PMC:7301886 / 17568-18052 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T201","span":{"begin":34,"end":47},"obj":"CHEBI:39867;CHEBI:39867"},{"id":"T202","span":{"begin":63,"end":69},"obj":"PR:000029554"},{"id":"T203","span":{"begin":75,"end":85},"obj":"GO:0010467"},{"id":"T204","span":{"begin":89,"end":95},"obj":"UBERON:0002405;CL:0000738"},{"id":"T205","span":{"begin":96,"end":101},"obj":"CL:0000738"},{"id":"T206","span":{"begin":109,"end":114},"obj":"UBERON:0000178"},{"id":"T207","span":{"begin":279,"end":292},"obj":"CHEBI:39867;CHEBI:39867"},{"id":"T208","span":{"begin":311,"end":326},"obj":"GO:0010628"},{"id":"T209","span":{"begin":350,"end":356},"obj":"PR:000029554"},{"id":"T70315","span":{"begin":34,"end":47},"obj":"CHEBI:39867;CHEBI:39867"},{"id":"T21276","span":{"begin":63,"end":69},"obj":"PR:000029554"},{"id":"T63254","span":{"begin":75,"end":85},"obj":"GO:0010467"},{"id":"T28820","span":{"begin":89,"end":95},"obj":"UBERON:0002405;CL:0000738"},{"id":"T11478","span":{"begin":96,"end":101},"obj":"CL:0000738"},{"id":"T7870","span":{"begin":109,"end":114},"obj":"UBERON:0000178"},{"id":"T42565","span":{"begin":279,"end":292},"obj":"CHEBI:39867;CHEBI:39867"},{"id":"T36537","span":{"begin":311,"end":326},"obj":"GO:0010628"},{"id":"T81133","span":{"begin":350,"end":356},"obj":"PR:000029554"}],"text":"In order to examine the effect of valproic acid therapy on the IFITM3 mRNA expression in immune cells of the blood, a publicly available transcriptomics dataset (GSE143272) was extracted and reanalyzed. Healthy controls were compared to responders and non-responders patients on valproic acid therapy. We found upregulation of the mRNA expression of IFITM3 in patients, and the difference was significant in the responder group only (p \u003c 0.05) compared to healthy controls (Figure 4)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T128","span":{"begin":70,"end":74},"obj":"Body_part"},{"id":"T129","span":{"begin":96,"end":101},"obj":"Body_part"},{"id":"T130","span":{"begin":109,"end":114},"obj":"Body_part"},{"id":"T131","span":{"begin":331,"end":335},"obj":"Body_part"}],"attributes":[{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A129","pred":"fma_id","subj":"T129","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma67122"}],"text":"In order to examine the effect of valproic acid therapy on the IFITM3 mRNA expression in immune cells of the blood, a publicly available transcriptomics dataset (GSE143272) was extracted and reanalyzed. Healthy controls were compared to responders and non-responders patients on valproic acid therapy. We found upregulation of the mRNA expression of IFITM3 in patients, and the difference was significant in the responder group only (p \u003c 0.05) compared to healthy controls (Figure 4)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T27","span":{"begin":109,"end":114},"obj":"Body_part"}],"attributes":[{"id":"A27","pred":"uberon_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"In order to examine the effect of valproic acid therapy on the IFITM3 mRNA expression in immune cells of the blood, a publicly available transcriptomics dataset (GSE143272) was extracted and reanalyzed. Healthy controls were compared to responders and non-responders patients on valproic acid therapy. We found upregulation of the mRNA expression of IFITM3 in patients, and the difference was significant in the responder group only (p \u003c 0.05) compared to healthy controls (Figure 4)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"776","span":{"begin":63,"end":69},"obj":"Gene"},{"id":"777","span":{"begin":350,"end":356},"obj":"Gene"},{"id":"778","span":{"begin":267,"end":275},"obj":"Species"},{"id":"779","span":{"begin":360,"end":368},"obj":"Species"},{"id":"780","span":{"begin":34,"end":47},"obj":"Chemical"},{"id":"781","span":{"begin":279,"end":292},"obj":"Chemical"}],"attributes":[{"id":"A776","pred":"tao:has_database_id","subj":"776","obj":"Gene:10410"},{"id":"A777","pred":"tao:has_database_id","subj":"777","obj":"Gene:10410"},{"id":"A778","pred":"tao:has_database_id","subj":"778","obj":"Tax:9606"},{"id":"A779","pred":"tao:has_database_id","subj":"779","obj":"Tax:9606"},{"id":"A780","pred":"tao:has_database_id","subj":"780","obj":"MESH:D014635"},{"id":"A781","pred":"tao:has_database_id","subj":"781","obj":"MESH:D014635"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In order to examine the effect of valproic acid therapy on the IFITM3 mRNA expression in immune cells of the blood, a publicly available transcriptomics dataset (GSE143272) was extracted and reanalyzed. Healthy controls were compared to responders and non-responders patients on valproic acid therapy. We found upregulation of the mRNA expression of IFITM3 in patients, and the difference was significant in the responder group only (p \u003c 0.05) compared to healthy controls (Figure 4)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T276","span":{"begin":96,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T277","span":{"begin":109,"end":114},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T278","span":{"begin":109,"end":114},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T279","span":{"begin":116,"end":117},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"In order to examine the effect of valproic acid therapy on the IFITM3 mRNA expression in immune cells of the blood, a publicly available transcriptomics dataset (GSE143272) was extracted and reanalyzed. Healthy controls were compared to responders and non-responders patients on valproic acid therapy. We found upregulation of the mRNA expression of IFITM3 in patients, and the difference was significant in the responder group only (p \u003c 0.05) compared to healthy controls (Figure 4)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T119","span":{"begin":34,"end":47},"obj":"Chemical"},{"id":"T120","span":{"begin":43,"end":47},"obj":"Chemical"},{"id":"T121","span":{"begin":279,"end":292},"obj":"Chemical"},{"id":"T122","span":{"begin":288,"end":292},"obj":"Chemical"},{"id":"T123","span":{"begin":422,"end":427},"obj":"Chemical"}],"attributes":[{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_39867"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_39867"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"}],"text":"In order to examine the effect of valproic acid therapy on the IFITM3 mRNA expression in immune cells of the blood, a publicly available transcriptomics dataset (GSE143272) was extracted and reanalyzed. Healthy controls were compared to responders and non-responders patients on valproic acid therapy. We found upregulation of the mRNA expression of IFITM3 in patients, and the difference was significant in the responder group only (p \u003c 0.05) compared to healthy controls (Figure 4)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T175","span":{"begin":203,"end":301},"obj":"Sentence"},{"id":"T176","span":{"begin":302,"end":484},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In order to examine the effect of valproic acid therapy on the IFITM3 mRNA expression in immune cells of the blood, a publicly available transcriptomics dataset (GSE143272) was extracted and reanalyzed. Healthy controls were compared to responders and non-responders patients on valproic acid therapy. We found upregulation of the mRNA expression of IFITM3 in patients, and the difference was significant in the responder group only (p \u003c 0.05) compared to healthy controls (Figure 4)."}