PMC:7294857 / 7394-9641 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7294857","sourcedb":"PMC","sourceid":"7294857","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7294857","text":"Table 1 Some of the studies included in the review\nARDS, acute respiratory distress syndrome\n[9-13]\nAuthor, Year of study Type of the study Purpose of the study Result/ Conclusion\nLi T (2020) Recommendation To give comprehensive recommendations about Severe Acute Respiratory Syndrome Corona-virus 2 (COVID-19).   A combination of anti-virals Lopinavir/Ritonavir is useful in some cases and can be used as needed. When a patient develops ARDS, A protective ventilation strategy should be used, and when it is severe, the authors recommended extracorporeal membrane oxygenation.\nArabi et al. (2020) Review article This review summarized the knowledge about management of adult acute respiratory infections and community-acquired viral pneumonia patients that needed ICU.   More research and studies are needed to test different antiviral therapies both alone and in combination, to find the best option in patients who develop serious complications.\nLu H. (2020) Review article This study reviewed the literature to identify which drug can be a suitable option in COVID -19 infection There are no specific antiviral drugs available and no vaccines for novel coronavirus. Based on previous experience with SARS and MERS, some antivirals are being used. However, their safety is yet to be established. The mainstay of treatment still is symptomatic support.\nLim et al. (2020) Case Report This case report reviewed the clinical findings and management in one of the patients of COVID-19, who was the first case of the tertiary spread of the virus out of China.   COVID-19 symptoms can be mild, and the patient may recover when the symptoms are mild but can transmit the disease. Lopinavir/Ritonavir combination reduced viral load and improved symptoms, so this combination can be used in high-risk patients. However, more clinical evidence is needed to establish its safety and efficacy.\nWang, Chao, et al. (2020) Case series Four patients with mild or severe COVID-19 improved after using lopinavir/ritonavir combination.   Three out of four patients improved clinically, especially their pneumonia-related symptoms, whereas others also showed significant improvement. 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