PMC:7295558 / 4018-7515 JSON TXT

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LitCovid-PMC-OGER-BB

LitCovid_Glycan-Motif-Structure

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":2232,"end":2236},"obj":"https://glytoucan.org/Structures/Glycans/G61168WC"},{"id":"T2","span":{"begin":2232,"end":2236},"obj":"https://glytoucan.org/Structures/Glycans/G79389NT"}],"text":"Case 1\nA 76-year-old man presented to the emergency room (ER) with a 10-day history of shortness of breath, fever and dry cough. He had a previous diagnosis of prostate cancer, currently in remittance. His baseline characteristics are shown in Table 1. He had leukopenia, elevated cardiac markers including creatine kinase (CK), creatine kinase myocardial band (CK-MB) and lactate dehydrogenase (LDH) and a severe acute respiratory distress syndrome (ARDS) with a PaO2/FiO2 ratio of 59, which was initially treated with a high-flow nasal cannula (HFNC) and supportive treatment. A TTE was performed during day 8 of his hospital stay. This revealed abnormal LV function with an LVEF of 35% and a GLS of -14%. Echocardiographic characteristics are shown in Table 2. He was intubated the next day and developed barotrauma with a right pneumothorax that required a pleural catheter for evacuation. Afterward, on his 10th day, he developed an acute kidney injury (AKI) with anuria, multiorgan failure and acidosis. He passed away on his 11th day.\nTable 1 Baseline Clinical and Laboratory Characteristics\nVariable Case 1 Case 2 Case 3 Case 4\nGender Male Male Male Male\nAge (years) 76 64 66 26\nComorbidities Prostate cancer HIV None None\nWhite blood cell count, /µL 11.2 8.6 14.3 8.1\nLymphocytes, /µL 0.306 0.483 0.563 1.4\nSerum creatinine, mg/dL 0.9 0.9 5.3 0.8\nAminotransferase\n Aspartate, U/L 44 96 99 68\n Alanine, U/L 40 108 43 85\n Albumin, g/dL 2.1 2 2.7 3.4\n hs-CRP, mg/dL 27 20.6 23.1 11.3\n ARDS Yes Yes Yes Yes\n PaO2/FiO2 ratio 59 66 180 258\nCardiac injury markers\n hs-TpnI, ng/L 2.8 5.4 5.6 1.4\n CK, U/L 721 868 517 50\n CK-MB, U/L 29 35.3 26.5 n/a\n LDH, U/L 312 259 424 317\nhs-CRP: high-sensitivity C-reactive protein; ARDS: acute respiratory distress syndrome; hs-TpnI: high-sensitivity troponin I; CK: creatine kinase; CK-MB: creatine kinase myocardial band; LDH: lactate dehydrogenase.\nTable 2 Echocardiographic characteristics and Recommended Reference Values\nVariable Case 1 Case 2 Case 3 Case 4 Reference value\nLV septal thickness, cm 0.8 1.2 1.1 0.7 0.6 - 1\nPosterior wall thickness, cm 0.8 1.1 0.8 0.9 0.6 - 1\nLV indexed mass, g/m2 80.7 56.5 81.4 73.6 49 - 115\nRelative wall thickness 0.31 0.47 0.32 0.37 0.24 - 0.42\nVfdVI MOD BP 38 76 n/a 83 62 - 150\nVfsVI MOD BP 25 26 n/a 56 21 - 61\nLVEF, % 35 66 65 33 52 - 72\nLeft atrial indexed volume, mL/m2 21.8 15.4 11.1 \u003c 34\nAverage GLS, % -14 -18 n/a -14 \u003c -18.5%\nAplax GLS, % -12 -18 n/a -14 \u003c -18.5%\na4C GLS, % -13 -18 n/a -13 \u003c -18.5%\na2C GLS, % -15 -19 n/a -14 \u003c -18.5%\nTAPSE, mm 25 26 20 20 \u003e 18\nS wave, cm/s 0.18 0.7 0.18 0.12 \u003e 0.095\nRV basal diameter, mm 33 34 47 39 25 - 41\nRV mid-cavity diameter, mm 29 22 45 34 19 - 35\nMV E wave velocity, m/s 0.5 0.83 0.54 0.38 \u003e 50\nMV deceleration time, ms 210 218 185 147 \u003e 200\nE/A ratio 0.63 1.03 0.69 0.44 ≥ 0.8\nSeptal e′ velocity, m/s 0.05 0.08 0.07 0.1 \u003e 7\nLateral e′ velocity, m/s 0.1 0.09 0.1 0.1 \u003e 10\nE/e′ ratio 6.6 9.66 6.27 3.78 \u003c 10\nData are shown as frequencies (%) and median (min. - max.) or mean ± SD. LV: left ventricular; LVEF: LV ejection fraction; GLS: global longitudinal strain; a4C: apical four-chamber view; APLAX: apical long axis view; a2C: apical two-chamber view; TAPSE: tricuspid annulus plane systolic excursion; RV: right ventricular; MV: mitral valve; n/a: not available."}

LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T5","span":{"begin":944,"end":950},"obj":"Body_part"},{"id":"T6","span":{"begin":1254,"end":1259},"obj":"Body_part"},{"id":"T7","span":{"begin":1341,"end":1346},"obj":"Body_part"},{"id":"T8","span":{"begin":3464,"end":3476},"obj":"Body_part"},{"id":"T9","span":{"begin":3471,"end":3476},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0002135"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0003978"}],"text":"Case 1\nA 76-year-old man presented to the emergency room (ER) with a 10-day history of shortness of breath, fever and dry cough. He had a previous diagnosis of prostate cancer, currently in remittance. His baseline characteristics are shown in Table 1. He had leukopenia, elevated cardiac markers including creatine kinase (CK), creatine kinase myocardial band (CK-MB) and lactate dehydrogenase (LDH) and a severe acute respiratory distress syndrome (ARDS) with a PaO2/FiO2 ratio of 59, which was initially treated with a high-flow nasal cannula (HFNC) and supportive treatment. A TTE was performed during day 8 of his hospital stay. This revealed abnormal LV function with an LVEF of 35% and a GLS of -14%. Echocardiographic characteristics are shown in Table 2. He was intubated the next day and developed barotrauma with a right pneumothorax that required a pleural catheter for evacuation. Afterward, on his 10th day, he developed an acute kidney injury (AKI) with anuria, multiorgan failure and acidosis. He passed away on his 11th day.\nTable 1 Baseline Clinical and Laboratory Characteristics\nVariable Case 1 Case 2 Case 3 Case 4\nGender Male Male Male Male\nAge (years) 76 64 66 26\nComorbidities Prostate cancer HIV None None\nWhite blood cell count, /µL 11.2 8.6 14.3 8.1\nLymphocytes, /µL 0.306 0.483 0.563 1.4\nSerum creatinine, mg/dL 0.9 0.9 5.3 0.8\nAminotransferase\n Aspartate, U/L 44 96 99 68\n Alanine, U/L 40 108 43 85\n Albumin, g/dL 2.1 2 2.7 3.4\n hs-CRP, mg/dL 27 20.6 23.1 11.3\n ARDS Yes Yes Yes Yes\n PaO2/FiO2 ratio 59 66 180 258\nCardiac injury markers\n hs-TpnI, ng/L 2.8 5.4 5.6 1.4\n CK, U/L 721 868 517 50\n CK-MB, U/L 29 35.3 26.5 n/a\n LDH, U/L 312 259 424 317\nhs-CRP: high-sensitivity C-reactive protein; ARDS: acute respiratory distress syndrome; hs-TpnI: high-sensitivity troponin I; CK: creatine kinase; CK-MB: creatine kinase myocardial band; LDH: lactate dehydrogenase.\nTable 2 Echocardiographic characteristics and Recommended Reference Values\nVariable Case 1 Case 2 Case 3 Case 4 Reference value\nLV septal thickness, cm 0.8 1.2 1.1 0.7 0.6 - 1\nPosterior wall thickness, cm 0.8 1.1 0.8 0.9 0.6 - 1\nLV indexed mass, g/m2 80.7 56.5 81.4 73.6 49 - 115\nRelative wall thickness 0.31 0.47 0.32 0.37 0.24 - 0.42\nVfdVI MOD BP 38 76 n/a 83 62 - 150\nVfsVI MOD BP 25 26 n/a 56 21 - 61\nLVEF, % 35 66 65 33 52 - 72\nLeft atrial indexed volume, mL/m2 21.8 15.4 11.1 \u003c 34\nAverage GLS, % -14 -18 n/a -14 \u003c -18.5%\nAplax GLS, % -12 -18 n/a -14 \u003c -18.5%\na4C GLS, % -13 -18 n/a -13 \u003c -18.5%\na2C GLS, % -15 -19 n/a -14 \u003c -18.5%\nTAPSE, mm 25 26 20 20 \u003e 18\nS wave, cm/s 0.18 0.7 0.18 0.12 \u003e 0.095\nRV basal diameter, mm 33 34 47 39 25 - 41\nRV mid-cavity diameter, mm 29 22 45 34 19 - 35\nMV E wave velocity, m/s 0.5 0.83 0.54 0.38 \u003e 50\nMV deceleration time, ms 210 218 185 147 \u003e 200\nE/A ratio 0.63 1.03 0.69 0.44 ≥ 0.8\nSeptal e′ velocity, m/s 0.05 0.08 0.07 0.1 \u003e 7\nLateral e′ velocity, m/s 0.1 0.09 0.1 0.1 \u003e 10\nE/e′ ratio 6.6 9.66 6.27 3.78 \u003c 10\nData are shown as frequencies (%) and median (min. - max.) or mean ± SD. LV: left ventricular; LVEF: LV ejection fraction; GLS: global longitudinal strain; a4C: apical four-chamber view; APLAX: apical long axis view; a2C: apical two-chamber view; TAPSE: tricuspid annulus plane systolic excursion; RV: right ventricular; MV: mitral valve; n/a: not available."}

LitCovid-PD-MONDO

LitCovid-PD-CLO

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T3","span":{"begin":362,"end":367},"obj":"http://purl.obolibrary.org/obo/GO_0004111"},{"id":"T4","span":{"begin":1692,"end":1697},"obj":"http://purl.obolibrary.org/obo/GO_0004111"},{"id":"T5","span":{"begin":1902,"end":1907},"obj":"http://purl.obolibrary.org/obo/GO_0004111"}],"text":"Case 1\nA 76-year-old man presented to the emergency room (ER) with a 10-day history of shortness of breath, fever and dry cough. He had a previous diagnosis of prostate cancer, currently in remittance. His baseline characteristics are shown in Table 1. He had leukopenia, elevated cardiac markers including creatine kinase (CK), creatine kinase myocardial band (CK-MB) and lactate dehydrogenase (LDH) and a severe acute respiratory distress syndrome (ARDS) with a PaO2/FiO2 ratio of 59, which was initially treated with a high-flow nasal cannula (HFNC) and supportive treatment. A TTE was performed during day 8 of his hospital stay. This revealed abnormal LV function with an LVEF of 35% and a GLS of -14%. Echocardiographic characteristics are shown in Table 2. He was intubated the next day and developed barotrauma with a right pneumothorax that required a pleural catheter for evacuation. Afterward, on his 10th day, he developed an acute kidney injury (AKI) with anuria, multiorgan failure and acidosis. He passed away on his 11th day.\nTable 1 Baseline Clinical and Laboratory Characteristics\nVariable Case 1 Case 2 Case 3 Case 4\nGender Male Male Male Male\nAge (years) 76 64 66 26\nComorbidities Prostate cancer HIV None None\nWhite blood cell count, /µL 11.2 8.6 14.3 8.1\nLymphocytes, /µL 0.306 0.483 0.563 1.4\nSerum creatinine, mg/dL 0.9 0.9 5.3 0.8\nAminotransferase\n Aspartate, U/L 44 96 99 68\n Alanine, U/L 40 108 43 85\n Albumin, g/dL 2.1 2 2.7 3.4\n hs-CRP, mg/dL 27 20.6 23.1 11.3\n ARDS Yes Yes Yes Yes\n PaO2/FiO2 ratio 59 66 180 258\nCardiac injury markers\n hs-TpnI, ng/L 2.8 5.4 5.6 1.4\n CK, U/L 721 868 517 50\n CK-MB, U/L 29 35.3 26.5 n/a\n LDH, U/L 312 259 424 317\nhs-CRP: high-sensitivity C-reactive protein; ARDS: acute respiratory distress syndrome; hs-TpnI: high-sensitivity troponin I; CK: creatine kinase; CK-MB: creatine kinase myocardial band; LDH: lactate dehydrogenase.\nTable 2 Echocardiographic characteristics and Recommended Reference Values\nVariable Case 1 Case 2 Case 3 Case 4 Reference value\nLV septal thickness, cm 0.8 1.2 1.1 0.7 0.6 - 1\nPosterior wall thickness, cm 0.8 1.1 0.8 0.9 0.6 - 1\nLV indexed mass, g/m2 80.7 56.5 81.4 73.6 49 - 115\nRelative wall thickness 0.31 0.47 0.32 0.37 0.24 - 0.42\nVfdVI MOD BP 38 76 n/a 83 62 - 150\nVfsVI MOD BP 25 26 n/a 56 21 - 61\nLVEF, % 35 66 65 33 52 - 72\nLeft atrial indexed volume, mL/m2 21.8 15.4 11.1 \u003c 34\nAverage GLS, % -14 -18 n/a -14 \u003c -18.5%\nAplax GLS, % -12 -18 n/a -14 \u003c -18.5%\na4C GLS, % -13 -18 n/a -13 \u003c -18.5%\na2C GLS, % -15 -19 n/a -14 \u003c -18.5%\nTAPSE, mm 25 26 20 20 \u003e 18\nS wave, cm/s 0.18 0.7 0.18 0.12 \u003e 0.095\nRV basal diameter, mm 33 34 47 39 25 - 41\nRV mid-cavity diameter, mm 29 22 45 34 19 - 35\nMV E wave velocity, m/s 0.5 0.83 0.54 0.38 \u003e 50\nMV deceleration time, ms 210 218 185 147 \u003e 200\nE/A ratio 0.63 1.03 0.69 0.44 ≥ 0.8\nSeptal e′ velocity, m/s 0.05 0.08 0.07 0.1 \u003e 7\nLateral e′ velocity, m/s 0.1 0.09 0.1 0.1 \u003e 10\nE/e′ ratio 6.6 9.66 6.27 3.78 \u003c 10\nData are shown as frequencies (%) and median (min. - max.) or mean ± SD. LV: left ventricular; LVEF: LV ejection fraction; GLS: global longitudinal strain; a4C: apical four-chamber view; APLAX: apical long axis view; a2C: apical two-chamber view; TAPSE: tricuspid annulus plane systolic excursion; RV: right ventricular; MV: mitral valve; n/a: not available."}

LitCovid-sentences

LitCovid-PD-HP

LitCovid-PubTator

PMC:7295558 / 4018-7515 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7295558 / 4018-7515 JSON TXT