PMC:7311890 / 1626-2023 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T8","span":{"begin":76,"end":107},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"},{"id":"T9","span":{"begin":191,"end":194},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T10","span":{"begin":191,"end":194},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"},{"id":"T11","span":{"begin":295,"end":298},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T12","span":{"begin":295,"end":298},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"}],"text":"distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma monosialodihexosyl gangliosides (GM3s) were negatively correlated with CD4+ T cell count in COVID-19 patients, and GM3-enriched exosomes were positively correlated with disease severity. These observations suggest that GM3-enriched exosomes may participate in pathological processes associated with COVID-19 progression.\n"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T9","span":{"begin":69,"end":75},"obj":"Body_part"},{"id":"T10","span":{"begin":95,"end":107},"obj":"Body_part"},{"id":"T11","span":{"begin":154,"end":158},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma monosialodihexosyl gangliosides (GM3s) were negatively correlated with CD4+ T cell count in COVID-19 patients, and GM3-enriched exosomes were positively correlated with disease severity. These observations suggest that GM3-enriched exosomes may participate in pathological processes associated with COVID-19 progression.\n"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T15","span":{"begin":14,"end":22},"obj":"Disease"},{"id":"T16","span":{"begin":168,"end":176},"obj":"Disease"},{"id":"T17","span":{"begin":375,"end":383},"obj":"Disease"}],"attributes":[{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma monosialodihexosyl gangliosides (GM3s) were negatively correlated with CD4+ T cell count in COVID-19 patients, and GM3-enriched exosomes were positively correlated with disease severity. These observations suggest that GM3-enriched exosomes may participate in pathological processes associated with COVID-19 progression.\n"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T10","span":{"begin":69,"end":75},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T11","span":{"begin":147,"end":150},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T12","span":{"begin":152,"end":158},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma monosialodihexosyl gangliosides (GM3s) were negatively correlated with CD4+ T cell count in COVID-19 patients, and GM3-enriched exosomes were positively correlated with disease severity. These observations suggest that GM3-enriched exosomes may participate in pathological processes associated with COVID-19 progression.\n"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T17","span":{"begin":95,"end":107},"obj":"Chemical"},{"id":"T18","span":{"begin":191,"end":194},"obj":"Chemical"},{"id":"T20","span":{"begin":295,"end":298},"obj":"Chemical"}],"attributes":[{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_15681"},{"id":"A19","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_84118"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_15681"},{"id":"A21","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_84118"}],"text":"distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma monosialodihexosyl gangliosides (GM3s) were negatively correlated with CD4+ T cell count in COVID-19 patients, and GM3-enriched exosomes were positively correlated with disease severity. These observations suggest that GM3-enriched exosomes may participate in pathological processes associated with COVID-19 progression.\n"}

{"project":"LitCovid-PubTator","denotations":[{"id":"66","span":{"begin":147,"end":150},"obj":"Gene"},{"id":"67","span":{"begin":23,"end":31},"obj":"Species"},{"id":"68","span":{"begin":177,"end":185},"obj":"Species"},{"id":"69","span":{"begin":76,"end":107},"obj":"Chemical"},{"id":"70","span":{"begin":109,"end":113},"obj":"Chemical"},{"id":"71","span":{"begin":191,"end":194},"obj":"Chemical"},{"id":"72","span":{"begin":295,"end":298},"obj":"Chemical"},{"id":"73","span":{"begin":14,"end":22},"obj":"Disease"},{"id":"74","span":{"begin":168,"end":176},"obj":"Disease"},{"id":"75","span":{"begin":375,"end":383},"obj":"Disease"}],"attributes":[{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"Gene:920"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"Tax:9606"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"Tax:9606"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"MESH:C000657245"},{"id":"A74","pred":"tao:has_database_id","subj":"74","obj":"MESH:C000657245"},{"id":"A75","pred":"tao:has_database_id","subj":"75","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma monosialodihexosyl gangliosides (GM3s) were negatively correlated with CD4+ T cell count in COVID-19 patients, and GM3-enriched exosomes were positively correlated with disease severity. These observations suggest that GM3-enriched exosomes may participate in pathological processes associated with COVID-19 progression.\n"}

{"project":"LitCovid-sentences","denotations":[{"id":"T18","span":{"begin":69,"end":262},"obj":"Sentence"},{"id":"T19","span":{"begin":263,"end":396},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma monosialodihexosyl gangliosides (GM3s) were negatively correlated with CD4+ T cell count in COVID-19 patients, and GM3-enriched exosomes were positively correlated with disease severity. These observations suggest that GM3-enriched exosomes may participate in pathological processes associated with COVID-19 progression.\n"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T52","span":{"begin":14,"end":22},"obj":"SP_7"},{"id":"T53","span":{"begin":69,"end":75},"obj":"UBERON:0001969"},{"id":"T54","span":{"begin":147,"end":150},"obj":"PR:000001004"},{"id":"T55","span":{"begin":152,"end":158},"obj":"CL:0000084"},{"id":"T56","span":{"begin":168,"end":176},"obj":"SP_7"},{"id":"T57","span":{"begin":204,"end":212},"obj":"GO:0070062"},{"id":"T58","span":{"begin":308,"end":316},"obj":"GO:0070062"},{"id":"T59","span":{"begin":375,"end":383},"obj":"SP_7"}],"text":"distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma monosialodihexosyl gangliosides (GM3s) were negatively correlated with CD4+ T cell count in COVID-19 patients, and GM3-enriched exosomes were positively correlated with disease severity. These observations suggest that GM3-enriched exosomes may participate in pathological processes associated with COVID-19 progression.\n"}