PMC:7294857 / 25622-26987
Annnotations
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T292 | 0-6 | UBERON:0002405 | denotes | Immune |
T293 | 17-22 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
T294 | 24-35 | CHEBI:3638;CHEBI:3638;DG_10 | denotes | Chloroquine |
T295 | 40-58 | CHEBI:5801;CHEBI:5801;DG_20 | denotes | hydroxychloroquine |
T296 | 64-70 | UBERON:0002405 | denotes | immune |
T297 | 81-86 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
T298 | 95-108 | CHEBI:35718;CHEBI:35718 | denotes | antimalarials |
T299 | 161-171 | UBERON:0002405 | denotes | autoimmune |
T300 | 216-220 | SP_10 | denotes | SARS |
T301 | 252-260 | SP_7 | denotes | COVID-19 |
T302 | 323-327 | CHEBI:36044;CHEBI:36044 | denotes | drug |
T303 | 505-511 | NCBITaxon:10239 | denotes | virals |
T304 | 517-527 | DG_28 | denotes | remdesivir |
T305 | 529-540 | NCBITaxon:31032;DG_17;CHEBI:119915;CHEBI:119915 | denotes | favipiravir |
T306 | 542-551 | DG_29;CHEBI:63580;CHEBI:63580 | denotes | ribavirin |
T307 | 552-563 | CHEBI:7956;CHEBI:7956 | denotes | penciclovir |
T308 | 569-580 | DG_10;CHEBI:3638;CHEBI:3638 | denotes | chloroquine |
T309 | 593-604 | DG_10;CHEBI:3638;CHEBI:3638 | denotes | chloroquine |
T310 | 609-619 | DG_28 | denotes | remdesivir |
T311 | 643-651 | SP_7 | denotes | COVID-19 |
T312 | 652-657 | NCBITaxon:10239 | denotes | virus |
T313 | 788-799 | CHEBI:3638;DG_10;CHEBI:3638 | denotes | chloroquine |
T314 | 869-878 | UBERON:0002048 | denotes | pneumonia |
T315 | 955-966 | CHEBI:3638;DG_10;CHEBI:3638 | denotes | Chloroquine |
T316 | 981-986 | NCBITaxon:10239 | denotes | viral |
T317 | 991-997 | UBERON:0002405 | denotes | immune |
T318 | 998-1008 | GO:0065007 | denotes | modulating |
T319 | 1070-1075 | NCBITaxon:10239;GO:0006260 | denotes | viral |
T320 | 1076-1087 | GO:0006260 | denotes | replication |
T321 | 1105-1116 | CHEBI:3638;DG_10;CHEBI:3638 | denotes | Chloroquine |
T322 | 1249-1256 | UBERON:0000948 | denotes | cardiac |
T44145 | 0-6 | UBERON:0002405 | denotes | Immune |
T15116 | 17-22 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
T21588 | 24-35 | CHEBI:3638;CHEBI:3638;DG_10 | denotes | Chloroquine |
T12774 | 40-58 | CHEBI:5801;CHEBI:5801;DG_20 | denotes | hydroxychloroquine |
T37913 | 64-70 | UBERON:0002405 | denotes | immune |
T61670 | 81-86 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
T62043 | 95-108 | CHEBI:35718;CHEBI:35718 | denotes | antimalarials |
T71098 | 161-171 | UBERON:0002405 | denotes | autoimmune |
T21156 | 216-220 | SP_10 | denotes | SARS |
T73764 | 252-260 | SP_7 | denotes | COVID-19 |
T76043 | 323-327 | CHEBI:36044;CHEBI:36044 | denotes | drug |
T22651 | 505-511 | NCBITaxon:10239 | denotes | virals |
T89411 | 517-527 | DG_28 | denotes | remdesivir |
T19427 | 529-540 | NCBITaxon:31032;DG_17;CHEBI:119915;CHEBI:119915 | denotes | favipiravir |
T89240 | 542-551 | DG_29;CHEBI:63580;CHEBI:63580 | denotes | ribavirin |
T7482 | 552-563 | CHEBI:7956;CHEBI:7956 | denotes | penciclovir |
T88094 | 569-580 | DG_10;CHEBI:3638;CHEBI:3638 | denotes | chloroquine |
T9950 | 593-604 | DG_10;CHEBI:3638;CHEBI:3638 | denotes | chloroquine |
T25430 | 609-619 | DG_28 | denotes | remdesivir |
T24476 | 643-651 | SP_7 | denotes | COVID-19 |
T450 | 652-657 | NCBITaxon:10239 | denotes | virus |
T50230 | 788-799 | CHEBI:3638;DG_10;CHEBI:3638 | denotes | chloroquine |
T17438 | 869-878 | UBERON:0002048 | denotes | pneumonia |
T98859 | 955-966 | CHEBI:3638;DG_10;CHEBI:3638 | denotes | Chloroquine |
T85193 | 981-986 | NCBITaxon:10239 | denotes | viral |
T86116 | 991-997 | UBERON:0002405 | denotes | immune |
T98779 | 998-1008 | GO:0065007 | denotes | modulating |
T41142 | 1070-1075 | NCBITaxon:10239;GO:0006260 | denotes | viral |
T80186 | 1076-1087 | GO:0006260 | denotes | replication |
T99214 | 1105-1116 | CHEBI:3638;DG_10;CHEBI:3638 | denotes | Chloroquine |
T59912 | 1249-1256 | UBERON:0000948 | denotes | cardiac |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T127 | 128-148 | Disease | denotes | Rheumatoid Arthritis | http://purl.obolibrary.org/obo/MONDO_0008383 |
T128 | 161-180 | Disease | denotes | autoimmune diseases | http://purl.obolibrary.org/obo/MONDO_0007179 |
T129 | 186-191 | Disease | denotes | Lupus | http://purl.obolibrary.org/obo/MONDO_0004670 |
T130 | 216-220 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T131 | 221-230 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T132 | 252-260 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T133 | 643-651 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T134 | 869-878 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T170 | 117-118 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T171 | 296-297 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T172 | 461-468 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
T173 | 652-657 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T174 | 967-970 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T68 | 17-22 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T69 | 24-35 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T70 | 40-58 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
T71 | 81-86 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T72 | 95-108 | Chemical | denotes | antimalarials | http://purl.obolibrary.org/obo/CHEBI_38068 |
T73 | 313-327 | Chemical | denotes | antiviral drug | http://purl.obolibrary.org/obo/CHEBI_36044 |
T74 | 313-322 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T75 | 323-327 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T76 | 517-527 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
T77 | 529-540 | Chemical | denotes | favipiravir | http://purl.obolibrary.org/obo/CHEBI_134722 |
T78 | 542-551 | Chemical | denotes | ribavirin | http://purl.obolibrary.org/obo/CHEBI_63580 |
T79 | 552-563 | Chemical | denotes | penciclovir | http://purl.obolibrary.org/obo/CHEBI_7956 |
T80 | 569-580 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T81 | 593-604 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T82 | 609-619 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
T83 | 788-799 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T84 | 955-966 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T85 | 1105-1116 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T86 | 1347-1352 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T86 | 130-150 | Phenotype | denotes | eumatoid Arthritis a | http://purl.obolibrary.org/obo/HP_0001370 |
T87 | 163-182 | Phenotype | denotes | toimmune diseases l | http://purl.obolibrary.org/obo/HP_0002960 |
T88 | 871-880 | Phenotype | denotes | eumonia, | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T19 | 1070-1087 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T20 | 1070-1087 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T213 | 0-23 | Sentence | denotes | Immune modulator drugs: |
T214 | 24-278 | Sentence | denotes | Chloroquine and hydroxychloroquine, the immune modulator drugs used as antimalarials, and as a DMARD in Rheumatoid Arthritis and also in autoimmune diseases like Lupus were found effective in SARS infection and so were tried in COVID-19 patients as well. |
T215 | 279-328 | Sentence | denotes | They also act as a broad-spectrum antiviral drug. |
T216 | 329-442 | Sentence | denotes | Several clinical trials are in progress throughout the world to assess its efficacy and safety in these patients. |
T217 | 443-672 | Sentence | denotes | An in-vitro study testing the efficacy of broad-spectrum anti-virals like remdesivir, favipiravir, ribavirin penciclovir, and chloroquine showed that chloroquine and remdesivir were effective against COVID-19 virus in-vitro [13]. |
T218 | 673-954 | Sentence | denotes | Another study involving 100 patients by Gao et al. also showed similar results; it showed an increased efficacy of chloroquine in preventing symptom exacerbation, preventing progression to severe pneumonia, and improving radiological findings without any serious side effects [26]. |
T219 | 955-1104 | Sentence | denotes | Chloroquine has both anti-viral and immune-modulating properties, which increase its effectiveness in stopping the viral replication in vivo [13,26]. |
T220 | 1105-1266 | Sentence | denotes | Chloroquine, however, is associated with some uncommon but serious side-effects like QT interval prolongation, which may be severely harmful in cardiac patients. |
T221 | 1267-1365 | Sentence | denotes | Therefore, more clinical trials are needed to assess its safety profile in this group of patients. |
TEST0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32550056-225-231-2286790 | 668-670 | ["32020029"] | denotes | 13 |
32550056-237-243-2286791 | 950-952 | ["32074550"] | denotes | 26 |
32550056-142-148-2286792 | 1097-1099 | ["32020029"] | denotes | 13 |
32550056-145-151-2286793 | 1100-1102 | ["32074550"] | denotes | 26 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32550056-32020029-23854246 | 668-670 | 32020029 | denotes | 13 |
32550056-32074550-23854247 | 950-952 | 32074550 | denotes | 26 |
32550056-32020029-23854248 | 1097-1099 | 32020029 | denotes | 13 |
32550056-32074550-23854249 | 1100-1102 | 32074550 | denotes | 26 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
644 | 261-269 | Species | denotes | patients | Tax:9606 |
645 | 433-441 | Species | denotes | patients | Tax:9606 |
646 | 643-657 | Species | denotes | COVID-19 virus | Tax:2697049 |
647 | 701-709 | Species | denotes | patients | Tax:9606 |
648 | 1257-1265 | Species | denotes | patients | Tax:9606 |
649 | 1356-1364 | Species | denotes | patients | Tax:9606 |
650 | 24-35 | Chemical | denotes | Chloroquine | MESH:D002738 |
651 | 40-58 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
652 | 517-527 | Chemical | denotes | remdesivir | MESH:C000606551 |
653 | 529-540 | Chemical | denotes | favipiravir | MESH:C462182 |
654 | 542-551 | Chemical | denotes | ribavirin | MESH:D012254 |
655 | 552-563 | Chemical | denotes | penciclovir | MESH:C053539 |
656 | 569-580 | Chemical | denotes | chloroquine | MESH:D002738 |
657 | 593-604 | Chemical | denotes | chloroquine | MESH:D002738 |
658 | 609-619 | Chemical | denotes | remdesivir | MESH:C000606551 |
659 | 788-799 | Chemical | denotes | chloroquine | MESH:D002738 |
660 | 955-966 | Chemical | denotes | Chloroquine | MESH:D002738 |
661 | 1105-1116 | Chemical | denotes | Chloroquine | MESH:D002738 |
662 | 128-148 | Disease | denotes | Rheumatoid Arthritis | MESH:D001172 |
663 | 161-180 | Disease | denotes | autoimmune diseases | MESH:D001327 |
664 | 216-220 | Disease | denotes | SARS | MESH:D045169 |
665 | 221-230 | Disease | denotes | infection | MESH:D007239 |
666 | 252-260 | Disease | denotes | COVID-19 | MESH:C000657245 |
667 | 869-878 | Disease | denotes | pneumonia | MESH:D011014 |