PMC:7299399 / 6162-6677 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T18","span":{"begin":115,"end":122},"obj":"Body_part"},{"id":"T19","span":{"begin":216,"end":221},"obj":"Body_part"},{"id":"T20","span":{"begin":290,"end":297},"obj":"Body_part"},{"id":"T21","span":{"begin":393,"end":400},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"At present, there are three main strategies to block ACE2 binding: (i) administration of soluble, recombinant ACE2 protein, which acts as a decoy receptor to scavenge the virus and, thus, to prevent uptake into host cells;21 (ii) vaccination with antibodies that specifically bind to the S protein and interfere with ACE2 interaction; and (iii) inhibition of host proteases that process the S protein and are essential for ACE2 binding and subsequent membrane fusion to enable intracellular delivery of the virus.23"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T59","span":{"begin":138,"end":139},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T60","span":{"begin":171,"end":176},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T61","span":{"begin":216,"end":221},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T62","span":{"begin":451,"end":459},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T63","span":{"begin":507,"end":512},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"At present, there are three main strategies to block ACE2 binding: (i) administration of soluble, recombinant ACE2 protein, which acts as a decoy receptor to scavenge the virus and, thus, to prevent uptake into host cells;21 (ii) vaccination with antibodies that specifically bind to the S protein and interfere with ACE2 interaction; and (iii) inhibition of host proteases that process the S protein and are essential for ACE2 binding and subsequent membrane fusion to enable intracellular delivery of the virus.23"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T21","span":{"begin":115,"end":122},"obj":"Chemical"},{"id":"T22","span":{"begin":290,"end":297},"obj":"Chemical"},{"id":"T23","span":{"begin":393,"end":400},"obj":"Chemical"}],"attributes":[{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"At present, there are three main strategies to block ACE2 binding: (i) administration of soluble, recombinant ACE2 protein, which acts as a decoy receptor to scavenge the virus and, thus, to prevent uptake into host cells;21 (ii) vaccination with antibodies that specifically bind to the S protein and interfere with ACE2 interaction; and (iii) inhibition of host proteases that process the S protein and are essential for ACE2 binding and subsequent membrane fusion to enable intracellular delivery of the virus.23"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T9","span":{"begin":199,"end":205},"obj":"http://purl.obolibrary.org/obo/GO_0098739"},{"id":"T10","span":{"begin":199,"end":205},"obj":"http://purl.obolibrary.org/obo/GO_0098657"},{"id":"T11","span":{"begin":451,"end":466},"obj":"http://purl.obolibrary.org/obo/GO_0061025"}],"text":"At present, there are three main strategies to block ACE2 binding: (i) administration of soluble, recombinant ACE2 protein, which acts as a decoy receptor to scavenge the virus and, thus, to prevent uptake into host cells;21 (ii) vaccination with antibodies that specifically bind to the S protein and interfere with ACE2 interaction; and (iii) inhibition of host proteases that process the S protein and are essential for ACE2 binding and subsequent membrane fusion to enable intracellular delivery of the virus.23"}

{"project":"LitCovid-sentences","denotations":[{"id":"T30","span":{"begin":0,"end":515},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"At present, there are three main strategies to block ACE2 binding: (i) administration of soluble, recombinant ACE2 protein, which acts as a decoy receptor to scavenge the virus and, thus, to prevent uptake into host cells;21 (ii) vaccination with antibodies that specifically bind to the S protein and interfere with ACE2 interaction; and (iii) inhibition of host proteases that process the S protein and are essential for ACE2 binding and subsequent membrane fusion to enable intracellular delivery of the virus.23"}

{"project":"LitCovid-PubTator","denotations":[{"id":"130","span":{"begin":53,"end":57},"obj":"Gene"},{"id":"131","span":{"begin":110,"end":114},"obj":"Gene"},{"id":"132","span":{"begin":317,"end":321},"obj":"Gene"},{"id":"133","span":{"begin":423,"end":427},"obj":"Gene"},{"id":"134","span":{"begin":391,"end":392},"obj":"Gene"},{"id":"135","span":{"begin":288,"end":289},"obj":"Gene"}],"attributes":[{"id":"A130","pred":"tao:has_database_id","subj":"130","obj":"Gene:59272"},{"id":"A131","pred":"tao:has_database_id","subj":"131","obj":"Gene:59272"},{"id":"A132","pred":"tao:has_database_id","subj":"132","obj":"Gene:59272"},{"id":"A133","pred":"tao:has_database_id","subj":"133","obj":"Gene:59272"},{"id":"A134","pred":"tao:has_database_id","subj":"134","obj":"Gene:43740568"},{"id":"A135","pred":"tao:has_database_id","subj":"135","obj":"Gene:43740568"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"At present, there are three main strategies to block ACE2 binding: (i) administration of soluble, recombinant ACE2 protein, which acts as a decoy receptor to scavenge the virus and, thus, to prevent uptake into host cells;21 (ii) vaccination with antibodies that specifically bind to the S protein and interfere with ACE2 interaction; and (iii) inhibition of host proteases that process the S protein and are essential for ACE2 binding and subsequent membrane fusion to enable intracellular delivery of the virus.23"}

{"project":"2_test","denotations":[{"id":"32519842-32333836-158460","span":{"begin":222,"end":224},"obj":"32333836"},{"id":"32519842-32142651-158461","span":{"begin":513,"end":515},"obj":"32142651"}],"text":"At present, there are three main strategies to block ACE2 binding: (i) administration of soluble, recombinant ACE2 protein, which acts as a decoy receptor to scavenge the virus and, thus, to prevent uptake into host cells;21 (ii) vaccination with antibodies that specifically bind to the S protein and interfere with ACE2 interaction; and (iii) inhibition of host proteases that process the S protein and are essential for ACE2 binding and subsequent membrane fusion to enable intracellular delivery of the virus.23"}