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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 29-41 Body_part denotes aortic valve http://purl.org/sig/ont/fma/fma7236
T2 450-459 Body_part denotes left lung http://purl.org/sig/ont/fma/fma7310
T3 829-841 Body_part denotes aortic valve http://purl.org/sig/ont/fma/fma7236
T4 901-913 Body_part denotes aortic valve http://purl.org/sig/ont/fma/fma7236
T5 1424-1431 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T6 1591-1600 Body_part denotes left lung http://purl.org/sig/ont/fma/fma7310
T7 2209-2214 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T8 4767-4772 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T9 4866-4878 Body_part denotes aortic valve http://purl.org/sig/ont/fma/fma7236
T10 5583-5600 Body_part denotes coronary arteries http://purl.org/sig/ont/fma/fma3800
T11 6370-6375 Body_part denotes Heart http://purl.org/sig/ont/fma/fma7088

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-5 Body_part denotes Valve http://purl.obolibrary.org/obo/UBERON_0003978
T2 9-14 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T3 29-41 Body_part denotes aortic valve http://purl.obolibrary.org/obo/UBERON_0002137
T4 36-41 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T5 450-459 Body_part denotes left lung http://purl.obolibrary.org/obo/UBERON_0002168
T6 455-459 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 829-841 Body_part denotes aortic valve http://purl.obolibrary.org/obo/UBERON_0002137
T8 836-841 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T9 901-913 Body_part denotes aortic valve http://purl.obolibrary.org/obo/UBERON_0002137
T10 908-913 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T11 1591-1600 Body_part denotes left lung http://purl.obolibrary.org/obo/UBERON_0002168
T12 1596-1600 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T13 1740-1756 Body_part denotes pleural effusion http://purl.obolibrary.org/obo/UBERON_0000175
T14 2209-2214 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T15 2591-2596 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T16 2600-2605 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T17 2650-2655 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T18 3255-3271 Body_part denotes pleural effusion http://purl.obolibrary.org/obo/UBERON_0000175
T19 4390-4406 Body_part denotes pleural effusion http://purl.obolibrary.org/obo/UBERON_0000175
T20 4767-4772 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T21 4837-4842 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T22 4846-4851 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T23 4866-4878 Body_part denotes aortic valve http://purl.obolibrary.org/obo/UBERON_0002137
T24 4873-4878 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T25 5374-5379 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T26 5383-5388 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T27 5583-5600 Body_part denotes coronary arteries http://purl.obolibrary.org/obo/UBERON_0001621
T28 6370-6375 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 90-98 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 99-108 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T3 147-155 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 313-333 Disease denotes aortic insufficiency http://purl.obolibrary.org/obo/MONDO_0005648
T5 485-493 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T6 494-503 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7 637-646 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T8 1299-1319 Disease denotes aortic insufficiency http://purl.obolibrary.org/obo/MONDO_0005648
T9 1645-1653 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 1654-1663 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T11 1853-1861 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 2082-2090 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 2091-2100 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T14 2131-2140 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T15 2209-2222 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T16 2406-2414 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 2415-2424 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T18 2479-2499 Disease denotes aortic insufficiency http://purl.obolibrary.org/obo/MONDO_0005648
T19 2945-2953 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T20 3000-3009 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T21 3194-3202 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 3203-3212 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T23 3300-3308 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 3350-3359 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T25 3365-3373 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T26 3443-3451 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T27 3452-3461 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T28 3861-3869 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T29 3870-3879 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T30 4081-4091 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T31 4252-4261 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T32 4448-4463 Disease denotes cardiac failure http://purl.obolibrary.org/obo/MONDO_0005252
T33 4483-4491 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T34 4503-4512 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T35 4619-4629 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T36 5927-5936 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T37 6135-6143 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T38 6168-6178 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T39 6575-6583 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T40 6584-6593 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 0-5 http://www.ebi.ac.uk/efo/EFO_0000825 denotes Valve
T2 9-14 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T3 29-35 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T4 36-41 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T5 57-58 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 78-79 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 110-111 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 197-198 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 207-208 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 221-225 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T11 221-225 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T12 313-319 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T13 371-372 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 450-459 http://purl.obolibrary.org/obo/UBERON_0002168 denotes left lung
T15 483-484 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 592-599 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T17 621-622 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 667-671 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T19 728-735 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T20 829-835 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T21 836-841 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T22 901-907 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T23 908-913 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T24 1076-1077 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 1132-1133 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T26 1146-1150 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T27 1146-1150 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T28 1167-1168 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 1196-1197 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 1299-1305 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T31 1384-1385 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 1401-1403 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T33 1411-1412 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 1591-1600 http://purl.obolibrary.org/obo/UBERON_0002168 denotes left lung
T35 1643-1644 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 1740-1756 http://purl.obolibrary.org/obo/UBERON_0000175 denotes pleural effusion
T37 1827-1833 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T38 1872-1877 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T39 2070-2077 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T40 2209-2214 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T41 2209-2214 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T42 2209-2214 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T43 2209-2214 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T44 2257-2258 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T45 2276-2283 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T46 2299-2301 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T47 2404-2405 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 2433-2434 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 2479-2485 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T50 2576-2577 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 2591-2596 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T52 2600-2605 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T53 2624-2625 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 2650-2655 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T55 3192-3193 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T56 3255-3271 http://purl.obolibrary.org/obo/UBERON_0000175 denotes pleural effusion
T57 3466-3467 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 3859-3860 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T59 3967-3972 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T60 4005-4008 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T61 4033-4040 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T62 4198-4202 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T63 4390-4406 http://purl.obolibrary.org/obo/UBERON_0000175 denotes pleural effusion
T64 4411-4412 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 4523-4524 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T66 4767-4772 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T67 4767-4772 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T68 4767-4772 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T69 4767-4772 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T70 4837-4842 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T71 4846-4851 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T72 4866-4872 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T73 4873-4878 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T74 4940-4941 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 5325-5331 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valves
T76 5374-5379 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T77 5383-5388 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T78 5463-5464 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 5592-5600 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arteries
T80 5592-5600 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arteries
T81 5628-5629 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82 5910-5911 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 6109-6110 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T84 6180-6181 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T85 6370-6375 http://purl.obolibrary.org/obo/UBERON_0000948 denotes Heart
T86 6370-6375 http://purl.obolibrary.org/obo/UBERON_0007100 denotes Heart
T87 6370-6375 http://purl.obolibrary.org/obo/UBERON_0015228 denotes Heart
T88 6370-6375 http://www.ebi.ac.uk/efo/EFO_0000815 denotes Heart
T89 6491-6492 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 6506-6507 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T91 6551-6552 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 221-225 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T2 1146-1150 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T3 1424-1431 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T4 2276-2283 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T5 2647-2649 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T6 5472-5474 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
4 65-72 Species denotes patient Tax:9606
5 90-98 Disease denotes COVID-19 MESH:C000657245
6 99-108 Disease denotes infection MESH:D007239
7 147-155 Disease denotes COVID-19 MESH:C000657245
16 226-233 Species denotes patient Tax:9606
17 353-360 Species denotes patient Tax:9606
18 750-757 Species denotes patient Tax:9606
19 313-333 Disease denotes aortic insufficiency MESH:D001022
20 485-493 Disease denotes COVID-19 MESH:C000657245
21 494-503 Disease denotes infection MESH:D007239
22 637-646 Disease denotes infection MESH:D007239
23 1094-1117 Disease denotes pulmonary complications MESH:D008171
50 1413-1431 Gene denotes C reactive protein Gene:1401
51 1280-1287 Species denotes patient Tax:9606
52 1728-1735 Species denotes patient Tax:9606
53 1815-1822 Species denotes patient Tax:9606
54 1904-1911 Species denotes patient Tax:9606
55 2162-2169 Species denotes patient Tax:9606
56 2541-2548 Species denotes patient Tax:9606
57 2821-2828 Species denotes patient Tax:9606
58 2834-2841 Species denotes patient Tax:9606
59 2933-2940 Species denotes patient Tax:9606
60 3015-3022 Species denotes patient Tax:9606
61 1299-1319 Disease denotes aortic insufficiency MESH:D001022
62 1349-1357 Disease denotes dyspnoea MESH:D004417
63 1645-1653 Disease denotes COVID-19 MESH:C000657245
64 1654-1663 Disease denotes infection MESH:D007239
65 1740-1756 Disease denotes pleural effusion MESH:D010996
66 1853-1861 Disease denotes COVID-19 MESH:C000657245
67 2082-2090 Disease denotes COVID-19 MESH:C000657245
68 2091-2100 Disease denotes infection MESH:D007239
69 2131-2140 Disease denotes infection MESH:D007239
70 2209-2222 Disease denotes heart failure MESH:D006333
71 2406-2414 Disease denotes COVID-19 MESH:C000657245
72 2415-2424 Disease denotes infection MESH:D007239
73 2479-2499 Disease denotes aortic insufficiency MESH:D001022
74 2945-2953 Disease denotes COVID-19 MESH:C000657245
75 3000-3009 Disease denotes infection MESH:D007239
78 3194-3202 Disease denotes COVID-19 MESH:C000657245
79 3203-3212 Disease denotes infection MESH:D007239
81 3255-3271 Disease denotes pleural effusion MESH:D010996
95 3377-3385 Species denotes patients Tax:9606
96 3557-3565 Species denotes patients Tax:9606
97 3781-3788 Species denotes patient Tax:9606
98 4214-4222 Species denotes patients Tax:9606
99 3300-3308 Disease denotes COVID-19 MESH:C000657245
100 3350-3359 Disease denotes infection MESH:D007239
101 3365-3373 Disease denotes COVID-19 MESH:C000657245
102 3443-3451 Disease denotes COVID-19 MESH:C000657245
103 3452-3461 Disease denotes infection MESH:D007239
104 3861-3869 Disease denotes COVID-19 MESH:C000657245
105 3870-3879 Disease denotes infection MESH:D007239
106 4081-4091 Disease denotes infections MESH:D007239
107 4252-4261 Disease denotes infection MESH:D007239
119 4304-4311 Species denotes patient Tax:9606
120 4669-4676 Species denotes patient Tax:9606
121 4806-4813 Species denotes patient Tax:9606
122 5136-5143 Species denotes patient Tax:9606
123 5636-5643 Species denotes patient Tax:9606
124 5732-5739 Species denotes patient Tax:9606
125 4390-4406 Disease denotes pleural effusion MESH:D010996
126 4448-4463 Disease denotes cardiac failure MESH:D006333
127 4483-4491 Disease denotes COVID-19 MESH:C000657245
128 4503-4512 Disease denotes pneumonia MESH:D011014
129 5927-5936 Disease denotes infection MESH:D007239
134 6047-6054 Species denotes patient Tax:9606
135 6493-6500 Species denotes patient Tax:9606
136 6135-6143 Disease denotes COVID-19 MESH:C000657245
137 6575-6593 Disease denotes COVID-19-infection MESH:C000657245

TEST0

Id Subject Object Predicate Lexical cue
32510155-193-198-6440 1697-1698 ["32291197"] denotes 1
32510155-234-239-6441 4293-4294 ["32101510"] denotes 2
32510155-235-240-6442 5333-5334 ["30732707"] denotes 3

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 535-556 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T2 543-556 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3 4150-4171 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T4 4158-4171 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-164 Sentence denotes Valve-in-valve transcatheter aortic valve replacement in a young patient with a suspected COVID-19 infection: a surgical dilemma in the era of the COVID-19 pandemic
T2 166-174 Sentence denotes Abstract
T3 175-183 Sentence denotes Abstract
T4 184-334 Sentence denotes We report on a case of a 57-year-old male patient, who underwent full root replacement in 2005 and now presented with high grade aortic insufficiency.
T5 335-600 Sentence denotes On admission, the patient underwent a computed tomography scan which demonstrated interstitial infiltration in the left lung, highly suspicious for a COVID-19 infection that could not be confirmed by reverse transcription polymerase chain reaction (RT-PCR) testing.
T6 601-736 Sentence denotes As there usually is a delay between infection and positive RT-PCR test results, the initial decision was to perform additional testing.
T7 737-864 Sentence denotes However, the patient deteriorated quickly in spite of optimal medical therapy making urgent aortic valve replacement necessary.
T8 865-1118 Sentence denotes We decided to perform transcatheter aortic valve replacement to avoid cardiopulmonary bypass with shorter operative times, presumably shorter ventilation times and duration of intensive care unit stay, and thus a lesser risk for pulmonary complications.
T9 1120-1131 Sentence denotes CASE REPORT
T10 1132-1275 Sentence denotes A 57-year-old male with history of a full root replacement with a 29-mm Medtronic Freestyle prosthesis in 2005 was admitted to our institution.
T11 1276-1458 Sentence denotes The patient had severe aortic insufficiency with progredient symptoms of dyspnoea in the last 2 weeks, with a proBNP of 1459 pg/ml and a C reactive protein of 22.8 mg/l at admission.
T12 1459-1503 Sentence denotes All other laboratory parameters were normal.
T13 1504-1709 Sentence denotes The preoperative computed tomography (CT) scan showed interstitial infiltration of the left lung that was considered highly suspicious for a COVID-19 infection by three different radiologists [1] (Fig. 1).
T14 1710-1810 Sentence denotes Additionally, the patient had pleural effusion indicating impending cardiac decompensation (Fig. 2).
T15 1811-1896 Sentence denotes The patient was tested twice with PCR for COVID-19, but both tests returned negative.
T16 1897-2141 Sentence denotes As the patient was initially clinically stable under medication, it was decided to postpone further surgical therapy for 2 weeks to in order to perform consecutive repeated testing for COVID-19 infection to safely confirm or rule out infection.
T17 2142-2305 Sentence denotes Two days later, the patient was readmitted with severe symptoms of heart failure and an increase in N-terminal pro-B-type natriuretic peptide levels to 1646 pg/ml.
T18 2306-2514 Sentence denotes It was not completely clear if the symptoms including interstitial infiltration had resulted from a COVID-19 infection or from a progression of symptoms from the high-grade aortic insufficiency, or even both.
T19 2515-2656 Sentence denotes After consulting with the patient, it was decided to perform a transfemoral valve-in-valve implantation with a 29-mm Edwards SAPIEN S3 valve.
T20 2657-2829 Sentence denotes In adherence to all safety precautions recommended so far, including N95-respirators, the procedure was successfully performed the day after the readmission of the patient.
T21 2830-2876 Sentence denotes The patient recovered well from the procedure.
T22 2877-3010 Sentence denotes During the whole hospital stay, it was assumed that the patient was COVID-19-positive, as we could not completely rule out infection.
T23 3011-3089 Sentence denotes The patient consented to having his information disclosed in this case report.
T24 3090-3099 Sentence denotes Figure 1:
T25 3101-3213 Sentence denotes Computed tomography scan on admission with interstitial infiltration highly suspicious for a COVID-19 infection.
T26 3214-3223 Sentence denotes Figure 2:
T27 3225-3272 Sentence denotes Computed tomography scan with pleural effusion.
T28 3274-3284 Sentence denotes DISCUSSION
T29 3285-3598 Sentence denotes In the current COVID-19-pandemic, it is important to rule out an infection with COVID-19 in patients undergoing cardiac surgery to prevent complications from COVID-19 infection for a variety of reasons—for example, there is currently no available information on how these patients tolerate cardiopulmonary bypass.
T30 3599-3773 Sentence denotes For this reason and to ensure the availability of intensive care unit (ICU) beds, most countries recommend postponing elective surgeries or interventions as much as possible.
T31 3774-3933 Sentence denotes In our patient, the CT scan with interstitial infiltration was highly suspicious for a COVID-19 infection that was confirmed by three independent radiologists.
T32 3934-3991 Sentence denotes In contrast, two consecutive PCR tests returned negative.
T33 3992-4296 Sentence denotes Recently, it has been discussed that PCR testing might be inferior to CT scans to detect infections as the average time between initial negative and positive reverse transcription polymerase chain reaction test results in patients who already display signs of infection on CT scans is 5.1 ± 1.5 days [2].
T34 4297-4464 Sentence denotes In the patient described above, our dilemma was that clinical symptoms, increasing bilateral pleural effusion and a rise in proBNP indicated impending cardiac failure.
T35 4465-4537 Sentence denotes At the same time, COVID-19-associated pneumonia was still a possibility.
T36 4538-4732 Sentence denotes As the intended waiting interval of 2 weeks to increase certainty concerning the infectious state could not be achieved due to the patient’s cardiac condition, immediate treatment was necessary.
T37 4733-5097 Sentence denotes Following discussion in the local heart team and with the consent of the patient, we decided to perform valve-in-valve transcatheter aortic valve replacement (TAVR) to prevent the potential complications of a prolonged re-root-replacement with its long operative and cardiopulmonary bypass times, which could lead to an increased time on the respirator in the ICU.
T38 5098-5336 Sentence denotes The decision was made even though the patient was only 57 years old and would have undergone an open surgical procedure under normal circumstances, especially as there is limited information available on the durability of TAVR valves [3].
T39 5337-5502 Sentence denotes Due to our extensive experience with valve-in-valve-TAVR into degenerated Freestyle-prostheses (>40 cases), we decided to use a SAPIEN S3 (Edwards Lifesciences Corp.
T40 5503-5644 Sentence denotes Irvine, CA, USA), which facilitates reoperation and preserves the access to the coronary arteries, which is of importance in a young patient.
T41 5645-5999 Sentence denotes We also decided to perform the procedure under general anaesthesia and to intubate the patient as we intended to perform intraoperative transoesophageal echocardiography and wanted to avoid the risk of an emergency intubation during the procedure, which would pose a higher risk of infection for the whole team than an intubation under normal conditions.
T42 6001-6011 Sentence denotes CONCLUSION
T43 6012-6179 Sentence denotes At the moment, we believe that any patient requiring urgent cardiac intervention or surgery with a reasonable suspicion of COVID-19 should be assumed to be infectious.
T44 6180-6261 Sentence denotes A less invasive treatment might be preferable to prevent potential complications.
T45 6262-6453 Sentence denotes However, any treatment strategy in challenging situations like these should be based on the decision of the Heart Team comprising surgeons, cardiologists, anaesthesiologists and intensivists.
T46 6454-6618 Sentence denotes Withholding or delaying treatment in a patient with a life-threatening condition on the basis of a possible or confirmed COVID-19-infection should not be an option.
T47 6619-6655 Sentence denotes Conflict of interest: none declared.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 313-333 Phenotype denotes aortic insufficiency http://purl.obolibrary.org/obo/HP_0001659
T2 1299-1319 Phenotype denotes aortic insufficiency http://purl.obolibrary.org/obo/HP_0001659
T3 1349-1357 Phenotype denotes dyspnoea http://purl.obolibrary.org/obo/HP_0002094
T4 1740-1756 Phenotype denotes pleural effusion http://purl.obolibrary.org/obo/HP_0002202
T5 2209-2222 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T6 2479-2499 Phenotype denotes aortic insufficiency http://purl.obolibrary.org/obo/HP_0001659
T7 3255-3271 Phenotype denotes pleural effusion http://purl.obolibrary.org/obo/HP_0002202
T8 4390-4406 Phenotype denotes pleural effusion http://purl.obolibrary.org/obo/HP_0002202
T9 4448-4463 Phenotype denotes cardiac failure http://purl.obolibrary.org/obo/HP_0001635
T10 4503-4512 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

0_colil

Id Subject Object Predicate Lexical cue
32510155-32291197-6440 1697-1698 32291197 denotes 1
32510155-32101510-6441 4293-4294 32101510 denotes 2
32510155-30732707-6442 5333-5334 30732707 denotes 3

2_test

Id Subject Object Predicate Lexical cue
32510155-32291197-28904703 1697-1698 32291197 denotes 1
32510155-32101510-28904704 4293-4294 32101510 denotes 2
32510155-30732707-28904705 5333-5334 30732707 denotes 3

MyTest

Id Subject Object Predicate Lexical cue
32510155-32291197-28904703 1697-1698 32291197 denotes 1
32510155-32101510-28904704 4293-4294 32101510 denotes 2
32510155-30732707-28904705 5333-5334 30732707 denotes 3

testtesttest

Id Subject Object Predicate Lexical cue uberon_id
T1 0-5 Body_part denotes Valve http://purl.obolibrary.org/obo/UBERON_0003978
T2 9-14 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T3 29-41 Body_part denotes aortic valve http://purl.obolibrary.org/obo/UBERON_0002137
T4 221-225 Body_part denotes male http://purl.obolibrary.org/obo/UBERON_0003101
T5 450-459 Body_part denotes left lung http://purl.obolibrary.org/obo/UBERON_0002168
T6 829-841 Body_part denotes aortic valve http://purl.obolibrary.org/obo/UBERON_0002137
T7 901-913 Body_part denotes aortic valve http://purl.obolibrary.org/obo/UBERON_0002137
T8 1146-1150 Body_part denotes male http://purl.obolibrary.org/obo/UBERON_0003101
T9 1591-1600 Body_part denotes left lung http://purl.obolibrary.org/obo/UBERON_0002168
T10 1740-1756 Body_part denotes pleural effusion http://purl.obolibrary.org/obo/UBERON_0000175
T11 1872-1877 Body_part denotes tests http://purl.obolibrary.org/obo/UBERON_0000473
T12 2209-2214 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T16 2591-2596 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T17 2600-2605 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T18 2650-2655 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T19 3255-3271 Body_part denotes pleural effusion http://purl.obolibrary.org/obo/UBERON_0000175
T20 3967-3972 Body_part denotes tests http://purl.obolibrary.org/obo/UBERON_0000473
T21 4390-4406 Body_part denotes pleural effusion http://purl.obolibrary.org/obo/UBERON_0000175
T22 4767-4772 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T26 4837-4842 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T27 4846-4851 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T28 4866-4878 Body_part denotes aortic valve http://purl.obolibrary.org/obo/UBERON_0002137
T29 5374-5379 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T30 5383-5388 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T31 5583-5600 Body_part denotes coronary arteries http://purl.obolibrary.org/obo/UBERON_0001621
T32 6370-6375 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230