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PMC:7309518 / 16371-17803 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T105 103-109 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T106 337-340 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T107 541-547 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T108 691-697 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T109 709-717 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T110 1025-1031 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T111 1126-1139 Body_part denotes muscle fibers http://purl.org/sig/ont/fma/fma67328
T112 1281-1285 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T113 1328-1333 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T114 1337-1347 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T115 1358-1370 Body_part denotes muscle fiber http://purl.org/sig/ont/fma/fma67328
T116 1414-1423 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T243 40-53 Disease denotes viral disease http://purl.obolibrary.org/obo/MONDO_0005108
T244 169-171 Disease denotes CK http://purl.obolibrary.org/obo/MONDO_0017941
T245 247-268 Disease denotes inflammatory myopathy http://purl.obolibrary.org/obo/MONDO_0007827
T246 260-268 Disease denotes myopathy http://purl.obolibrary.org/obo/MONDO_0005336
T247 292-295 Disease denotes NAM http://purl.obolibrary.org/obo/MONDO_0009722|http://purl.obolibrary.org/obo/MONDO_0016098
T249 396-399 Disease denotes NAM http://purl.obolibrary.org/obo/MONDO_0009722|http://purl.obolibrary.org/obo/MONDO_0016098
T251 520-522 Disease denotes CK http://purl.obolibrary.org/obo/MONDO_0017941
T252 577-585 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T253 641-649 Disease denotes myopathy http://purl.obolibrary.org/obo/MONDO_0005336
T254 895-903 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T255 915-923 Disease denotes myositis http://purl.obolibrary.org/obo/MONDO_0008054|http://purl.obolibrary.org/obo/MONDO_0021167
T257 970-978 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T258 1057-1065 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T259 1191-1199 Disease denotes myositis http://purl.obolibrary.org/obo/MONDO_0008054|http://purl.obolibrary.org/obo/MONDO_0021167

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T122 22-23 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T123 103-109 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T124 103-109 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T125 103-109 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T126 103-109 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T127 487-489 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T128 541-547 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T129 541-547 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T130 541-547 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T131 541-547 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T132 606-607 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T133 650-653 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T134 691-697 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T135 691-697 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T136 691-697 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T137 691-697 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T138 1016-1031 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T139 1016-1031 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T140 1016-1031 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T141 1090-1095 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T142 1126-1132 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T143 1126-1132 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T144 1126-1132 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T145 1126-1132 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T146 1153-1160 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T147 1200-1203 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T148 1254-1261 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T149 1279-1285 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T150 1326-1333 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T151 1358-1364 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T152 1358-1364 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T153 1358-1364 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T154 1358-1364 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T93 416-422 Chemical denotes statin http://purl.obolibrary.org/obo/CHEBI_87631

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
627 959-964 Gene denotes ACE-2 Gene:59272
628 169-171 Gene denotes CK Gene:51727
629 520-522 Gene denotes CK Gene:51727
630 595-603 Species denotes patients Tax:9606
631 756-764 Species denotes patients Tax:9606
632 970-978 Species denotes SARS-CoV Tax:694009
633 0-18 Disease denotes Myopathic symptoms MESH:D051271
634 40-53 Disease denotes viral disease MESH:D001102
635 103-118 Disease denotes muscle weakness MESH:D018908
636 260-268 Disease denotes myopathy MESH:D009135
637 337-340 Disease denotes HIV MESH:D015658
638 458-472 Disease denotes paraneoplastic MESH:D010257
639 533-556 Disease denotes painful muscle weakness MESH:D018908
640 577-585 Disease denotes COVID-19 MESH:C000657245
641 630-649 Disease denotes autoimmune myopathy MESH:D009135
642 895-903 Disease denotes COVID-19 MESH:C000657245
643 915-923 Disease denotes myositis MESH:D009220
644 1057-1065 Disease denotes COVID-19 MESH:C000657245
645 1191-1199 Disease denotes myositis MESH:D009220

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T63 0-677 Sentence denotes Myopathic symptoms in a severe systemic viral disease are multifactorial, but an acute onset of severe muscle weakness with increased inflammatory markers and very high CK levels in the thousands, as described above, is consistent with autoimmune inflammatory myopathy within the spectrum of NAM, similar to what was first reported with HIV early in that epidemic.22,23 The most common causes of NAM are not chronic statin use as overstated, but autoimmune, paraneoplastic, or postviral.22–25 Considering that very high CK level and painful muscle weakness were seen in 10% of COVID-19–positive patients,6 a potentially treatable autoimmune myopathy has been likely overlooked.
T64 678-1140 Sentence denotes Studies with muscle biopsy and antibody screening are urgently needed in such patients because therapy with IVIg can improve strength, reduce morbidity, and facilitate recovery, as reported in the first 2 cases.20,21 COVID-19–associated myositis is also highly interesting because ACE-2, the SARS-CoV receptor, is reportedly expressed in skeletal muscle.26 If this is confirmed, COVID-19 may represent the first virus directly capable of infecting muscle fibers.
T65 1141-1432 Sentence denotes None of the viruses implicated in viral-triggered myositis has so far been shown to infect muscle27,28; instead, viruses induce an immune T cell with clonal expansion of viral-specific T cells or macrophage-mediated, muscle fiber autoinvasion with abundant proinflammatory cytokines.22,29,30

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T120 103-118 Phenotype denotes muscle weakness http://purl.obolibrary.org/obo/HP_0001324
T121 247-268 Phenotype denotes inflammatory myopathy http://purl.obolibrary.org/obo/HP_0009071
T122 541-556 Phenotype denotes muscle weakness http://purl.obolibrary.org/obo/HP_0001324
T123 641-649 Phenotype denotes myopathy http://purl.obolibrary.org/obo/HP_0003198
T124 915-923 Phenotype denotes myositis http://purl.obolibrary.org/obo/HP_0100614
T125 1191-1199 Phenotype denotes myositis http://purl.obolibrary.org/obo/HP_0100614

2_test

Id Subject Object Predicate Lexical cue
32518172-25923553-75850518 364-366 25923553 denotes 22
32518172-3464769-75850519 367-369 3464769 denotes 23
32518172-25923553-75850520 487-489 25923553 denotes 22
32518172-3464769-75850520 487-489 3464769 denotes 22
32518172-27147697-75850521 490-492 27147697 denotes 25
32518172-32382463-75850522 889-891 32382463 denotes 20
32518172-25764065-75850523 1032-1034 25764065 denotes 26
32518172-1349938-75850524 1238-1240 1349938 denotes 27
32518172-8455655-75850525 1241-1243 8455655 denotes 28
32518172-25923553-75850526 1424-1426 25923553 denotes 22
32518172-1859178-75850527 1427-1429 1859178 denotes 29
32518172-17366634-75850528 1430-1432 17366634 denotes 30