> top > docs > PMC:7307149 > annotations

PMC:7307149 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 6-15 Body_part denotes Leukocyte http://purl.org/sig/ont/fma/fma62852
T2 39-42 Body_part denotes Map http://purl.org/sig/ont/fma/fma67847
T3 95-98 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T4 114-117 Body_part denotes Map http://purl.org/sig/ont/fma/fma67847
T5 302-305 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T6 405-408 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T7 453-456 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T8 692-695 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T9 796-828 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T10 830-833 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T11 856-865 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T12 877-880 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T13 1160-1163 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T14 1200-1203 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T15 1472-1475 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T16 1508-1511 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T17 1890-1893 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T18 2080-2084 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T19 2146-2149 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T20 2406-2409 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T21 2509-2512 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T22 2557-2560 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T23 2796-2799 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T24 3178-3181 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T25 4268-4281 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T26 4626-4635 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T27 4645-4648 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T28 4959-4962 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T29 5007-5010 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T30 5140-5143 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T31 5156-5159 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T32 5173-5176 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T33 5255-5258 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T34 5274-5277 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T35 5290-5293 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T36 5647-5650 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T37 5693-5697 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T38 5878-5910 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T39 5912-5915 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T40 5963-5966 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T41 6055-6058 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T42 6116-6119 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T43 6326-6329 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T44 6496-6499 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T45 6809-6812 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T46 6871-6874 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T47 6890-6893 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T48 7100-7103 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T49 7278-7281 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T50 7434-7437 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T51 7659-7662 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T52 8388-8396 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T53 8522-8532 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T54 9197-9207 Body_part denotes Amino acid http://purl.org/sig/ont/fma/fma82739
T55 9300-9308 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T56 9310-9317 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T57 9639-9646 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T58 9730-9737 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T59 9947-9957 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T60 10058-10069 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T61 10260-10263 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T62 10363-10366 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T63 10561-10564 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T64 10574-10577 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T65 10591-10594 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T66 10688-10691 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T67 10934-10937 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T68 11066-11069 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T69 11233-11236 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T70 11424-11427 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T71 11658-11661 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T72 11883-11886 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T73 12347-12350 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T74 12563-12566 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T75 12573-12576 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T76 13186-13189 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T77 13219-13222 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T78 13226-13229 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T79 13237-13240 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T80 13626-13637 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T81 13677-13688 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T82 13767-13778 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T83 13780-13782 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T84 13912-13915 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T85 14017-14021 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T86 14088-14091 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T87 14360-14363 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T88 14509-14512 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T89 14584-14587 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T90 14636-14639 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T91 14775-14778 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T92 14788-14791 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T93 14805-14808 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T94 15101-15104 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T95 15114-15117 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T96 15131-15134 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T97 15290-15293 Body_part denotes map http://purl.org/sig/ont/fma/fma67847
T98 15333-15336 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T99 15540-15543 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T100 15824-15827 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T101 15863-15866 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T102 15927-15930 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T103 15940-15943 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T104 15957-15960 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T105 15982-15985 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T106 15995-15998 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T107 16012-16015 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T108 16354-16357 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T109 16602-16605 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T110 16759-16762 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T111 16772-16775 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T112 16785-16788 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T113 16802-16805 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T114 17047-17050 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T115 17060-17063 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T116 17077-17080 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T117 17619-17622 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T118 17637-17640 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T119 17769-17772 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T120 17827-17830 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T121 17988-17991 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T122 18231-18234 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T123 18311-18314 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T124 18484-18487 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T125 18928-18932 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T126 18951-18959 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T127 18971-18975 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T128 19018-19022 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T129 19433-19436 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T130 19633-19636 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T131 19757-19760 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T132 19890-19893 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T133 19968-19972 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T134 20015-20019 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T135 20197-20201 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T136 20332-20335 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T137 20633-20636 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T138 20782-20790 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T139 20854-20860 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T140 20898-20906 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T141 20934-20938 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T142 21173-21176 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T143 21218-21221 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T144 21649-21656 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T145 21671-21678 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T146 21693-21700 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T147 21723-21730 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T148 21995-22002 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T149 22202-22209 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T150 22401-22408 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T151 23197-23207 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T152 23908-23919 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T153 24162-24172 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T154 24538-24541 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T155 24602-24609 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T156 24837-24840 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T157 24902-24905 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T158 24978-24981 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T159 25224-25235 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T160 25366-25369 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T161 26354-26357 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T162 26449-26452 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T163 26487-26490 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T164 26700-26705 Body_part denotes digit http://purl.org/sig/ont/fma/fma85518
T165 26820-26823 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T166 26866-26869 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T167 26901-26904 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 4268-4281 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T2 26700-26705 Body_part denotes digit http://purl.obolibrary.org/obo/UBERON_0002544

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 47-94 Disease denotes Severe Acute Respiratory Syndrome Coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T2 122-130 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 331-339 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 469-477 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 541-554 Disease denotes viral disease http://purl.obolibrary.org/obo/MONDO_0005108
T6 621-629 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 655-663 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 970-1017 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T9 970-1003 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T10 1019-1027 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 1058-1082 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T12 1084-1092 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 1236-1244 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 1389-1397 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 1566-1574 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 1657-1665 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 1707-1711 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T18 1959-1967 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T19 2435-2443 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T20 2573-2581 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T21 2645-2658 Disease denotes viral disease http://purl.obolibrary.org/obo/MONDO_0005108
T22 2725-2733 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T23 2759-2767 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 2901-2948 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T25 2901-2934 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T26 2953-2961 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 3191-3199 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 3248-3267 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T29 3304-3315 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T30 3417-3450 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T31 3464-3472 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 3575-3583 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T33 3699-3716 Disease denotes pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005275
T34 3767-3775 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T35 3858-3866 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 3972-3981 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T37 4321-4329 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 4373-4381 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 4499-4508 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T40 4889-4897 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 5114-5130 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T42 5233-5239 Disease denotes dengue http://purl.obolibrary.org/obo/MONDO_0005502
T43 5431-5439 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T44 5599-5607 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 5988-5996 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 6180-6188 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 6528-6536 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 6757-6765 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 6948-6956 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 7015-7023 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T51 7148-7156 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 7329-7337 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 8180-8188 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 8799-8807 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T55 9465-9473 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T56 9477-9485 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T57 10449-10457 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 10779-10787 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T59 11195-11203 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 11551-11559 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T61 12287-12295 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 12655-12663 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T63 13039-13047 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T64 13158-13166 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 13833-13841 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T66 13979-13987 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 14904-14912 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T68 15207-15215 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 15784-15792 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 16048-16056 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T71 16446-16454 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T72 16563-16571 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T73 16664-16672 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T74 16875-16883 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 16943-16951 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T76 17156-17164 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 17315-17323 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T78 17917-17925 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 17928-17937 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T80 18043-18052 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T81 18079-18087 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T82 18121-18129 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T83 18134-18142 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T84 18553-18561 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T85 18565-18573 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 18832-18840 Disease denotes vaccinia http://purl.obolibrary.org/obo/MONDO_0002595
T87 19259-19267 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T88 19489-19497 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T89 20168-20177 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T90 20270-20279 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91 20515-20523 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 20911-20919 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T93 21234-21242 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T94 21918-21926 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T95 21928-21936 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T96 23728-23736 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T97 23949-23957 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T98 24190-24198 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T99 24636-24644 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T100 24651-24659 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T101 25722-25730 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 26025-26033 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T103 26047-26055 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 0-5 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T2 227-228 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 229-234 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T4 242-243 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 478-485 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T6 603-604 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 637-642 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T8 843-848 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T9 850-855 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T10 874-875 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T11 881-882 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T12 886-887 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T13 896-901 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T14 1036-1041 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T15 1108-1109 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 1152-1159 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T17 1204-1205 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T18 1208-1209 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T19 1247-1255 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T20 1364-1369 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T21 1457-1458 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T22 1512-1513 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T23 1553-1561 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T24 1721-1725 http://purl.obolibrary.org/obo/CLO_0004265 denotes H.-T
T25 1737-1738 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T26 1894-1895 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T27 1970-1978 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T28 2008-2013 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T29 2078-2084 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T30 2331-2332 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 2333-2338 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T32 2346-2347 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 2582-2589 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T34 2707-2708 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 2741-2746 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T36 2868-2869 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 2976-2977 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 3022-3034 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T39 3182-3189 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T40 3271-3277 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T41 3868-3870 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T42 4023-4025 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T43 4232-4234 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T44 4268-4281 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T45 4357-4359 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T46 4418-4424 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T47 4510-4512 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T48 4574-4576 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T49 4612-4614 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T50 4615-4617 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T51 4620-4625 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T52 4963-4964 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T53 5083-5090 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T54 5108-5113 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T55 5131-5136 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T56 5177-5178 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T57 5240-5245 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T58 5278-5279 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T59 5294-5295 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T60 5691-5697 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T61 5826-5827 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T62 5870-5877 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T63 6047-6048 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T64 6219-6227 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T65 6280-6288 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T66 6416-6424 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T67 6471-6472 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T68 6671-6673 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T69 6875-6876 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T70 6935-6943 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T71 7043-7045 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T72 7104-7105 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T73 7157-7165 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T74 7374-7382 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T75 7394-7396 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T76 7458-7459 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77 7587-7595 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T78 7663-7664 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T79 7667-7668 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T80 7762-7770 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T81 8069-8074 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T82 8405-8407 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T83 8467-8472 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T84 8502-8504 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T85 8563-8565 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T86 8687-8695 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T87 8748-8755 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T88 8891-8898 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T89 8953-8958 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T90 8995-8997 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T91 8995-8997 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T92 9032-9040 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T93 9155-9163 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T94 9245-9252 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T95 9282-9287 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T96 9370-9378 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T97 9440-9445 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T98 9527-9532 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T99 9925-9926 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 10046-10054 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T101 10149-10151 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T102 10149-10151 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T103 10206-10214 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T104 10367-10368 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T105 10371-10372 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T106 10529-10537 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T107 10565-10566 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T108 10578-10579 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T109 10640-10648 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T110 10790-10798 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T111 10811-10812 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T112 10884-10889 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T113 10938-10939 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T114 11025-11032 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T115 11266-11267 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T116 11381-11385 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T117 11397-11399 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T118 11397-11399 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T119 11470-11475 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T120 11488-11496 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T121 11595-11603 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T122 11643-11644 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T123 11682-11683 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T124 11811-11819 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T125 11887-11888 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T126 11891-11892 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T127 11986-11994 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T128 12503-12510 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T129 12567-12568 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T130 12731-12736 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T131 12772-12779 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T132 12850-12857 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T133 12918-12925 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T134 12995-13002 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T135 13050-13058 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T136 13223-13224 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T137 13230-13231 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T138 13407-13415 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T139 13458-13459 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T140 13551-13559 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T141 13749-13757 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T142 13780-13782 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T143 13963-13964 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T144 14013-14014 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T145 14015-14021 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T146 14177-14179 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T147 14177-14179 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T148 14263-14264 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T149 14272-14273 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T150 14329-14330 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T151 14338-14339 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T152 14364-14365 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T153 14368-14369 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T154 14566-14568 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T155 14640-14641 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T156 14644-14645 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T157 14779-14780 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T158 14792-14793 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T159 15105-15106 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T160 15118-15119 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T161 15544-15545 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T162 15546-15547 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T163 15687-15688 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T164 15931-15932 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T165 15944-15945 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T166 15986-15987 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T167 15999-16000 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T168 16286-16288 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T169 16303-16305 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T170 16303-16305 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T171 16428-16436 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T172 16479-16480 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T173 16521-16528 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extreme
T174 16574-16581 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T175 16675-16682 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T176 16776-16777 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T177 16789-16790 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T178 16954-16961 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T179 17051-17052 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T180 17064-17065 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T181 17326-17334 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T182 17603-17604 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T183 17641-17648 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T184 17992-17993 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T185 18145-18152 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T186 18180-18181 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T187 18576-18584 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T188 18626-18633 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T189 18765-18770 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T190 18841-18846 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T191 18876-18883 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T192 18921-18924 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T193 18926-18932 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T194 18964-18967 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T195 18969-18975 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T196 19046-19053 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T197 19174-19175 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T198 19268-19276 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T199 19351-19352 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T200 19882-19889 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T201 19940-19941 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T202 19966-19972 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T203 20013-20019 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T204 20150-20151 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T205 20195-20201 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T206 20262-20263 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T207 20298-20299 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T208 20398-20399 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T209 20430-20432 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T210 20934-20938 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T211 21177-21184 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T212 21243-21250 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T213 21301-21302 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T214 21517-21518 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T215 21540-21547 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T216 21658-21666 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T217 21767-21769 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T218 21891-21896 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T219 22071-22073 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T220 22236-22240 http://purl.obolibrary.org/obo/CLO_0007653 denotes M, E
T221 22254-22256 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T222 22698-22705 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T223 22748-22756 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T224 22786-22794 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T225 22871-22878 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T226 22946-22948 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T227 23135-23137 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T228 23152-23153 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T229 23299-23300 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T230 23569-23574 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T231 23715-23717 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T232 23827-23832 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T233 23845-23853 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T234 23881-23882 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T235 23983-23988 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T236 24046-24048 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T237 24046-24048 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T238 24079-24087 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T239 24235-24240 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T240 24310-24318 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T241 24320-24325 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T242 24386-24387 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T243 24530-24537 http://purl.obolibrary.org/obo/PR_000018263 denotes Peptide
T244 24849-24856 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T245 25084-25086 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T246 25207-25215 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T247 25253-25255 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T248 25297-25305 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T249 25578-25580 http://purl.obolibrary.org/obo/CLO_0008935 denotes S9
T250 25674-25682 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T251 25961-25968 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T252 26133-26140 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T253 26250-26251 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T254 26300-26308 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T255 26418-26427 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide’s
T256 26491-26492 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T257 26495-26496 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T258 26595-26597 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T259 26700-26705 http://www.ebi.ac.uk/efo/EFO_0000881 denotes digit
T260 27004-27005 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 866-873 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T2 1152-1159 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T3 1247-1255 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T4 1553-1561 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T5 1716-1719 Chemical denotes Lin http://purl.obolibrary.org/obo/CHEBI_32386
T6 1768-1771 Chemical denotes BMC http://purl.obolibrary.org/obo/CHEBI_3392
T7 1970-1978 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T8 4182-4191 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T9 4636-4643 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T10 4702-4709 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T11 5707-5716 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T12 5870-5877 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T13 6080-6089 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T14 6219-6227 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T15 6280-6288 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T16 6338-6345 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T17 6416-6424 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T18 6768-6775 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T19 6935-6943 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T20 7157-7165 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T21 7374-7382 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T22 7587-7595 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T23 7762-7770 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T24 8388-8396 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T25 8417-8422 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T26 8522-8532 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T27 8522-8527 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T28 8528-8532 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T29 8687-8695 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T30 8748-8755 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T31 8891-8898 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T32 8899-8906 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T33 8995-8997 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T34 9032-9040 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T35 9155-9163 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T36 9186-9188 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T37 9197-9207 Chemical denotes Amino acid http://purl.obolibrary.org/obo/CHEBI_33704
T38 9203-9207 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T39 9245-9252 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T40 9300-9308 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T41 9310-9317 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T42 9639-9646 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43 9730-9737 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T44 9947-9957 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T45 9947-9952 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T46 9953-9957 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T47 10046-10054 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T48 10058-10069 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T49 10058-10063 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T50 10064-10069 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T51 10149-10151 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T52 10206-10214 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T53 10272-10279 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T54 10404-10406 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T55 10529-10537 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T56 10640-10648 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T57 10790-10798 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T58 11025-11032 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T59 11397-11399 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T60 11488-11496 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T61 11595-11603 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T62 11615-11617 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T63 11811-11819 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T64 11986-11994 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T65 12413-12420 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T66 12503-12510 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T67 12666-12674 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T68 12772-12779 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T69 12819-12821 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T70 12850-12857 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T71 12918-12925 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T72 12995-13002 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T73 13050-13058 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T74 13065-13067 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T75 13407-13415 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T76 13551-13559 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T77 13626-13637 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T78 13626-13631 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T79 13632-13637 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T80 13677-13688 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T81 13677-13682 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T82 13683-13688 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T83 13749-13757 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T84 13767-13778 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T85 13767-13772 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T86 13773-13778 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T87 13780-13782 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T90 14177-14179 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T91 15177-15184 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T92 16059-16066 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T93 16286-16288 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T94 16303-16305 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T95 16428-16436 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T96 16574-16581 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T97 16675-16682 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T98 16954-16961 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T99 17126-17133 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T100 17326-17334 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T101 17641-17648 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T102 17781-17788 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T103 18145-18152 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T104 18576-18584 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T105 18626-18633 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T106 18783-18790 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T107 18876-18883 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T108 18884-18892 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T109 19046-19053 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T110 19268-19276 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T111 19288-19290 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T112 19882-19889 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T113 20782-20790 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T114 20798-20809 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T115 20854-20860 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T116 20898-20906 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T117 21649-21656 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T118 21671-21678 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T119 21693-21700 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T120 21723-21730 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T121 21798-21803 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T122 21995-22002 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T123 22071-22073 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T124 22202-22209 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T125 22401-22408 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T126 22627-22630 Chemical denotes HMM http://purl.obolibrary.org/obo/CHEBI_24564
T127 22698-22705 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T128 22748-22756 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T129 22786-22794 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T130 22871-22878 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T131 23197-23207 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T132 23197-23202 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T133 23203-23207 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T134 23664-23669 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T135 23845-23853 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T136 23908-23919 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T137 23908-23913 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T138 23914-23919 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T139 24046-24048 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T140 24079-24087 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T141 24162-24172 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T142 24162-24167 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T143 24168-24172 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T144 24297-24299 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T145 24310-24318 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T146 24327-24331 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T147 24530-24537 Chemical denotes Peptide http://purl.obolibrary.org/obo/CHEBI_16670
T148 24602-24609 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 24849-24856 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T150 25084-25086 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T151 25207-25215 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T152 25224-25235 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T153 25224-25229 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T154 25230-25235 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T155 25297-25305 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T156 25570-25572 Chemical denotes S8 http://purl.obolibrary.org/obo/CHEBI_29385
T157 25674-25682 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T158 25786-25788 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T159 25961-25968 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T160 26133-26140 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T161 26300-26308 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T162 26366-26373 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T163 27593-27596 Chemical denotes MIT http://purl.obolibrary.org/obo/CHEBI_27847|http://purl.obolibrary.org/obo/CHEBI_53620
T165 27617-27619 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 0-5 Species denotes Human Tax:9606
8 423-427 Gene denotes fast Gene:10922
9 621-631 Species denotes SARS-CoV-2 Tax:2697049
10 331-339 Disease denotes COVID-19 MESH:C000657245
11 469-477 Disease denotes COVID-19 MESH:C000657245
12 541-554 Disease denotes viral disease MESH:D001102
13 655-663 Disease denotes COVID-19 MESH:C000657245
33 877-895 Gene denotes HLA-A], -B, and -C Gene:3105
34 1508-1513 Gene denotes HLA-B Gene:3106
35 1890-1895 Gene denotes HLA-B Gene:3106
36 1713-1714 Gene denotes M Gene:43740571
37 970-1017 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
38 1019-1029 Species denotes SARS-CoV-2 Tax:2697049
39 1236-1246 Species denotes SARS-CoV-2 Tax:2697049
40 1364-1369 Species denotes human Tax:9606
41 1370-1383 Species denotes coronaviruses Tax:11118
42 1389-1399 Species denotes SARS-CoV-2 Tax:2697049
43 1566-1576 Species denotes SARS-CoV-2 Tax:2697049
44 1959-1969 Species denotes SARS-CoV-2 Tax:2697049
45 2008-2013 Species denotes human Tax:9606
46 2014-2027 Species denotes coronaviruses Tax:11118
47 850-855 Species denotes human Tax:9606
48 1200-1217 Gene denotes HLA-A, -B, and -C Gene:3106
49 1058-1082 Disease denotes coronavirus disease 2019 MESH:C000657245
50 1084-1092 Disease denotes COVID-19 MESH:C000657245
51 1657-1665 Disease denotes COVID-19 MESH:C000657245
58 2527-2531 Gene denotes fast Gene:10922
59 2725-2735 Species denotes SARS-CoV-2 Tax:2697049
60 2435-2443 Disease denotes COVID-19 MESH:C000657245
61 2573-2581 Disease denotes COVID-19 MESH:C000657245
62 2645-2658 Disease denotes viral disease MESH:D001102
63 2759-2767 Disease denotes COVID-19 MESH:C000657245
94 2884-2899 Species denotes betacoronavirus Tax:694002
95 2901-2948 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
96 2953-2963 Species denotes SARS-CoV-2 Tax:2697049
97 3121-3132 Species denotes coronavirus Tax:11118
98 3191-3201 Species denotes SARS-CoV-2 Tax:2697049
99 3271-3277 Species denotes humans Tax:9606
100 3357-3412 Species denotes Middle East respiratory syndrome coronavirus (MERS-CoV) Tax:1335626
101 3417-3462 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
102 3464-3472 Species denotes SARS-CoV Tax:694009
103 4373-4381 Species denotes SARS-CoV Tax:694009
104 4386-4394 Species denotes MERS-CoV Tax:1335626
107 24190-24200 Species denotes SARS-CoV-2 Tax:2697049
111 3248-3267 Disease denotes respiratory disease MESH:D012140
112 3348-3356 Disease denotes zoonotic MESH:D015047
113 3551-3573 Disease denotes coronavirus disease 19 MESH:C000657245
114 3575-3583 Disease denotes COVID-19 MESH:C000657245
115 3607-3613 Disease denotes deaths MESH:D003643
116 3680-3716 Disease denotes cardiovascular and pulmonary disease MESH:D002318
117 3754-3763 Disease denotes mortality MESH:D003643
118 3767-3775 Disease denotes COVID-19 MESH:C000657245
119 3804-3812 Disease denotes infected MESH:D007239
131 4959-4964 Gene denotes HLA-B Gene:3106
132 5173-5178 Gene denotes HLA-A Gene:3105
133 5274-5279 Gene denotes HLA-A Gene:3105
134 5290-5295 Gene denotes HLA-B Gene:3106
135 4889-4897 Species denotes SARS-CoV Tax:694009
136 5108-5138 Species denotes human immunodeficiency virus 1 Tax:11676
137 5140-5145 Species denotes HIV-1 Tax:11676
138 5233-5245 Species denotes dengue virus Tax:12637
139 4620-4625 Species denotes Human Tax:9606
143 5599-5609 Species denotes SARS-CoV-2 Tax:2697049
144 5988-5998 Species denotes SARS-CoV-2 Tax:2697049
145 5431-5439 Disease denotes COVID-19 MESH:C000657245
155 6326-6345 Gene denotes MHC class I antigen Gene:100507703
156 6871-6876 Gene denotes HLA-B Gene:3106
157 7100-7105 Gene denotes HLA-B Gene:3106
158 6180-6190 Species denotes SARS-CoV-2 Tax:2697049
159 6528-6538 Species denotes SARS-CoV-2 Tax:2697049
160 6948-6958 Species denotes SARS-CoV-2 Tax:2697049
161 7015-7023 Species denotes SARS-CoV Tax:694009
162 7148-7156 Species denotes SARS-CoV Tax:694009
163 6757-6767 Species denotes SARS-CoV-2 Tax:2697049
166 7659-7676 Gene denotes HLA-A, -B, and -C Gene:3105
167 7329-7339 Species denotes SARS-CoV-2 Tax:2697049
179 8365-8371 Gene denotes ORF1ab Gene:43740578
180 8069-8074 Species denotes human Tax:9606
181 8075-8088 Species denotes coronaviruses Tax:11118
182 8180-8190 Species denotes SARS-CoV-2 Tax:2697049
183 8215-8226 Species denotes coronavirus Tax:11118
184 8428-8445 Species denotes betacoronaviruses Tax:694002
185 8467-8472 Species denotes human Tax:9606
186 8473-8486 Species denotes coronaviruses Tax:11118
187 8799-8809 Species denotes SARS-CoV-2 Tax:2697049
188 8953-8970 Species denotes human coronavirus Tax:694448
189 9032-9040 Chemical denotes peptides MESH:D010455
199 9408-9416 Gene denotes helicase Gene:164045
200 9282-9299 Species denotes human coronavirus Tax:694448
201 9440-9445 Species denotes human Tax:9606
202 9446-9463 Species denotes betacoronaviruses Tax:694002
203 9465-9475 Species denotes SARS-CoV-2 Tax:2697049
204 9477-9485 Species denotes SARS-CoV Tax:694009
205 9503-9511 Species denotes MERS-CoV Tax:1335626
206 9527-9532 Species denotes human Tax:9606
207 9675-9686 Species denotes coronavirus Tax:11118
220 10260-10279 Gene denotes MHC class I antigen Gene:100507703
221 10363-10380 Gene denotes HLA-A, -B, and -C Gene:3105
222 10561-10566 Gene denotes HLA-A Gene:3105
223 10574-10579 Gene denotes HLA-B Gene:3106
224 10934-10939 Gene denotes HLA-B Gene:3106
225 10591-10596 Gene denotes HLA-C Gene:3107
226 10449-10459 Species denotes SARS-CoV-2 Tax:2697049
227 10779-10789 Species denotes SARS-CoV-2 Tax:2697049
228 10884-10889 Species denotes human Tax:9606
229 10890-10903 Species denotes coronaviruses Tax:11118
230 11195-11205 Species denotes SARS-CoV-2 Tax:2697049
231 11334-11345 Species denotes coronavirus Tax:11118
235 11883-11900 Gene denotes HLA-A, -B, and -C Gene:3105
236 11470-11487 Species denotes human coronavirus Tax:694448
237 11551-11559 Disease denotes COVID-19 MESH:C000657245
243 12563-12568 Gene denotes HLA-A Gene:3105
244 12573-12578 Gene denotes HLA-C Gene:3107
245 12287-12297 Species denotes SARS-CoV-2 Tax:2697049
246 13039-13049 Species denotes SARS-CoV-2 Tax:2697049
247 12655-12665 Species denotes SARS-CoV-2 Tax:2697049
256 13219-13224 Gene denotes HLA-A Gene:3105
257 13226-13231 Gene denotes HLA-B Gene:3106
258 13237-13242 Gene denotes HLA-C Gene:3107
259 13576-13582 Gene denotes ORF1ab Gene:43740578
260 13641-13646 Gene denotes ORF1a Gene:43740578
261 13692-13697 Gene denotes ORF1a Gene:43740578
262 13715-13721 Gene denotes ORF1ab Gene:43740578
263 13158-13168 Species denotes SARS-CoV-2 Tax:2697049
267 14360-14377 Gene denotes HLA-A, -B, and -C Gene:3105
268 13979-13989 Species denotes SARS-CoV-2 Tax:2697049
269 13833-13841 Disease denotes COVID-19 MESH:C000657245
279 14636-14653 Gene denotes HLA-A, -B, and -C Gene:3105
280 14775-14780 Gene denotes HLA-A Gene:3105
281 14788-14793 Gene denotes HLA-B Gene:3106
282 14805-14810 Gene denotes HLA-C Gene:3107
283 15101-15106 Gene denotes HLA-A Gene:3105
284 15114-15119 Gene denotes HLA-B Gene:3106
285 15131-15136 Gene denotes HLA-C Gene:3107
286 14904-14914 Species denotes SARS-CoV-2 Tax:2697049
287 15207-15217 Species denotes SARS-CoV-2 Tax:2697049
298 15540-15547 Gene denotes HLA-A/B Gene:3105
299 15927-15932 Gene denotes HLA-A Gene:3105
300 15940-15945 Gene denotes HLA-B Gene:3106
301 15957-15962 Gene denotes HLA-C Gene:3107
302 15982-15987 Gene denotes HLA-A Gene:3105
303 15995-16000 Gene denotes HLA-B Gene:3106
304 16012-16017 Gene denotes HLA-C Gene:3107
305 15784-15794 Species denotes SARS-CoV-2 Tax:2697049
306 16048-16058 Species denotes SARS-CoV-2 Tax:2697049
307 16446-16456 Species denotes SARS-CoV-2 Tax:2697049
320 16772-16777 Gene denotes HLA-A Gene:3105
321 16785-16790 Gene denotes HLA-B Gene:3106
322 16802-16807 Gene denotes HLA-C Gene:3107
323 17047-17052 Gene denotes HLA-A Gene:3105
324 17060-17065 Gene denotes HLA-B Gene:3106
325 17077-17082 Gene denotes HLA-C Gene:3107
326 16563-16573 Species denotes SARS-CoV-2 Tax:2697049
327 16664-16674 Species denotes SARS-CoV-2 Tax:2697049
328 16875-16885 Species denotes SARS-CoV-2 Tax:2697049
329 16943-16953 Species denotes SARS-CoV-2 Tax:2697049
330 17156-17166 Species denotes SARS-CoV-2 Tax:2697049
331 17315-17325 Species denotes SARS-CoV-2 Tax:2697049
346 17988-17993 Gene denotes HLA-B Gene:3106
347 18921-18924 Gene denotes CD8 Gene:925
348 18964-18967 Gene denotes CD4 Gene:920
349 17731-17742 Species denotes coronavirus Tax:11118
350 18079-18087 Species denotes SARS-CoV Tax:694009
351 18121-18129 Species denotes SARS-CoV Tax:694009
352 18134-18144 Species denotes SARS-CoV-2 Tax:2697049
353 18553-18561 Species denotes SARS-CoV Tax:694009
354 18565-18575 Species denotes SARS-CoV-2 Tax:2697049
355 18765-18782 Species denotes human coronavirus Tax:694448
356 18832-18846 Species denotes vaccinia virus Tax:10245
357 17769-17788 Gene denotes MHC class I antigen Gene:100507703
358 17917-17937 Disease denotes SARS-CoV-2 infection MESH:C000657245
359 18043-18052 Disease denotes infection MESH:D007239
371 20798-20829 Gene denotes angiotensin converting enzyme 2 Gene:59272
372 20831-20835 Gene denotes ACE2 Gene:59272
373 20840-20871 Gene denotes transmembrane serine protease 2 Gene:7113
374 20873-20880 Gene denotes TMPRSS2 Gene:7113
375 19259-19267 Species denotes SARS-CoV Tax:694009
376 20515-20525 Species denotes SARS-CoV-2 Tax:2697049
377 20689-20693 Species denotes ncov Tax:2697049
378 20911-20921 Species denotes SARS-CoV-2 Tax:2697049
379 19489-19497 Disease denotes COVID-19 MESH:C000657245
380 20168-20177 Disease denotes infection MESH:D007239
381 20270-20279 Disease denotes infection MESH:D007239
383 21234-21242 Disease denotes COVID-19 MESH:C000657245
395 21630-21636 Gene denotes ORF1ab Gene:43740578
396 22225-22231 Gene denotes ORF1ab Gene:43740578
397 22732-22737 Gene denotes ORF1a Gene:43740578
398 22742-22747 Gene denotes ORF1b Gene:43740578
399 21808-21825 Species denotes betacoronaviruses Tax:694002
400 21891-21896 Species denotes human Tax:9606
401 21897-21910 Species denotes coronaviruses Tax:11118
402 21918-21926 Species denotes SARS-CoV Tax:694009
403 21928-21938 Species denotes SARS-CoV-2 Tax:2697049
404 21940-21948 Species denotes MERS-CoV Tax:1335626
405 22257-22268 Species denotes coronavirus Tax:11118
418 23569-23574 Species denotes human Tax:9606
419 23585-23596 Species denotes coronavirus Tax:11118
420 23620-23635 Species denotes betacoronavirus Tax:694002
421 23675-23690 Species denotes betacoronavirus Tax:694002
422 23728-23738 Species denotes SARS-CoV-2 Tax:2697049
423 23827-23844 Species denotes human coronavirus Tax:694448
424 23949-23959 Species denotes SARS-CoV-2 Tax:2697049
425 23983-24000 Species denotes human coronavirus Tax:694448
427 24235-24240 Species denotes human Tax:9606
428 24241-24254 Species denotes coronaviruses Tax:11118
429 24320-24325 Species denotes human Tax:9606
436 26354-26373 Gene denotes MHC class I antigen Gene:100507703
437 24636-24646 Species denotes SARS-CoV-2 Tax:2697049
438 24651-24659 Species denotes SARS-CoV Tax:694009
439 25722-25730 Species denotes SARS-CoV Tax:694009
440 26025-26033 Species denotes SARS-CoV Tax:694009
441 26047-26057 Species denotes SARS-CoV-2 Tax:2697049
444 26487-26504 Gene denotes HLA-A, -B, and -C Gene:3106
445 26685-26696 Species denotes major/minor Tax:1925466

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 207-223 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T2 796-828 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T3 830-833 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T4 1160-1163 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T5 2311-2327 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T6 4702-4722 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T7 5575-5590 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T8 5707-5725 http://purl.obolibrary.org/obo/GO_0051607 denotes antiviral response
T9 5878-5910 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T10 5912-5915 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T11 6080-6098 http://purl.obolibrary.org/obo/GO_0051607 denotes antiviral response
T12 6326-6329 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T13 6338-6356 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen processing
T14 6768-6788 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T15 10260-10263 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T16 10272-10290 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen processing
T17 11233-11236 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T18 12347-12350 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T19 12413-12433 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T20 12944-12960 http://purl.obolibrary.org/obo/GO_0019058 denotes viral life cycle
T21 14028-14043 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T22 17637-17640 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T23 17769-17772 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T24 17781-17801 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T25 18656-18673 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T26 18656-18673 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T27 18805-18820 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T28 19633-19636 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T29 19890-19893 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T30 20195-20208 http://purl.obolibrary.org/obo/GO_0002870 denotes T-cell anergy
T31 20617-20626 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T32 20617-20626 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T33 24538-24541 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T34 24837-24840 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T35 24902-24905 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T36 25366-25369 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T37 26354-26357 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T38 26366-26384 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen processing

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 6336-6345 GlycoEpitope denotes I antigen http://www.glycoepitope.jp/epitopes/EP0138
T2 10270-10279 GlycoEpitope denotes I antigen http://www.glycoepitope.jp/epitopes/EP0138
T3 17779-17788 GlycoEpitope denotes I antigen http://www.glycoepitope.jp/epitopes/EP0138
T4 26364-26373 GlycoEpitope denotes I antigen http://www.glycoepitope.jp/epitopes/EP0138

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 5114-5130 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T2 18036-18052 Phenotype denotes severe infection http://purl.obolibrary.org/obo/HP_0032169

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-94 Sentence denotes Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2
T2 95-132 Sentence denotes HLA Susceptibility Map for SARS-CoV-2
T3 133-146 Sentence denotes Nguyen et al.
T4 148-255 Sentence denotes Individual genetic variation may help to explain different immune responses to a virus across a population.
T5 256-404 Sentence denotes In particular, understanding how variation in HLA may affect the course of COVID-19 could help identify individuals at higher risk from the disease.
T6 405-444 Sentence denotes HLA typing can be fast and inexpensive.
T7 445-573 Sentence denotes Pairing HLA typing with COVID-19 testing where feasible could improve assessment of severity of viral disease in the population.
T8 574-739 Sentence denotes Following the development of a vaccine against SARS-CoV-2, the virus that causes COVID-19, individuals with high-risk HLA types could be prioritized for vaccination.
T9 741-749 Sentence denotes Abstract
T10 750-758 Sentence denotes ABSTRACT
T11 759-1094 Sentence denotes Genetic variability across the three major histocompatibility complex (MHC) class I genes (human leukocyte antigen A [HLA-A], -B, and -C genes) may affect susceptibility to and severity of the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19).
T12 1095-1256 Sentence denotes We performed a comprehensive in silico analysis of viral peptide-MHC class I binding affinity across 145 HLA-A, -B, and -C genotypes for all SARS-CoV-2 peptides.
T13 1257-1384 Sentence denotes We further explored the potential for cross-protective immunity conferred by prior exposure to four common human coronaviruses.
T14 1385-1484 Sentence denotes The SARS-CoV-2 proteome was successfully sampled and was represented by a diversity of HLA alleles.
T15 1485-1715 Sentence denotes However, we found that HLA-B*46:01 had the fewest predicted binding peptides for SARS-CoV-2, suggesting that individuals with this allele may be particularly vulnerable to COVID-19, as they were previously shown to be for SARS (M.
T16 1716-1726 Sentence denotes Lin, H.-T.
T17 1727-1736 Sentence denotes Tseng, J.
T18 1737-1739 Sentence denotes A.
T19 1740-1754 Sentence denotes Trejaut, H.-L.
T20 1755-1863 Sentence denotes Lee, et al., BMC Med Genet 4:9, 2003, https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-4-9).
T21 1864-2100 Sentence denotes Conversely, we found that HLA-B*15:03 showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting that it could enable cross-protective T-cell-based immunity.
T22 2101-2240 Sentence denotes Finally, we reported global distributions of HLA types with potential epidemiological ramifications in the setting of the current pandemic.
T23 2241-2359 Sentence denotes IMPORTANCE Individual genetic variation may help to explain different immune responses to a virus across a population.
T24 2360-2508 Sentence denotes In particular, understanding how variation in HLA may affect the course of COVID-19 could help identify individuals at higher risk from the disease.
T25 2509-2548 Sentence denotes HLA typing can be fast and inexpensive.
T26 2549-2677 Sentence denotes Pairing HLA typing with COVID-19 testing where feasible could improve assessment of severity of viral disease in the population.
T27 2678-2843 Sentence denotes Following the development of a vaccine against SARS-CoV-2, the virus that causes COVID-19, individuals with high-risk HLA types could be prioritized for vaccination.
T28 2845-2857 Sentence denotes INTRODUCTION
T29 2858-3107 Sentence denotes Recently, a new strain of betacoronavirus (severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2) emerged as a global pathogen, prompting the World Health Organization in January 2020 to declare an international public health emergency (1).
T30 3108-3474 Sentence denotes In the large coronavirus family, comprising enveloped positive-strand RNA viruses, SARS-CoV-2 is the seventh encountered strain that causes respiratory disease in humans (2) ranging from mild—the common cold—to severe—disease caused by the zoonotic Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV).
T31 3475-3635 Sentence denotes As of April 2020, there are over one million presumed or confirmed cases of coronavirus disease 19 (COVID-19) worldwide, with total deaths exceeding 50,000 (3).
T32 3636-3849 Sentence denotes While age and many comorbidities, including cardiovascular and pulmonary disease, appear to increase the severity and mortality of COVID-19 (4–9), approximately 80% of infected individuals have mild symptoms (10).
T33 3850-4208 Sentence denotes As with SARS-CoV (11, 12) and MERS-CoV (13, 14), children seem to have low susceptibility to the disease (15–17); despite infection rates similar to those seen with adults (18), only 5.9% of pediatric cases are severe or critical, possibly due to lower binding ability of the ACE2 receptor in children or generally higher levels of antiviral antibodies (19).
T34 4209-4619 Sentence denotes Other similarities (20–22), including genomic (23, 24) and immune system response (25–33) similarities, between SARS-CoV-2 and other coronaviruses (34), especially SARS-CoV and MERS-CoV, are topics of ongoing active research, results of which may inform an understanding of the severity of infection (35) and improve the ongoing work of immune landscape profiling (36–40) and vaccine discovery (28, 37, 41–48).
T35 4620-4836 Sentence denotes Human leukocyte antigen (HLA) alleles, which are critical components of the viral antigen presentation pathway, have been shown in previous studies to confer differential viral susceptibility and severity of disease.
T36 4837-4985 Sentence denotes For instance, disease caused by the closely related SARS-CoV (23, 24) shows increased severity among individuals with the HLA-B*46:01 genotype (49).
T37 4986-5091 Sentence denotes Associations between HLA genotype and disease severity extend broadly to several other unrelated viruses.
T38 5092-5381 Sentence denotes For example, in human immunodeficiency virus 1 (HIV-1), certain HLA types (e.g., HLA-A*02:05) may reduce risk of seroconversion (50), and in dengue virus, certain HLA alleles (e.g., HLA-A*02:07 and HLA-B*51) are associated with increased secondary disease severity among ethnic Thais (51).
T39 5382-5615 Sentence denotes While the details of the clinical picture of the COVID-19 pandemic continue to emerge, there remain substantial unanswered questions regarding the role of individual genetic variability in the immune response against SARS-CoV-2 (51).
T40 5616-5797 Sentence denotes We hypothesize that individual HLA genotypes may differentially induce the T-cell mediated antiviral response and could potentially alter the course of disease and its transmission.
T41 5798-6008 Sentence denotes In this study, we performed a comprehensive in silico analysis of viral peptide-major histocompatibility complex (MHC) class I binding affinity across 145 different HLA types for the entire SARS-CoV-2 proteome.
T42 6010-6017 Sentence denotes RESULTS
T43 6018-6229 Sentence denotes To explore the potential for a given HLA allele to produce an antiviral response, we assessed the HLA binding affinity of all possible 8-mers to 12-mers from the SARS-CoV-2 proteome (n = 48,395 unique peptides).
T44 6230-6390 Sentence denotes We then removed from further consideration 16,138 peptides that were not predicted to enter the MHC class I antigen processing pathway via proteasomal cleavage.
T45 6391-6704 Sentence denotes For the remaining 32,257 peptides, we repeated binding affinity predictions for a total of 145 different HLA types, and we show here the SARS-CoV-2-specific distribution of per-allele proteome presentation (predicted binding affinity threshold of <500 nM) (Fig. 1; see also Table S1 in the supplemental material).
T46 6705-6858 Sentence denotes Importantly, we note that the putative capacity for SARS-CoV-2 antigen presentation is unrelated to the HLA allelic frequency in the population (Fig. 1).
T47 6859-6959 Sentence denotes We identify HLA-B*46:01 as the HLA allele with the fewest predicted binding peptides for SARS-CoV-2.
T48 6960-7255 Sentence denotes We performed the same analyses for the closely related SARS-CoV proteome (see Fig. S1 in the supplemental material) and similarly note that HLA-B*46:01 was predicted to present the fewest SARS-CoV peptides, in keeping with previous clinical data associating this allele with severe disease (49).
T49 7256-7349 Sentence denotes FIG 1 Distribution of HLA allelic presentation of 8- to 12-mers from the SARS-CoV-2 proteome.
T50 7350-7699 Sentence denotes At right, the number of peptides (see Table S1) that putatively bind to each of 145 HLA alleles is shown as a series of horizontal bars, with dark and light shading indicating the number of tightly (<50 nM) and loosely (<500 nM) binding peptides, respectively, and with green, orange, and purple representing HLA-A, -B, and -C alleles, respectively.
T51 7700-7796 Sentence denotes Alleles are sorted in descending order based on the number of peptides that they bind (<500 nM).
T52 7797-8282 Sentence denotes The corresponding estimated allelic frequency in the global population is also shown (left), with the length of each horizontal bar indicating absolute frequency in the population.To assess the potential for cross-protective immunity conferred by prior exposure to common human coronaviruses (i.e., HKU1, OC43, NL63, and 229E), we next sought to characterize the conservation of the SARS-CoV-2 proteome across diverse coronavirus subgenera to identify highly conserved linear epitopes.
T53 8283-8596 Sentence denotes After aligning reference proteome sequence data for 5 essential viral components (ORF1ab, S, E, M, and N proteins) across 34 distinct alpha- and betacoronaviruses, including all known human coronaviruses, we identified 48 highly conserved amino acid sequence spans (see Data File S1 in the supplemental material).
T54 8597-8764 Sentence denotes Acknowledging the challenges to inferring cross-protective immunity among closely related peptides, we confined our attention exclusively to identical peptide matches.
T55 8765-8999 Sentence denotes Among the conserved sequences, 44 SARS-CoV-2 sequences would each be anticipated to generate at least one 8- to 12-mer linear peptide epitope also present within at least one other common human coronavirus (Fig. 2; see also Table S2).
T56 9000-9190 Sentence denotes In total, 564 such 8- to 12-mer peptides were found to share 100% identity with corresponding OC43, HKU1, NL63, and 229E sequences (467, 460, 179, and 157 peptides, respectively) (Table S3).
T57 9191-9309 Sentence denotes FIG 2 Amino acid sequence conservation of four linear peptide example sequences from three human coronavirus proteins.
T58 9310-9568 Sentence denotes Protein sequence alignments are shown for nucleocapsid (N), membrane (M), and ORF1ab polyprotein (helicase) across all five known human betacoronaviruses (SARS-CoV-2, SARS-CoV, HKU1, OC43, and MERS-CoV) and two known human alphacoronaviruses (229E and NL63).
T59 9569-9827 Sentence denotes Each row in the three depicted sequence alignments corresponds to the protein sequence from the indicated coronavirus, with the starting coordinate of the viral protein sequence shown at left and position coordinates of the overall alignment displayed above.
T60 9828-9979 Sentence denotes Blue shading indicates the extent of sequence identity, with the darkest blue shading indicating a 100% match for that amino acid across all sequences.
T61 9980-10408 Sentence denotes The four red-highlighted sequences correspond to highly conserved peptides ≥8 amino acids in length (PRWYFYYLGTGP, WSFNPETN, QPPGTGKSH, and VYTACSHAAVDALCEKA, see Table S2).For the subset of these potentially cross-protective peptides that are anticipated to be generated via the MHC class I antigen processing pathway, we performed binding affinity predictions across 145 different HLA-A, -B, and -C alleles (see Data File S3).
T62 10409-10538 Sentence denotes As described above, we demonstrated the SARS-CoV-2-specific distribution of per-allele presentation for these conserved peptides.
T63 10539-10649 Sentence denotes We found that alleles HLA-A*02:02, HLA-B*15:03, and HLA-C*12:03 were the top presenters of conserved peptides.
T64 10650-10904 Sentence denotes Conversely, we note that 56 different HLA alleles demonstrated no appreciable binding affinity (<500 nM) to any of the conserved SARS-CoV-2 peptides, suggesting a concomitant lack of potential for cross-protective immunity from other human coronaviruses.
T65 10905-10970 Sentence denotes We note, in particular, that HLA-B*46:01 was among these alleles.
T66 10971-11115 Sentence denotes We note also that the putative capacity for conserved peptide presentation is unrelated to the HLA allelic frequency in the population (Fig. 3).
T67 11116-11401 Sentence denotes Moreover, we see no appreciable global correlation between conservation of the SARS-CoV-2 proteome and its predicted MHC binding affinity, suggesting a lack of selective pressure for or against the capacity to present coronavirus epitopes (P = 0.27 [Fisher’s exact test]; see Fig. S2).
T68 11402-11560 Sentence denotes FIG 3 Distribution of HLA allelic presentations of highly conserved human coronavirus peptides with potential to elicit cross-protective immunity to COVID-19.
T69 11561-11923 Sentence denotes At right, the number of conserved peptides (see Table S3) that putatively bind to a subset of 89 HLA alleles is shown as a series of horizontal bars, with dark and light shading indicating the number of tightly (<50 nM) and loosely (<500 nM) binding peptides, respectively, and with green, orange, and purple representing HLA-A, -B, and -C alleles, respectively.
T70 11924-12055 Sentence denotes Alleles are sorted in descending order based on the number of peptides they are anticipated to present (binding affinity, <500 nM).
T71 12056-12367 Sentence denotes The corresponding allelic frequency in the global population is also shown (left), with the length of each horizontal bar indicating absolute frequency in the population.We were further interested in whether certain regions of the SARS-CoV-2 proteome showed differential presentation by the MHC class I pathway.
T72 12368-12530 Sentence denotes Accordingly, we surveyed the distribution of antigen presentation capacity across the entire proteome, highlighting its most conserved peptide sequences (Fig. 4).
T73 12531-12689 Sentence denotes Throughout the entire proteome, HLA-A and HLA-C alleles exhibited the relatively largest and smallest capacities to present SARS-CoV-2 antigens, respectively.
T74 12690-12823 Sentence denotes However, each of the three major class I genes exhibited very similar patterns of peptide presentation across the proteome (Fig. S3).
T75 12824-13069 Sentence denotes We additionally note that peptide presentation appears to be independent of estimated time of peptide production during viral life cycle, with indistinguishable levels of peptide presentation of both early and late SARS-CoV-2 peptides (Fig. S4).
T76 13070-13430 Sentence denotes FIG 4 Distribution of allelic presentation of conserved 8- to 12-mers across the entire SARS-CoV-2 proteome for all HLA alleles and individually for HLA-A, HLA-B, and HLA-C (first, second, third, and fourth plots from top, respectively) with dark and light shading indicating the number of tightly (<50 nM) and loosely (<500 nM) binding peptides, respectively.
T77 13431-13534 Sentence denotes Positions are derived from a concatenation of coding sequences (CDSs) as indicated in the bottom panel.
T78 13535-13583 Sentence denotes Tightly binding peptides are confined to ORF1ab.
T79 13584-14044 Sentence denotes The sequence begins with only the last 12 amino acids of ORF1a because all but the last four amino acids of ORF1a are contained in ORF1ab, and we considered binding peptides up to 12 amino acids (AA) in length.Given the global nature of the current COVID-19 pandemic, we sought to describe population-level distributions of the HLA alleles most (and least) capable of generating a repertoire of SARS-CoV-2 epitopes in support of a T-cell-based immune response.
T80 14045-14395 Sentence denotes While we present global maps of individual HLA allele frequencies for the full set of 145 different alleles studied here (Data File S2), we specifically highlight the global distributions of the three best-presenting (A*02:02, B*15:03, and C*12:03) and three of the worst-presenting (A*25:01, B*46:01, and C*01:02) HLA-A, -B, and -C alleles (Fig. 5).
T81 14396-14570 Sentence denotes Note that all allelic frequencies are aggregated by country but that they implicitly reflect the distribution of HLA data available on the Allele Frequency Net Database (52).
T82 14571-14662 Sentence denotes FIG 5 Global HLA allele frequency distribution heat maps for six HLA-A, -B, and -C alleles.
T83 14663-14987 Sentence denotes The leftmost panels show the global allele frequency distributions by country for three representative alleles (HLA-A*02:02, HLA-B*15:03, and HLA-C*12:03) with the predicted capacities to present the greatest repertoire of epitopes from the SARS-CoV-2 proteome (21.1%, 19.1%, and 7.9% of presentable epitopes, respectively).
T84 14988-15284 Sentence denotes The rightmost panels show the global allele frequency distributions by country for three representative alleles (HLA-A*25:01, HLA-B*46:01, and HLA-C*01:02) with the lowest predicted levels epitope presentation from the SARS-CoV-2 proteome (0.2%, 0%, and 0% of presentable epitopes, respectively).
T85 15285-15721 Sentence denotes Heat map coloring corresponds to the individual HLA allele frequency within each country, ranging from lowest (white/yellow) to highest (red) frequency as indicated in the legend below each map.Finally, we acknowledge that nearly all individuals have two HLA-A/B/C haplotypes constituting as few as three but as many as six distinct alleles, potentially buffering against the lack of presentation from a single poorly presenting allele.
T86 15722-15877 Sentence denotes We sought to determine whether allele-specific variability in SARS-CoV-2 presentation extends to full HLA haplotypes and to whole individual HLA genotypes.
T87 15878-16223 Sentence denotes For six representative alleles with the highest (HLA-A*02:02, HLA-B*15:03, and HLA-C*12:03) and lowest (HLA-A*25:01, HLA-B*46:01, and HLA-C*01:02) predicted capacity for SARS-CoV-2 epitope presentation, these differences remain significant at the haplotype level, albeit with wide variability in presentation among different haplotypes (Fig. 6).
T88 16224-16306 Sentence denotes Haplotype-level data for all 145 alleles are included in Fig. S5 and Data File S2.
T89 16307-16539 Sentence denotes We then identified 3,382 individuals with full HLA genotype data and noted wide variability in their capacity to present peptides from the SARS-CoV-2 proteome, albeit with a small minority of individuals at either extreme (Fig. S6).
T90 16540-16617 Sentence denotes FIG 6 Distributions of SARS-CoV-2 peptide presentation across HLA haplotypes.
T91 16618-16895 Sentence denotes The leftmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative HLA alleles (HLA-A*02:02, HLA-B*15:03, and HLA-C*12:03) with the greatest predicted repertoire of epitopes from the SARS-CoV-2 proteome.
T92 16896-17176 Sentence denotes The rightmost panels show the distributions of SARS-CoV-2 peptide presentation capacity for haplotypes containing one of three representative alleles (HLA-A*25:01, HLA-B*46:01, and HLA-C*01:02) with the lowest predicted levels of epitope presentation from the SARS-CoV-2 proteome.
T93 17177-17249 Sentence denotes Black and gray bars represent full and partial haplotypes, respectively.
T94 17250-17477 Sentence denotes Blue and red dashed lines represent the percentages of presented SARS-CoV-2 peptides for the indicated allele itself (blue) and its global population frequency weighted average presentation across its observed haplotypes (red).
T95 17479-17489 Sentence denotes DISCUSSION
T96 17490-17677 Sentence denotes To the best of our knowledge, this was the first study to evaluate per-allele viral proteome presentation across a wide range of HLA alleles using MHC-peptide binding affinity predictors.
T97 17678-17802 Sentence denotes This report also introduces the relationship between coronavirus sequence conservation and MHC class I antigen presentation.
T98 17803-18093 Sentence denotes We show that individual HLA, haplotype, and full-genotype variability likely influence the capacity to respond to SARS-CoV-2 infection, and we note certain alleles in particular (e.g., HLA-B*46:01) that could be associated with more-severe infection, as previously shown with SARS-CoV (49).
T99 18094-18241 Sentence denotes Indeed, we further compare SARS-CoV and SARS-CoV-2 peptide presentation data and note a high degree of similarity between the two across HLA types.
T100 18242-18420 Sentence denotes Finally, this is the first report to present global distributions of HLA types and haplotypes with potential epidemiological ramifications in the setting of the current pandemic.
T101 18421-18680 Sentence denotes We found that, in general, there is no correlation between the HLA allelic frequency in the population and allelic capacity to bind SARS-CoV or SARS-CoV-2 peptides, irrespective of the estimated timing of peptide production during the viral replication cycle.
T102 18681-19083 Sentence denotes While we are not aware of any studies explicitly reporting the relationship between human coronavirus epitope abundance and immune response, there are vaccinia virus data that suggest that early peptide antigens are more likely to generate CD8+ T-cell responses whereas antibody and CD4+ T-cell responses are more likely to target later mRNA expression with higher peptide abundance in the virion (53).
T103 19084-19134 Sentence denotes We note, however, several limitations to our work.
T104 19135-19388 Sentence denotes First and foremost, while we note that a few of our binding affinity predictions were borne out in experimentally validated SARS-CoV peptides (see Table S4 in the supplemental material), we acknowledge that ours was a study performed entirely in silico.
T105 19389-19696 Sentence denotes As we are unable to obtain individual-level HLA typing and clinical outcome data for any real-world COVID-19 populations at this time, the data presented are theoretical in nature and are subject to many of the same limitations implicit in the MHC binding affinity prediction tool(s) upon which it is based.
T106 19697-19860 Sentence denotes As such, we are unable to assess the relative importance of HLA type compared to known disease-modifying risk factors such as age and clinical comorbidities (4–9).
T107 19861-20035 Sentence denotes We further note that peptide-MHC binding affinity is limited in its utility as a predictor of subsequent T-cell responses (54–56), and we did not study T-cell responses here.
T108 20036-20280 Sentence denotes As such, we are ill-equipped to explore phenomena such as original antigenic sin (57–59), where prior exposure to a closely related infection(s) might trigger T-cell anergy (60–62) or immunopathogenesis (63) in the setting of a novel infection.
T109 20281-20434 Sentence denotes We explored only a limited set of 145 well-studied HLA alleles but note that this analysis could be performed across a wider diversity of genotypes (48).
T110 20435-20695 Sentence denotes Additionally, we did not assess genotypic heterogeneity or in vivo evolution of SARS-CoV-2, which could modify the repertoire of viral epitopes presented or could otherwise modulate virulence in an HLA-independent manner (64, 65) (https://nextstrain.org/ncov).
T111 20696-20991 Sentence denotes We also did not address the potential for individual-level genetic variation in other proteins (e.g., angiotensin converting enzyme 2 [ACE2] or transmembrane serine protease 2 [TMPRSS2], essential host proteins for SARS-CoV-2 priming and cell entry [66]) to modulate the host-pathogen interface.
T112 20992-21118 Sentence denotes Unless and until the findings we present here are clinically validated, they should not be employed for any clinical purposes.
T113 21119-21447 Sentence denotes However, we do at this juncture recommend integrating HLA testing into clinical trials and pairing HLA typing with COVID-19 testing where feasible to more rapidly develop and deploy a predictor(s) of viral severity in the population and, potentially, to tailor future vaccination strategies to genotypically at-risk populations.
T114 21448-21548 Sentence denotes This approach may have additional implications for the management of a broad array of other viruses.
T115 21550-21571 Sentence denotes MATERIALS AND METHODS
T116 21573-21607 Sentence denotes Sequence retrieval and alignments.
T117 21608-21978 Sentence denotes Full polyprotein 1ab (ORF1ab), spike (S) protein, membrane (M) protein, envelope (E) protein, and nucleocapsid (N) protein sequences were obtained for each of 34 distinct but representative alpha and betacoronaviruses from broad genus and subgenus distributions, including all known human coronaviruses (i.e., SARS-CoV, SARS-CoV-2, MERS-CoV, HKU1, OC43, NL63, and 229E).
T118 21979-22185 Sentence denotes FASTA-formatted protein sequence data (the full accession number list is available in Table S5 in the supplemental material) were retrieved from the National Center of Biotechnology Information (NCBI) (67).
T119 22186-22652 Sentence denotes For each of the protein classes (i.e., ORF1ab, S, M, E, and N), all 34 coronavirus sequences were aligned using the Clustal Omega v1.2.4 multisequence aligner tool employing the following parameters: sequence type [Protein], output alignment format [clustal_num], dealign [false], mBed-like clustering guide-tree [true], mBed-like clustering iteration [true], number of combined iterations 0, maximum guide tree iterations [-1], and maximum HMM iterations [-1] (68).
T120 22653-22859 Sentence denotes For the purposes of estimating time of viral peptide production, we classified ORF1a and ORF1b peptides as “early” whereas all other peptides produced by subgenomic mRNAs were classified as “late” (69, 70).
T121 22861-22890 Sentence denotes Conserved peptide assessment.
T122 22891-22938 Sentence denotes Aligned sequences were imported into Jalview v.
T123 22939-23474 Sentence denotes 2.1.1 (71) with automated generation of the following alignment annotations: (i) sequence consensus, calculated as the percentage of the modal residue per column; (ii) sequence conservation (0 to 11), measured as a numerical index reflecting conservation of amino acid physicochemical properties in the alignment; (iii) alignment quality (0 to 1), measured as a normalized sum of BLOSUM62 ratios for all residues at each position; and (iv) occupancy, calculated as the number of aligned residues (not including gaps) for each position.
T124 23475-23719 Sentence denotes In all cases, sequence conservation was assessed for each of the following three groups: only human-infecting coronavirus sequences (n = 7), all betacoronavirus sequences (n = 16), and all alpha- and betacoronavirus sequences combined (n = 34).
T125 23720-23816 Sentence denotes Aligned SARS-CoV-2 sequences and all annotations were manually exported for subsequent analysis.
T126 23817-24050 Sentence denotes Conserved human coronavirus peptides were defined as those with a length of ≥8 consecutive amino acids, each showing agreement with SARS-CoV-2 sequences and ≥4 other human coronavirus sequences with the consensus sequence (Table S2).
T127 24051-24301 Sentence denotes For each of these conserved peptides, we also assessed the component number of 8- to 12-mers sharing identical amino acid sequence between SARS-CoV-2 and each of the four other common human coronaviruses (i.e., OC43, HKU1, NL63, and 229E) (Table S3).
T128 24302-24528 Sentence denotes For all peptides, human, beta, and combined conservation scores were obtained using a custom R v.3.6.2 script representing mean sequence conservation (minus gap penalties where relevant) (see https://github.com/pdxgx/covid19).
T129 24530-24579 Sentence denotes Peptide-MHC class I binding affinity predictions.
T130 24580-24771 Sentence denotes FASTA-formatted input protein sequences from the entire SARS-CoV-2 and SARS-CoV proteomes were obtained from the NCBI RefSeq database (67) under accession numbers NC_045512.2 and NC_004718.3.
T131 24772-24901 Sentence denotes We kmerized each of these sequences into 8- to 12-mers to assess MHC class I-peptide binding affinity across the entire proteome.
T132 24902-25257 Sentence denotes MHC class I binding affinity predictions were performed using 145 different HLA alleles for which global allele frequency data were available as described previously (72) (see Table S5) with netMHCpan v4.0 (73) using the ‘-BA’ option to include binding affinity predictions and the ‘-l’ option to specify peptides 8 to 12 amino acids in length (Table S1).
T133 25258-25354 Sentence denotes Binding affinity was not predicted for peptides containing the character ‘|’ in their sequences.
T134 25355-25630 Sentence denotes Additional MHC class I binding affinity predictions were performed on all 66 MHCflurry-supported alleles (–list-supported-alleles; Table S6) using both MHCnuggets 2.3.2 (74) and MHCflurry 1.4.3 (75) (see Tables S7, S8, and S9 and Fig. S7 to S10 in the supplemental material).
T135 25631-25795 Sentence denotes We further cross-referenced these lists of peptides with existing experimentally validated SARS-CoV epitopes present in the Immune Epitope Database (Table S4) (76).
T136 25796-26016 Sentence denotes We then performed consensus binding affinity predictions for the 66 supported alleles shared by all three tools by taking the union set of alleles and filtering for peptide-allele pairs matching the union set of alleles.
T137 26017-26185 Sentence denotes For the SARS-CoV-specific and SARS-CoV-2-specific distributions of per-allele proteome presentation, we exclude all peptide-allele pairs with >500 nM predicted binding.
T138 26186-26440 Sentence denotes In all cases, we used the netchop v3.0 (77) “C-term” model with a cleavage threshold of 0.1 to further remove any peptides that were not predicted to undergo canonical MHC class I antigen processing via proteasomal cleavage (of the peptide’s C terminus).
T139 26442-26486 Sentence denotes Global HLA allele and haplotype frequencies.
T140 26487-26795 Sentence denotes HLA-A, -B, and -C allele and haplotype frequency data were obtained from the Allele Frequency Net Database (52) for 805 distinct populations pertaining to 101 different countries and 2,628 distinct major/minor (4-digit) alleles, corresponding to 20,478 distinct haplotypes (https://github.com/pdxgx/covid19).
T141 26796-26926 Sentence denotes We also identified full HLA genotype data for 3,382 individuals whose HLA types were confined to the 145 HLA alleles studied here.
T142 26927-27199 Sentence denotes Population allele and haplotype frequency data were aggregated by country as a mean of all constituent population allele or haplotype frequencies weighted by sample size of the population but not accounting for the representative ethnic demographic size of the population.
T143 27200-27462 Sentence denotes Global allele frequency maps were generated using the rworldmap v1.3-6 package (78), with total global allele and haplotype frequency estimates calculated as the mean of per-country allele and haplotype frequencies, weighted by each country’s population in 2005.
T144 27464-27482 Sentence denotes Data availability.
T145 27483-27606 Sentence denotes Source code is available at https://github.com/pdxgx/covid19 under the Massachusetts Institute of Technology (MIT) license.
T146 27607-27712 Sentence denotes Data File S4 can be found at https://github.com/pdxgx/covid19/blob/master/supporting_data/Appendix_4.zip.
T147 27714-27736 Sentence denotes Supplementary Material
T148 27737-27756 Sentence denotes Supplemental file 1
T149 27757-27776 Sentence denotes Supplemental file 2
T150 27777-27796 Sentence denotes Supplemental file 3
T151 27797-27816 Sentence denotes Supplemental file 4
T152 27818-27865 Sentence denotes Supplemental material is available online only.
T153 27867-27882 Sentence denotes ACKNOWLEDGMENTS
T154 27883-27973 Sentence denotes We thank Christopher Loo and Jeffrey Barnet for their critical readings of the manuscript.
T155 27974-28043 Sentence denotes We thank Jonah Sacha and Paul Spellman for their helpful discussions.
T156 28044-28107 Sentence denotes The contents do not necessarily represent the views of the U.S.
T157 28108-28171 Sentence denotes Department of Veterans Affairs or the United States Government.
T158 28172-28204 Sentence denotes R.F.T. was supported by the U.S.
T159 28205-28317 Sentence denotes Department of Veterans Affairs under award number 1IK2CX002049-01 and by the Sunlin & Priscilla Chou Foundation.

2_test

Id Subject Object Predicate Lexical cue
32303592-31978945-65501616 3279-3280 31978945 denotes 2
32303592-32064853-65501617 3845-3847 32064853 denotes 10
32303592-15030689-65501618 3868-3870 15030689 denotes 11
32303592-15577575-65501619 3872-3874 15577575 denotes 12
32303592-25828287-65501620 3890-3892 25828287 denotes 13
32303592-27872828-65501621 3894-3896 27872828 denotes 14
32303592-32139299-65501622 3956-3958 32139299 denotes 15
32303592-32143502-65501623 4229-4231 32143502 denotes 20
32303592-32027036-65501624 4256-4258 32027036 denotes 23
32303592-32007145-65501625 4260-4262 32007145 denotes 24
32303592-32105090-65501626 4292-4294 32105090 denotes 25
32303592-32092539-65501627 4510-4512 32092539 denotes 35
32303592-32106567-65501628 4604-4606 32106567 denotes 28
32303592-32027036-65501629 4899-4901 32027036 denotes 23
32303592-32007145-65501630 4903-4905 32007145 denotes 24
32303592-12969506-65501631 4981-4983 12969506 denotes 49
32303592-10823757-65501632 5221-5223 10823757 denotes 50
32303592-12472660-65501633 5377-5379 12472660 denotes 51
32303592-12472660-65501634 5611-5613 12472660 denotes 51
32303592-12969506-65501635 7251-7253 12969506 denotes 49
32303592-25414323-65501636 14566-14568 25414323 denotes 52
32303592-12969506-65501637 18089-18091 12969506 denotes 49
32303592-20006135-65501638 19079-19081 20006135 denotes 53
32303592-30053426-65501639 19984-19986 30053426 denotes 54
32303592-30886616-65501639 19984-19986 30886616 denotes 54
32303592-19182777-65501640 19987-19989 19182777 denotes 56
32303592-28479213-65501641 20118-20120 28479213 denotes 57
32303592-27799871-65501641 20118-20120 27799871 denotes 57
32303592-15812491-65501642 20121-20123 15812491 denotes 59
32303592-12471109-65501643 20210-20212 12471109 denotes 60
32303592-23580623-65501643 20210-20212 23580623 denotes 60
32303592-9697771-65501644 20213-20215 9697771 denotes 62
32303592-21760609-65501645 20240-20242 21760609 denotes 63
32303592-26553804-65501646 22181-22183 26553804 denotes 67
32303592-21988835-65501647 22648-22650 21988835 denotes 68
32303592-15680415-65501648 22851-22853 15680415 denotes 69
32303592-19151095-65501649 22946-22948 19151095 denotes 71
32303592-26553804-65501650 24715-24717 26553804 denotes 67
32303592-29653567-65501651 25069-25071 29653567 denotes 72
32303592-28978689-65501652 25109-25111 28978689 denotes 73
32303592-31871119-65501653 25525-25527 31871119 denotes 74
32303592-29960884-65501654 25550-25552 29960884 denotes 75
32303592-30357391-65501655 25791-25793 30357391 denotes 76
32303592-15744535-65501656 26226-26228 15744535 denotes 77
32303592-25414323-65501657 26595-26597 25414323 denotes 52