PMC:7299399 / 5784-6231 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T16","span":{"begin":71,"end":78},"obj":"Body_part"},{"id":"T17","span":{"begin":243,"end":250},"obj":"Body_part"}],"attributes":[{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"in (i.e., receptor-binding domain of the envelope-embedded spike (S) 1 protein) of SARS-CoV-2 binds ACE2. The molecular details of this interaction have been provided by solving the crystal structure of the complex.24 Because binding of the S protein to ACE2 is critical for the first steps of infection, the most common treatment approaches focus on disrupting this key event. At present, there are three main strategies to block ACE2 binding: (i"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T36","span":{"begin":83,"end":91},"obj":"Disease"},{"id":"T37","span":{"begin":294,"end":303},"obj":"Disease"}],"attributes":[{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"in (i.e., receptor-binding domain of the envelope-embedded spike (S) 1 protein) of SARS-CoV-2 binds ACE2. The molecular details of this interaction have been provided by solving the crystal structure of the complex.24 Because binding of the S protein to ACE2 is critical for the first steps of infection, the most common treatment approaches focus on disrupting this key event. At present, there are three main strategies to block ACE2 binding: (i"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T57","span":{"begin":65,"end":70},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T58","span":{"begin":342,"end":347},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"}],"text":"in (i.e., receptor-binding domain of the envelope-embedded spike (S) 1 protein) of SARS-CoV-2 binds ACE2. The molecular details of this interaction have been provided by solving the crystal structure of the complex.24 Because binding of the S protein to ACE2 is critical for the first steps of infection, the most common treatment approaches focus on disrupting this key event. At present, there are three main strategies to block ACE2 binding: (i"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T19","span":{"begin":71,"end":78},"obj":"Chemical"},{"id":"T20","span":{"begin":243,"end":250},"obj":"Chemical"}],"attributes":[{"id":"A19","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"in (i.e., receptor-binding domain of the envelope-embedded spike (S) 1 protein) of SARS-CoV-2 binds ACE2. The molecular details of this interaction have been provided by solving the crystal structure of the complex.24 Because binding of the S protein to ACE2 is critical for the first steps of infection, the most common treatment approaches focus on disrupting this key event. At present, there are three main strategies to block ACE2 binding: (i"}

{"project":"LitCovid-sentences","denotations":[{"id":"T29","span":{"begin":106,"end":377},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"in (i.e., receptor-binding domain of the envelope-embedded spike (S) 1 protein) of SARS-CoV-2 binds ACE2. The molecular details of this interaction have been provided by solving the crystal structure of the complex.24 Because binding of the S protein to ACE2 is critical for the first steps of infection, the most common treatment approaches focus on disrupting this key event. At present, there are three main strategies to block ACE2 binding: (i"}

{"project":"LitCovid-PubTator","denotations":[{"id":"128","span":{"begin":100,"end":104},"obj":"Gene"},{"id":"129","span":{"begin":254,"end":258},"obj":"Gene"},{"id":"130","span":{"begin":431,"end":435},"obj":"Gene"},{"id":"136","span":{"begin":83,"end":93},"obj":"Species"},{"id":"137","span":{"begin":294,"end":303},"obj":"Disease"}],"attributes":[{"id":"A128","pred":"tao:has_database_id","subj":"128","obj":"Gene:59272"},{"id":"A129","pred":"tao:has_database_id","subj":"129","obj":"Gene:59272"},{"id":"A130","pred":"tao:has_database_id","subj":"130","obj":"Gene:59272"},{"id":"A136","pred":"tao:has_database_id","subj":"136","obj":"Tax:2697049"},{"id":"A137","pred":"tao:has_database_id","subj":"137","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"in (i.e., receptor-binding domain of the envelope-embedded spike (S) 1 protein) of SARS-CoV-2 binds ACE2. The molecular details of this interaction have been provided by solving the crystal structure of the complex.24 Because binding of the S protein to ACE2 is critical for the first steps of infection, the most common treatment approaches focus on disrupting this key event. At present, there are three main strategies to block ACE2 binding: (i"}

{"project":"2_test","denotations":[{"id":"32519842-32275855-158459","span":{"begin":215,"end":217},"obj":"32275855"}],"text":"in (i.e., receptor-binding domain of the envelope-embedded spike (S) 1 protein) of SARS-CoV-2 binds ACE2. The molecular details of this interaction have been provided by solving the crystal structure of the complex.24 Because binding of the S protein to ACE2 is critical for the first steps of infection, the most common treatment approaches focus on disrupting this key event. At present, there are three main strategies to block ACE2 binding: (i"}