PMC:7311890 / 32739-34425
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T245 | 228-241 | Body_part | denotes | phospholipids | http://purl.org/sig/ont/fma/fma82779 |
| T246 | 355-359 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T247 | 441-461 | Body_part | denotes | alveolar macrophages | http://purl.org/sig/ont/fma/fma83023 |
| T248 | 500-511 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T249 | 853-873 | Body_part | denotes | alveolar macrophages | http://purl.org/sig/ont/fma/fma83023 |
| T250 | 997-1006 | Body_part | denotes | endosomes | http://purl.org/sig/ont/fma/fma67180 |
| T251 | 1316-1318 | Body_part | denotes | A1 | http://purl.org/sig/ont/fma/fma66592 |
| T252 | 1393-1413 | Body_part | denotes | alveolar macrophages | http://purl.org/sig/ont/fma/fma83023 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T155 | 53-61 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T156 | 738-746 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T157 | 879-888 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T158 | 1178-1186 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T159 | 1324-1332 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T160 | 1665-1673 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T291 | 92-96 | http://purl.obolibrary.org/obo/CLO_0054057 | denotes | 18:1 |
| T292 | 197-198 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T293 | 355-364 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell-type |
| T294 | 533-535 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T295 | 669-673 | http://purl.obolibrary.org/obo/CLO_0054057 | denotes | 18:1 |
| T296 | 693-695 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T297 | 1094-1098 | http://purl.obolibrary.org/obo/CLO_0054057 | denotes | 18:1 |
| T298 | 1312-1318 | http://purl.obolibrary.org/obo/CLO_0053413 | denotes | apo-A1 |
| T299 | 1430-1434 | http://purl.obolibrary.org/obo/CLO_0054057 | denotes | 18:1 |
| T300 | 1467-1469 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T301 | 1619-1620 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T302 | 1682-1684 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T303 | 1682-1684 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T512 | 29-32 | Chemical | denotes | CEs | http://purl.obolibrary.org/obo/CHEBI_17002 |
| T513 | 69-71 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T514 | 82-85 | Chemical | denotes | BMP | http://purl.obolibrary.org/obo/CHEBI_60815 |
| T515 | 97-101 | Chemical | denotes | 20:4 | http://purl.obolibrary.org/obo/CHEBI_36033 |
| T516 | 136-154 | Chemical | denotes | cholesteryl esters | http://purl.obolibrary.org/obo/CHEBI_17002 |
| T517 | 148-154 | Chemical | denotes | esters | http://purl.obolibrary.org/obo/CHEBI_35701 |
| T518 | 156-159 | Chemical | denotes | CEs | http://purl.obolibrary.org/obo/CHEBI_17002 |
| T519 | 228-241 | Chemical | denotes | phospholipids | http://purl.obolibrary.org/obo/CHEBI_16247 |
| T520 | 282-293 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
| T521 | 500-511 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T522 | 506-511 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T523 | 519-532 | Chemical | denotes | linoleic acid | http://purl.obolibrary.org/obo/CHEBI_17351 |
| T524 | 528-532 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T525 | 533-537 | Chemical | denotes | 18:2 | http://purl.obolibrary.org/obo/CHEBI_24993|http://purl.obolibrary.org/obo/CHEBI_25627 |
| T527 | 542-558 | Chemical | denotes | arachidonic acid | http://purl.obolibrary.org/obo/CHEBI_15843 |
| T528 | 554-558 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T529 | 559-563 | Chemical | denotes | 20:4 | http://purl.obolibrary.org/obo/CHEBI_36033 |
| T530 | 660-663 | Chemical | denotes | BMP | http://purl.obolibrary.org/obo/CHEBI_60815 |
| T531 | 674-678 | Chemical | denotes | 20:4 | http://purl.obolibrary.org/obo/CHEBI_36033 |
| T532 | 684-687 | Chemical | denotes | BMP | http://purl.obolibrary.org/obo/CHEBI_60815 |
| T533 | 693-697 | Chemical | denotes | 18:2 | http://purl.obolibrary.org/obo/CHEBI_24993|http://purl.obolibrary.org/obo/CHEBI_25627 |
| T535 | 698-702 | Chemical | denotes | 20:4 | http://purl.obolibrary.org/obo/CHEBI_36033 |
| T536 | 784-786 | Chemical | denotes | S4 | http://purl.obolibrary.org/obo/CHEBI_29401 |
| T537 | 938-949 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
| T538 | 965-976 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
| T539 | 1085-1088 | Chemical | denotes | BMP | http://purl.obolibrary.org/obo/CHEBI_60815 |
| T540 | 1099-1103 | Chemical | denotes | 20:4 | http://purl.obolibrary.org/obo/CHEBI_36033 |
| T541 | 1117-1120 | Chemical | denotes | CEs | http://purl.obolibrary.org/obo/CHEBI_17002 |
| T542 | 1421-1424 | Chemical | denotes | BMP | http://purl.obolibrary.org/obo/CHEBI_60815 |
| T543 | 1435-1439 | Chemical | denotes | 20:4 | http://purl.obolibrary.org/obo/CHEBI_36033 |
| T544 | 1458-1461 | Chemical | denotes | BMP | http://purl.obolibrary.org/obo/CHEBI_60815 |
| T545 | 1467-1471 | Chemical | denotes | 18:2 | http://purl.obolibrary.org/obo/CHEBI_24993|http://purl.obolibrary.org/obo/CHEBI_25627 |
| T547 | 1472-1476 | Chemical | denotes | 20:4 | http://purl.obolibrary.org/obo/CHEBI_36033 |
| T548 | 1532-1535 | Chemical | denotes | CEs | http://purl.obolibrary.org/obo/CHEBI_17002 |
| T549 | 1537-1539 | Chemical | denotes | CE | http://purl.obolibrary.org/obo/CHEBI_3663 |
| T550 | 1540-1544 | Chemical | denotes | 14:0 | http://purl.obolibrary.org/obo/CHEBI_28875 |
| T551 | 1558-1560 | Chemical | denotes | CE | http://purl.obolibrary.org/obo/CHEBI_3663 |
| T552 | 1682-1684 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 913 | 53-61 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 933 | 1312-1318 | Gene | denotes | apo-A1 | Gene:335 |
| 934 | 1637-1645 | Species | denotes | patients | Tax:9606 |
| 935 | 82-85 | Chemical | denotes | BMP | MESH:C012786 |
| 936 | 136-154 | Chemical | denotes | cholesteryl esters | MESH:D002788 |
| 937 | 228-241 | Chemical | denotes | phospholipids | MESH:D010743 |
| 938 | 282-293 | Chemical | denotes | cholesterol | MESH:D002784 |
| 939 | 496-511 | Chemical | denotes | n-6 fatty acids | MESH:D043371 |
| 940 | 519-532 | Chemical | denotes | linoleic acid | MESH:D019787 |
| 941 | 542-558 | Chemical | denotes | arachidonic acid | MESH:D016718 |
| 942 | 660-663 | Chemical | denotes | BMP | MESH:C012786 |
| 943 | 684-687 | Chemical | denotes | BMP | MESH:C012786 |
| 944 | 938-949 | Chemical | denotes | cholesterol | MESH:D002784 |
| 945 | 965-976 | Chemical | denotes | cholesterol | MESH:D002784 |
| 946 | 1085-1088 | Chemical | denotes | BMP | MESH:C012786 |
| 947 | 738-746 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 948 | 879-888 | Disease | denotes | infection | MESH:D007239 |
| 949 | 1178-1186 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 950 | 1324-1332 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 951 | 1665-1673 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T52 | 282-305 | http://purl.obolibrary.org/obo/GO_0042632 | denotes | cholesterol homeostasis |
| T53 | 294-305 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
| T54 | 965-984 | http://purl.obolibrary.org/obo/GO_0010878 | denotes | cholesterol storage |
| T55 | 977-984 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | storage |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T208 | 0-61 | Sentence | denotes | Correlation between BMPs and CEs Was Altered in Mild COVID-19 |
| T209 | 62-181 | Sentence | denotes | Module II comprises BMP 38:5 (18:1/20:4) as the hub connected to numerous cholesteryl esters (CEs) by blue lines (+/−). |
| T210 | 182-336 | Sentence | denotes | BMPs represent a class of structurally unique phospholipids enriched in MVBs implicated in cellular cholesterol homeostasis (Hullin-Matsuda et al., 2009). |
| T211 | 337-608 | Sentence | denotes | BMPs also exhibit cell-type-specific compositions in their esterified fatty acyl chains, with pulmonary alveolar macrophages exhibiting distinct enrichment in n-6 fatty acids (i.e., linoleic acid 18:2 and arachidonic acid 20:4) (Cochran et al., 1987; Mason et al., 1972). |
| T212 | 609-889 | Sentence | denotes | Among the various BMPs analyzed in our study, only BMP 38:5(18:1/20:4) and BMP 38:6(18:2/20:4) were specifically reduced in mild COVID-19 relative to healthy controls (Figure S4), suggesting that these reductions might be specific to pulmonary alveolar macrophages upon infection. |
| T213 | 890-1141 | Sentence | denotes | BMPs were shown to influence cellular export of cholesterol by controlling cholesterol storage capacity of endosomes (Chevallier et al., 2008), which may explain the positive correlation between BMP 38:5(18:1/20:4) and several CEs in healthy controls. |
| T214 | 1142-1346 | Sentence | denotes | The changes in correlations in mild COVID-19 (i.e., +/− and +/0) suggested that this process might be perturbed, in agreement with the observed reductions in circulating apo-A1 with COVID-19 (Figure S1C). |
| T215 | 1347-1686 | Sentence | denotes | Of interest, we noticed that BMPs enriched in alveolar macrophages, i.e., BMP 38:5(18:1/20:4) (p = 0.0054) and BMP 38:6(18:2/20:4) (p = 0.0004), increased longitudinally with saturated CEs (CE 14:0, p = 0.0017; CE 16:0, p = 0.0092) from hospital admission to discharge in a small subset of patients who recovered from COVID-19 (Figure S2). |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T735 | 53-61 | SP_7 | denotes | COVID-19 |
| T736 | 82-85 | PR:000000034 | denotes | BMP |
| T737 | 136-147 | CHEBI:16113;CHEBI:16113 | denotes | cholesteryl |
| T738 | 148-154 | CHEBI:35701;CHEBI:35701 | denotes | esters |
| T739 | 228-241 | CHEBI:16247;CHEBI:16247 | denotes | phospholipids |
| T740 | 273-281 | GO:0019725 | denotes | cellular |
| T741 | 282-293 | CHEBI:16113;CHEBI:16113;GO:0042632 | denotes | cholesterol |
| T742 | 294-305 | GO:0042632 | denotes | homeostasis |
| T743 | 407-412 | CHEBI:35366;CHEBI:35366 | denotes | fatty |
| T744 | 413-417 | CHEBI:22221;CHEBI:22221 | denotes | acyl |
| T745 | 418-424 | CHEBI:35366;CHEBI:35366 | denotes | chains |
| T746 | 431-440 | CL:0000082;UBERON:0002299 | denotes | pulmonary |
| T747 | 441-449 | UBERON:0002299;CL:0000583 | denotes | alveolar |
| T748 | 450-461 | CL:0000583 | denotes | macrophages |
| T749 | 496-497 | CHEBI:29021;CHEBI:29021 | denotes | n |
| T750 | 497-499 | CHEBI:15904;CHEBI:15904 | denotes | -6 |
| T751 | 500-511 | CHEBI:35366;CHEBI:35366 | denotes | fatty acids |
| T752 | 519-532 | CHEBI:17351;CHEBI:17351 | denotes | linoleic acid |
| T753 | 542-558 | CHEBI:15843;CHEBI:15843 | denotes | arachidonic acid |
| T754 | 660-663 | PR:000000034 | denotes | BMP |
| T755 | 684-687 | PR:000000034 | denotes | BMP |
| T756 | 738-746 | SP_7 | denotes | COVID-19 |
| T757 | 843-852 | CL:0000082;UBERON:0002299 | denotes | pulmonary |
| T758 | 853-861 | UBERON:0002299;CL:0000583 | denotes | alveolar |
| T759 | 862-873 | CL:0000583 | denotes | macrophages |
| T760 | 919-934 | GO:0051168 | denotes | cellular export |
| T761 | 935-937 | GO:0030301 | denotes | of |
| T762 | 938-949 | CHEBI:16113;CHEBI:16113 | denotes | cholesterol |
| T763 | 953-964 | GO:0065007 | denotes | controlling |
| T764 | 965-976 | CHEBI:16113;CHEBI:16113;GO:0010878 | denotes | cholesterol |
| T765 | 977-984 | GO:0010878 | denotes | storage |
| T766 | 997-1006 | GO:0005768 | denotes | endosomes |
| T767 | 1085-1088 | PR:000000034 | denotes | BMP |
| T768 | 1178-1186 | SP_7 | denotes | COVID-19 |
| T769 | 1324-1332 | SP_7 | denotes | COVID-19 |
| T770 | 1393-1401 | UBERON:0003215;CL:0000583 | denotes | alveolar |
| T771 | 1402-1413 | CL:0000583 | denotes | macrophages |
| T772 | 1421-1424 | PR:000000034 | denotes | BMP |
| T773 | 1458-1461 | PR:000000034 | denotes | BMP |
| T774 | 1665-1673 | SP_7 | denotes | COVID-19 |
| T1880 | 194-199 | CHEBI:18059;CHEBI:18059 | denotes | nt a |
| T93373 | 239-244 | CHEBI:18059;CHEBI:18059 | denotes | ds en |
| T72052 | 307-312 | CHEBI:18059;CHEBI:18059 | denotes | Hulli |
| T57620 | 314-333 | CHEBI:37739;CHEBI:37739 | denotes | Matsuda et al., 200 |
| T14009 | 339-349 | CHEBI:26739;CHEBI:26739 | denotes | Ps also ex |
| T519 | 380-386 | UBERON:0001969 | denotes | itions |
| T520 | 387-392 | CHEBI:18059;CHEBI:18059 | denotes | in th |
| T521 | 421-429 | SP_7 | denotes | ins, wit |
| T522 | 510-514 | CHEBI:18059;CHEBI:18059 | denotes | s (i |
| T523 | 656-664 | SP_7 | denotes | nly BMP |
| T524 | 672-677 | CHEBI:18059;CHEBI:18059 | denotes | 1/20: |
| T525 | 919-924 | CHEBI:18059;CHEBI:18059 | denotes | cellu |
| T526 | 963-968 | CHEBI:18059;CHEBI:18059 | denotes | g cho |
| T527 | 1031-1036 | CHEBI:18059;CHEBI:18059 | denotes | ), wh |
| T528 | 1038-1057 | CHEBI:37739;CHEBI:37739 | denotes | h may explain the p |
| T529 | 1063-1073 | CHEBI:26739;CHEBI:26739 | denotes | e correlat |
| T5599 | 1110-1116 | UBERON:0001969 | denotes | everal |
| T85766 | 1117-1122 | CHEBI:18059;CHEBI:18059 | denotes | CEs i |
| T81294 | 1190-1196 | UBERON:0001969 | denotes | e., +/ |
| T88483 | 1197-1202 | CHEBI:18059;CHEBI:18059 | denotes | and |
| T57621 | 1214-1222 | SP_7 | denotes | ed that |
| T36589 | 1576-1580 | PR:000001393 | denotes | 2) f |
| T78099 | 1679-1685 | UBERON:0001969 | denotes | re S2) |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32610096-19857945-19699509 | 330-334 | 19857945 | denotes | 2009 |
| 32610096-3102603-19699510 | 582-586 | 3102603 | denotes | 1987 |
| 32610096-4344731-19699511 | 602-606 | 4344731 | denotes | 1972 |
| 32610096-18644787-19699512 | 1027-1031 | 18644787 | denotes | 2008 |