PMC:7306567 / 16292-17641
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T20 | 791-797 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T21 | 1203-1209 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 181 | 45-57 | Chemical | denotes | voriconazole | MESH:D065819 |
| 182 | 62-75 | Chemical | denotes | isavuconazole | MESH:C508735 |
| 183 | 108-121 | Chemical | denotes | echinocandins | MESH:D054714 |
| 184 | 152-158 | Chemical | denotes | azoles | MESH:D001393 |
| 185 | 174-188 | Chemical | denotes | amphotericin B | MESH:D000666 |
| 186 | 190-195 | Chemical | denotes | L-AmB | MESH:C068538 |
| 187 | 227-232 | Chemical | denotes | azole | MESH:D001393 |
| 188 | 285-290 | Chemical | denotes | L-AmB | MESH:C068538 |
| 189 | 467-472 | Chemical | denotes | L-AmB | MESH:C068538 |
| 190 | 546-552 | Chemical | denotes | azoles | MESH:D001393 |
| 191 | 699-711 | Chemical | denotes | voriconazole | MESH:D065819 |
| 192 | 805-817 | Chemical | denotes | voriconazole | MESH:D065819 |
| 193 | 1162-1175 | Chemical | denotes | isavuconazole | MESH:C508735 |
| 194 | 774-782 | Disease | denotes | toxicity | MESH:D064420 |
| 195 | 1013-1028 | Disease | denotes | (neuro)toxicity | MESH:C536203 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T81 | 916-918 | Disease | denotes | IA | http://purl.obolibrary.org/obo/MONDO_0000240 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T102 | 77-79 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T103 | 187-188 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T104 | 190-195 | http://purl.obolibrary.org/obo/NCBITaxon_9940 | denotes | L-AmB |
| T105 | 243-244 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T106 | 285-290 | http://purl.obolibrary.org/obo/NCBITaxon_9940 | denotes | L-AmB |
| T107 | 467-472 | http://purl.obolibrary.org/obo/NCBITaxon_9940 | denotes | L-AmB |
| T108 | 642-644 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
| T109 | 718-719 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T110 | 791-797 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T111 | 924-925 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T112 | 1153-1155 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
| T113 | 1203-1209 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T114 | 1295-1296 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T103 | 33-36 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T105 | 45-57 | Chemical | denotes | voriconazole | http://purl.obolibrary.org/obo/CHEBI_10023 |
| T106 | 62-75 | Chemical | denotes | isavuconazole | http://purl.obolibrary.org/obo/CHEBI_85979 |
| T107 | 108-121 | Chemical | denotes | echinocandins | http://purl.obolibrary.org/obo/CHEBI_57248 |
| T108 | 152-158 | Chemical | denotes | azoles | http://purl.obolibrary.org/obo/CHEBI_68452 |
| T109 | 174-188 | Chemical | denotes | amphotericin B | http://purl.obolibrary.org/obo/CHEBI_2682 |
| T110 | 227-232 | Chemical | denotes | azole | http://purl.obolibrary.org/obo/CHEBI_68452 |
| T111 | 348-352 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T112 | 481-494 | Chemical | denotes | echinocandins | http://purl.obolibrary.org/obo/CHEBI_57248 |
| T113 | 496-500 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T114 | 546-552 | Chemical | denotes | azoles | http://purl.obolibrary.org/obo/CHEBI_68452 |
| T115 | 615-619 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T116 | 673-677 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T117 | 699-711 | Chemical | denotes | voriconazole | http://purl.obolibrary.org/obo/CHEBI_10023 |
| T118 | 805-817 | Chemical | denotes | voriconazole | http://purl.obolibrary.org/obo/CHEBI_10023 |
| T119 | 916-918 | Chemical | denotes | IA | http://purl.obolibrary.org/obo/CHEBI_74062 |
| T120 | 1162-1175 | Chemical | denotes | isavuconazole | http://purl.obolibrary.org/obo/CHEBI_85979 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T28 | 33-36 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T109 | 0-85 | Sentence | denotes | First-line treatment options for IPA include voriconazole and isavuconazole [35, 43]. |
| T110 | 86-328 | Sentence | denotes | Other options include echinocandins in combination with anti-mold azoles, and liposomal amphotericin B (L-AmB) in regions with high rates of azole-resistant A. fumigatus, although clinical data with L-AmB in ICU patients are limited [43, 44]. |
| T111 | 329-459 | Sentence | denotes | Achieving adequate drug exposure is challenging in ICU patients with multiple factors contributing to pharmacokinetic variability. |
| T112 | 460-646 | Sentence | denotes | Unlike L-AmB and the echinocandins, drug interactions are clinically relevant for the azoles and pharmacogenetic factors are important in inter-individual drug exposure variability [45]. |
| T113 | 647-783 | Sentence | denotes | The impact of therapeutic drug monitoring (TDM) for voriconazole shows a clear relation between exposure and both efficacy and toxicity. |
| T114 | 784-1029 | Sentence | denotes | Target plasma trough voriconazole concentrations of ≥ 1.5–2 mg/L are associated with near-maximal clinical response in treatment of IA with a wild-type phenotype [46–51], with higher exposures (> 5.5 mg/L) increasing the risk of (neuro)toxicity. |
| T115 | 1030-1157 | Sentence | denotes | Higher trough concentrations (> 2 mg/L) are recommended for treatment of pathogens with elevated MICs (e.g., > 0.25 mg/L) [52]. |
| T116 | 1158-1349 | Sentence | denotes | For isavuconazole, there is no robust target plasma concentration, and the population average exposure of participants that demonstrated a favorable response (2–4 mg/L) is commonly used [43]. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T121 | 45-57 | CHEBI:10023;CHEBI:10023 | denotes | voriconazole |
| T122 | 62-75 | CHEBI:85979;CHEBI:85979 | denotes | isavuconazole |
| T123 | 108-121 | CHEBI:57248;CHEBI:57248 | denotes | echinocandins |
| T124 | 174-188 | CHEBI:2682;CHEBI:2682 | denotes | amphotericin B |
| T125 | 227-232 | CHEBI:68452;CHEBI:68452 | denotes | azole |
| T126 | 244-255 | NCBITaxon:31032 | denotes | . fumigatus |
| T127 | 348-352 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T128 | 431-446 | CHEBI:52217;CHEBI:52217 | denotes | pharmacokinetic |
| T129 | 481-494 | CHEBI:57248;CHEBI:57248 | denotes | echinocandins |
| T130 | 496-500 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T131 | 546-552 | CHEBI:68452;CHEBI:68452 | denotes | azoles |
| T132 | 557-572 | CHEBI:52217;CHEBI:52217 | denotes | pharmacogenetic |
| T133 | 604-614 | NCBITaxon:1 | denotes | individual |
| T134 | 615-619 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T135 | 673-677 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T136 | 699-711 | CHEBI:10023;CHEBI:10023 | denotes | voriconazole |
| T137 | 791-797 | UBERON:0001969 | denotes | plasma |
| T138 | 805-817 | CHEBI:10023;CHEBI:10023 | denotes | voriconazole |
| T139 | 1162-1175 | CHEBI:85979;CHEBI:85979 | denotes | isavuconazole |
| T140 | 1203-1209 | UBERON:0001969 | denotes | plasma |
| T5801 | 45-57 | CHEBI:10023;CHEBI:10023 | denotes | voriconazole |
| T2719 | 62-75 | CHEBI:85979;CHEBI:85979 | denotes | isavuconazole |
| T2586 | 108-121 | CHEBI:57248;CHEBI:57248 | denotes | echinocandins |
| T84468 | 174-188 | CHEBI:2682;CHEBI:2682 | denotes | amphotericin B |
| T79778 | 227-232 | CHEBI:68452;CHEBI:68452 | denotes | azole |
| T89235 | 244-255 | NCBITaxon:31032 | denotes | . fumigatus |
| T94377 | 348-352 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T13252 | 431-446 | CHEBI:52217;CHEBI:52217 | denotes | pharmacokinetic |
| T78758 | 481-494 | CHEBI:57248;CHEBI:57248 | denotes | echinocandins |
| T29529 | 496-500 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T38907 | 546-552 | CHEBI:68452;CHEBI:68452 | denotes | azoles |
| T39277 | 557-572 | CHEBI:52217;CHEBI:52217 | denotes | pharmacogenetic |
| T4074 | 604-614 | NCBITaxon:1 | denotes | individual |
| T42152 | 615-619 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T23351 | 673-677 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T23219 | 699-711 | CHEBI:10023;CHEBI:10023 | denotes | voriconazole |
| T6563 | 791-797 | UBERON:0001969 | denotes | plasma |
| T68072 | 805-817 | CHEBI:10023;CHEBI:10023 | denotes | voriconazole |
| T73675 | 1162-1175 | CHEBI:85979;CHEBI:85979 | denotes | isavuconazole |
| T42840 | 1203-1209 | UBERON:0001969 | denotes | plasma |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32572532-27365388-47963434 | 77-79 | 27365388 | denotes | 35 |
| 32572532-29544767-47963435 | 81-83 | 29544767 | denotes | 43 |
| 32572532-29544767-47963436 | 320-322 | 29544767 | denotes | 43 |
| 32572532-26282594-47963437 | 324-326 | 26282594 | denotes | 44 |
| 32572532-19361301-47963438 | 642-644 | 19361301 | denotes | 45 |
| 32572532-22610925-47963439 | 947-949 | 22610925 | denotes | 46 |
| 32572532-18171251-47963439 | 947-949 | 18171251 | denotes | 46 |
| 32572532-21768513-47963439 | 947-949 | 21768513 | denotes | 46 |
| 32572532-22751544-47963439 | 947-949 | 22751544 | denotes | 46 |
| 32572532-24550381-47963440 | 1153-1155 | 24550381 | denotes | 52 |
| 32572532-29544767-47963441 | 1345-1347 | 29544767 | denotes | 43 |
| T59357 | 77-79 | 27365388 | denotes | 35 |
| T21297 | 81-83 | 29544767 | denotes | 43 |
| T78250 | 320-322 | 29544767 | denotes | 43 |
| T9616 | 324-326 | 26282594 | denotes | 44 |
| T50130 | 642-644 | 19361301 | denotes | 45 |
| T88155 | 947-949 | 22610925 | denotes | 46 |
| T71393 | 947-949 | 18171251 | denotes | 46 |
| T75852 | 947-949 | 21768513 | denotes | 46 |
| T42515 | 947-949 | 22751544 | denotes | 46 |
| T71499 | 1153-1155 | 24550381 | denotes | 52 |
| T51946 | 1345-1347 | 29544767 | denotes | 43 |