PMC:7299399 / 31638-32333 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7299399","sourcedb":"PMC","sourceid":"7299399","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7299399","text":"een and lymph nodes.100 Notably, immunohistochemical and immunofluorescence analyses of lymph nodes and spleen tissue from autopsy samples of patients who died from COVID-19 revealed lymphocytic apoptosis. The tissues infected by SARS-CoV-2 also showed an upregulated expression of Fas, suggesting a role for CD169+ macrophages in viral spreading, aberrant inflammation, and activation-induced lymphocyte apoptosis. Moreover, histological examinations of biopsy samples of patients who died from COVID-19 revealed an increased alveolar exudate due to the extended neutrophil and monocyte infiltrate in lung capillaries with fibrin deposition, probably leading to difficulties in gas exchange. Th","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T143","span":{"begin":8,"end":19},"obj":"Body_part"},{"id":"T144","span":{"begin":8,"end":13},"obj":"Body_part"},{"id":"T145","span":{"begin":88,"end":99},"obj":"Body_part"},{"id":"T146","span":{"begin":88,"end":93},"obj":"Body_part"},{"id":"T147","span":{"begin":104,"end":110},"obj":"Body_part"},{"id":"T148","span":{"begin":111,"end":117},"obj":"Body_part"},{"id":"T149","span":{"begin":183,"end":194},"obj":"Body_part"},{"id":"T150","span":{"begin":210,"end":217},"obj":"Body_part"},{"id":"T151","span":{"begin":316,"end":327},"obj":"Body_part"},{"id":"T152","span":{"begin":394,"end":404},"obj":"Body_part"},{"id":"T153","span":{"begin":527,"end":535},"obj":"Body_part"},{"id":"T154","span":{"begin":564,"end":574},"obj":"Body_part"},{"id":"T155","span":{"begin":579,"end":587},"obj":"Body_part"},{"id":"T156","span":{"begin":602,"end":606},"obj":"Body_part"},{"id":"T157","span":{"begin":607,"end":618},"obj":"Body_part"}],"attributes":[{"id":"A143","pred":"fma_id","subj":"T143","obj":"http://purl.org/sig/ont/fma/fma5034"},{"id":"A144","pred":"fma_id","subj":"T144","obj":"http://purl.org/sig/ont/fma/fma9671"},{"id":"A145","pred":"fma_id","subj":"T145","obj":"http://purl.org/sig/ont/fma/fma5034"},{"id":"A146","pred":"fma_id","subj":"T146","obj":"http://purl.org/sig/ont/fma/fma9671"},{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma7196"},{"id":"A148","pred":"fma_id","subj":"T148","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A149","pred":"fma_id","subj":"T149","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A150","pred":"fma_id","subj":"T150","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A151","pred":"fma_id","subj":"T151","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A152","pred":"fma_id","subj":"T152","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A155","pred":"fma_id","subj":"T155","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A157","pred":"fma_id","subj":"T157","obj":"http://purl.org/sig/ont/fma/fma63194"},{"subj":"T143","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T144","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T145","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T146","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T147","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T148","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T149","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T151","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T152","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T155","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T157","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T34","span":{"begin":8,"end":19},"obj":"Body_part"},{"id":"T35","span":{"begin":8,"end":13},"obj":"Body_part"},{"id":"T36","span":{"begin":88,"end":99},"obj":"Body_part"},{"id":"T37","span":{"begin":88,"end":93},"obj":"Body_part"},{"id":"T38","span":{"begin":104,"end":110},"obj":"Body_part"},{"id":"T39","span":{"begin":111,"end":117},"obj":"Body_part"},{"id":"T40","span":{"begin":536,"end":543},"obj":"Body_part"},{"id":"T41","span":{"begin":602,"end":606},"obj":"Body_part"}],"attributes":[{"id":"A34","pred":"uberon_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"A35","pred":"uberon_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/UBERON_0002391"},{"id":"A36","pred":"uberon_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"A37","pred":"uberon_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/UBERON_0002391"},{"id":"A38","pred":"uberon_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/UBERON_0002106"},{"id":"A39","pred":"uberon_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A40","pred":"uberon_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/UBERON_0007780"},{"id":"A41","pred":"uberon_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T119","span":{"begin":165,"end":173},"obj":"Disease"},{"id":"T120","span":{"begin":230,"end":238},"obj":"Disease"},{"id":"T121","span":{"begin":357,"end":369},"obj":"Disease"},{"id":"T122","span":{"begin":496,"end":504},"obj":"Disease"}],"attributes":[{"id":"A119","pred":"mondo_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A120","pred":"mondo_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A121","pred":"mondo_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A122","pred":"mondo_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T120","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T121","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T289","span":{"begin":8,"end":19},"obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"T290","span":{"begin":88,"end":99},"obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"T291","span":{"begin":104,"end":110},"obj":"http://purl.obolibrary.org/obo/UBERON_0002106"},{"id":"T292","span":{"begin":298,"end":299},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T293","span":{"begin":375,"end":385},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T294","span":{"begin":579,"end":587},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T295","span":{"begin":602,"end":606},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T296","span":{"begin":602,"end":606},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"attributes":[{"subj":"T289","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T290","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T291","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T292","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T293","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T294","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T295","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T296","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T41","span":{"begin":183,"end":204},"obj":"http://purl.obolibrary.org/obo/GO_0070227"},{"id":"T42","span":{"begin":195,"end":204},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T43","span":{"begin":195,"end":204},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T44","span":{"begin":357,"end":369},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T45","span":{"begin":394,"end":414},"obj":"http://purl.obolibrary.org/obo/GO_0070227"},{"id":"T46","span":{"begin":405,"end":414},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T47","span":{"begin":405,"end":414},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T48","span":{"begin":683,"end":691},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"attributes":[{"subj":"T41","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T124","span":{"begin":206,"end":415},"obj":"Sentence"},{"id":"T125","span":{"begin":416,"end":692},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T124","pred":"source","obj":"LitCovid-sentences"},{"subj":"T125","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"509","span":{"begin":309,"end":314},"obj":"Gene"},{"id":"512","span":{"begin":142,"end":150},"obj":"Species"},{"id":"513","span":{"begin":230,"end":240},"obj":"Species"},{"id":"514","span":{"begin":473,"end":481},"obj":"Species"},{"id":"522","span":{"begin":155,"end":159},"obj":"Disease"},{"id":"523","span":{"begin":165,"end":173},"obj":"Disease"},{"id":"524","span":{"begin":218,"end":226},"obj":"Disease"},{"id":"525","span":{"begin":357,"end":369},"obj":"Disease"},{"id":"526","span":{"begin":486,"end":490},"obj":"Disease"},{"id":"527","span":{"begin":496,"end":504},"obj":"Disease"}],"attributes":[{"id":"A509","pred":"tao:has_database_id","subj":"509","obj":"Gene:6614"},{"id":"A512","pred":"tao:has_database_id","subj":"512","obj":"Tax:9606"},{"id":"A513","pred":"tao:has_database_id","subj":"513","obj":"Tax:2697049"},{"id":"A514","pred":"tao:has_database_id","subj":"514","obj":"Tax:9606"},{"id":"A522","pred":"tao:has_database_id","subj":"522","obj":"MESH:D003643"},{"id":"A523","pred":"tao:has_database_id","subj":"523","obj":"MESH:C000657245"},{"id":"A524","pred":"tao:has_database_id","subj":"524","obj":"MESH:D007239"},{"id":"A525","pred":"tao:has_database_id","subj":"525","obj":"MESH:D007249"},{"id":"A526","pred":"tao:has_database_id","subj":"526","obj":"MESH:D003643"},{"id":"A527","pred":"tao:has_database_id","subj":"527","obj":"MESH:C000657245"},{"subj":"509","pred":"source","obj":"LitCovid-PubTator"},{"subj":"512","pred":"source","obj":"LitCovid-PubTator"},{"subj":"513","pred":"source","obj":"LitCovid-PubTator"},{"subj":"514","pred":"source","obj":"LitCovid-PubTator"},{"subj":"522","pred":"source","obj":"LitCovid-PubTator"},{"subj":"523","pred":"source","obj":"LitCovid-PubTator"},{"subj":"524","pred":"source","obj":"LitCovid-PubTator"},{"subj":"525","pred":"source","obj":"LitCovid-PubTator"},{"subj":"526","pred":"source","obj":"LitCovid-PubTator"},{"subj":"527","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#a793ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#98ec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93b2"},{"id":"LitCovid-PD-CLO","color":"#93ccec"},{"id":"LitCovid-PD-GO-BP","color":"#e6ec93"},{"id":"LitCovid-sentences","color":"#d893ec"},{"id":"LitCovid-PubTator","color":"#93ecbe"}]}]}}