PMC:7299399 / 29992-30592 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T126","span":{"begin":51,"end":62},"obj":"Body_part"},{"id":"T127","span":{"begin":64,"end":66},"obj":"Body_part"},{"id":"T128","span":{"begin":204,"end":206},"obj":"Body_part"},{"id":"T129","span":{"begin":231,"end":233},"obj":"Body_part"},{"id":"T130","span":{"begin":245,"end":253},"obj":"Body_part"},{"id":"T131","span":{"begin":273,"end":275},"obj":"Body_part"},{"id":"T132","span":{"begin":324,"end":332},"obj":"Body_part"},{"id":"T133","span":{"begin":526,"end":530},"obj":"Body_part"}],"attributes":[{"id":"A126","pred":"fma_id","subj":"T126","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A127","pred":"fma_id","subj":"T127","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A129","pred":"fma_id","subj":"T129","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A133","pred":"fma_id","subj":"T133","obj":"http://purl.org/sig/ont/fma/fma256135"}],"text":"in critical patients.98 In particular, the role of interleukin (IL)-6 has been highlighted in patients requiring assisted ventilation. Ongoing clinical trials are testing drugs that block the receptor of IL-6 (Tocilizumab, an anti-IL-6 receptor antibody, and Sarilumab) or IL-6 itself (Siltuximab).\nWhereas a well-regulated cytokine response that is rapidly triggered by the host’s innate immunity can serve to prevent and to counteract an infection, an excessive, unbalanced, prolonged immune response can seriously harm the body. Therefore, therapeutic strategies aimed at effectively suppressing t"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T116","span":{"begin":440,"end":449},"obj":"Disease"}],"attributes":[{"id":"A116","pred":"mondo_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"in critical patients.98 In particular, the role of interleukin (IL)-6 has been highlighted in patients requiring assisted ventilation. Ongoing clinical trials are testing drugs that block the receptor of IL-6 (Tocilizumab, an anti-IL-6 receptor antibody, and Sarilumab) or IL-6 itself (Siltuximab).\nWhereas a well-regulated cytokine response that is rapidly triggered by the host’s innate immunity can serve to prevent and to counteract an infection, an excessive, unbalanced, prolonged immune response can seriously harm the body. Therefore, therapeutic strategies aimed at effectively suppressing t"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T279","span":{"begin":70,"end":73},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T280","span":{"begin":163,"end":170},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T281","span":{"begin":307,"end":308},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"in critical patients.98 In particular, the role of interleukin (IL)-6 has been highlighted in patients requiring assisted ventilation. Ongoing clinical trials are testing drugs that block the receptor of IL-6 (Tocilizumab, an anti-IL-6 receptor antibody, and Sarilumab) or IL-6 itself (Siltuximab).\nWhereas a well-regulated cytokine response that is rapidly triggered by the host’s innate immunity can serve to prevent and to counteract an infection, an excessive, unbalanced, prolonged immune response can seriously harm the body. Therefore, therapeutic strategies aimed at effectively suppressing t"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T219","span":{"begin":64,"end":66},"obj":"Chemical"},{"id":"T221","span":{"begin":171,"end":176},"obj":"Chemical"},{"id":"T222","span":{"begin":204,"end":206},"obj":"Chemical"},{"id":"T224","span":{"begin":231,"end":233},"obj":"Chemical"},{"id":"T226","span":{"begin":273,"end":275},"obj":"Chemical"}],"attributes":[{"id":"A219","pred":"chebi_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A220","pred":"chebi_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A221","pred":"chebi_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A222","pred":"chebi_id","subj":"T222","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A223","pred":"chebi_id","subj":"T222","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A224","pred":"chebi_id","subj":"T224","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A225","pred":"chebi_id","subj":"T224","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A226","pred":"chebi_id","subj":"T226","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A227","pred":"chebi_id","subj":"T226","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"in critical patients.98 In particular, the role of interleukin (IL)-6 has been highlighted in patients requiring assisted ventilation. Ongoing clinical trials are testing drugs that block the receptor of IL-6 (Tocilizumab, an anti-IL-6 receptor antibody, and Sarilumab) or IL-6 itself (Siltuximab).\nWhereas a well-regulated cytokine response that is rapidly triggered by the host’s innate immunity can serve to prevent and to counteract an infection, an excessive, unbalanced, prolonged immune response can seriously harm the body. Therefore, therapeutic strategies aimed at effectively suppressing t"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T38","span":{"begin":382,"end":397},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T39","span":{"begin":487,"end":502},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"in critical patients.98 In particular, the role of interleukin (IL)-6 has been highlighted in patients requiring assisted ventilation. Ongoing clinical trials are testing drugs that block the receptor of IL-6 (Tocilizumab, an anti-IL-6 receptor antibody, and Sarilumab) or IL-6 itself (Siltuximab).\nWhereas a well-regulated cytokine response that is rapidly triggered by the host’s innate immunity can serve to prevent and to counteract an infection, an excessive, unbalanced, prolonged immune response can seriously harm the body. Therefore, therapeutic strategies aimed at effectively suppressing t"}

{"project":"LitCovid-sentences","denotations":[{"id":"T117","span":{"begin":135,"end":298},"obj":"Sentence"},{"id":"T118","span":{"begin":299,"end":531},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"in critical patients.98 In particular, the role of interleukin (IL)-6 has been highlighted in patients requiring assisted ventilation. Ongoing clinical trials are testing drugs that block the receptor of IL-6 (Tocilizumab, an anti-IL-6 receptor antibody, and Sarilumab) or IL-6 itself (Siltuximab).\nWhereas a well-regulated cytokine response that is rapidly triggered by the host’s innate immunity can serve to prevent and to counteract an infection, an excessive, unbalanced, prolonged immune response can seriously harm the body. Therefore, therapeutic strategies aimed at effectively suppressing t"}

{"project":"LitCovid-PubTator","denotations":[{"id":"464","span":{"begin":51,"end":69},"obj":"Gene"},{"id":"465","span":{"begin":204,"end":208},"obj":"Gene"},{"id":"466","span":{"begin":231,"end":235},"obj":"Gene"},{"id":"467","span":{"begin":273,"end":277},"obj":"Gene"},{"id":"469","span":{"begin":12,"end":20},"obj":"Species"},{"id":"470","span":{"begin":94,"end":102},"obj":"Species"},{"id":"471","span":{"begin":210,"end":221},"obj":"Chemical"},{"id":"472","span":{"begin":259,"end":268},"obj":"Chemical"},{"id":"473","span":{"begin":286,"end":296},"obj":"Chemical"},{"id":"481","span":{"begin":440,"end":449},"obj":"Disease"}],"attributes":[{"id":"A464","pred":"tao:has_database_id","subj":"464","obj":"Gene:3569"},{"id":"A465","pred":"tao:has_database_id","subj":"465","obj":"Gene:3569"},{"id":"A466","pred":"tao:has_database_id","subj":"466","obj":"Gene:3569"},{"id":"A467","pred":"tao:has_database_id","subj":"467","obj":"Gene:3569"},{"id":"A469","pred":"tao:has_database_id","subj":"469","obj":"Tax:9606"},{"id":"A470","pred":"tao:has_database_id","subj":"470","obj":"Tax:9606"},{"id":"A471","pred":"tao:has_database_id","subj":"471","obj":"MESH:C502936"},{"id":"A472","pred":"tao:has_database_id","subj":"472","obj":"MESH:C000592401"},{"id":"A473","pred":"tao:has_database_id","subj":"473","obj":"MESH:C504234"},{"id":"A481","pred":"tao:has_database_id","subj":"481","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"in critical patients.98 In particular, the role of interleukin (IL)-6 has been highlighted in patients requiring assisted ventilation. Ongoing clinical trials are testing drugs that block the receptor of IL-6 (Tocilizumab, an anti-IL-6 receptor antibody, and Sarilumab) or IL-6 itself (Siltuximab).\nWhereas a well-regulated cytokine response that is rapidly triggered by the host’s innate immunity can serve to prevent and to counteract an infection, an excessive, unbalanced, prolonged immune response can seriously harm the body. Therefore, therapeutic strategies aimed at effectively suppressing t"}