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PMC:7307149 / 759-2240 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T9 37-69 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T10 71-74 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T11 97-106 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T12 118-121 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T13 401-404 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T14 441-444 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T15 713-716 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T16 749-752 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T17 1131-1134 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T18 1321-1325 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T19 1387-1390 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T8 211-258 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T9 211-244 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T10 260-268 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 299-323 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T12 325-333 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 477-485 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 630-638 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 807-815 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 898-906 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 948-952 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T18 1200-1208 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T8 84-89 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T9 91-96 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T10 115-116 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T11 122-123 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T12 127-128 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T13 137-142 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T14 277-282 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T15 349-350 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 393-400 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T17 445-446 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T18 449-450 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T19 488-496 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T20 605-610 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T21 698-699 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T22 753-754 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T23 794-802 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T24 962-966 http://purl.obolibrary.org/obo/CLO_0004265 denotes H.-T
T25 978-979 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T26 1135-1136 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T27 1211-1219 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T28 1249-1254 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T29 1319-1325 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 107-114 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T2 393-400 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T3 488-496 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T4 794-802 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T5 957-960 Chemical denotes Lin http://purl.obolibrary.org/obo/CHEBI_32386
T6 1009-1012 Chemical denotes BMC http://purl.obolibrary.org/obo/CHEBI_3392
T7 1211-1219 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
33 118-136 Gene denotes HLA-A], -B, and -C Gene:3105
34 749-754 Gene denotes HLA-B Gene:3106
35 1131-1136 Gene denotes HLA-B Gene:3106
36 954-955 Gene denotes M Gene:43740571
37 211-258 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
38 260-270 Species denotes SARS-CoV-2 Tax:2697049
39 477-487 Species denotes SARS-CoV-2 Tax:2697049
40 605-610 Species denotes human Tax:9606
41 611-624 Species denotes coronaviruses Tax:11118
42 630-640 Species denotes SARS-CoV-2 Tax:2697049
43 807-817 Species denotes SARS-CoV-2 Tax:2697049
44 1200-1210 Species denotes SARS-CoV-2 Tax:2697049
45 1249-1254 Species denotes human Tax:9606
46 1255-1268 Species denotes coronaviruses Tax:11118
47 91-96 Species denotes human Tax:9606
48 441-458 Gene denotes HLA-A, -B, and -C Gene:3106
49 299-323 Disease denotes coronavirus disease 2019 MESH:C000657245
50 325-333 Disease denotes COVID-19 MESH:C000657245
51 898-906 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T2 37-69 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T3 71-74 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T4 401-404 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T11 0-335 Sentence denotes Genetic variability across the three major histocompatibility complex (MHC) class I genes (human leukocyte antigen A [HLA-A], -B, and -C genes) may affect susceptibility to and severity of the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19).
T12 336-497 Sentence denotes We performed a comprehensive in silico analysis of viral peptide-MHC class I binding affinity across 145 HLA-A, -B, and -C genotypes for all SARS-CoV-2 peptides.
T13 498-625 Sentence denotes We further explored the potential for cross-protective immunity conferred by prior exposure to four common human coronaviruses.
T14 626-725 Sentence denotes The SARS-CoV-2 proteome was successfully sampled and was represented by a diversity of HLA alleles.
T15 726-956 Sentence denotes However, we found that HLA-B*46:01 had the fewest predicted binding peptides for SARS-CoV-2, suggesting that individuals with this allele may be particularly vulnerable to COVID-19, as they were previously shown to be for SARS (M.
T16 957-967 Sentence denotes Lin, H.-T.
T17 968-977 Sentence denotes Tseng, J.
T18 978-980 Sentence denotes A.
T19 981-995 Sentence denotes Trejaut, H.-L.
T20 996-1104 Sentence denotes Lee, et al., BMC Med Genet 4:9, 2003, https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-4-9).
T21 1105-1341 Sentence denotes Conversely, we found that HLA-B*15:03 showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting that it could enable cross-protective T-cell-based immunity.
T22 1342-1481 Sentence denotes Finally, we reported global distributions of HLA types with potential epidemiological ramifications in the setting of the current pandemic.