PMC:7301188 / 1619-2626 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7301188","sourcedb":"PMC","sourceid":"7301188","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7301188","text":"1. Introduction\nCOVID-19 which emerged in Wuhan, Hubei Province, China, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is typically spread via respiratory droplets and during close contact. The main clinical manifestation is lung injury[1, 2]. Most of the patients have a favorable prognosis, but some rapidly progress to severe and critical cases with respiratory distress syndrome, coagulation dysfunction, multiple organ failure, etc.[3, 4]. Therefore, early identification of the severity is very important to the clinical diagnosis of and treatment for COVID-19. Commonly used clinical laboratory coagulation indexes, such as D-dimer (DD), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (Fg), could sensitively reflect the clotting state of the body.\nThe aim of the report is to investigate role of the dynamic changes of DD, PT, APTT, TT, and Fg in predicting the severity and prognosis in patients with 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