PMC:7305584 / 1992-3865 JSONTXT

{"project":"2_test","denotations":[{"id":"32563264-23242844-12762887","span":{"begin":173,"end":174},"obj":"23242844"},{"id":"32563264-16286400-12762888","span":{"begin":176,"end":177},"obj":"16286400"},{"id":"32563264-16286400-12762889","span":{"begin":387,"end":388},"obj":"16286400"},{"id":"32563264-17110667-12762889","span":{"begin":387,"end":388},"obj":"17110667"},{"id":"32563264-16971618-12762889","span":{"begin":387,"end":388},"obj":"16971618"},{"id":"32563264-22680247-12762890","span":{"begin":670,"end":671},"obj":"22680247"},{"id":"32563264-25653228-12762890","span":{"begin":670,"end":671},"obj":"25653228"},{"id":"32563264-27048958-12762890","span":{"begin":670,"end":671},"obj":"27048958"},{"id":"32563264-27028475-12762890","span":{"begin":670,"end":671},"obj":"27028475"},{"id":"32563264-9530305-12762891","span":{"begin":770,"end":771},"obj":"9530305"},{"id":"32563264-30692833-12762891","span":{"begin":770,"end":771},"obj":"30692833"},{"id":"32563264-10835455-12762891","span":{"begin":770,"end":771},"obj":"10835455"},{"id":"32563264-20933644-12762892","span":{"begin":1042,"end":1044},"obj":"20933644"},{"id":"32563264-11990810-12762893","span":{"begin":1046,"end":1048},"obj":"11990810"},{"id":"32563264-15749975-12762894","span":{"begin":1188,"end":1190},"obj":"15749975"},{"id":"32563264-25564234-12762894","span":{"begin":1188,"end":1190},"obj":"25564234"},{"id":"32563264-16971634-12762894","span":{"begin":1188,"end":1190},"obj":"16971634"},{"id":"32563264-25388677-12762894","span":{"begin":1188,"end":1190},"obj":"25388677"},{"id":"32563264-25564234-12762895","span":{"begin":1283,"end":1285},"obj":"25564234"},{"id":"32563264-17110667-12762896","span":{"begin":1338,"end":1339},"obj":"17110667"},{"id":"32563264-17564178-12762897","span":{"begin":1341,"end":1343},"obj":"17564178"}],"text":"Background\nIn patients with cerebral aneurysms, numerical simulation could provide important hemodynamic information about the aneurysm formation, enlargement, and rupture [1, 2]. Accurate computation fluid dynamic calculations are based on 2 basic conditions: 1) detailed 3-dimensional (3D) angio-architecture and 2) accurate/reasonable physiologic setting of the target vascular tree [2–4]. However, essential patient-specific physiologic data, such as flow volume and flow rate of the proximal parent artery, are usually lacking for numerical analysis. Consequently, average blood flow data from the general population, rather than patient-specific values, are used [5–8].\nIt is reported that approximately half of the population has Circle of Willis (COW) variants [9–12]. On the other hand, cerebral aneurysms are not uncommon in patients with asymmetric COW variants, such as anterior communicating artery (AcomA) aneurysms in A1 aplasia, and posterior communicating artery (PcomA) aneurysms in fetal posterior cerebral artery (F-PCA) [13, 14]. Moreover, carotid flow contralateral to A1 aplasia, and ipsilateral to F-PCA, has been shown to be greater than those with a normal COW [15–18]. Total brain blood flow and distribution in different COW-types also had been proposed [16]. It had been shown that inflow boundary condition [3, 19], especially parent artery flow volume and the conjoint inflow ratio, affect the hemodynamic parameters of cerebral aneurysms. Therefore, adjustment of inflow boundary conditions for cerebral aneurysm analysis according to different COW types is important for obtaining reliable simulation results.\nThus, the purpose of this study was to investigate the association of bilateral ICA flow in healthy adults with asymmetric COW variants, and develop a method for predicting COW asymmetry and the representative carotid flow volume."}