PMC:7309518 / 17805-19128 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T117","span":{"begin":160,"end":169},"obj":"Body_part"},{"id":"T118","span":{"begin":355,"end":364},"obj":"Body_part"},{"id":"T119","span":{"begin":610,"end":619},"obj":"Body_part"},{"id":"T120","span":{"begin":692,"end":705},"obj":"Body_part"},{"id":"T121","span":{"begin":749,"end":755},"obj":"Body_part"},{"id":"T122","span":{"begin":776,"end":788},"obj":"Body_part"},{"id":"T123","span":{"begin":870,"end":885},"obj":"Body_part"}],"attributes":[{"id":"A117","pred":"fma_id","subj":"T117","obj":"http://purl.org/sig/ont/fma/fma79876"},{"id":"A118","pred":"fma_id","subj":"T118","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A119","pred":"fma_id","subj":"T119","obj":"http://purl.org/sig/ont/fma/fma79876"},{"id":"A120","pred":"fma_id","subj":"T120","obj":"http://purl.org/sig/ont/fma/fma61825"},{"id":"A121","pred":"fma_id","subj":"T121","obj":"http://purl.org/sig/ont/fma/fma264279"},{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma83929"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma86464"}],"text":"Other emerging postinfectious autoimmune neurologic disorders\nAcute disseminated encephalomyelitis, as described for the other coronaviruses, or postinfectious brainstem encephalitis, myelitis, and radiculoneuropathies will not be unexpected. An atypical case of acute necrotizing encephalopathy, attributed to immune-mediated process and proinflammatory cytokines, and another with meningoencephalitis and leptomeningeal enhancement have been already noted.31 This picture is now becoming more clear with 2 reports in this issue of the Journal, documented by impressive MRIs; one, a case of acute necrotizing brainstem encephalopathy, presented with epilepsy and changes in the right mesial temporal lobe and hippocampus32 and another with altered mental status and multiple white matter tumefactive lesions with postgadolinium enhancement in periventricular areas and corpus callosum suggestive of demyelination.33 Not underestimating the overwhelming burden of acute COVID-19 to medical staff, vigilance for these disorders is needed along with screening for autoimmune encephalitis autoantibodies14 because these cases can potentially respond to early initiation of immunotherapy, especially with IVIg, whenever indicated, which may additionally offer various potentially protective antibodies and anticytokine effects."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T40","span":{"begin":160,"end":169},"obj":"Body_part"},{"id":"T41","span":{"begin":610,"end":619},"obj":"Body_part"},{"id":"T42","span":{"begin":692,"end":705},"obj":"Body_part"},{"id":"T43","span":{"begin":701,"end":705},"obj":"Body_part"},{"id":"T44","span":{"begin":776,"end":788},"obj":"Body_part"},{"id":"T45","span":{"begin":870,"end":885},"obj":"Body_part"},{"id":"T46","span":{"begin":870,"end":876},"obj":"Body_part"}],"attributes":[{"id":"A40","pred":"uberon_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/UBERON_0002298"},{"id":"A41","pred":"uberon_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/UBERON_0002298"},{"id":"A42","pred":"uberon_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/UBERON_0001871"},{"id":"A43","pred":"uberon_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/UBERON_3010752"},{"id":"A44","pred":"uberon_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/UBERON_0002316"},{"id":"A45","pred":"uberon_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/UBERON_0002336"},{"id":"A46","pred":"uberon_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/UBERON_3000645"}],"text":"Other emerging postinfectious autoimmune neurologic disorders\nAcute disseminated encephalomyelitis, as described for the other coronaviruses, or postinfectious brainstem encephalitis, myelitis, and radiculoneuropathies will not be unexpected. An atypical case of acute necrotizing encephalopathy, attributed to immune-mediated process and proinflammatory cytokines, and another with meningoencephalitis and leptomeningeal enhancement have been already noted.31 This picture is now becoming more clear with 2 reports in this issue of the Journal, documented by impressive MRIs; one, a case of acute necrotizing brainstem encephalopathy, presented with epilepsy and changes in the right mesial temporal lobe and hippocampus32 and another with altered mental status and multiple white matter tumefactive lesions with postgadolinium enhancement in periventricular areas and corpus callosum suggestive of demyelination.33 Not underestimating the overwhelming burden of acute COVID-19 to medical staff, vigilance for these disorders is needed along with screening for autoimmune encephalitis autoantibodies14 because these cases can potentially respond to early initiation of immunotherapy, especially with IVIg, whenever indicated, which may additionally offer various potentially protective antibodies and anticytokine effects."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T261","span":{"begin":41,"end":61},"obj":"Disease"},{"id":"T262","span":{"begin":62,"end":98},"obj":"Disease"},{"id":"T263","span":{"begin":81,"end":98},"obj":"Disease"},{"id":"T264","span":{"begin":170,"end":192},"obj":"Disease"},{"id":"T265","span":{"begin":170,"end":182},"obj":"Disease"},{"id":"T266","span":{"begin":184,"end":192},"obj":"Disease"},{"id":"T267","span":{"begin":263,"end":295},"obj":"Disease"},{"id":"T268","span":{"begin":281,"end":295},"obj":"Disease"},{"id":"T269","span":{"begin":383,"end":402},"obj":"Disease"},{"id":"T270","span":{"begin":620,"end":634},"obj":"Disease"},{"id":"T271","span":{"begin":651,"end":659},"obj":"Disease"},{"id":"T272","span":{"begin":970,"end":978},"obj":"Disease"},{"id":"T273","span":{"begin":1062,"end":1085},"obj":"Disease"},{"id":"T274","span":{"begin":1073,"end":1085},"obj":"Disease"}],"attributes":[{"id":"A261","pred":"mondo_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/MONDO_0005071"},{"id":"A262","pred":"mondo_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/MONDO_0019383"},{"id":"A263","pred":"mondo_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/MONDO_0005156"},{"id":"A264","pred":"mondo_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/MONDO_0005156"},{"id":"A265","pred":"mondo_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/MONDO_0019956"},{"id":"A266","pred":"mondo_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/MONDO_0002565"},{"id":"A267","pred":"mondo_id","subj":"T267","obj":"http://purl.obolibrary.org/obo/MONDO_0003336"},{"id":"A268","pred":"mondo_id","subj":"T268","obj":"http://purl.obolibrary.org/obo/MONDO_0005560"},{"id":"A269","pred":"mondo_id","subj":"T269","obj":"http://purl.obolibrary.org/obo/MONDO_0005845"},{"id":"A270","pred":"mondo_id","subj":"T270","obj":"http://purl.obolibrary.org/obo/MONDO_0005560"},{"id":"A271","pred":"mondo_id","subj":"T271","obj":"http://purl.obolibrary.org/obo/MONDO_0005027"},{"id":"A272","pred":"mondo_id","subj":"T272","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A273","pred":"mondo_id","subj":"T273","obj":"http://purl.obolibrary.org/obo/MONDO_0020640"},{"id":"A274","pred":"mondo_id","subj":"T274","obj":"http://purl.obolibrary.org/obo/MONDO_0019956"}],"text":"Other emerging postinfectious autoimmune neurologic disorders\nAcute disseminated encephalomyelitis, as described for the other coronaviruses, or postinfectious brainstem encephalitis, myelitis, and radiculoneuropathies will not be unexpected. An atypical case of acute necrotizing encephalopathy, attributed to immune-mediated process and proinflammatory cytokines, and another with meningoencephalitis and leptomeningeal enhancement have been already noted.31 This picture is now becoming more clear with 2 reports in this issue of the Journal, documented by impressive MRIs; one, a case of acute necrotizing brainstem encephalopathy, presented with epilepsy and changes in the right mesial temporal lobe and hippocampus32 and another with altered mental status and multiple white matter tumefactive lesions with postgadolinium enhancement in periventricular areas and corpus callosum suggestive of demyelination.33 Not underestimating the overwhelming burden of acute COVID-19 to medical staff, vigilance for these disorders is needed along with screening for autoimmune encephalitis autoantibodies14 because these cases can potentially respond to early initiation of immunotherapy, especially with IVIg, whenever indicated, which may additionally offer various potentially protective antibodies and anticytokine effects."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T155","span":{"begin":582,"end":583},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Other emerging postinfectious autoimmune neurologic disorders\nAcute disseminated encephalomyelitis, as described for the other coronaviruses, or postinfectious brainstem encephalitis, myelitis, and radiculoneuropathies will not be unexpected. An atypical case of acute necrotizing encephalopathy, attributed to immune-mediated process and proinflammatory cytokines, and another with meningoencephalitis and leptomeningeal enhancement have been already noted.31 This picture is now becoming more clear with 2 reports in this issue of the Journal, documented by impressive MRIs; one, a case of acute necrotizing brainstem encephalopathy, presented with epilepsy and changes in the right mesial temporal lobe and hippocampus32 and another with altered mental status and multiple white matter tumefactive lesions with postgadolinium enhancement in periventricular areas and corpus callosum suggestive of demyelination.33 Not underestimating the overwhelming burden of acute COVID-19 to medical staff, vigilance for these disorders is needed along with screening for autoimmune encephalitis autoantibodies14 because these cases can potentially respond to early initiation of immunotherapy, especially with IVIg, whenever indicated, which may additionally offer various potentially protective antibodies and anticytokine effects."}

{"project":"LitCovid-PubTator","denotations":[{"id":"647","span":{"begin":30,"end":61},"obj":"Disease"},{"id":"661","span":{"begin":127,"end":140},"obj":"Species"},{"id":"662","span":{"begin":81,"end":98},"obj":"Disease"},{"id":"663","span":{"begin":170,"end":182},"obj":"Disease"},{"id":"664","span":{"begin":184,"end":192},"obj":"Disease"},{"id":"665","span":{"begin":198,"end":218},"obj":"Disease"},{"id":"666","span":{"begin":263,"end":295},"obj":"Disease"},{"id":"667","span":{"begin":383,"end":402},"obj":"Disease"},{"id":"668","span":{"begin":620,"end":634},"obj":"Disease"},{"id":"669","span":{"begin":651,"end":659},"obj":"Disease"},{"id":"670","span":{"begin":776,"end":808},"obj":"Disease"},{"id":"671","span":{"begin":900,"end":913},"obj":"Disease"},{"id":"672","span":{"begin":970,"end":978},"obj":"Disease"},{"id":"673","span":{"begin":1062,"end":1085},"obj":"Disease"}],"attributes":[{"id":"A647","pred":"tao:has_database_id","subj":"647","obj":"MESH:D020274"},{"id":"A661","pred":"tao:has_database_id","subj":"661","obj":"Tax:11118"},{"id":"A662","pred":"tao:has_database_id","subj":"662","obj":"MESH:D004679"},{"id":"A663","pred":"tao:has_database_id","subj":"663","obj":"MESH:D004660"},{"id":"A664","pred":"tao:has_database_id","subj":"664","obj":"MESH:D009187"},{"id":"A665","pred":"tao:has_database_id","subj":"665","obj":"MESH:C564857"},{"id":"A666","pred":"tao:has_database_id","subj":"666","obj":"OMIM:608033"},{"id":"A667","pred":"tao:has_database_id","subj":"667","obj":"MESH:D008590"},{"id":"A668","pred":"tao:has_database_id","subj":"668","obj":"MESH:D001927"},{"id":"A669","pred":"tao:has_database_id","subj":"669","obj":"MESH:D004827"},{"id":"A670","pred":"tao:has_database_id","subj":"670","obj":"MESH:D056784"},{"id":"A671","pred":"tao:has_database_id","subj":"671","obj":"MESH:D003711"},{"id":"A672","pred":"tao:has_database_id","subj":"672","obj":"MESH:C000657245"},{"id":"A673","pred":"tao:has_database_id","subj":"673","obj":"MESH:C535841"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Other emerging postinfectious autoimmune neurologic disorders\nAcute disseminated encephalomyelitis, as described for the other coronaviruses, or postinfectious brainstem encephalitis, myelitis, and radiculoneuropathies will not be unexpected. An atypical case of acute necrotizing encephalopathy, attributed to immune-mediated process and proinflammatory cytokines, and another with meningoencephalitis and leptomeningeal enhancement have been already noted.31 This picture is now becoming more clear with 2 reports in this issue of the Journal, documented by impressive MRIs; one, a case of acute necrotizing brainstem encephalopathy, presented with epilepsy and changes in the right mesial temporal lobe and hippocampus32 and another with altered mental status and multiple white matter tumefactive lesions with postgadolinium enhancement in periventricular areas and corpus callosum suggestive of demyelination.33 Not underestimating the overwhelming burden of acute COVID-19 to medical staff, vigilance for these disorders is needed along with screening for autoimmune encephalitis autoantibodies14 because these cases can potentially respond to early initiation of immunotherapy, especially with IVIg, whenever indicated, which may additionally offer various potentially protective antibodies and anticytokine effects."}

{"project":"LitCovid-sentences","denotations":[{"id":"T66","span":{"begin":0,"end":61},"obj":"Sentence"},{"id":"T67","span":{"begin":62,"end":242},"obj":"Sentence"},{"id":"T68","span":{"begin":243,"end":1323},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Other emerging postinfectious autoimmune neurologic disorders\nAcute disseminated encephalomyelitis, as described for the other coronaviruses, or postinfectious brainstem encephalitis, myelitis, and radiculoneuropathies will not be unexpected. An atypical case of acute necrotizing encephalopathy, attributed to immune-mediated process and proinflammatory cytokines, and another with meningoencephalitis and leptomeningeal enhancement have been already noted.31 This picture is now becoming more clear with 2 reports in this issue of the Journal, documented by impressive MRIs; one, a case of acute necrotizing brainstem encephalopathy, presented with epilepsy and changes in the right mesial temporal lobe and hippocampus32 and another with altered mental status and multiple white matter tumefactive lesions with postgadolinium enhancement in periventricular areas and corpus callosum suggestive of demyelination.33 Not underestimating the overwhelming burden of acute COVID-19 to medical staff, vigilance for these disorders is needed along with screening for autoimmune encephalitis autoantibodies14 because these cases can potentially respond to early initiation of immunotherapy, especially with IVIg, whenever indicated, which may additionally offer various potentially protective antibodies and anticytokine effects."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T126","span":{"begin":170,"end":182},"obj":"Phenotype"},{"id":"T127","span":{"begin":184,"end":192},"obj":"Phenotype"},{"id":"T128","span":{"begin":263,"end":295},"obj":"Phenotype"},{"id":"T129","span":{"begin":407,"end":433},"obj":"Phenotype"},{"id":"T130","span":{"begin":620,"end":634},"obj":"Phenotype"},{"id":"T131","span":{"begin":651,"end":659},"obj":"Phenotype"},{"id":"T132","span":{"begin":900,"end":913},"obj":"Phenotype"},{"id":"T133","span":{"begin":1073,"end":1085},"obj":"Phenotype"}],"attributes":[{"id":"A126","pred":"hp_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/HP_0002383"},{"id":"A127","pred":"hp_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/HP_0012486"},{"id":"A128","pred":"hp_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/HP_0006965"},{"id":"A129","pred":"hp_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/HP_0032070"},{"id":"A130","pred":"hp_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/HP_0001298"},{"id":"A131","pred":"hp_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A132","pred":"hp_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/HP_0011096"},{"id":"A133","pred":"hp_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/HP_0002383"}],"text":"Other emerging postinfectious autoimmune neurologic disorders\nAcute disseminated encephalomyelitis, as described for the other coronaviruses, or postinfectious brainstem encephalitis, myelitis, and radiculoneuropathies will not be unexpected. An atypical case of acute necrotizing encephalopathy, attributed to immune-mediated process and proinflammatory cytokines, and another with meningoencephalitis and leptomeningeal enhancement have been already noted.31 This picture is now becoming more clear with 2 reports in this issue of the Journal, documented by impressive MRIs; one, a case of acute necrotizing brainstem encephalopathy, presented with epilepsy and changes in the right mesial temporal lobe and hippocampus32 and another with altered mental status and multiple white matter tumefactive lesions with postgadolinium enhancement in periventricular areas and corpus callosum suggestive of demyelination.33 Not underestimating the overwhelming burden of acute COVID-19 to medical staff, vigilance for these disorders is needed along with screening for autoimmune encephalitis autoantibodies14 because these cases can potentially respond to early initiation of immunotherapy, especially with IVIg, whenever indicated, which may additionally offer various potentially protective antibodies and anticytokine effects."}

{"project":"2_test","denotations":[{"id":"32518172-32251791-75850529","span":{"begin":458,"end":460},"obj":"32251791"},{"id":"32518172-32457227-75850530","span":{"begin":721,"end":723},"obj":"32457227"},{"id":"32518172-32444427-75850531","span":{"begin":914,"end":916},"obj":"32444427"},{"id":"32518172-30049614-75850532","span":{"begin":1100,"end":1102},"obj":"30049614"}],"text":"Other emerging postinfectious autoimmune neurologic disorders\nAcute disseminated encephalomyelitis, as described for the other coronaviruses, or postinfectious brainstem encephalitis, myelitis, and radiculoneuropathies will not be unexpected. An atypical case of acute necrotizing encephalopathy, attributed to immune-mediated process and proinflammatory cytokines, and another with meningoencephalitis and leptomeningeal enhancement have been already noted.31 This picture is now becoming more clear with 2 reports in this issue of the Journal, documented by impressive MRIs; one, a case of acute necrotizing brainstem encephalopathy, presented with epilepsy and changes in the right mesial temporal lobe and hippocampus32 and another with altered mental status and multiple white matter tumefactive lesions with postgadolinium enhancement in periventricular areas and corpus callosum suggestive of demyelination.33 Not underestimating the overwhelming burden of acute COVID-19 to medical staff, vigilance for these disorders is needed along with screening for autoimmune encephalitis autoantibodies14 because these cases can potentially respond to early initiation of immunotherapy, especially with IVIg, whenever indicated, which may additionally offer various potentially protective antibodies and anticytokine effects."}