PMC:7306567 / 12363-13083 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"124","span":{"begin":305,"end":310},"obj":"Chemical"},{"id":"125","span":{"begin":393,"end":398},"obj":"Chemical"}],"attributes":[{"id":"A124","pred":"tao:has_database_id","subj":"124","obj":"MESH:D001393"},{"id":"A125","pred":"tao:has_database_id","subj":"125","obj":"MESH:D001393"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"IAPA needs to be considered in patients admitted to the ICU with influenza and where indicated these patients should undergo early BAL for Aspergillus antigen testing, culture and microscopy. Patients who test positive require anti-Aspergillus therapy, and the BAL fluid sample should be fast-tracked for azole resistance testing by PCR (and culture when positive) in regions with high (\u003e 5%) azole resistance rates [34]. This would enable diagnostic assessment and initiation of adequate antifungal therapy within 24–48 h of ICU admission. Diagnostic workup for IAPA may be repeated in patients deteriorating while on antivirals and/or appropriate antibiotics or when initiating corticosteroid treatment is unavoidable."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T66","span":{"begin":65,"end":74},"obj":"Disease"}],"attributes":[{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"}],"text":"IAPA needs to be considered in patients admitted to the ICU with influenza and where indicated these patients should undergo early BAL for Aspergillus antigen testing, culture and microscopy. Patients who test positive require anti-Aspergillus therapy, and the BAL fluid sample should be fast-tracked for azole resistance testing by PCR (and culture when positive) in regions with high (\u003e 5%) azole resistance rates [34]. This would enable diagnostic assessment and initiation of adequate antifungal therapy within 24–48 h of ICU admission. Diagnostic workup for IAPA may be repeated in patients deteriorating while on antivirals and/or appropriate antibiotics or when initiating corticosteroid treatment is unavoidable."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T76","span":{"begin":159,"end":166},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T77","span":{"begin":205,"end":209},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T78","span":{"begin":322,"end":329},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T79","span":{"begin":417,"end":419},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T80","span":{"begin":518,"end":520},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"}],"text":"IAPA needs to be considered in patients admitted to the ICU with influenza and where indicated these patients should undergo early BAL for Aspergillus antigen testing, culture and microscopy. Patients who test positive require anti-Aspergillus therapy, and the BAL fluid sample should be fast-tracked for azole resistance testing by PCR (and culture when positive) in regions with high (\u003e 5%) azole resistance rates [34]. This would enable diagnostic assessment and initiation of adequate antifungal therapy within 24–48 h of ICU admission. Diagnostic workup for IAPA may be repeated in patients deteriorating while on antivirals and/or appropriate antibiotics or when initiating corticosteroid treatment is unavoidable."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T65","span":{"begin":131,"end":134},"obj":"Chemical"},{"id":"T66","span":{"begin":151,"end":158},"obj":"Chemical"},{"id":"T67","span":{"begin":261,"end":264},"obj":"Chemical"},{"id":"T68","span":{"begin":305,"end":310},"obj":"Chemical"},{"id":"T69","span":{"begin":393,"end":398},"obj":"Chemical"},{"id":"T70","span":{"begin":489,"end":499},"obj":"Chemical"},{"id":"T71","span":{"begin":619,"end":629},"obj":"Chemical"},{"id":"T72","span":{"begin":649,"end":660},"obj":"Chemical"},{"id":"T73","span":{"begin":680,"end":694},"obj":"Chemical"}],"attributes":[{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_64198"},{"id":"A66","pred":"chebi_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A67","pred":"chebi_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/CHEBI_64198"},{"id":"A68","pred":"chebi_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/CHEBI_68452"},{"id":"A69","pred":"chebi_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/CHEBI_68452"},{"id":"A70","pred":"chebi_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A71","pred":"chebi_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A72","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_33281"},{"id":"A73","pred":"chebi_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"}],"text":"IAPA needs to be considered in patients admitted to the ICU with influenza and where indicated these patients should undergo early BAL for Aspergillus antigen testing, culture and microscopy. Patients who test positive require anti-Aspergillus therapy, and the BAL fluid sample should be fast-tracked for azole resistance testing by PCR (and culture when positive) in regions with high (\u003e 5%) azole resistance rates [34]. This would enable diagnostic assessment and initiation of adequate antifungal therapy within 24–48 h of ICU admission. Diagnostic workup for IAPA may be repeated in patients deteriorating while on antivirals and/or appropriate antibiotics or when initiating corticosteroid treatment is unavoidable."}

{"project":"LitCovid-sentences","denotations":[{"id":"T80","span":{"begin":0,"end":191},"obj":"Sentence"},{"id":"T81","span":{"begin":192,"end":421},"obj":"Sentence"},{"id":"T82","span":{"begin":422,"end":540},"obj":"Sentence"},{"id":"T83","span":{"begin":541,"end":720},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"IAPA needs to be considered in patients admitted to the ICU with influenza and where indicated these patients should undergo early BAL for Aspergillus antigen testing, culture and microscopy. Patients who test positive require anti-Aspergillus therapy, and the BAL fluid sample should be fast-tracked for azole resistance testing by PCR (and culture when positive) in regions with high (\u003e 5%) azole resistance rates [34]. This would enable diagnostic assessment and initiation of adequate antifungal therapy within 24–48 h of ICU admission. Diagnostic workup for IAPA may be repeated in patients deteriorating while on antivirals and/or appropriate antibiotics or when initiating corticosteroid treatment is unavoidable."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T90","span":{"begin":151,"end":158},"obj":"CHEBI:59132;CHEBI:59132"},{"id":"T91","span":{"begin":261,"end":270},"obj":"UBERON:0006314"},{"id":"T92","span":{"begin":305,"end":310},"obj":"CHEBI:68452;CHEBI:68452"},{"id":"T93","span":{"begin":393,"end":398},"obj":"CHEBI:68452;CHEBI:68452"},{"id":"T94","span":{"begin":649,"end":660},"obj":"CHEBI:33282;CHEBI:33282"},{"id":"T95","span":{"begin":680,"end":694},"obj":"CHEBI:50858;CHEBI:50858"},{"id":"T68219","span":{"begin":151,"end":158},"obj":"CHEBI:59132;CHEBI:59132"},{"id":"T22792","span":{"begin":261,"end":270},"obj":"UBERON:0006314"},{"id":"T68159","span":{"begin":305,"end":310},"obj":"CHEBI:68452;CHEBI:68452"},{"id":"T29336","span":{"begin":393,"end":398},"obj":"CHEBI:68452;CHEBI:68452"},{"id":"T94543","span":{"begin":649,"end":660},"obj":"CHEBI:33282;CHEBI:33282"},{"id":"T54450","span":{"begin":680,"end":694},"obj":"CHEBI:50858;CHEBI:50858"}],"text":"IAPA needs to be considered in patients admitted to the ICU with influenza and where indicated these patients should undergo early BAL for Aspergillus antigen testing, culture and microscopy. Patients who test positive require anti-Aspergillus therapy, and the BAL fluid sample should be fast-tracked for azole resistance testing by PCR (and culture when positive) in regions with high (\u003e 5%) azole resistance rates [34]. This would enable diagnostic assessment and initiation of adequate antifungal therapy within 24–48 h of ICU admission. Diagnostic workup for IAPA may be repeated in patients deteriorating while on antivirals and/or appropriate antibiotics or when initiating corticosteroid treatment is unavoidable."}

{"project":"2_test","denotations":[{"id":"32572532-30580035-47963427","span":{"begin":417,"end":419},"obj":"30580035"},{"id":"T67090","span":{"begin":417,"end":419},"obj":"30580035"}],"text":"IAPA needs to be considered in patients admitted to the ICU with influenza and where indicated these patients should undergo early BAL for Aspergillus antigen testing, culture and microscopy. Patients who test positive require anti-Aspergillus therapy, and the BAL fluid sample should be fast-tracked for azole resistance testing by PCR (and culture when positive) in regions with high (\u003e 5%) azole resistance rates [34]. This would enable diagnostic assessment and initiation of adequate antifungal therapy within 24–48 h of ICU admission. Diagnostic workup for IAPA may be repeated in patients deteriorating while on antivirals and/or appropriate antibiotics or when initiating corticosteroid treatment is unavoidable."}