":"UBERON:0000062"},{"id":"T32","span":{"begin":737,"end":745},"obj":"SP_7"},{"id":"T33","span":{"begin":795,"end":813},"obj":"CHEBI:35705;CHEBI:35705"},{"id":"T34","span":{"begin":913,"end":918},"obj":"NCBITaxon:10239"},{"id":"T35","span":{"begin":1019,"end":1032},"obj":"PR:000001393"},{"id":"T36","span":{"begin":1034,"end":1038},"obj":"PR:000001393"},{"id":"T37","span":{"begin":1067,"end":1071},"obj":"UBERON:0002048;GO:0030324"},{"id":"T38","span":{"begin":1072,"end":1078},"obj":"GO:0006281"},{"id":"T39","span":{"begin":1089,"end":1094},"obj":"NCBITaxon:10239"},{"id":"T40","span":{"begin":1129,"end":1133},"obj":"PR:000001393"},{"id":"T41","span":{"begin":1134,"end":1143},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T42","span":{"begin":1144,"end":1149},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T43","span":{"begin":1197,"end":1205},"obj":"SP_7"},{"id":"T44","span":{"begin":1224,"end":1230},"obj":"UBERON:0002113"},{"id":"T45","span":{"begin":1235,"end":1240},"obj":"UBERON:0002107"},{"id":"T46","span":{"begin":1275,"end":1279},"obj":"PR:000001393"},{"id":"T47","span":{"begin":1280,"end":1289},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T26793","span":{"begin":82,"end":90},"obj":"SP_7"},{"id":"T17320","span":{"begin":113,"end":119},"obj":"GO:0016265"},{"id":"T29874","span":{"begin":168,"end":179},"obj":"NCBITaxon:11118"},{"id":"T65188","span":{"begin":286,"end":294},"obj":"SP_7"},{"id":"T18243","span":{"begin":303,"end":309},"obj":"GO:0016265"},{"id":"T75932","span":{"begin":359,"end":367},"obj":"SP_7"},{"id":"T83510","span":{"begin":424,"end":436},"obj":"UBERON:0001852"},{"id":"T83503","span":{"begin":595,"end":603},"obj":"SP_7"},{"id":"T80946","span":{"begin":638,"end":643},"obj":"UBERON:0000062"},{"id":"T2797","span":{"begin":737,"end":745},"obj":"SP_7"},{"id":"T18817","span":{"begin":795,"end":813},"obj":"CHEBI:35705;CHEBI:35705"},{"id":"T49695","span":{"begin":913,"end":918},"obj":"NCBITaxon:10239"},{"id":"T30614","span":{"begin":1019,"end":1032},"obj":"PR:000001393"},{"id":"T71673","span":{"begin":1034,"end":1038},"obj":"PR:000001393"},{"id":"T97545","span":{"begin":1067,"end":1071},"obj":"UBERON:0002048;GO:0030324"},{"id":"T69652","span":{"begin":1072,"end":1078},"obj":"GO:0006281"},{"id":"T14865","span":{"begin":1089,"end":1094},"obj":"NCBITaxon:10239"},{"id":"T99385","span":{"begin":1129,"end":1133},"obj":"PR:000001393"},{"id":"T38399","span":{"begin":1134,"end":1143},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T45524","span":{"begin":1144,"end":1149},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T52740","span":{"begin":1197,"end":1205},"obj":"SP_7"},{"id":"T66483","span":{"begin":1224,"end":1230},"obj":"UBERON:0002113"},{"id":"T65017","span":{"begin":1235,"end":1240},"obj":"UBERON:0002107"},{"id":"T45829","span":{"begin":1275,"end":1279},"obj":"PR:000001393"},{"id":"T679","span":{"begin":1280,"end":1289},"obj":"CHEBI:35222;CHEBI:35222"}],"text":"As of May 14, 2020, the World Health Organization has reported 4,248,386 cases of COVID-19 with 294,046 reported deaths secondary to complications related to the novel Coronavirus [1]. In the United States, the Center for Disease Control (CDC) reported 1,364,061 total cases and 82,246 COVID-19 related deaths [2]. A common complication reported secondary to COVID-19 is Acute Respiratory Distress Syndrome (ARDS) requiring endotracheal intubation and ventilator management. Experts currently believe that ARDS possibly results from a state of hyper-inflammation mediated by a cytokine storm in COVID-19 patients [3]. Recipients of solid organ transplants are included in a special population of patients who may face increased risks of COVID-19 related complications given their use of chronic immunosuppressants. Immunosuppression in this population can further reduce cell-mediated immunity, which may prolong viral shedding and increase the risk of COVID related complications [3]. As reported by McGonagle et al., interleukin-6 (IL-6) plays an important role in lung repair following viral insults and the administration of IL-6 inhibitor drugs may be time-sensitive [3]. We report a case of COVID-19 in a patient with kidney and liver transplant and discuss the use of IL-6 inhibitor to prevent a cytokine storm in this setting."}
LitCovid-PD-FMA-UBERON
{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T8","span":{"begin":577,"end":585},"obj":"Body_part"},{"id":"T9","span":{"begin":632,"end":643},"obj":"Body_part"},{"id":"T10","span":{"begin":713,"end":717},"obj":"Body_part"},{"id":"T11","span":{"begin":871,"end":875},"obj":"Body_part"},{"id":"T12","span":{"begin":1019,"end":1032},"obj":"Body_part"},{"id":"T13","span":{"begin":1067,"end":1071},"obj":"Body_part"},{"id":"T14","span":{"begin":1224,"end":1230},"obj":"Body_part"},{"id":"T15","span":{"begin":1235,"end":1240},"obj":"Body_part"},{"id":"T16","span":{"begin":1303,"end":1311},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma55670"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma24728"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma264829"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"As of May 14, 2020, the World Health Organization has reported 4,248,386 cases of COVID-19 with 294,046 reported deaths secondary to complications related to the novel Coronavirus [1]. In the United States, the Center for Disease Control (CDC) reported 1,364,061 total cases and 82,246 COVID-19 related deaths [2]. A common complication reported secondary to COVID-19 is Acute Respiratory Distress Syndrome (ARDS) requiring endotracheal intubation and ventilator management. Experts currently believe that ARDS possibly results from a state of hyper-inflammation mediated by a cytokine storm in COVID-19 patients [3]. Recipients of solid organ transplants are included in a special population of patients who may face increased risks of COVID-19 related complications given their use of chronic immunosuppressants. Immunosuppression in this population can further reduce cell-mediated immunity, which may prolong viral shedding and increase the risk of COVID related complications [3]. As reported by McGonagle et al., interleukin-6 (IL-6) plays an important role in lung repair following viral insults and the administration of IL-6 inhibitor drugs may be time-sensitive [3]. We report a case of COVID-19 in a patient with kidney and liver transplant and discuss the use of IL-6 inhibitor to prevent a cytokine storm in this setting."}
LitCovid-PD-UBERON
{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T6","span":{"begin":638,"end":643},"obj":"Body_part"},{"id":"T7","span":{"begin":713,"end":717},"obj":"Body_part"},{"id":"T8","span":{"begin":1067,"end":1071},"obj":"Body_part"},{"id":"T9","span":{"begin":1224,"end":1230},"obj":"Body_part"},{"id":"T10","span":{"begin":1235,"end":1240},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0001456"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"As of May 14, 2020, the World Health Organization has reported 4,248,386 cases of COVID-19 with 294,046 reported deaths secondary to complications related to the novel Coronavirus [1]. In the United States, the Center for Disease Control (CDC) reported 1,364,061 total cases and 82,246 COVID-19 related deaths [2]. A common complication reported secondary to COVID-19 is Acute Respiratory Distress Syndrome (ARDS) requiring endotracheal intubation and ventilator management. Experts currently believe that ARDS possibly results from a state of hyper-inflammation mediated by a cytokine storm in COVID-19 patients [3]. Recipients of solid organ transplants are included in a special population of patients who may face increased risks of COVID-19 related complications given their use of chronic immunosuppressants. Immunosuppression in this population can further reduce cell-mediated immunity, which may prolong viral shedding and increase the risk of COVID related complications [3]. As reported by McGonagle et al., interleukin-6 (IL-6) plays an important role in lung repair following viral insults and the administration of IL-6 inhibitor drugs may be time-sensitive [3]. We report a case of COVID-19 in a patient with kidney and liver transplant and discuss the use of IL-6 inhibitor to prevent a cytokine storm in this setting."}
LitCovid-PD-MONDO
{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T13","span":{"begin":82,"end":90},"obj":"Disease"},{"id":"T14","span":{"begin":286,"end":294},"obj":"Disease"},{"id":"T15","span":{"begin":359,"end":367},"obj":"Disease"},{"id":"T16","span":{"begin":371,"end":406},"obj":"Disease"},{"id":"T17","span":{"begin":377,"end":406},"obj":"Disease"},{"id":"T18","span":{"begin":408,"end":412},"obj":"Disease"},{"id":"T19","span":{"begin":506,"end":510},"obj":"Disease"},{"id":"T20","span":{"begin":550,"end":562},"obj":"Disease"},{"id":"T21","span":{"begin":595,"end":603},"obj":"Disease"},{"id":"T22","span":{"begin":737,"end":745},"obj":"Disease"},{"id":"T23","span":{"begin":1197,"end":1205},"obj":"Disease"}],"attributes":[{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A22","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"As of May 14, 2020, the World Health Organization has reported 4,248,386 cases of COVID-19 with 294,046 reported deaths secondary to complications related to the novel Coronavirus [1]. In the United States, the Center for Disease Control (CDC) reported 1,364,061 total cases and 82,246 COVID-19 related deaths [2]. A common complication reported secondary to COVID-19 is Acute Respiratory Distress Syndrome (ARDS) requiring endotracheal intubation and ventilator management. Experts currently believe that ARDS possibly results from a state of hyper-inflammation mediated by a cytokine storm in COVID-19 patients [3]. Recipients of solid organ transplants are included in a special population of patients who may face increased risks of COVID-19 related complications given their use of chronic immunosuppressants. Immunosuppression in this population can further reduce cell-mediated immunity, which may prolong viral shedding and increase the risk of COVID related complications [3]. As reported by McGonagle et al., interleukin-6 (IL-6) plays an important role in lung repair following viral insults and the administration of IL-6 inhibitor drugs may be time-sensitive [3]. We report a case of COVID-19 in a patient with kidney and liver transplant and discuss the use of IL-6 inhibitor to prevent a cytokine storm in this setting."}
LitCovid-PD-CLO
{"project":"LitCovid-PD-CLO","denotations":[{"id":"T16","span":{"begin":37,"end":49},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T17","span":{"begin":50,"end":53},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T18","span":{"begin":239,"end":242},"obj":"http://purl.obolibrary.org/obo/CL_0000990"},{"id":"T19","span":{"begin":311,"end":316},"obj":"http://purl.obolibrary.org/obo/CLO_0001236"},{"id":"T20","span":{"begin":533,"end":534},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T21","span":{"begin":575,"end":576},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T22","span":{"begin":638,"end":643},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T23","span":{"begin":672,"end":673},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T24","span":{"begin":713,"end":717},"obj":"http://purl.obolibrary.org/obo/UBERON_0001456"},{"id":"T25","span":{"begin":871,"end":875},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T26","span":{"begin":1019,"end":1032},"obj":"http://purl.obolibrary.org/obo/PR_000001393"},{"id":"T27","span":{"begin":1067,"end":1071},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T28","span":{"begin":1067,"end":1071},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T29","span":{"begin":1187,"end":1188},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T30","span":{"begin":1209,"end":1210},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T31","span":{"begin":1224,"end":1230},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T32","span":{"begin":1224,"end":1230},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T33","span":{"begin":1224,"end":1230},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T34","span":{"begin":1235,"end":1240},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T35","span":{"begin":1235,"end":1240},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T36","span":{"begin":1301,"end":1302},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"As of May 14, 2020, the World Health Organization has reported 4,248,386 cases of COVID-19 with 294,046 reported deaths secondary to complications related to the novel Coronavirus [1]. In the United States, the Center for Disease Control (CDC) reported 1,364,061 total cases and 82,246 COVID-19 related deaths [2]. A common complication reported secondary to COVID-19 is Acute Respiratory Distress Syndrome (ARDS) requiring endotracheal intubation and ventilator management. Experts currently believe that ARDS possibly results from a state of hyper-inflammation mediated by a cytokine storm in COVID-19 patients [3]. Recipients of solid organ transplants are included in a special population of patients who may face increased risks of COVID-19 related complications given their use of chronic immunosuppressants. Immunosuppression in this population can further reduce cell-mediated immunity, which may prolong viral shedding and increase the risk of COVID related complications [3]. As reported by McGonagle et al., interleukin-6 (IL-6) plays an important role in lung repair following viral insults and the administration of IL-6 inhibitor drugs may be time-sensitive [3]. We report a case of COVID-19 in a patient with kidney and liver transplant and discuss the use of IL-6 inhibitor to prevent a cytokine storm in this setting."}
LitCovid-PD-CHEBI
{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T7","span":{"begin":1034,"end":1036},"obj":"Chemical"},{"id":"T9","span":{"begin":1129,"end":1131},"obj":"Chemical"},{"id":"T11","span":{"begin":1134,"end":1143},"obj":"Chemical"},{"id":"T12","span":{"begin":1144,"end":1149},"obj":"Chemical"},{"id":"T13","span":{"begin":1275,"end":1277},"obj":"Chemical"},{"id":"T15","span":{"begin":1280,"end":1289},"obj":"Chemical"}],"attributes":[{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A8","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A10","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A14","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"As of May 14, 2020, the World Health Organization has reported 4,248,386 cases of COVID-19 with 294,046 reported deaths secondary to complications related to the novel Coronavirus [1]. In the United States, the Center for Disease Control (CDC) reported 1,364,061 total cases and 82,246 COVID-19 related deaths [2]. A common complication reported secondary to COVID-19 is Acute Respiratory Distress Syndrome (ARDS) requiring endotracheal intubation and ventilator management. Experts currently believe that ARDS possibly results from a state of hyper-inflammation mediated by a cytokine storm in COVID-19 patients [3]. Recipients of solid organ transplants are included in a special population of patients who may face increased risks of COVID-19 related complications given their use of chronic immunosuppressants. Immunosuppression in this population can further reduce cell-mediated immunity, which may prolong viral shedding and increase the risk of COVID related complications [3]. As reported by McGonagle et al., interleukin-6 (IL-6) plays an important role in lung repair following viral insults and the administration of IL-6 inhibitor drugs may be time-sensitive [3]. We report a case of COVID-19 in a patient with kidney and liver transplant and discuss the use of IL-6 inhibitor to prevent a cytokine storm in this setting."}
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"61","span":{"begin":1019,"end":1032},"obj":"Gene"},{"id":"62","span":{"begin":1034,"end":1038},"obj":"Gene"},{"id":"63","span":{"begin":1129,"end":1133},"obj":"Gene"},{"id":"64","span":{"begin":1275,"end":1279},"obj":"Gene"},{"id":"65","span":{"begin":162,"end":179},"obj":"Species"},{"id":"66","span":{"begin":604,"end":612},"obj":"Species"},{"id":"67","span":{"begin":696,"end":704},"obj":"Species"},{"id":"68","span":{"begin":1211,"end":1218},"obj":"Species"},{"id":"69","span":{"begin":82,"end":90},"obj":"Disease"},{"id":"70","span":{"begin":113,"end":119},"obj":"Disease"},{"id":"71","span":{"begin":286,"end":294},"obj":"Disease"},{"id":"72","span":{"begin":303,"end":309},"obj":"Disease"},{"id":"73","span":{"begin":359,"end":367},"obj":"Disease"},{"id":"74","span":{"begin":377,"end":406},"obj":"Disease"},{"id":"75","span":{"begin":408,"end":412},"obj":"Disease"},{"id":"76","span":{"begin":506,"end":510},"obj":"Disease"},{"id":"77","span":{"begin":544,"end":562},"obj":"Disease"},{"id":"78","span":{"begin":595,"end":603},"obj":"Disease"},{"id":"79","span":{"begin":737,"end":745},"obj":"Disease"},{"id":"80","span":{"begin":953,"end":958},"obj":"Disease"},{"id":"81","span":{"begin":1197,"end":1205},"obj":"Disease"}],"attributes":[{"id":"A61","pred":"tao:has_database_id","subj":"61","obj":"Gene:3569"},{"id":"A62","pred":"tao:has_database_id","subj":"62","obj":"Gene:3569"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"Gene:3569"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"Gene:3569"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"Tax:2697049"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"Tax:9606"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"Tax:9606"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"Tax:9606"},{"id":"A69","pred":"tao:has_database_id","subj":"69","obj":"MESH:C000657245"},{"id":"A70","pred":"tao:has_database_id","subj":"70","obj":"MESH:D003643"},{"id":"A71","pred":"tao:has_database_id","subj":"71","obj":"MESH:C000657245"},{"id":"A72","pred":"tao:has_database_id","subj":"72","obj":"MESH:D003643"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"MESH:C000657245"},{"id":"A74","pred":"tao:has_database_id","subj":"74","obj":"MESH:D012128"},{"id":"A75","pred":"tao:has_database_id","subj":"75","obj":"MESH:D012128"},{"id":"A76","pred":"tao:has_database_id","subj":"76","obj":"MESH:D012128"},{"id":"A77","pred":"tao:has_database_id","subj":"77","obj":"MESH:D007249"},{"id":"A78","pred":"tao:has_database_id","subj":"78","obj":"MESH:C000657245"},{"id":"A79","pred":"tao:has_database_id","subj":"79","obj":"MESH:C000657245"},{"id":"A80","pred":"tao:has_database_id","subj":"80","obj":"MESH:C000657245"},{"id":"A81","pred":"tao:has_database_id","subj":"81","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"As of May 14, 2020, the World Health Organization has reported 4,248,386 cases of COVID-19 with 294,046 reported deaths secondary to complications related to the novel Coronavirus [1]. In the United States, the Center for Disease Control (CDC) reported 1,364,061 total cases and 82,246 COVID-19 related deaths [2]. A common complication reported secondary to COVID-19 is Acute Respiratory Distress Syndrome (ARDS) requiring endotracheal intubation and ventilator management. Experts currently believe that ARDS possibly results from a state of hyper-inflammation mediated by a cytokine storm in COVID-19 patients [3]. Recipients of solid organ transplants are included in a special population of patients who may face increased risks of COVID-19 related complications given their use of chronic immunosuppressants. Immunosuppression in this population can further reduce cell-mediated immunity, which may prolong viral shedding and increase the risk of COVID related complications [3]. As reported by McGonagle et al., interleukin-6 (IL-6) plays an important role in lung repair following viral insults and the administration of IL-6 inhibitor drugs may be time-sensitive [3]. We report a case of COVID-19 in a patient with kidney and liver transplant and discuss the use of IL-6 inhibitor to prevent a cytokine storm in this setting."}
LitCovid-PD-HP
{"project":"LitCovid-PD-HP","denotations":[{"id":"T5","span":{"begin":377,"end":397},"obj":"Phenotype"},{"id":"T6","span":{"begin":577,"end":591},"obj":"Phenotype"},{"id":"T7","span":{"begin":1303,"end":1317},"obj":"Phenotype"}],"attributes":[{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"As of May 14, 2020, the World Health Organization has reported 4,248,386 cases of COVID-19 with 294,046 reported deaths secondary to complications related to the novel Coronavirus [1]. In the United States, the Center for Disease Control (CDC) reported 1,364,061 total cases and 82,246 COVID-19 related deaths [2]. A common complication reported secondary to COVID-19 is Acute Respiratory Distress Syndrome (ARDS) requiring endotracheal intubation and ventilator management. Experts currently believe that ARDS possibly results from a state of hyper-inflammation mediated by a cytokine storm in COVID-19 patients [3]. Recipients of solid organ transplants are included in a special population of patients who may face increased risks of COVID-19 related complications given their use of chronic immunosuppressants. Immunosuppression in this population can further reduce cell-mediated immunity, which may prolong viral shedding and increase the risk of COVID related complications [3]. As reported by McGonagle et al., interleukin-6 (IL-6) plays an important role in lung repair following viral insults and the administration of IL-6 inhibitor drugs may be time-sensitive [3]. We report a case of COVID-19 in a patient with kidney and liver transplant and discuss the use of IL-6 inhibitor to prevent a cytokine storm in this setting."}
LitCovid-PD-GO-BP
{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":550,"end":562},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T2","span":{"begin":871,"end":893},"obj":"http://purl.obolibrary.org/obo/GO_0002456"},{"id":"T3","span":{"begin":871,"end":893},"obj":"http://purl.obolibrary.org/obo/GO_0002449"},{"id":"T4","span":{"begin":913,"end":927},"obj":"http://purl.obolibrary.org/obo/GO_0019076"}],"text":"As of May 14, 2020, the World Health Organization has reported 4,248,386 cases of COVID-19 with 294,046 reported deaths secondary to complications related to the novel Coronavirus [1]. In the United States, the Center for Disease Control (CDC) reported 1,364,061 total cases and 82,246 COVID-19 related deaths [2]. A common complication reported secondary to COVID-19 is Acute Respiratory Distress Syndrome (ARDS) requiring endotracheal intubation and ventilator management. Experts currently believe that ARDS possibly results from a state of hyper-inflammation mediated by a cytokine storm in COVID-19 patients [3]. Recipients of solid organ transplants are included in a special population of patients who may face increased risks of COVID-19 related complications given their use of chronic immunosuppressants. Immunosuppression in this population can further reduce cell-mediated immunity, which may prolong viral shedding and increase the risk of COVID related complications [3]. As reported by McGonagle et al., interleukin-6 (IL-6) plays an important role in lung repair following viral insults and the administration of IL-6 inhibitor drugs may be time-sensitive [3]. We report a case of COVID-19 in a patient with kidney and liver transplant and discuss the use of IL-6 inhibitor to prevent a cytokine storm in this setting."}
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T9","span":{"begin":0,"end":184},"obj":"Sentence"},{"id":"T10","span":{"begin":185,"end":314},"obj":"Sentence"},{"id":"T11","span":{"begin":315,"end":474},"obj":"Sentence"},{"id":"T12","span":{"begin":475,"end":617},"obj":"Sentence"},{"id":"T13","span":{"begin":618,"end":814},"obj":"Sentence"},{"id":"T14","span":{"begin":815,"end":985},"obj":"Sentence"},{"id":"T15","span":{"begin":986,"end":1176},"obj":"Sentence"},{"id":"T16","span":{"begin":1177,"end":1334},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"As of May 14, 2020, the World Health Organization has reported 4,248,386 cases of COVID-19 with 294,046 reported deaths secondary to complications related to the novel Coronavirus [1]. In the United States, the Center for Disease Control (CDC) reported 1,364,061 total cases and 82,246 COVID-19 related deaths [2]. A common complication reported secondary to COVID-19 is Acute Respiratory Distress Syndrome (ARDS) requiring endotracheal intubation and ventilator management. Experts currently believe that ARDS possibly results from a state of hyper-inflammation mediated by a cytokine storm in COVID-19 patients [3]. Recipients of solid organ transplants are included in a special population of patients who may face increased risks of COVID-19 related complications given their use of chronic immunosuppressants. Immunosuppression in this population can further reduce cell-mediated immunity, which may prolong viral shedding and increase the risk of COVID related complications [3]. As reported by McGonagle et al., interleukin-6 (IL-6) plays an important role in lung repair following viral insults and the administration of IL-6 inhibitor drugs may be time-sensitive [3]. We report a case of COVID-19 in a patient with kidney and liver transplant and discuss the use of IL-6 inhibitor to prevent a cytokine storm in this setting."}