PMC:7307149 / 16546-17477 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T109","span":{"begin":56,"end":59},"obj":"Body_part"},{"id":"T110","span":{"begin":213,"end":216},"obj":"Body_part"},{"id":"T111","span":{"begin":226,"end":229},"obj":"Body_part"},{"id":"T112","span":{"begin":239,"end":242},"obj":"Body_part"},{"id":"T113","span":{"begin":256,"end":259},"obj":"Body_part"},{"id":"T114","span":{"begin":501,"end":504},"obj":"Body_part"},{"id":"T115","span":{"begin":514,"end":517},"obj":"Body_part"},{"id":"T116","span":{"begin":531,"end":534},"obj":"Body_part"}],"attributes":[{"id":"A109","pred":"fma_id","subj":"T109","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A110","pred":"fma_id","subj":"T110","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A111","pred":"fma_id","subj":"T111","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A112","pred":"fma_id","subj":"T112","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A113","pred":"fma_id","subj":"T113","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A114","pred":"fma_id","subj":"T114","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A115","pred":"fma_id","subj":"T115","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A116","pred":"fma_id","subj":"T116","obj":"http://purl.org/sig/ont/fma/fma84795"}],"text":"Distributions of SARS-CoV-2 peptide presentation across HLA haplotypes. The leftmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative HLA alleles (HLA-A*02:02, HLA-B*15:03, and HLA-C*12:03) with the greatest predicted repertoire of epitopes from the SARS-CoV-2 proteome. The rightmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative alleles (HLA-A*25:01, HLA-B*46:01, and HLA-C*01:02) with the lowest predicted levels of epitope presentation from the SARS-CoV-2 proteome. Black and gray bars represent full and partial haplotypes, respectively. Blue and red dashed lines represent the percentages of presented SARS-CoV-2 peptides for the indicated allele itself (blue) and its global population frequency weighted average presentation across its observed haplotypes (red)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T72","span":{"begin":17,"end":25},"obj":"Disease"},{"id":"T73","span":{"begin":118,"end":126},"obj":"Disease"},{"id":"T74","span":{"begin":329,"end":337},"obj":"Disease"},{"id":"T75","span":{"begin":397,"end":405},"obj":"Disease"},{"id":"T76","span":{"begin":610,"end":618},"obj":"Disease"},{"id":"T77","span":{"begin":769,"end":777},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A75","pred":"mondo_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A76","pred":"mondo_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A77","pred":"mondo_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Distributions of SARS-CoV-2 peptide presentation across HLA haplotypes. The leftmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative HLA alleles (HLA-A*02:02, HLA-B*15:03, and HLA-C*12:03) with the greatest predicted repertoire of epitopes from the SARS-CoV-2 proteome. The rightmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative alleles (HLA-A*25:01, HLA-B*46:01, and HLA-C*01:02) with the lowest predicted levels of epitope presentation from the SARS-CoV-2 proteome. Black and gray bars represent full and partial haplotypes, respectively. Blue and red dashed lines represent the percentages of presented SARS-CoV-2 peptides for the indicated allele itself (blue) and its global population frequency weighted average presentation across its observed haplotypes (red)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T174","span":{"begin":28,"end":35},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T175","span":{"begin":129,"end":136},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T176","span":{"begin":230,"end":231},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T177","span":{"begin":243,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T178","span":{"begin":408,"end":415},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T179","span":{"begin":505,"end":506},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T180","span":{"begin":518,"end":519},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T181","span":{"begin":780,"end":788},"obj":"http://purl.obolibrary.org/obo/PR_000018263"}],"text":"Distributions of SARS-CoV-2 peptide presentation across HLA haplotypes. The leftmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative HLA alleles (HLA-A*02:02, HLA-B*15:03, and HLA-C*12:03) with the greatest predicted repertoire of epitopes from the SARS-CoV-2 proteome. The rightmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative alleles (HLA-A*25:01, HLA-B*46:01, and HLA-C*01:02) with the lowest predicted levels of epitope presentation from the SARS-CoV-2 proteome. Black and gray bars represent full and partial haplotypes, respectively. Blue and red dashed lines represent the percentages of presented SARS-CoV-2 peptides for the indicated allele itself (blue) and its global population frequency weighted average presentation across its observed haplotypes (red)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T96","span":{"begin":28,"end":35},"obj":"Chemical"},{"id":"T97","span":{"begin":129,"end":136},"obj":"Chemical"},{"id":"T98","span":{"begin":408,"end":415},"obj":"Chemical"},{"id":"T99","span":{"begin":580,"end":587},"obj":"Chemical"},{"id":"T100","span":{"begin":780,"end":788},"obj":"Chemical"}],"attributes":[{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"}],"text":"Distributions of SARS-CoV-2 peptide presentation across HLA haplotypes. The leftmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative HLA alleles (HLA-A*02:02, HLA-B*15:03, and HLA-C*12:03) with the greatest predicted repertoire of epitopes from the SARS-CoV-2 proteome. The rightmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative alleles (HLA-A*25:01, HLA-B*46:01, and HLA-C*01:02) with the lowest predicted levels of epitope presentation from the SARS-CoV-2 proteome. Black and gray bars represent full and partial haplotypes, respectively. Blue and red dashed lines represent the percentages of presented SARS-CoV-2 peptides for the indicated allele itself (blue) and its global population frequency weighted average presentation across its observed haplotypes (red)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"320","span":{"begin":226,"end":231},"obj":"Gene"},{"id":"321","span":{"begin":239,"end":244},"obj":"Gene"},{"id":"322","span":{"begin":256,"end":261},"obj":"Gene"},{"id":"323","span":{"begin":501,"end":506},"obj":"Gene"},{"id":"324","span":{"begin":514,"end":519},"obj":"Gene"},{"id":"325","span":{"begin":531,"end":536},"obj":"Gene"},{"id":"326","span":{"begin":17,"end":27},"obj":"Species"},{"id":"327","span":{"begin":118,"end":128},"obj":"Species"},{"id":"328","span":{"begin":329,"end":339},"obj":"Species"},{"id":"329","span":{"begin":397,"end":407},"obj":"Species"},{"id":"330","span":{"begin":610,"end":620},"obj":"Species"},{"id":"331","span":{"begin":769,"end":779},"obj":"Species"}],"attributes":[{"id":"A320","pred":"tao:has_database_id","subj":"320","obj":"Gene:3105"},{"id":"A321","pred":"tao:has_database_id","subj":"321","obj":"Gene:3106"},{"id":"A322","pred":"tao:has_database_id","subj":"322","obj":"Gene:3107"},{"id":"A323","pred":"tao:has_database_id","subj":"323","obj":"Gene:3105"},{"id":"A324","pred":"tao:has_database_id","subj":"324","obj":"Gene:3106"},{"id":"A325","pred":"tao:has_database_id","subj":"325","obj":"Gene:3107"},{"id":"A326","pred":"tao:has_database_id","subj":"326","obj":"Tax:2697049"},{"id":"A327","pred":"tao:has_database_id","subj":"327","obj":"Tax:2697049"},{"id":"A328","pred":"tao:has_database_id","subj":"328","obj":"Tax:2697049"},{"id":"A329","pred":"tao:has_database_id","subj":"329","obj":"Tax:2697049"},{"id":"A330","pred":"tao:has_database_id","subj":"330","obj":"Tax:2697049"},{"id":"A331","pred":"tao:has_database_id","subj":"331","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Distributions of SARS-CoV-2 peptide presentation across HLA haplotypes. The leftmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative HLA alleles (HLA-A*02:02, HLA-B*15:03, and HLA-C*12:03) with the greatest predicted repertoire of epitopes from the SARS-CoV-2 proteome. The rightmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative alleles (HLA-A*25:01, HLA-B*46:01, and HLA-C*01:02) with the lowest predicted levels of epitope presentation from the SARS-CoV-2 proteome. Black and gray bars represent full and partial haplotypes, respectively. Blue and red dashed lines represent the percentages of presented SARS-CoV-2 peptides for the indicated allele itself (blue) and its global population frequency weighted average presentation across its observed haplotypes (red)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T91","span":{"begin":72,"end":349},"obj":"Sentence"},{"id":"T92","span":{"begin":350,"end":630},"obj":"Sentence"},{"id":"T93","span":{"begin":631,"end":703},"obj":"Sentence"},{"id":"T94","span":{"begin":704,"end":931},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Distributions of SARS-CoV-2 peptide presentation across HLA haplotypes. The leftmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative HLA alleles (HLA-A*02:02, HLA-B*15:03, and HLA-C*12:03) with the greatest predicted repertoire of epitopes from the SARS-CoV-2 proteome. The rightmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative alleles (HLA-A*25:01, HLA-B*46:01, and HLA-C*01:02) with the lowest predicted levels of epitope presentation from the SARS-CoV-2 proteome. Black and gray bars represent full and partial haplotypes, respectively. Blue and red dashed lines represent the percentages of presented SARS-CoV-2 peptides for the indicated allele itself (blue) and its global population frequency weighted average presentation across its observed haplotypes (red)."}