PMC:7299399 / 45147-45693 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T213","span":{"begin":48,"end":55},"obj":"Body_part"},{"id":"T214","span":{"begin":88,"end":101},"obj":"Body_part"},{"id":"T215","span":{"begin":88,"end":92},"obj":"Body_part"},{"id":"T216","span":{"begin":261,"end":263},"obj":"Body_part"},{"id":"T217","span":{"begin":368,"end":372},"obj":"Body_part"}],"attributes":[{"id":"A213","pred":"fma_id","subj":"T213","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A214","pred":"fma_id","subj":"T214","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A215","pred":"fma_id","subj":"T215","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A216","pred":"fma_id","subj":"T216","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A217","pred":"fma_id","subj":"T217","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"In this case, viral recognition via its surface protein hemagglutinin of SA on the host cell membrane was a prerequisite for cellular entry.127 More recently, Cagno et al. reported antiviral NPs (Au and iron oxide core) with long and flexible linkers mimicking HS that strongly bind and inactivate viruses such as respiratory syncytial virus in vitro and in vivo in a lung infection model and even led to irreversible viral deformation.53 Hence, there is ample evidence that biocompatible, functionalized NPs can act as broad-spectrum antivirals."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T53","span":{"begin":368,"end":372},"obj":"Body_part"}],"attributes":[{"id":"A53","pred":"uberon_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"In this case, viral recognition via its surface protein hemagglutinin of SA on the host cell membrane was a prerequisite for cellular entry.127 More recently, Cagno et al. reported antiviral NPs (Au and iron oxide core) with long and flexible linkers mimicking HS that strongly bind and inactivate viruses such as respiratory syncytial virus in vitro and in vivo in a lung infection model and even led to irreversible viral deformation.53 Hence, there is ample evidence that biocompatible, functionalized NPs can act as broad-spectrum antivirals."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T143","span":{"begin":373,"end":382},"obj":"Disease"}],"attributes":[{"id":"A143","pred":"mondo_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"In this case, viral recognition via its surface protein hemagglutinin of SA on the host cell membrane was a prerequisite for cellular entry.127 More recently, Cagno et al. reported antiviral NPs (Au and iron oxide core) with long and flexible linkers mimicking HS that strongly bind and inactivate viruses such as respiratory syncytial virus in vitro and in vivo in a lung infection model and even led to irreversible viral deformation.53 Hence, there is ample evidence that biocompatible, functionalized NPs can act as broad-spectrum antivirals."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T415","span":{"begin":88,"end":92},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T416","span":{"begin":93,"end":101},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T417","span":{"begin":106,"end":107},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T418","span":{"begin":298,"end":305},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T419","span":{"begin":336,"end":341},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T420","span":{"begin":366,"end":367},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T421","span":{"begin":368,"end":372},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T422","span":{"begin":368,"end":372},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":"In this case, viral recognition via its surface protein hemagglutinin of SA on the host cell membrane was a prerequisite for cellular entry.127 More recently, Cagno et al. reported antiviral NPs (Au and iron oxide core) with long and flexible linkers mimicking HS that strongly bind and inactivate viruses such as respiratory syncytial virus in vitro and in vivo in a lung infection model and even led to irreversible viral deformation.53 Hence, there is ample evidence that biocompatible, functionalized NPs can act as broad-spectrum antivirals."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T370","span":{"begin":48,"end":55},"obj":"Chemical"},{"id":"T371","span":{"begin":73,"end":75},"obj":"Chemical"},{"id":"T376","span":{"begin":181,"end":190},"obj":"Chemical"},{"id":"T377","span":{"begin":191,"end":194},"obj":"Chemical"},{"id":"T378","span":{"begin":196,"end":198},"obj":"Chemical"},{"id":"T379","span":{"begin":203,"end":213},"obj":"Chemical"},{"id":"T381","span":{"begin":203,"end":207},"obj":"Chemical"},{"id":"T382","span":{"begin":208,"end":213},"obj":"Chemical"},{"id":"T384","span":{"begin":261,"end":263},"obj":"Chemical"},{"id":"T386","span":{"begin":505,"end":508},"obj":"Chemical"},{"id":"T387","span":{"begin":535,"end":545},"obj":"Chemical"}],"attributes":[{"id":"A370","pred":"chebi_id","subj":"T370","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A371","pred":"chebi_id","subj":"T371","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A372","pred":"chebi_id","subj":"T371","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A373","pred":"chebi_id","subj":"T371","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A374","pred":"chebi_id","subj":"T371","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A375","pred":"chebi_id","subj":"T371","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A376","pred":"chebi_id","subj":"T376","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A377","pred":"chebi_id","subj":"T377","obj":"http://purl.obolibrary.org/obo/CHEBI_50803"},{"id":"A378","pred":"chebi_id","subj":"T378","obj":"http://purl.obolibrary.org/obo/CHEBI_29287"},{"id":"A379","pred":"chebi_id","subj":"T379","obj":"http://purl.obolibrary.org/obo/CHEBI_50816"},{"id":"A380","pred":"chebi_id","subj":"T379","obj":"http://purl.obolibrary.org/obo/CHEBI_50820"},{"id":"A381","pred":"chebi_id","subj":"T381","obj":"http://purl.obolibrary.org/obo/CHEBI_18248"},{"id":"A382","pred":"chebi_id","subj":"T382","obj":"http://purl.obolibrary.org/obo/CHEBI_25741"},{"id":"A383","pred":"chebi_id","subj":"T382","obj":"http://purl.obolibrary.org/obo/CHEBI_29356"},{"id":"A384","pred":"chebi_id","subj":"T384","obj":"http://purl.obolibrary.org/obo/CHEBI_74056"},{"id":"A385","pred":"chebi_id","subj":"T384","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A386","pred":"chebi_id","subj":"T386","obj":"http://purl.obolibrary.org/obo/CHEBI_50803"},{"id":"A387","pred":"chebi_id","subj":"T387","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"}],"text":"In this case, viral recognition via its surface protein hemagglutinin of SA on the host cell membrane was a prerequisite for cellular entry.127 More recently, Cagno et al. reported antiviral NPs (Au and iron oxide core) with long and flexible linkers mimicking HS that strongly bind and inactivate viruses such as respiratory syncytial virus in vitro and in vivo in a lung infection model and even led to irreversible viral deformation.53 Hence, there is ample evidence that biocompatible, functionalized NPs can act as broad-spectrum antivirals."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T5","span":{"begin":261,"end":263},"obj":"GlycoEpitope"}],"attributes":[{"id":"A5","pred":"glyco_epitope_db_id","subj":"T5","obj":"http://www.glycoepitope.jp/epitopes/EP0086"}],"text":"In this case, viral recognition via its surface protein hemagglutinin of SA on the host cell membrane was a prerequisite for cellular entry.127 More recently, Cagno et al. reported antiviral NPs (Au and iron oxide core) with long and flexible linkers mimicking HS that strongly bind and inactivate viruses such as respiratory syncytial virus in vitro and in vivo in a lung infection model and even led to irreversible viral deformation.53 Hence, there is ample evidence that biocompatible, functionalized NPs can act as broad-spectrum antivirals."}

{"project":"LitCovid-sentences","denotations":[{"id":"T176","span":{"begin":0,"end":546},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In this case, viral recognition via its surface protein hemagglutinin of SA on the host cell membrane was a prerequisite for cellular entry.127 More recently, Cagno et al. reported antiviral NPs (Au and iron oxide core) with long and flexible linkers mimicking HS that strongly bind and inactivate viruses such as respiratory syncytial virus in vitro and in vivo in a lung infection model and even led to irreversible viral deformation.53 Hence, there is ample evidence that biocompatible, functionalized NPs can act as broad-spectrum antivirals."}

{"project":"LitCovid-PubTator","denotations":[{"id":"676","span":{"begin":314,"end":341},"obj":"Species"},{"id":"681","span":{"begin":73,"end":75},"obj":"Chemical"},{"id":"682","span":{"begin":203,"end":213},"obj":"Chemical"},{"id":"686","span":{"begin":368,"end":382},"obj":"Disease"},{"id":"687","span":{"begin":418,"end":435},"obj":"Disease"}],"attributes":[{"id":"A676","pred":"tao:has_database_id","subj":"676","obj":"Tax:12814"},{"id":"A681","pred":"tao:has_database_id","subj":"681","obj":"MESH:D012794"},{"id":"A682","pred":"tao:has_database_id","subj":"682","obj":"MESH:C000499"},{"id":"A686","pred":"tao:has_database_id","subj":"686","obj":"MESH:D012141"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In this case, viral recognition via its surface protein hemagglutinin of SA on the host cell membrane was a prerequisite for cellular entry.127 More recently, Cagno et al. reported antiviral NPs (Au and iron oxide core) with long and flexible linkers mimicking HS that strongly bind and inactivate viruses such as respiratory syncytial virus in vitro and in vivo in a lung infection model and even led to irreversible viral deformation.53 Hence, there is ample evidence that biocompatible, functionalized NPs can act as broad-spectrum antivirals."}

{"project":"2_test","denotations":[{"id":"32519842-21104827-158551","span":{"begin":140,"end":143},"obj":"21104827"},{"id":"32519842-29251725-158552","span":{"begin":436,"end":438},"obj":"29251725"}],"text":"In this case, viral recognition via its surface protein hemagglutinin of SA on the host cell membrane was a prerequisite for cellular entry.127 More recently, Cagno et al. reported antiviral NPs (Au and iron oxide core) with long and flexible linkers mimicking HS that strongly bind and inactivate viruses such as respiratory syncytial virus in vitro and in vivo in a lung infection model and even led to irreversible viral deformation.53 Hence, there is ample evidence that biocompatible, functionalized NPs can act as broad-spectrum antivirals."}