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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7317273","sourcedb":"PMC","sourceid":"7317273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7317273","text":"For instance, the priming of MSCs by proinflammatory cytokines may negatively affect the MHC class I and class II level; Hormones and/or growth factors may affect the differentiation capacity of MSCs; Priming by hypoxia may induce oxidative stress in MSCs; Growth factors may negatively affect the differentiation capacity of MSCs; Spheroid cultures owing to the variability in their size may lead to the necrotic spheroid core, thus, may interfere with the effectiveness of MSCs after transplantation.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T146","span":{"begin":53,"end":62},"obj":"Body_part"},{"id":"T147","span":{"begin":89,"end":92},"obj":"Body_part"},{"id":"T148","span":{"begin":121,"end":129},"obj":"Body_part"}],"attributes":[{"id":"A146","pred":"fma_id","subj":"T146","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma84079"},{"id":"A148","pred":"fma_id","subj":"T148","obj":"http://purl.org/sig/ont/fma/fma12278"},{"subj":"T146","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T147","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T148","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T93","span":{"begin":111,"end":113},"obj":"Chemical"}],"attributes":[{"id":"A93","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"361","span":{"begin":212,"end":219},"obj":"Disease"},{"id":"362","span":{"begin":405,"end":422},"obj":"Disease"}],"attributes":[{"id":"A361","pred":"tao:has_database_id","subj":"361","obj":"MESH:D000860"},{"id":"A362","pred":"tao:has_database_id","subj":"362","obj":"MESH:C000598645"},{"subj":"361","pred":"source","obj":"LitCovid-PubTator"},{"subj":"362","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T23","span":{"begin":137,"end":143},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T24","span":{"begin":257,"end":263},"obj":"http://purl.obolibrary.org/obo/GO_0040007"}],"attributes":[{"subj":"T23","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T331","span":{"begin":0,"end":502},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T331","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T28","span":{"begin":212,"end":219},"obj":"Phenotype"},{"id":"T29","span":{"begin":231,"end":247},"obj":"Phenotype"}],"attributes":[{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0025464"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T380","span":{"begin":29,"end":33},"obj":"DG_47"},{"id":"T381","span":{"begin":89,"end":100},"obj":"GO:0042613"},{"id":"T382","span":{"begin":195,"end":199},"obj":"DG_47"},{"id":"T383","span":{"begin":231,"end":240},"obj":"MOP:0000568"},{"id":"T384","span":{"begin":251,"end":255},"obj":"DG_47"},{"id":"T385","span":{"begin":326,"end":330},"obj":"DG_47"},{"id":"T386","span":{"begin":414,"end":422},"obj":"GO:0044317"},{"id":"T387","span":{"begin":475,"end":479},"obj":"DG_47"}],"attributes":[{"subj":"T380","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T381","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T382","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T383","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T384","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T385","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T386","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T387","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#d593ec","default":true},{"id":"LitCovid-PD-CHEBI","color":"#93ecbb"},{"id":"LitCovid-PubTator","color":"#eca193"},{"id":"LitCovid-PD-GO-BP","color":"#939eec"},{"id":"LitCovid-sentences","color":"#b8ec93"},{"id":"LitCovid-PD-HP","color":"#ec93d2"},{"id":"LitCovid-PMC-OGER-BB","color":"#93ecec"}]}]}}