PMC:7306567 / 18219-18952 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T22","span":{"begin":248,"end":255},"obj":"Body_part"}],"attributes":[{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma7394"}],"text":"Aerosolized antifungal treatment may be a useful adjunctive therapy to systemic antifungal therapy for patients with confirmed Aspergillus tracheobronchitis, to achieve good endobronchial exposure [35, 54]. However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy. The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43, 55]. Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T18","span":{"begin":248,"end":255},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0003126"}],"text":"Aerosolized antifungal treatment may be a useful adjunctive therapy to systemic antifungal therapy for patients with confirmed Aspergillus tracheobronchitis, to achieve good endobronchial exposure [35, 54]. However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy. The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43, 55]. Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis."}

{"project":"LitCovid-PubTator","denotations":[{"id":"208","span":{"begin":535,"end":541},"obj":"Chemical"},{"id":"209","span":{"begin":127,"end":156},"obj":"Disease"}],"attributes":[{"id":"A208","pred":"tao:has_database_id","subj":"208","obj":"MESH:D001393"},{"id":"A209","pred":"tao:has_database_id","subj":"209","obj":"MESH:D001228"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Aerosolized antifungal treatment may be a useful adjunctive therapy to systemic antifungal therapy for patients with confirmed Aspergillus tracheobronchitis, to achieve good endobronchial exposure [35, 54]. However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy. The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43, 55]. Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T83","span":{"begin":139,"end":156},"obj":"Disease"}],"attributes":[{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0021925"}],"text":"Aerosolized antifungal treatment may be a useful adjunctive therapy to systemic antifungal therapy for patients with confirmed Aspergillus tracheobronchitis, to achieve good endobronchial exposure [35, 54]. However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy. The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43, 55]. Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T118","span":{"begin":40,"end":41},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T119","span":{"begin":198,"end":200},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T120","span":{"begin":668,"end":669},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Aerosolized antifungal treatment may be a useful adjunctive therapy to systemic antifungal therapy for patients with confirmed Aspergillus tracheobronchitis, to achieve good endobronchial exposure [35, 54]. However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy. The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43, 55]. Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T130","span":{"begin":12,"end":22},"obj":"Chemical"},{"id":"T131","span":{"begin":80,"end":90},"obj":"Chemical"},{"id":"T132","span":{"begin":351,"end":362},"obj":"Chemical"},{"id":"T133","span":{"begin":484,"end":495},"obj":"Chemical"},{"id":"T134","span":{"begin":535,"end":541},"obj":"Chemical"},{"id":"T135","span":{"begin":566,"end":574},"obj":"Chemical"},{"id":"T136","span":{"begin":710,"end":720},"obj":"Chemical"}],"attributes":[{"id":"A130","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A131","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A132","pred":"chebi_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A133","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_68452"},{"id":"A135","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_48121"},{"id":"A136","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"}],"text":"Aerosolized antifungal treatment may be a useful adjunctive therapy to systemic antifungal therapy for patients with confirmed Aspergillus tracheobronchitis, to achieve good endobronchial exposure [35, 54]. However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy. The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43, 55]. Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis."}

{"project":"LitCovid-sentences","denotations":[{"id":"T121","span":{"begin":0,"end":206},"obj":"Sentence"},{"id":"T122","span":{"begin":207,"end":389},"obj":"Sentence"},{"id":"T123","span":{"begin":390,"end":623},"obj":"Sentence"},{"id":"T124","span":{"begin":624,"end":733},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Aerosolized antifungal treatment may be a useful adjunctive therapy to systemic antifungal therapy for patients with confirmed Aspergillus tracheobronchitis, to achieve good endobronchial exposure [35, 54]. However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy. The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43, 55]. Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T150","span":{"begin":127,"end":138},"obj":"NCBITaxon:5052"},{"id":"T151","span":{"begin":139,"end":156},"obj":"UBERON:0007196"},{"id":"T152","span":{"begin":174,"end":187},"obj":"UBERON:0001852"},{"id":"T153","span":{"begin":248,"end":255},"obj":"UBERON:0003126"},{"id":"T154","span":{"begin":351,"end":362},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T155","span":{"begin":410,"end":421},"obj":"NCBITaxon:5052"},{"id":"T156","span":{"begin":445,"end":456},"obj":"CHEBI:50905;CHEBI:50905"},{"id":"T157","span":{"begin":461,"end":470},"obj":"CHEBI:25435;CHEBI:25435"},{"id":"T158","span":{"begin":484,"end":495},"obj":"CHEBI:35718;CHEBI:35718"},{"id":"T159","span":{"begin":505,"end":514},"obj":"GO:0007565"},{"id":"T160","span":{"begin":634,"end":642},"obj":"GO:0007565"},{"id":"T48860","span":{"begin":127,"end":138},"obj":"NCBITaxon:5052"},{"id":"T84649","span":{"begin":139,"end":156},"obj":"UBERON:0007196"},{"id":"T69891","span":{"begin":174,"end":187},"obj":"UBERON:0001852"},{"id":"T67622","span":{"begin":248,"end":255},"obj":"UBERON:0003126"},{"id":"T4317","span":{"begin":351,"end":362},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T80540","span":{"begin":410,"end":421},"obj":"NCBITaxon:5052"},{"id":"T31714","span":{"begin":445,"end":456},"obj":"CHEBI:50905;CHEBI:50905"},{"id":"T16663","span":{"begin":461,"end":470},"obj":"CHEBI:25435;CHEBI:25435"},{"id":"T53462","span":{"begin":484,"end":495},"obj":"CHEBI:35718;CHEBI:35718"},{"id":"T49738","span":{"begin":505,"end":514},"obj":"GO:0007565"},{"id":"T22501","span":{"begin":634,"end":642},"obj":"GO:0007565"}],"text":"Aerosolized antifungal treatment may be a useful adjunctive therapy to systemic antifungal therapy for patients with confirmed Aspergillus tracheobronchitis, to achieve good endobronchial exposure [35, 54]. However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy. The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43, 55]. Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis."}

{"project":"2_test","denotations":[{"id":"32572532-27365388-47963444","span":{"begin":198,"end":200},"obj":"27365388"},{"id":"32572532-10525567-47963445","span":{"begin":202,"end":204},"obj":"10525567"},{"id":"32572532-29544767-47963446","span":{"begin":615,"end":617},"obj":"29544767"},{"id":"T52492","span":{"begin":198,"end":200},"obj":"27365388"},{"id":"T28103","span":{"begin":202,"end":204},"obj":"10525567"},{"id":"T58235","span":{"begin":615,"end":617},"obj":"29544767"}],"text":"Aerosolized antifungal treatment may be a useful adjunctive therapy to systemic antifungal therapy for patients with confirmed Aspergillus tracheobronchitis, to achieve good endobronchial exposure [35, 54]. However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy. The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43, 55]. Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis."}