PMC:7306567 / 17643-19217
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T22 | 824-831 | Body_part | denotes | trachea | http://purl.org/sig/ont/fma/fma7394 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T18 | 824-831 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/UBERON_0003126 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 201 | 233-245 | Chemical | denotes | voriconazole | MESH:D065819 |
| 202 | 330-344 | Chemical | denotes | flucloxacillin | MESH:D005436 |
| 203 | 466-472 | Chemical | denotes | azoles | MESH:D001393 |
| 204 | 508-514 | Chemical | denotes | azoles | MESH:D001393 |
| 205 | 166-179 | Disease | denotes | co-infections | MESH:D060085 |
| 208 | 1111-1117 | Chemical | denotes | azoles | MESH:D001393 |
| 209 | 703-732 | Disease | denotes | Aspergillus tracheobronchitis | MESH:D001228 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T82 | 169-179 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T83 | 715-732 | Disease | denotes | tracheobronchitis | http://purl.obolibrary.org/obo/MONDO_0021925 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T115 | 78-79 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T116 | 275-277 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T117 | 571-573 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
| T118 | 616-617 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T119 | 774-776 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T120 | 1244-1245 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T121 | 14-24 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T122 | 89-93 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T123 | 94-98 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T124 | 233-245 | Chemical | denotes | voriconazole | http://purl.obolibrary.org/obo/CHEBI_10023 |
| T125 | 330-344 | Chemical | denotes | flucloxacillin | http://purl.obolibrary.org/obo/CHEBI_5098 |
| T126 | 466-472 | Chemical | denotes | azoles | http://purl.obolibrary.org/obo/CHEBI_68452 |
| T127 | 485-489 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T128 | 508-514 | Chemical | denotes | azoles | http://purl.obolibrary.org/obo/CHEBI_68452 |
| T129 | 519-524 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T130 | 588-598 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T131 | 656-666 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T132 | 927-938 | Chemical | denotes | antifungals | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T133 | 1060-1071 | Chemical | denotes | antifungals | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T134 | 1111-1117 | Chemical | denotes | azoles | http://purl.obolibrary.org/obo/CHEBI_68452 |
| T135 | 1142-1150 | Chemical | denotes | polyenes | http://purl.obolibrary.org/obo/CHEBI_48121 |
| T136 | 1286-1296 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T137 | 1360-1375 | Chemical | denotes | antifungal drug | http://purl.obolibrary.org/obo/CHEBI_35718|http://purl.obolibrary.org/obo/CHEBI_86327 |
| T139 | 1371-1375 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T140 | 1399-1412 | Chemical | denotes | echinocandins | http://purl.obolibrary.org/obo/CHEBI_57248 |
| T141 | 1506-1516 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T142 | 1560-1564 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T117 | 0-77 | Sentence | denotes | Discussion on antifungal treatment options and challenges for IAPA in the ICU |
| T118 | 78-414 | Sentence | denotes | A specific drug–drug interaction is relevant for patients with IAPA given the fact that co-infections with S. aureus are frequently observed; undetectable voriconazole levels have been observed in 11 of 20 patients, who were concomitantly treated with flucloxacillin [53], but the mechanisms of interaction are not yet fully understood. |
| T119 | 415-473 | Sentence | denotes | Similar interactions have not been seen with other azoles. |
| T120 | 474-575 | Sentence | denotes | Many other drug interactions with azoles and drugs commonly deployed in the ICU can be expected [45]. |
| T121 | 576-782 | Sentence | denotes | Aerosolized antifungal treatment may be a useful adjunctive therapy to systemic antifungal therapy for patients with confirmed Aspergillus tracheobronchitis, to achieve good endobronchial exposure [35, 54]. |
| T122 | 783-965 | Sentence | denotes | However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy. |
| T123 | 966-1199 | Sentence | denotes | The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43, 55]. |
| T124 | 1200-1309 | Sentence | denotes | Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis. |
| T125 | 1310-1390 | Sentence | denotes | There is little evidence on the impact of ECMO on antifungal drug exposure [56]. |
| T126 | 1391-1448 | Sentence | denotes | For the echinocandins, an impact of ECMO is not expected. |
| T127 | 1449-1574 | Sentence | denotes | Experts felt that, given these uncertainties, TDM of any antifungal used would be advised to ensure sufficient drug exposure. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T141 | 89-93 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T142 | 94-98 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T143 | 185-186 | NCBITaxon:4932 | denotes | S |
| T144 | 186-187 | NCBITaxon:562 | denotes | . |
| T145 | 233-245 | CHEBI:10023;CHEBI:10023 | denotes | voriconazole |
| T146 | 330-344 | CHEBI:5098;CHEBI:5098 | denotes | flucloxacillin |
| T147 | 485-489 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T148 | 508-514 | CHEBI:68452;CHEBI:68452 | denotes | azoles |
| T149 | 519-524 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
| T150 | 703-714 | NCBITaxon:5052 | denotes | Aspergillus |
| T151 | 715-732 | UBERON:0007196 | denotes | tracheobronchitis |
| T152 | 750-763 | UBERON:0001852 | denotes | endobronchial |
| T153 | 824-831 | UBERON:0003126 | denotes | trachea |
| T154 | 927-938 | CHEBI:67079;CHEBI:67079 | denotes | antifungals |
| T155 | 986-997 | NCBITaxon:5052 | denotes | Aspergillus |
| T156 | 1021-1032 | CHEBI:50905;CHEBI:50905 | denotes | teratogenic |
| T157 | 1037-1046 | CHEBI:25435;CHEBI:25435 | denotes | mutagenic |
| T158 | 1060-1071 | CHEBI:35718;CHEBI:35718 | denotes | antifungals |
| T159 | 1081-1090 | GO:0007565 | denotes | pregnancy |
| T160 | 1210-1218 | GO:0007565 | denotes | pregnant |
| T161 | 1360-1370 | CHEBI:35718;CHEBI:35718 | denotes | antifungal |
| T162 | 1371-1375 | CHEBI:86327;CHEBI:86327 | denotes | drug |
| T163 | 1399-1412 | CHEBI:57248;CHEBI:57248 | denotes | echinocandins |
| T164 | 1506-1516 | CHEBI:35718;CHEBI:35718 | denotes | antifungal |
| T165 | 1560-1564 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T5704 | 89-93 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T23687 | 94-98 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T76380 | 185-186 | NCBITaxon:4932 | denotes | S |
| T2256 | 186-187 | NCBITaxon:562 | denotes | . |
| T62223 | 233-245 | CHEBI:10023;CHEBI:10023 | denotes | voriconazole |
| T32565 | 330-344 | CHEBI:5098;CHEBI:5098 | denotes | flucloxacillin |
| T43236 | 485-489 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T38702 | 508-514 | CHEBI:68452;CHEBI:68452 | denotes | azoles |
| T74202 | 519-524 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
| T48860 | 703-714 | NCBITaxon:5052 | denotes | Aspergillus |
| T84649 | 715-732 | UBERON:0007196 | denotes | tracheobronchitis |
| T69891 | 750-763 | UBERON:0001852 | denotes | endobronchial |
| T67622 | 824-831 | UBERON:0003126 | denotes | trachea |
| T4317 | 927-938 | CHEBI:67079;CHEBI:67079 | denotes | antifungals |
| T80540 | 986-997 | NCBITaxon:5052 | denotes | Aspergillus |
| T31714 | 1021-1032 | CHEBI:50905;CHEBI:50905 | denotes | teratogenic |
| T16663 | 1037-1046 | CHEBI:25435;CHEBI:25435 | denotes | mutagenic |
| T53462 | 1060-1071 | CHEBI:35718;CHEBI:35718 | denotes | antifungals |
| T49738 | 1081-1090 | GO:0007565 | denotes | pregnancy |
| T22501 | 1210-1218 | GO:0007565 | denotes | pregnant |
| T23823 | 1360-1370 | CHEBI:35718;CHEBI:35718 | denotes | antifungal |
| T93737 | 1371-1375 | CHEBI:86327;CHEBI:86327 | denotes | drug |
| T6922 | 1399-1412 | CHEBI:57248;CHEBI:57248 | denotes | echinocandins |
| T46107 | 1506-1516 | CHEBI:35718;CHEBI:35718 | denotes | antifungal |
| T54949 | 1560-1564 | CHEBI:23888;CHEBI:23888 | denotes | drug |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32572532-28717040-47963442 | 346-348 | 28717040 | denotes | 53 |
| 32572532-19361301-47963443 | 571-573 | 19361301 | denotes | 45 |
| 32572532-27365388-47963444 | 774-776 | 27365388 | denotes | 35 |
| 32572532-10525567-47963445 | 778-780 | 10525567 | denotes | 54 |
| 32572532-29544767-47963446 | 1191-1193 | 29544767 | denotes | 43 |
| 32572532-29623451-47963447 | 1386-1388 | 29623451 | denotes | 56 |
| T52416 | 346-348 | 28717040 | denotes | 53 |
| T67943 | 571-573 | 19361301 | denotes | 45 |
| T52492 | 774-776 | 27365388 | denotes | 35 |
| T28103 | 778-780 | 10525567 | denotes | 54 |
| T58235 | 1191-1193 | 29544767 | denotes | 43 |
| T25290 | 1386-1388 | 29623451 | denotes | 56 |