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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T97 28-35 UBERON:0000948 denotes cardiac
T98 78-86 SP_7 denotes COVID-19
T99 104-115 UBERON:0002082 denotes ventricular
T100 149-158 UBERON:0000440 denotes tricuspid
T101 178-183 UBERON:0000948 denotes heart
T102 336-347 UBERON:0002082 denotes ventricular
T103 423-431 SP_7 denotes COVID-19
T104 436-446 UBERON:0002349 denotes myocardial
T105 573-580 UBERON:0000948 denotes cardiac
T106 737-744 UBERON:0000948 denotes cardiac
T107 783-801 PR:000005897 denotes C-reactive protein
T108 803-806 PR:000005897 denotes CRP
T109 935-945 UBERON:0002349 denotes myocardial
T110 971-982 UBERON:0002082 denotes ventricular
T111 1061-1071 UBERON:0002349 denotes myocardial
T112 1292-1299 UBERON:0000948 denotes cardiac
T113 1330-1340 UBERON:0002349 denotes myocardial
T114 1437-1447 UBERON:0002349 denotes myocardial
T115 1502-1510 SP_7 denotes COVID-19
T116 1521-1531 UBERON:0002349 denotes myocardial
T117 1610-1619 UBERON:0003126 denotes tricuspid
T118 1639-1648 UBERON:0003126 denotes tricuspid
T119 1685-1690 UBERON:0000178 denotes blood
T120 1750-1758 SP_10 denotes SARS-CoV
T121 1863-1871 SP_7 denotes COVID-19
T122 1883-1895 GO:0050817 denotes coagulopathy
T123 2001-2011 GO:0007596 denotes thrombotic
T124 2043-2051 SP_7 denotes COVID-19
T125 2060-2069 UBERON:0002048 denotes pulmonary
T126 2213-2222 UBERON:0002048 denotes pulmonary
T127 2332-2350 GO:0007596 denotes thromboprophylaxis
T128 2384-2392 UBERON:0010210 denotes thrombus
T129 2479-2483 UBERON:0002084 denotes LVEF
T130 2511-2519 SP_7 denotes COVID-19
T131 2582-2590 SP_7 denotes COVID-19
T132 2603-2612 UBERON:0003126 denotes tricuspid
T133 2658-2675 UBERON:0002080 denotes right ventricular
T134 2975-2996 UBERON:0004535 denotes cardiovascular system
T135 3000-3008 SP_7 denotes COVID-19
T136 3132-3146 UBERON:0000467 denotes health systems
T137 3162-3170 SP_7 denotes COVID-19
T138 3724-3732 SP_7 denotes COVID-19
T139 3839-3841 UBERON:0002084 denotes LV
T140 3892-3900 SP_7 denotes COVID-19
T141 3926-3936 UBERON:0002349 denotes myocardial
T11783 28-35 UBERON:0000948 denotes cardiac
T53834 78-86 SP_7 denotes COVID-19
T57764 104-115 UBERON:0002082 denotes ventricular
T73813 149-158 UBERON:0000440 denotes tricuspid
T46513 178-183 UBERON:0000948 denotes heart
T65862 336-347 UBERON:0002082 denotes ventricular
T80905 423-431 SP_7 denotes COVID-19
T30298 436-446 UBERON:0002349 denotes myocardial
T85721 573-580 UBERON:0000948 denotes cardiac
T21366 737-744 UBERON:0000948 denotes cardiac
T61564 783-801 PR:000005897 denotes C-reactive protein
T1212 803-806 PR:000005897 denotes CRP
T82092 935-945 UBERON:0002349 denotes myocardial
T30925 971-982 UBERON:0002082 denotes ventricular
T20891 1061-1071 UBERON:0002349 denotes myocardial
T63600 1292-1299 UBERON:0000948 denotes cardiac
T61077 1330-1340 UBERON:0002349 denotes myocardial
T88255 1437-1447 UBERON:0002349 denotes myocardial
T99292 1502-1510 SP_7 denotes COVID-19
T27430 1521-1531 UBERON:0002349 denotes myocardial
T28250 1610-1619 UBERON:0003126 denotes tricuspid
T15014 1639-1648 UBERON:0003126 denotes tricuspid
T8599 1685-1690 UBERON:0000178 denotes blood
T57055 1750-1758 SP_10 denotes SARS-CoV
T53160 1863-1871 SP_7 denotes COVID-19
T45664 1883-1895 GO:0050817 denotes coagulopathy
T77693 2001-2011 GO:0007596 denotes thrombotic
T68410 2043-2051 SP_7 denotes COVID-19
T1894 2060-2069 UBERON:0002048 denotes pulmonary
T50114 2213-2222 UBERON:0002048 denotes pulmonary
T22379 2332-2350 GO:0007596 denotes thromboprophylaxis
T60869 2384-2392 UBERON:0010210 denotes thrombus
T56248 2479-2483 UBERON:0002084 denotes LVEF
T35096 2511-2519 SP_7 denotes COVID-19
T52514 2582-2590 SP_7 denotes COVID-19
T95335 2603-2612 UBERON:0003126 denotes tricuspid
T975 2658-2675 UBERON:0002080 denotes right ventricular
T8000 2975-2996 UBERON:0004535 denotes cardiovascular system
T3799 3000-3008 SP_7 denotes COVID-19
T92270 3132-3146 UBERON:0000467 denotes health systems
T54715 3162-3170 SP_7 denotes COVID-19
T32846 3724-3732 SP_7 denotes COVID-19
T96327 3839-3841 UBERON:0002084 denotes LV
T46728 3892-3900 SP_7 denotes COVID-19
T4318 3926-3936 UBERON:0002349 denotes myocardial

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T26 178-183 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T27 544-553 Body_part denotes troponins http://purl.org/sig/ont/fma/fma62338
T28 745-754 Body_part denotes troponins http://purl.org/sig/ont/fma/fma62338
T29 794-801 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T30 818-827 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T31 1157-1166 Body_part denotes troponins http://purl.org/sig/ont/fma/fma62338
T32 1207-1216 Body_part denotes troponins http://purl.org/sig/ont/fma/fma62338
T33 1685-1690 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T34 2975-2996 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T15 178-183 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T16 1685-1690 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T17 2409-2414 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T18 2975-2996 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T68 78-86 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T69 178-191 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T70 423-431 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T71 581-587 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T72 946-952 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T73 954-966 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T74 1316-1318 Disease denotes CK http://purl.obolibrary.org/obo/MONDO_0017941
T75 1320-1322 Disease denotes CK http://purl.obolibrary.org/obo/MONDO_0017941
T76 1502-1510 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T77 1639-1662 Disease denotes tricuspid regurgitation http://purl.obolibrary.org/obo/MONDO_0002870
T78 1750-1768 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T79 1759-1768 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T80 1790-1802 Disease denotes endocarditis http://purl.obolibrary.org/obo/MONDO_0005025
T81 1863-1871 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T82 1883-1895 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T83 1897-1900 Disease denotes CAC http://purl.obolibrary.org/obo/MONDO_0001531
T84 1919-1937 Disease denotes hypercoagulability http://purl.obolibrary.org/obo/MONDO_0002305
T85 2043-2051 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T86 2060-2078 Disease denotes pulmonary embolism http://purl.obolibrary.org/obo/MONDO_0005279
T87 2384-2392 Disease denotes thrombus http://purl.obolibrary.org/obo/MONDO_0000831
T88 2511-2519 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T89 2582-2590 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T90 3000-3008 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T91 3162-3170 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T92 3724-3732 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T93 3892-3900 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T124 147-148 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T125 178-183 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T126 178-183 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T127 178-183 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T128 178-183 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T129 197-198 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 234-235 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 847-848 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T132 866-873 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T133 920-921 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T134 1323-1325 http://purl.obolibrary.org/obo/PR_000010213 denotes MB
T135 1476-1477 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T136 1608-1609 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 1685-1690 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T138 1685-1690 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T139 1861-1862 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T140 1938-1941 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T141 1987-1988 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T142 2115-2116 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T143 2382-2383 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T144 2409-2414 http://www.ebi.ac.uk/efo/EFO_0000825 denotes valve
T145 2466-2467 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T146 2534-2535 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T147 2552-2553 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T148 2975-2996 http://purl.obolibrary.org/obo/UBERON_0004535 denotes cardiovascular system
T149 2975-2996 http://www.ebi.ac.uk/efo/EFO_0000791 denotes cardiovascular system
T150 3193-3196 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T151 3448-3449 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T38 692-695 Chemical denotes Guo http://purl.obolibrary.org/obo/CHEBI_16750
T39 794-801 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T40 866-873 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T41 2487-2489 Chemical denotes LV http://purl.obolibrary.org/obo/CHEBI_73579
T42 2881-2883 Chemical denotes LV http://purl.obolibrary.org/obo/CHEBI_73579
T43 3839-3841 Chemical denotes LV http://purl.obolibrary.org/obo/CHEBI_73579

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T6 954-966 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T7 1320-1325 http://purl.obolibrary.org/obo/GO_0004111 denotes CK-MB

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T135 0-10 Sentence denotes Discussion
T136 11-87 Sentence denotes We found several cardiac manifestations in subjects with confirmed COVID-19.
T137 88-277 Sentence denotes One subject had ventricular concentric remodeling, one had a tricuspid vegetation and two heart failure with a reduced ejection fraction (one was a young patient with no other comorbidity).
T138 278-360 Sentence denotes Also, subjects available for GLS analysis showed signs of ventricular dysfunction.
T139 361-454 Sentence denotes Several recent studies have explored the relationship between COVID-19 and myocardial damage.
T140 455-651 Sentence denotes Two recent studies have reported increased mortality in subjects with an elevation in hs-troponins, and have proposed cardiac injury as an independent risk factor for mortality (hazard ratio (HR):
T141 652-665 Sentence denotes 4.26) [5, 6].
T142 666-995 Sentence denotes Importantly, the study by Guo et al [5] also showed that elevations in cardiac troponins were associated with higher C-reactive protein (CRP), D-dimer, cytokines and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, suggesting there might be a link between myocardial injury, inflammation and ventricular dysfunction.
T143 996-1084 Sentence denotes None of these trials have reported echocardiographic evidence of myocardial dysfunction.
T144 1085-1167 Sentence denotes Similar to other reports, our subjects had normal baseline levels of hs-troponins.
T145 1168-1380 Sentence denotes In this series, serial measurements of troponins or D-dimer determination were not available, but increased levels of other cardiac markers such as CK, CK-MB and myocardial dysfunction detected by TTE were found.
T146 1381-1425 Sentence denotes None of our patients had previous known CVD.
T147 1426-1583 Sentence denotes Therefore, myocardial dysfunction could represent a direct manifestation of COVID-19, and also myocardial abnormalities seen in critically ill patients [13].
T148 1584-1700 Sentence denotes One of our patients had a tricuspid vegetation, severe tricuspid regurgitation and repeated negative blood cultures.
T149 1701-1834 Sentence denotes Interestingly, previous reports in subjects with SARS-CoV infection show the presence of endocarditis with marantic vegetations [14].
T150 1835-2088 Sentence denotes Recently, the presence of a COVID-19-associated coagulopathy (CAC) characterized by hypercoagulability has been proposed, and recent studies have found a presence of thrombotic events in 31% of subjects with COVID-19, mainly pulmonary embolism [15, 16].
T151 2089-2287 Sentence denotes We were unable to perform a pathologic evaluation of our subject’s vegetation for this report, and computed tomography (CT)-pulmonary angiography was not available because of his clinical condition.
T152 2288-2423 Sentence denotes Although all of our subjects were receiving thromboprophylaxis, the possibility of this being a thrombus attached to the valve remains.
T153 2424-2533 Sentence denotes Currently, the impact on the prognosis of a diminished LVEF or LV GLS in subjects with COVID-19 is not clear.
T154 2534-2846 Sentence denotes A recent study in a cohort of 120 subjects with COVID-19, found that tricuspid annular plane systolic excursion (TAPSE) and right ventricular GLS were significantly related to mortality, even though the values found in deceased subjects were within normal reference values, like the patients here presented [17].
T155 2847-2888 Sentence denotes No information is presented about LV GLS.
T156 2889-3009 Sentence denotes More research is urgently needed to elucidate the pathophysiological affection of the cardiovascular system in COVID-19.
T157 3010-3180 Sentence denotes Tools for the detection of high-risk subjects for management and resource allocation are vital, considering the strain of health systems because of the COVID-19 pandemic.
T158 3181-3217 Sentence denotes This report has several limitations.
T159 3218-3400 Sentence denotes First, image acquisition in these subjects is difficult: PPE is required to minimize exposure of all the personnel involved, and all equipments need to be sterilized between studies.
T160 3401-3487 Sentence denotes Currently, the use of TTE must be evaluated on a case-by-case basis at every location.
T161 3488-3561 Sentence denotes Second, we were not able to obtain D-dimer values or CT for our subjects.
T162 3562-3593 Sentence denotes Also, our sample size is small.
T163 3594-3733 Sentence denotes Finally, even though none of our subjects had previous known CVD, some of the findings we report could predate the acquisition of COVID-19.
T164 3734-3785 Sentence denotes However, amid this pandemic, the data are of value.
T165 3786-3877 Sentence denotes In conclusion, all of our subjects showed an altered LV function, assessed by LVEF and GLS.
T166 3878-3999 Sentence denotes Subjects with COVID-19 present several types of myocardial dysfunction assessed by TTE, even in the absence of prior CVD.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T48 178-191 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T49 199-224 Phenotype denotes reduced ejection fraction http://purl.obolibrary.org/obo/HP_0012664
T50 1639-1662 Phenotype denotes tricuspid regurgitation http://purl.obolibrary.org/obo/HP_0005180
T51 1790-1802 Phenotype denotes endocarditis http://purl.obolibrary.org/obo/HP_0100584
T52 1883-1895 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T53 1897-1900 Phenotype denotes CAC http://purl.obolibrary.org/obo/HP_0003256
T54 1919-1937 Phenotype denotes hypercoagulability http://purl.obolibrary.org/obo/HP_0100724
T55 2060-2078 Phenotype denotes pulmonary embolism http://purl.obolibrary.org/obo/HP_0002204

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
201 242-249 Species denotes patient Tax:9606
202 78-86 Disease denotes COVID-19 MESH:C000657245
203 104-137 Disease denotes ventricular concentric remodeling MESH:D020257
204 178-191 Disease denotes heart failure MESH:D006333
205 336-359 Disease denotes ventricular dysfunction MESH:D018754
217 783-801 Gene denotes C-reactive protein Gene:1401
218 803-806 Gene denotes CRP Gene:1401
219 423-431 Disease denotes COVID-19 MESH:C000657245
220 436-453 Disease denotes myocardial damage MESH:D009202
221 498-507 Disease denotes mortality MESH:D003643
222 573-587 Disease denotes cardiac injury MESH:D006331
223 622-631 Disease denotes mortality MESH:D003643
224 935-952 Disease denotes myocardial injury MESH:D009202
225 954-966 Disease denotes inflammation MESH:D007249
226 971-994 Disease denotes ventricular dysfunction MESH:D018754
227 1061-1083 Disease denotes myocardial dysfunction MESH:D009202
248 1316-1318 Gene denotes CK Gene:51727
249 1393-1401 Species denotes patients Tax:9606
250 1569-1577 Species denotes patients Tax:9606
251 1595-1603 Species denotes patients Tax:9606
252 1330-1352 Disease denotes myocardial dysfunction MESH:D009202
253 1421-1424 Disease denotes CVD MESH:D002318
254 1437-1459 Disease denotes myocardial dysfunction MESH:D009202
255 1502-1510 Disease denotes COVID-19 MESH:C000657245
256 1521-1545 Disease denotes myocardial abnormalities MESH:D009202
257 1554-1568 Disease denotes critically ill MESH:D016638
258 1639-1662 Disease denotes tricuspid regurgitation MESH:D014262
259 1750-1768 Disease denotes SARS-CoV infection MESH:C000657245
260 1790-1802 Disease denotes endocarditis MESH:D004696
261 1863-1871 Disease denotes COVID-19 MESH:C000657245
262 1883-1895 Disease denotes coagulopathy MESH:D001778
263 1919-1937 Disease denotes hypercoagulability MESH:D019851
264 2001-2011 Disease denotes thrombotic MESH:D013927
265 2043-2051 Disease denotes COVID-19 MESH:C000657245
266 2060-2078 Disease denotes pulmonary embolism MESH:D011655
267 2384-2392 Disease denotes thrombus MESH:D013927
274 2817-2825 Species denotes patients Tax:9606
275 2511-2519 Disease denotes COVID-19 MESH:C000657245
276 2582-2590 Disease denotes COVID-19 MESH:C000657245
277 2710-2719 Disease denotes mortality MESH:D003643
278 3000-3008 Disease denotes COVID-19 MESH:C000657245
279 3162-3170 Disease denotes COVID-19 MESH:C000657245
282 3655-3658 Disease denotes CVD MESH:D002318
283 3724-3732 Disease denotes COVID-19 MESH:C000657245
287 3892-3900 Disease denotes COVID-19 MESH:C000657245
288 3926-3948 Disease denotes myocardial dysfunction MESH:D009202
289 3995-3998 Disease denotes CVD MESH:D002318

2_test

Id Subject Object Predicate Lexical cue
32595812-32211816-18405866 662-663 32211816 denotes 6
32595812-30521759-18405867 1579-1581 30521759 denotes 13
32595812-14736283-18405868 1830-1832 14736283 denotes 14
32595812-32302453-18405869 2084-2086 32302453 denotes 16