PMC:7305584 / 16708-18442 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7305584","sourcedb":"PMC","sourceid":"7305584","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7305584","text":"A moderately positive linear correlation between ICA diameter and ICA flow in the AA group (R2 = 0.238) was noted (Fig. 4a) According to the linear equation, there was a 62.6 ml increase in the ICA flow volume per 1 mm increase in the ICA diameter. Based on the average ICA flow volume of 265.9 ml/min in the AA group, it implied a change of 23.5% of the ICA flow volume per 1 mm change in the ICA diameter. On the other hand, no significant association was noted between ICA diameter and flow volume in either the PA (Fig. 4b) and symmetric groups (Fig. 4c). Carotid diameter and flow differences for each group of COW variants are shown in Table 2. All parameters, including ICA diameter difference, ICA flow difference, ICA flow difference percentage, and product of bilateral ICA diameter and flow difference (ICA-PDF) of each AA group exhibited significant differences. Among them, ICA-PDF had the highest area under the ROC curve (AUC = 0.807) for discriminating the AA1 and AA2 groups from the others, followed by ICA diameter difference (AUC = 0.771), ICA flow difference percentage (AUC = 0.703), and ICA flow difference (AUC = 0.695) (Fig. 5a). For the prediction of A1 absence, ICA-PDF and ICA-diameter difference exhibited even higher accuracy for discriminating the AA1 group from the other groups (Fig. 5b). The optimal cutoff value for bilateral A1 asymmetry ≥50% was a PDF = 4.31 with a sensitivity of 0.81 and specificity of 0.76.\nFig. 4 Linear regression analysis of ICA diameter and ICA flow in each group of COW variants. (a) AA group, (b) PA group, and (c) symmetric group\nFig. 5 ROC curve of all parameters of ICA diameter and flow difference of different AA groups. (a) AA1 \u0026 AA2 vs others and (b) AA1 vs others","divisions":[{"label":"figure","span":{"begin":1448,"end":1593}},{"label":"label","span":{"begin":1448,"end":1454}},{"label":"caption","span":{"begin":1455,"end":1593}},{"label":"p","span":{"begin":1455,"end":1593}},{"label":"label","span":{"begin":1594,"end":1600}}],"tracks":[]}