PMC:7306567 / 2305-4276
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T3 | 159-169 | Body_part | denotes | neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T4 | 185-189 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T5 | 479-483 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 53 | 529-554 | Disease | denotes | graft-versus-host disease | MESH:D006086 |
| 46 | 723-732 | Chemical | denotes | ibrutinib | MESH:C551803 |
| 47 | 13-45 | Disease | denotes | Invasive pulmonary aspergillosis | MESH:D055744 |
| 48 | 126-147 | Disease | denotes | prolonged neutropenia | MESH:D009503 |
| 49 | 159-197 | Disease | denotes | neutrophil disorders or T cell defects | MESH:C563515 |
| 50 | 351-373 | Disease | denotes | invasive aspergillosis | MESH:D055744 |
| 51 | 431-445 | Disease | denotes | acute leukemia | MESH:D015470 |
| 52 | 447-449 | Disease | denotes | AL | MESH:D009101 |
| 58 | 1050-1073 | Disease | denotes | pulmonary aspergillosis | MESH:D055732 |
| 59 | 1150-1156 | Disease | denotes | Cancer | MESH:D009369 |
| 60 | 1165-1172 | Disease | denotes | Mycosis | MESH:D015821 |
| 61 | 1512-1535 | Disease | denotes | invasive fungal disease | MESH:D000072742 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T21 | 32-45 | Disease | denotes | aspergillosis | http://purl.obolibrary.org/obo/MONDO_0005657 |
| T22 | 136-147 | Disease | denotes | neutropenia | http://purl.obolibrary.org/obo/MONDO_0001475 |
| T23 | 351-373 | Disease | denotes | invasive aspergillosis | http://purl.obolibrary.org/obo/MONDO_0000240 |
| T24 | 360-373 | Disease | denotes | aspergillosis | http://purl.obolibrary.org/obo/MONDO_0005657 |
| T25 | 375-377 | Disease | denotes | IA | http://purl.obolibrary.org/obo/MONDO_0000240 |
| T26 | 431-445 | Disease | denotes | acute leukemia | http://purl.obolibrary.org/obo/MONDO_0010643 |
| T27 | 437-445 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
| T28 | 447-449 | Disease | denotes | AL | http://purl.obolibrary.org/obo/MONDO_0010643 |
| T29 | 529-554 | Disease | denotes | graft-versus-host disease | http://purl.obolibrary.org/obo/MONDO_0013730 |
| T30 | 792-801 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T31 | 987-996 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T32 | 1029-1038 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T33 | 1060-1073 | Disease | denotes | aspergillosis | http://purl.obolibrary.org/obo/MONDO_0005657 |
| T34 | 1150-1156 | Disease | denotes | Cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T35 | 1165-1172 | Disease | denotes | Mycosis | http://purl.obolibrary.org/obo/MONDO_0002041 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T15 | 55-56 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T16 | 183-189 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T17 | 479-483 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T18 | 734-738 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 4, 5 |
| T19 | 777-778 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T20 | 810-813 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T21 | 1107-1119 | http://purl.obolibrary.org/obo/OBI_0000245 | denotes | Organization |
| T22 | 1259-1260 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T23 | 1540-1541 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T24 | 1745-1747 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T4 | 47-50 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T6 | 375-377 | Chemical | denotes | IA | http://purl.obolibrary.org/obo/CHEBI_74062 |
| T7 | 447-449 | Chemical | denotes | AL | http://purl.obolibrary.org/obo/CHEBI_73770 |
| T8 | 565-575 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T9 | 723-732 | Chemical | denotes | ibrutinib | http://purl.obolibrary.org/obo/CHEBI_76612 |
| T10 | 806-809 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T12 | 940-943 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T14 | 1324-1327 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T16 | 1716-1719 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1822-1834 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T6 | 13-45 | Phenotype | denotes | Invasive pulmonary aspergillosis | http://purl.obolibrary.org/obo/HP_0020103 |
| T7 | 47-50 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T8 | 136-147 | Phenotype | denotes | neutropenia | http://purl.obolibrary.org/obo/HP_0001875 |
| T9 | 431-445 | Phenotype | denotes | acute leukemia | http://purl.obolibrary.org/obo/HP_0002488 |
| T10 | 447-449 | Phenotype | denotes | AL | http://purl.obolibrary.org/obo/HP_0002488 |
| T11 | 806-809 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T12 | 940-943 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T13 | 1150-1156 | Phenotype | denotes | Cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T14 | 1324-1327 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T15 | 1716-1719 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T19 | 0-12 | Sentence | denotes | Introduction |
| T20 | 13-318 | Sentence | denotes | Invasive pulmonary aspergillosis (IPA) is a well-recognized disease affecting immunocompromised individuals with prolonged neutropenia, inherited neutrophil disorders or T cell defects, with the risk depending on the patients’ underlying disease and the type and duration of immunosuppressive therapy [1]. |
| T21 | 319-620 | Sentence | denotes | Patients at the highest risk of invasive aspergillosis (IA) include those undergoing intensive chemotherapy for acute leukemia (AL) or recipients of allogeneic cell transplantation (alloHCT) who develop severe graft-versus-host disease, for whom antifungal prophylaxis is currently recommended [2, 3]. |
| T22 | 621-740 | Sentence | denotes | With changing treatment modalities, new risk groups continue to emerge, such as patients treated with ibrutinib [4, 5]. |
| T23 | 741-1003 | Sentence | denotes | Although over the past four decades a link between influenza and IPA has been noted in single cases [6], recent cohort studies provide new insights into the epidemiology and clinical presentation of IPA in intensive care unit (ICU) patients with influenza [7–9]. |
| T24 | 1004-1370 | Sentence | denotes | Patients presenting with influenza-associated pulmonary aspergillosis (IAPA) may have classic European Organization for Research and Treatment of Cancer (EORTC)/Mycosis Study Group Education and Research Consortium (MSGERC)-defined host factors [10], but a notable proportion of patients was deemed to be at low risk of IPA, including previously healthy individuals. |
| T25 | 1371-1536 | Sentence | denotes | In addition, the clinical and radiological presentation was often atypical with radiological features that were not considered suggestive of invasive fungal disease. |
| T26 | 1537-1749 | Sentence | denotes | As a consequence, we cannot classify these patients according to existing consensus definitions, i.e., the EORTC/MSGERC definitions and the AspICU algorithm for classification of IPA patients in the ICU [10, 11]. |
| T27 | 1750-1971 | Sentence | denotes | We therefore set out to discuss current insights into the epidemiology, pathogenesis, diagnosis and management of IAPA and to propose case definitions that can facilitate homogeneity and comparability in clinical studies. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T29 | 22-31 | UBERON:0002048 | denotes | pulmonary |
| T30 | 109-120 | NCBITaxon:1 | denotes | individuals |
| T31 | 159-169 | CL:0000775 | denotes | neutrophil |
| T32 | 183-189 | CL:0000084 | denotes | T cell |
| T33 | 288-305 | CHEBI:35705;CHEBI:35705 | denotes | immunosuppressive |
| T34 | 723-732 | CHEBI:76612;CHEBI:76612 | denotes | ibrutinib |
| T35 | 947-966 | UBERON:0007221 | denotes | intensive care unit |
| T36 | 1050-1059 | UBERON:0002048 | denotes | pulmonary |
| T37 | 1358-1369 | NCBITaxon:1 | denotes | individuals |
| T38 | 1611-1620 | SO:0000993 | denotes | consensus |
| T81322 | 22-31 | UBERON:0002048 | denotes | pulmonary |
| T51311 | 109-120 | NCBITaxon:1 | denotes | individuals |
| T81106 | 159-169 | CL:0000775 | denotes | neutrophil |
| T17383 | 183-189 | CL:0000084 | denotes | T cell |
| T96288 | 288-305 | CHEBI:35705;CHEBI:35705 | denotes | immunosuppressive |
| T80755 | 723-732 | CHEBI:76612;CHEBI:76612 | denotes | ibrutinib |
| T56421 | 947-966 | UBERON:0007221 | denotes | intensive care unit |
| T62889 | 1050-1059 | UBERON:0002048 | denotes | pulmonary |
| T75194 | 1358-1369 | NCBITaxon:1 | denotes | individuals |
| T71433 | 1611-1620 | SO:0000993 | denotes | consensus |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32572532-25354514-47963394 | 315-316 | 25354514 | denotes | 1 |
| 32572532-29437588-47963395 | 734-735 | 29437588 | denotes | 4 |
| 32572532-372590-47963396 | 842-843 | 372590 | denotes | 6 |
| 32572532-22895826-47963397 | 998-999 | 22895826 | denotes | 7 |
| 32572532-28387526-47963397 | 998-999 | 28387526 | denotes | 7 |
| 32572532-30076119-47963397 | 998-999 | 30076119 | denotes | 7 |
| 32572532-22517788-47963398 | 1745-1747 | 22517788 | denotes | 11 |
| T48775 | 315-316 | 25354514 | denotes | 1 |
| T15892 | 734-735 | 29437588 | denotes | 4 |
| T86053 | 842-843 | 372590 | denotes | 6 |
| T17737 | 998-999 | 22895826 | denotes | 7 |
| T34194 | 998-999 | 28387526 | denotes | 7 |
| T96222 | 998-999 | 30076119 | denotes | 7 |
| T22940 | 1745-1747 | 22517788 | denotes | 11 |