PMC:7306567 / 17721-18218 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"201","span":{"begin":155,"end":167},"obj":"Chemical"},{"id":"202","span":{"begin":252,"end":266},"obj":"Chemical"},{"id":"203","span":{"begin":388,"end":394},"obj":"Chemical"},{"id":"204","span":{"begin":430,"end":436},"obj":"Chemical"},{"id":"205","span":{"begin":88,"end":101},"obj":"Disease"}],"attributes":[{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"MESH:D065819"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"MESH:D005436"},{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"MESH:D001393"},{"id":"A204","pred":"tao:has_database_id","subj":"204","obj":"MESH:D001393"},{"id":"A205","pred":"tao:has_database_id","subj":"205","obj":"MESH:D060085"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"A specific drug–drug interaction is relevant for patients with IAPA given the fact that co-infections with S. aureus are frequently observed; undetectable voriconazole levels have been observed in 11 of 20 patients, who were concomitantly treated with flucloxacillin [53], but the mechanisms of interaction are not yet fully understood. Similar interactions have not been seen with other azoles. Many other drug interactions with azoles and drugs commonly deployed in the ICU can be expected [45]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T82","span":{"begin":91,"end":101},"obj":"Disease"}],"attributes":[{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"A specific drug–drug interaction is relevant for patients with IAPA given the fact that co-infections with S. aureus are frequently observed; undetectable voriconazole levels have been observed in 11 of 20 patients, who were concomitantly treated with flucloxacillin [53], but the mechanisms of interaction are not yet fully understood. Similar interactions have not been seen with other azoles. Many other drug interactions with azoles and drugs commonly deployed in the ICU can be expected [45]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T115","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T116","span":{"begin":197,"end":199},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T117","span":{"begin":493,"end":495},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"}],"text":"A specific drug–drug interaction is relevant for patients with IAPA given the fact that co-infections with S. aureus are frequently observed; undetectable voriconazole levels have been observed in 11 of 20 patients, who were concomitantly treated with flucloxacillin [53], but the mechanisms of interaction are not yet fully understood. Similar interactions have not been seen with other azoles. Many other drug interactions with azoles and drugs commonly deployed in the ICU can be expected [45]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T122","span":{"begin":11,"end":15},"obj":"Chemical"},{"id":"T123","span":{"begin":16,"end":20},"obj":"Chemical"},{"id":"T124","span":{"begin":155,"end":167},"obj":"Chemical"},{"id":"T125","span":{"begin":252,"end":266},"obj":"Chemical"},{"id":"T126","span":{"begin":388,"end":394},"obj":"Chemical"},{"id":"T127","span":{"begin":407,"end":411},"obj":"Chemical"},{"id":"T128","span":{"begin":430,"end":436},"obj":"Chemical"},{"id":"T129","span":{"begin":441,"end":446},"obj":"Chemical"}],"attributes":[{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_10023"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_5098"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_68452"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A128","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_68452"},{"id":"A129","pred":"chebi_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"A specific drug–drug interaction is relevant for patients with IAPA given the fact that co-infections with S. aureus are frequently observed; undetectable voriconazole levels have been observed in 11 of 20 patients, who were concomitantly treated with flucloxacillin [53], but the mechanisms of interaction are not yet fully understood. Similar interactions have not been seen with other azoles. Many other drug interactions with azoles and drugs commonly deployed in the ICU can be expected [45]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T118","span":{"begin":0,"end":336},"obj":"Sentence"},{"id":"T119","span":{"begin":337,"end":395},"obj":"Sentence"},{"id":"T120","span":{"begin":396,"end":497},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A specific drug–drug interaction is relevant for patients with IAPA given the fact that co-infections with S. aureus are frequently observed; undetectable voriconazole levels have been observed in 11 of 20 patients, who were concomitantly treated with flucloxacillin [53], but the mechanisms of interaction are not yet fully understood. Similar interactions have not been seen with other azoles. Many other drug interactions with azoles and drugs commonly deployed in the ICU can be expected [45]."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T141","span":{"begin":11,"end":15},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T142","span":{"begin":16,"end":20},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T143","span":{"begin":107,"end":108},"obj":"NCBITaxon:4932"},{"id":"T144","span":{"begin":108,"end":109},"obj":"NCBITaxon:562"},{"id":"T145","span":{"begin":155,"end":167},"obj":"CHEBI:10023;CHEBI:10023"},{"id":"T146","span":{"begin":252,"end":266},"obj":"CHEBI:5098;CHEBI:5098"},{"id":"T147","span":{"begin":407,"end":411},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T148","span":{"begin":430,"end":436},"obj":"CHEBI:68452;CHEBI:68452"},{"id":"T149","span":{"begin":441,"end":446},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T5704","span":{"begin":11,"end":15},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T23687","span":{"begin":16,"end":20},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T76380","span":{"begin":107,"end":108},"obj":"NCBITaxon:4932"},{"id":"T2256","span":{"begin":108,"end":109},"obj":"NCBITaxon:562"},{"id":"T62223","span":{"begin":155,"end":167},"obj":"CHEBI:10023;CHEBI:10023"},{"id":"T32565","span":{"begin":252,"end":266},"obj":"CHEBI:5098;CHEBI:5098"},{"id":"T43236","span":{"begin":407,"end":411},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T38702","span":{"begin":430,"end":436},"obj":"CHEBI:68452;CHEBI:68452"},{"id":"T74202","span":{"begin":441,"end":446},"obj":"CHEBI:23888;CHEBI:23888"}],"text":"A specific drug–drug interaction is relevant for patients with IAPA given the fact that co-infections with S. aureus are frequently observed; undetectable voriconazole levels have been observed in 11 of 20 patients, who were concomitantly treated with flucloxacillin [53], but the mechanisms of interaction are not yet fully understood. Similar interactions have not been seen with other azoles. Many other drug interactions with azoles and drugs commonly deployed in the ICU can be expected [45]."}

{"project":"2_test","denotations":[{"id":"32572532-28717040-47963442","span":{"begin":268,"end":270},"obj":"28717040"},{"id":"32572532-19361301-47963443","span":{"begin":493,"end":495},"obj":"19361301"},{"id":"T52416","span":{"begin":268,"end":270},"obj":"28717040"},{"id":"T67943","span":{"begin":493,"end":495},"obj":"19361301"}],"text":"A specific drug–drug interaction is relevant for patients with IAPA given the fact that co-infections with S. aureus are frequently observed; undetectable voriconazole levels have been observed in 11 of 20 patients, who were concomitantly treated with flucloxacillin [53], but the mechanisms of interaction are not yet fully understood. Similar interactions have not been seen with other azoles. Many other drug interactions with azoles and drugs commonly deployed in the ICU can be expected [45]."}